CN107823553A - 一种治疗乳腺癌的胶囊剂药物及制备方法 - Google Patents
一种治疗乳腺癌的胶囊剂药物及制备方法 Download PDFInfo
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Abstract
本发明属于中药制剂领域,目的是根据中医治疗乳腺癌的认识机理而提供一种治疗乳腺癌的胶囊剂药物,所述药物的各个组分及其质量份比如下:败酱草60~160g、王不留行80~160g、当归80~180g、川芎30~120g、党参60~160g、莪术30~120g、白僵蚕30~120g、夏枯草60~180g、黄芪150~360g、红藤100~360g、甘草50~150g,辅料:淀粉适量;本发明提供的药物是一个很好的中药组方。
Description
技术领域
本发明属于中药制剂领域,具体涉及一种治疗乳腺癌的胶囊剂药物,特别是供乳腺癌患者使用的胶囊剂药物及制备方法的领域。
背景技术
据有关文献显示:女性乳腺是由皮肤、纤维组织、乳腺腺体和脂肪组成的,乳腺癌是发生在乳腺腺上皮组织的恶性肿瘤。乳腺癌中99%发生在女性,男性仅占1%。
乳腺并不是维持人体生命活动的重要器官,原位乳腺癌并不致命;但由于乳腺癌细胞丧失了正常细胞的特性,细胞之间连接松散,容易脱落。癌细胞一旦脱落,游离的癌细胞可以随血液或淋巴液播散全身,形成转移,危及生命。目前乳腺癌已成为威胁女性身心健康的常见肿瘤。
全球乳腺癌发病率自20世纪70年代末开始一直呈上升趋势。美国8名妇女一生中就会有1人患乳腺癌。中国不是乳腺癌的高发国家,但不宜乐观,近年我国乳腺癌发病率的增长速度却高出高发国家1~2个百分点。据国家癌症中心和卫生部疾病预防控制局2012年公布的2009年乳腺癌发病数据显示:全国肿瘤登记地区乳腺癌发病率位居女性恶性肿瘤的第1位,女性乳腺癌发病率(粗率)全国合计为42.55/10万,城市为51.91/10万,农村为23.12/10万。
那么,就如何找到一种可有效治疗乳腺癌的中药组合物,是本领域技术人员亟待要解决的问题。
发明内容
随着我国中医中药学的不断发展,在治疗乳腺癌上,人们逐渐意识到了中医治疗乳腺癌的优点,且在治疗过程中疗效好、见效快、毒副作用小等优势,针对现有西医治疗乳腺癌的现状,本发明的目的是在于提供一种治疗乳腺癌的胶囊剂药物,以解决乳腺癌患者早日恢复健康和延长生存期的问题。该药物是以常见的中药为原料,通过选择合理的药物及质量份比,可有效治疗上述乳腺癌。
为达到上述发明的目的,本发明所采用的技术方案为:提供一种治疗乳腺癌的胶囊剂药物及制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
败酱草60~160g、王不留行80~160g、当归80~180g、川芎30~120g、党参60~160g、莪术30~120g、白僵蚕30~120g、夏枯草60~180g、黄芪150~360g、红藤100~360g、甘草50~150g,辅料:淀粉适量。
一种治疗乳腺癌的胶囊剂药物及制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
败酱草70~140g、王不留行90~140g、当归90~160g、川芎38~105g、党参70~140g、莪术38~105g、白僵蚕38~105g、夏枯草70~160g、黄芪180~320g、红藤115~320g、甘草58~130g,辅料:淀粉适量。
一种治疗乳腺癌的胶囊剂药物及制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
败酱草130g、王不留行130g、当归140g、川芎95g、党参1240g、莪术95g、白僵蚕95g、夏枯草140g、黄芪260g、红藤260g、甘草118g,辅料:淀粉适量。
一种治疗乳腺癌的胶囊剂药物及制备方法,其特征在于,所述方法包括如下步骤制备而成:
A、将上述原料中药拣去杂质和粉尘后,按照质量份比分别粉碎成粗粒状包煎;
B、将包好的原料中药放入冷开水中浸泡35min后,再将浸泡好的药物放入砂锅内煎煮三次:①加水量为药材总量的9~10倍,先进行武火煎煮,待煎煮到15min时,转文火熬制110min,滤取药液;②加水量为干药渣总量的8~9 倍,先进行武火煎煮,待煎煮到10min时,转文火熬制100 min,滤取药液;③加水量为干药渣总量的7~8 倍,先进行武火煎煮,待煎煮到8min时,转文火熬制90 min,滤取药液;④合并三次药液,并减压浓缩至每毫升含生药3g的标准后,即得到药物浸膏。
C、将上述“B”中制备好的浸膏干燥、消毒,并按照质量份比共研为极细末备用;
D、按照传统的常规工艺及辅料制备中药胶囊剂的方法,将“C”中研磨好的极细末药物过筛后,和辅料一并放入药器中混合均匀,然后制备成胶囊剂(其胶囊锁合后的总长度为23.3mm,药粉容量0.4~0.5g/粒),继而抛光、分装密封即可。
一种治疗乳腺癌的胶囊剂药物及制备方法,其特征在于,所述服用方法为:将制备好的胶囊剂药物以每日三次服用,早中晚各服一次,给药量2g(5粒)/次,温开水送服。21天为一个疗程,服药2~4个疗程后,症状全部缓解:肿瘤消失,病获痊愈。半年后随访,未再见复异常。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料,充分发挥各组分的药理功效:
王不留行,性味:苦、平,具有行血通经、催生下乳、消肿敛疮之功效,用于治疗妇女经闭、乳汁不通、难产、血淋、金疮出血、通经下乳、活血消肿、瘀血肿块、疮痈肿毒;
当归,性味:味甘、辛、微苦、性温,具有补血和血、调经止痛、润燥滑肠之功效,用于治疗月经不调、经闭腹痛、癥瘕结聚、崩漏、血虚头痛、眩晕、痿痹、肠燥便难、赤痢后重、痈疽疮窃、跌扑损伤等病症;
川芎,性味:味辛、性温,具有活血祛瘀、行气开郁、祛风止痛之功效,用于治疗月经不调、经闭痛经、产后瘀滞腥痛、症瘕肿块、胸胁疼痛、头痛眩晕、风寒湿痹、跌打损伤、痈疽疮疡;
党参,性味:味甘、性平,具有健脾补肺、益气生津之功效,用于治疗脾胃虚弱、食少便溏、四肢乏力、肺虚喘咳、气短自汗、气微两亏诸证;
莪术,性味:苦辛、温,具有破血行气,消积止痛之功效,用于治疗血气心痛、饮食积滞、脘腹胀痛、血滞经闭、痛经、症瘕瘤痞块、跌打损伤,还用于血瘀腹痛、肝脾肿大、心腹胀痛、积聚、症瘕肿块、妇女血瘀经闭、跌打损伤作痛饮食积滞,现代药理学表明茵陈具有抗肿瘤作用:其莪术油制剂在体外对小鼠艾氏腹水癌细胞、615 纯系小鼠的L615 白血病及腹水型肝癌细胞等多种瘤株的生长有明显抑制和破坏作用。临床以莪术油作瘤内注射治疗宫颈癌,治疗后可见瘤组织坏死脱落,局部淋巴细胞浸润,部分病例肿块消失,宫颈光滑,提示莪术有直接杀瘤细胞的作用;
白僵蚕,性味:味辛、咸、性平,具有祛风止痉、化痰散结、解毒利咽之功效,用于治疗惊痫抽搐、中风口歪、眼斜、偏正头痛、咽喉肿痛、瘰疬、痄腮、风疹、疮毒等症;
夏枯草,性味:味苦、辛、性寒,具有清肝明目、散结解毒之功效,用于治疗目亦羞明、目珠疼痛、头痛眩晕、耳鸣、瘰疬、瘿瘤、乳痈、痄腮、痈疖肿毒、急、慢性肝炎、高血压病;
黄芪,性味:甘、微温,具有补气固表、利尿托毒、排脓、敛疮生肌之功效,用于治疗气虚乏力、食少便溏、中气下陷、久泻脱肛、便血崩漏、表虚自汗、气虚水肿、痈疽难溃、久溃不敛、血虚痿黄、内热消渴、慢性肾炎蛋白尿、糖尿病等症;
红藤,性味:苦平,具有清热解毒、活血散瘀、祛风杀虫之功效,用于治疗肠痈腹痛、风湿痹痛、跌打伤痛、妇女痛经、赤痢、血淋、疳积虫痛等症;
甘草,性味:甘、平,具有益气补中、缓急止痛、润肺止咳、泻火解毒、调和诸药之功效,用于治疗倦怠食少、肌瘦面黄、心悸气短、腹痛便溏、四肢挛急疼痛、脏躁、咳嗽气喘、咽喉肿痛、痈疮肿痛、小儿胎毒及药物、食物中毒等症。
本发明药物是基于中医治疗乳腺癌的原则,从依据乳腺癌的病理机制及药理作用认为:就乳腺癌,本发明所提供的药物中的各原料中药药效共奏,对上述疾病有很好的治疗效果。
具体实施方式
本发明就是针对上述乳腺癌的治疗而提出的一种中药配方,采用该配方制备的药物药效好,见效快,是一个很好的中药组方,特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述:
实施例1:
一种治疗乳腺癌的胶囊剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
败酱草130g、王不留行130g、当归140g、川芎95g、党参1240g、莪术95g、白僵蚕95g、夏枯草140g、黄芪260g、红藤260g、甘草118g,辅料:淀粉适量。
实施例2:
一种治疗乳腺癌的胶囊剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
败酱草140g、王不留行140g、当归160g、川芎105g、党参140g、莪术105g、白僵蚕105g、夏枯草160g、黄芪320g、红藤320g、甘草130g,辅料:淀粉适量。
实施例3:
一种治疗乳腺癌的胶囊剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
败酱草160g、王不留行160g、当归180g、川芎120g、党参160g、莪术120g、白僵蚕120g、夏枯草180g、黄芪360g、红藤360g、甘草150g,辅料:淀粉适量。
典型病例
经临床诊断治疗乳腺癌患者共860例,年龄为36岁以上的530例,只有330例为36岁以下。860例患者中痊愈和延长生存期的有189例,有效的327例,无效的344例。总有效率达60%。
Claims (3)
1.一种治疗乳腺癌的胶囊剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
败酱草60~160g、王不留行80~160g、当归80~180g、川芎30~120g、党参60~160g、莪术30~120g、白僵蚕30~120g、夏枯草60~180g、黄芪150~360g、红藤100~360g、甘草50~150g,辅料:淀粉适量。
2.根据权利要求1所述的治疗乳腺癌的胶囊剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
败酱草70~140g、王不留行90~140g、当归90~160g、川芎38~105g、党参70~140g、莪术38~105g、白僵蚕38~105g、夏枯草70~160g、黄芪180~320g、红藤115~320g、甘草58~130g,辅料:淀粉适量。
3.根据权利要求1至2所述的治疗乳腺癌的胶囊剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
败酱草130g、王不留行130g、当归140g、川芎95g、党参1240g、莪术95g、白僵蚕95g、夏枯草140g、黄芪260g、红藤260g、甘草118g,辅料:淀粉适量。
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