CN106798888A - 一种治疗心肌缺血及心悸怔忡病证的丸剂药物及制备方法 - Google Patents

一种治疗心肌缺血及心悸怔忡病证的丸剂药物及制备方法 Download PDF

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CN106798888A
CN106798888A CN201710093129.5A CN201710093129A CN106798888A CN 106798888 A CN106798888 A CN 106798888A CN 201710093129 A CN201710093129 A CN 201710093129A CN 106798888 A CN106798888 A CN 106798888A
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root
radix
palpitation
disease
medicine
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孙素蓉
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Chengdu Fengmi Biotechnology Co Ltd
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Chengdu Fengmi Biotechnology Co Ltd
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Abstract

本发明属于中药制剂领域，目的是根据中医对心肌缺血及心悸怔忡病证的认识机理而提供的一种治疗心肌缺血及心悸怔忡病证的丸剂药物，所述药物的各个组分及其质量份比如下：党参200g、白芍165g、当归120g、陈皮100g、香附120g、郁金90g、山茱萸（去核）90g、生黄芪480g、西洋参50g、山药250g、肉桂40g、甘草115g、石菖蒲50g、安息香14g、杜仲120g、远志120g、熟地黄260g、何首乌170g、沙参120g、茯苓120g、石斛120g、玉竹95g、天门冬120g、酸枣仁200g、丹参120g、红花95g、桃仁120g、川芎95g、神曲120g、麦芽120g、人参120g、白术120g、苏合香8g、冰片4g、蟾酥2g、生地黄12g、牡蛎280g、合欢皮120g、柏子仁120g、夜交藤170g、灵芝120g；本发明提供的药物是一个标本兼治的中药组方。

Description

一种治疗心肌缺血及心悸怔忡病证的丸剂药物及制备方法
技术领域
本发明属于中药制剂领域，具体涉及一种治疗心肌缺血及心悸怔忡病证的丸剂药物，特别是供心肌缺血及心悸怔忡病证患者使用的丸剂药物及制备方法的领域。
背景技术
医者认为：心肌缺血（myocardial ischemia）是指心脏的血液灌注减少，导致心脏的供氧减少，心肌能量代谢不正常，不能支持心脏正常工作的一种病理状态。心脏活动所需要的能量几乎完全靠有氧代谢提供，所以即便在安静的时候，心肌的血氧摄取率也很高（约为70%），正常情况下，机体可通过自身调节，促使血液供需相对恒定，保证心脏正常工作。当某种原因导致心肌血液供需失衡，就构成了真正意义上的心肌缺血。而冠心病是引起心肌缺血最主要、最常见的病因。随着人民生活水平的提高，目前心肌缺血在我国的患病率呈逐年上升的趋势，已成为中老年人的常见病和多发病，但也有一些20～30岁的年轻人也出现心肌缺血的表现。
怔忡为病名，首见于《济生方·惊悸怔忡健忘门》中“惊者，心卒动而不宁也；悸者,心跳动而怕惊也；怔忡者，心中躁动不安，惕惕然后人将捕之也”,是心悸的一种，是指多因久病体虚、心脏受损导致气血、阴阳亏虚，或邪毒、痰饮、瘀血阻滞心脉，日久导致心失濡养，心脉不畅，从而引起的心中剔剔不安，不能自控的一种病证，常和惊悸合并称为心悸。
那么，就如何找到一种可有效治疗上述心肌缺血及心悸怔忡病证的中药组合物，是本领域技术人员亟待要解决的问题。
发明内容
随着我国中医中药学的不断发展，在治疗心肌缺血及心悸怔忡病证上，人们逐渐意识到了中医治疗心肌缺血及心悸怔忡病证的优点，且在治疗过程中疗效好、见效快、毒副作用小等优势，针对现有西医治疗心肌缺血及心悸怔忡病证的现状，本发明的目的是在于提供一种治疗心肌缺血及心悸怔忡病证的丸剂药物，以解决心肌缺血及心悸怔忡病证患者早日恢复健康的问题。该药物是以常见的中药为原料，通过选择合理的药物及质量份比，可有效治疗心肌缺血及心悸怔忡病证。
为达到上述发明的目的，本发明所采用的技术方案为：提供一种治疗心肌缺血及心悸怔忡病证的丸剂药物及制备方法，其特征在于，所述药物的各个组分及其质量份比如下所示：
党参150～260g、白芍100～220g、当归80～160g、陈皮30～130g、香附80～160g、郁金30～120g、山茱萸（去核）60～120g、生黄芪100～660g、西洋参30～70g、山药150～320g、肉桂20～60g、甘草30～150g、石菖蒲30～70g、安息香3～18g、杜仲60～160g、远志50～160g、熟地黄100～350g、何首乌100～220g、沙参100～160g、茯苓100～160g、石斛60～160g、玉竹60～120g、天门冬60～160g、酸枣仁100～260g、丹参80～160g、红花50～120g、桃仁80～160g、川芎50～120g、神曲100～160g、麦芽100～160g、人参30～160g、白术30～160g、苏合香3～10g、冰片2～5g、蟾酥1.5～3g、生地黄9～16g、牡蛎150～360g、合欢皮100～160g、柏子仁100～160g、夜交藤100～220g、灵芝100～160g。
一种治疗心肌缺血及心悸怔忡病证的丸剂药物及制备方法，其特征在于，所述药物的各个组分及其质量份比如下所示：
党参170～230g、白芍115～190g、当归90～140g、陈皮40～115g、香附90～140g、郁金40～105g、山茱萸（去核）70～105g、生黄芪115～560g、西洋参40～60g、山药170～280g、肉桂30～50g、甘草40～135g、石菖蒲40～60g、安息香6～16g、杜仲70～140g、远志60～140g、熟地黄115～300g、何首乌115～200g、沙参115～140g、茯苓115～140g、石斛70～140g、玉竹70～105g、天门冬70～140g、酸枣仁115～230g、丹参90～140g、红花60～105g、桃仁90～140g、川芎60～105g、神曲115～140g、麦芽115～140g、人参40～140g、白术40～140g、苏合香5～9g、冰片3～4.5g、蟾酥1.8～2.5g、生地黄10～14g、牡蛎170～320g、合欢皮115～140g、柏子仁115～140g、夜交藤115～200g、灵芝115～140g。
一种治疗心肌缺血及心悸怔忡病证的丸剂药物及制备方法，其特征在于，所述“最佳方案”的药物的各个组分及其质量份比如下所示：
党参200g、白芍165g、当归120g、陈皮100g、香附120g、郁金90g、山茱萸（去核）90g、生黄芪480g、西洋参50g、山药250g、肉桂40g、甘草115g、石菖蒲50g、安息香14g、杜仲120g、远志120g、熟地黄260g、何首乌170g、沙参120g、茯苓120g、石斛120g、玉竹95g、天门冬120g、酸枣仁200g、丹参120g、红花95g、桃仁120g、川芎95g、神曲120g、麦芽120g、人参120g、白术120g、苏合香8g、冰片4g、蟾酥2g、生地黄12g、牡蛎280g、合欢皮120g、柏子仁120g、夜交藤170g、灵芝120g。
一种治疗心肌缺血及心悸怔忡病证的丸剂药物及制备方法，其特征在于，所述方法包括如下步骤制备而成：
A、将上述原料中药拣去杂质、粉尘、干燥及灭菌后，按照质量份比共研为极细末待用；
B、按照传统制备中药水丸剂的方法，将研磨好的极细末药物过筛后，放入药器中混合拌均，然后制备成水丸剂（其水丸的粒度为：3.8mm～4.0mm），进而晒干，分装密封即可。
一种治疗心肌缺血及心悸怔忡病证的丸剂药物及制备方法，其特征在于，所述服用方法为：将制备好的水丸剂药物以每日三次服用，早中晚各服一次，给药量5g/次，温开水送服。一个月为一疗程，服药1～4个疗程，症状逐渐消失或痊愈。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料，充分发挥各组分的药理功效：
党参，性味：味甘、性平，具有健脾补肺、益气生津之功效，用于治疗脾胃虚弱、食少便溏、四肢乏力、肺虚喘咳、气短自汗、气微两亏等症；
白芍，性味：苦酸、凉，具有养血柔肝、缓中止痛、敛阴收汗之功效，用于治疗胸腹胁肋疼痛、泻痢腹痛、自汗盗汗、阴虚发热、月经不调、崩漏、带下等症；
当归，性味：性温、味甘辛,具有补血和血、调经止痛、润燥滑肠之功效，用于治疗血虚、面色萎黄、眩晕心悸、血虚、或兼有瘀滞的月经不调、经闭、痛经、虚寒性腹痛、冠心病心绞痛、风湿痹痛、跌打损伤；
陈皮，性味：苦、辛、温，具有理气健脾、调中、燥湿、化痰之功效，用于治疗脾胃气滞之脘腹胀满或疼痛、消化不良、湿浊阻中之胸闷腹胀、纳呆便溏、痰湿壅肺之咳嗽气喘、食少吐泻、咳嗽痰多；
香附，性味：味辛、微寒，无毒，具有理气解郁、调经止痛、安胎之功效，用于治疗胁肋胀痛、乳房胀育、疝气疼痛、月经不调、脘腹痞满疼痛、嗳气吞酸、呕恶、经行腹痛、崩漏带下、胎动不安、肝郁气滞、消化不良，经闭痛经；
郁金，性味：味辛、苦、性寒，具有活血止能、行气解郁、清心凉血、疏肝利胆之功效，用于治疗胸腹胁肋诸痛、妇女痛经、经闭、癥瘕结块、热病神昏、癫狂、惊痫、吐血、衄备、血淋、砂淋、黄疸等症；
山茱萸（去核），性味：酸、涩、微温，具有补益肝肾、涩精固脱之功效，用于治疗眩晕耳鸣、腰膝酸痛、阳痿遗精、遗尿尿频、崩漏带下、大汗虚脱、内热消渴，此外，本品又能固经止血，可用治妇女体虚、月经过多等症；
生黄芪，性味：甘、微温，具有补气固表、利尿托毒、排脓、敛疮生肌之功效，用于治疗气虚乏力、食少便溏、中气下陷、久泻脱肛、便血崩漏、表虚自汗、气虚水肿、痈疽难溃、久溃不敛、血虚痿黄、内热消渴、慢性肾炎蛋白尿、糖尿病等症；
西洋参，性味：味甘、微苦、性寒，具有补气养阴、清火生津气之功效，用于治疗虚阴专火旺、咳嗽痰血、虚热烦烦倦、内热消渴、口燥烟干等症；
山药，性味：甘、平，具有补脾、养肺、固肾、益精之功效，用于治疗脾虚泄泻、食少浮肿、肺虚咳喘、消渴、遗精、带下、肾虚尿频，外用治痈肿、瘰疬等症；
肉桂，性味：性大热、味辛、甘，具有补火助阳、引火归源、散寒止痛、活血通经之功效，用于治疗阳痿、宫冷、心腹冷痛、虚寒吐泻、经闭、痛经等症；
甘草，性味：甘、平，具有益气补中、缓急止痛、润肺止咳、泻火解毒、调和诸药之功效，用于治疗倦怠食少、肌瘦面黄、心悸气短、腹痛便溏、四肢挛急疼痛、脏躁、咳嗽气喘、咽喉肿痛、痈疮肿痛、小儿胎毒及药物、食物中毒等症；
石菖蒲，性味：味辛、苦、性微温，具有化痰开窍、化湿行气、祛风利痹、消肿止痛之功效，用于治疗热病神昏、痰厥、健忘、耳鸣、耳聋、脘腹胀痛、噤口痢、风湿痹痛、跌打损伤、痈疽疥癣；
安息香，性味：辛、苦、性平，具有平开窍醒神、豁痰辟秽、行气活血、止痛之功效，用于治疗中风痰劂、惊痫昏迷、产后血晕、心腹疼痛、风痹肢节痛；
杜仲，性味：甘、微辛、性温，具有补肝肾、强筋骨、安胎之功效，用于治疗腰脊酸疼、阳痿、尿频、小便余沥、风湿痹痛、胎动不安、习惯性流产；
远志，性味：辛、苦、性微温，具有宁心安神、祛痰开窍、解毒消肿之功效，用于治疗心神不安、惊悸失眠、健忘、惊痫、咳嗽痰多、痈疽发背、乳房肿痛；
熟地黄，性味：味甘、性温，具有补血滋润、益精填髓之功效，用于治疗血虎萎黄、眩晕心悸、月经不调、崩不止、肝肾阴亏、潮热盗汗、遗精阳痿、不育不孕、腰膝酸软、耳鸣耳聋、头目昏花、须发早白、消渴、便秘、肾虚喘促等症；
何首乌，性味：苦、甘、涩、性微温，具有养血滋阴、润肠通便、截疟、祛风、解毒之功效，用于治疗血虚头昏目眩、心悸、失眠、肝肾阴虚之腰膝酸软、须发早白、耳鸣、遗精、肠燥便秘、久疟体虚、风疹瘙痒、疮痈、瘰疬、痔疮等症；
沙参，性味：味甘、微苦、性微寒，具有养阴清热、润肺化痰、益胃生津之功效，用于治疗阴虚久咳、痨嗽痰血、燥咳痰少、虚热喉痹、津伤口渴等症；
茯苓，性味：甘、淡、平，具有利水药、渗湿利尿药之功效，用于治疗小便不利、水肿胀满、痰饮咳逆、呕吐、脾虚食少、泄泻、心悸不安、失眠健忘、遗精白浊；
石斛，性味：甘、微寒，具有生津益胃、滋阴清热、润肺益肾、明目强腰之功效，用于治疗热病伤津、口干烦渴、胃阴不足、胃痛干呕、肺燥干咳、虚热不退、阴伤目暗、腰膝软弱等症；
玉竹，性味：甘、平，具有滋阴润肺、养胃生津之功效，用于治疗燥咳、劳嗽、热病阴液耗伤之咽干口渴、内热消渴、阴虚外感、头昏眩晕、筋脉挛痛等症；
天门冬，性味：味甘、苦、性寒，具有滋阴润燥、清肺降火之功效，用于治疗燥热咳嗽、阴虚劳嗽、热病伤阴、内热消渴、肠燥便秘、咽喉肿痛等症；
酸枣仁，性味：甘、平，具有养肝、宁心、安神、敛汗之功效，用于治疗虚烦不眠、惊悸怔忡、烦渴、虚汗等症；
丹参，性味：味苦、性微寒，具有活血祛瘀、调经止痛、养血安神、凉血消痈之功效，用于治疗妇女月经不调、痛经、经闭、产后瘀滞腹痛、心腹疼痛、症瘕积聚、热痹肿痛、跌打损伤、热入营血、烦躁不安、心烦失眠、痈疮肿毒；
红花，性味：味辛、性温，具有活血能经、祛瘀止痛之功效，用于治疗经闭、痛经、产后瘀阻腹痛、胞痹心痛症瘕积聚、跌打损伤、关节疼痛、中风偏竣、斑疹等症；
桃仁，性味：苦甘、平，无毒，具有破血行瘀、润燥滑肠之功效，用于治疗经闭、癥瘕、热病蓄血、风痹、疟疾、跌打损伤、瘀血肿痛、血燥便秘等症；
川芎，性味：辛、温，具有行气开郁、法风燥湿、活血止痛之功效，用于治疗风冷头痛旋晕、胁痛腹疼、寒痹筋挛、经闭、难产、产后瘀阻块痛、痈疽疮疡、月经不调、瘕腹痛、胸胁刺痛、跌扑肿痛、风湿痹痛等症；
神曲，性味：甘、辛、温，无毒，具有健脾和胃、消食化积之功效，用于治疗饮食停滞、消化不良、脘腹胀满、食欲不振、呕吐泻痢等症；
麦芽，性味：甘、平,具有消食化积、回乳之功效，用于治疗食积不消、腹满泄泻、恶心哎吐、食欲不振、乳汁郁积、乳房胀痛；
人参，性味：甘微苦、温，具有大补元气、固脱生津、安神之功效，用于治疗劳伤虚损、食少、倦怠、反胃吐食、大便滑泄、虚咳喘促、自汗暴脱、惊悸、健忘、眩晕头痛、阳痿、尿频、消渴、妇女崩漏、小儿慢惊、及久虚不复、一切气血津液不足；
白术，性味：味苦、甘、性温，具有健脾益气、燥湿利水、止汗、安胎之功效，用于治疗脾气虚弱、神疲乏力、食少少腹胀、大便溏薄、水饮内停、小便不利、水肿、痰饮眩晕、温痹酸痛、气虚自汗、胎动不安等症；
苏合香，性味：辛、甘、温、无毒，具有通窍辟秽、开郁豁痰、行气止痛之功效，用于治疗中风、痰厥、气厥之寒闭症、温疟、惊痫、湿浊吐利、心腹卒痛以及冻疮、疥癣等症；
冰片，性味：辛、苦、微寒，具有开窍醒神、清热止痛之功效，用于治疗热病神昏、痉厥、中风痰厥、气郁暴厥、中恶昏迷、目赤、口疮、咽喉肿痛、耳道流脓等症；
蟾酥，性味：甘辛、温，有毒，具有解毒、消肿、强心、止痛之功效，用于治疗疔疮、痈疽、发背、瘰疬、慢性骨髓炎、咽喉肿痛、小儿疳积、心衰、风虫牙痛等症；
生地黄，性味：甘、寒，具有清热凉血、养阴、生津之功效，用于治疗热病舌绛烦渴、阴虚内热、骨蒸劳热、内热消渴、吐血、衄血、发斑发疹；
牡蛎，性味：味咸、性微寒，具有平肝潜阳、重镇安神、软坚散结、收敛固涩之功效，用于治疗眩晕耳鸣、惊悸失眠、瘰疬瘿瘤、癥瘕痞块、自汗盗汗、遗精、崩漏、带下等症；
合欢皮，性味：甘、平，具有安神解郁、活血消痈之功效，用于治疗心神不安、忧郁、不眠、内外痈疡、跌打损伤；
柏子仁，性味：甘、性平，具有养心安神、敛汗、润肠通便之功效，用于治疗惊悸怔忡、失眠健忘、盗汗、肠燥便秘等症；
夜交藤，性味：甘、微苦、性平，具有养心安神、祛风、通络之功效，用于治疗失眠、多梦、血虚身痛、肌肤麻木、风湿痹痛、风疹瘙痒等症；
灵芝，性味：甘、平，无毒，具有益气血、安心神、健脾胃之功效，用于治疗虚劳、心悸、失眠、头晕、神疲乏力、久咳气喘、冠心病、矽肺、肿瘤等症。
本发明药物是基于中医治疗心肌缺血及心悸怔忡病证的原则，从依据心肌缺血及心悸怔忡病证的病理机制及药理作用认为：就心肌缺血及心悸怔忡病证，本发明所提供的药物中的各原料中药药效共奏，对上述疾病有很好的治疗效果。
具体实施方式
本发明就是针对上述心肌缺血及心悸怔忡病证的治疗而提出的一种中药配方，采用该配方制备的药物药效好，见效快，是一个标本兼治的中药组方，特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述：
实施例1：
一种治疗心肌缺血及心悸怔忡病证的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
党参200g、白芍165g、当归120g、陈皮100g、香附120g、郁金90g、山茱萸（去核）90g、生黄芪480g、西洋参50g、山药250g、肉桂40g、甘草115g、石菖蒲50g、安息香14g、杜仲120g、远志120g、熟地黄260g、何首乌170g、沙参120g、茯苓120g、石斛120g、玉竹95g、天门冬120g、酸枣仁200g、丹参120g、红花95g、桃仁120g、川芎95g、神曲120g、麦芽120g、人参120g、白术120g、苏合香8g、冰片4g、蟾酥2g、生地黄12g、牡蛎280g、合欢皮120g、柏子仁120g、夜交藤170g、灵芝120g。
实施例2：
一种治疗心肌缺血及心悸怔忡病证的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
党参230g、白芍190g、当归140g、陈皮115g、香附140g、郁金105g、山茱萸（去核）105g、生黄芪560g、西洋参60g、山药280g、肉桂50g、甘草135g、石菖蒲60g、安息香16g、杜仲140g、远志140g、熟地黄300g、何首乌200g、沙参140g、茯苓140g、石斛140g、玉竹105g、天门冬140g、酸枣仁230g、丹参140g、红花105g、桃仁140g、川芎105g、神曲140g、麦芽140g、人参140g、白术140g、苏合香9g、冰片4.5g、蟾酥2.5g、生地黄14g、牡蛎320g、合欢皮140g、柏子仁140g、夜交藤200g、灵芝140g。
实施例3：
一种治疗心肌缺血及心悸怔忡病证的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
党参260g、白芍220g、当归160g、陈皮130g、香附160g、郁金120g、山茱萸（去核）120g、生黄芪660g、西洋参70g、山药320g、肉桂60g、甘草150g、石菖蒲70g、安息香18g、杜仲160g、远志160g、熟地黄350g、何首乌220g、沙参160g、茯苓160g、石斛160g、玉竹120g、天门冬160g、酸枣仁260g、丹参160g、红花120g、桃仁160g、川芎120g、神曲160g、麦芽160g、人参160g、白术160g、苏合香10g、冰片5g、蟾酥3g、生地黄16g、牡蛎360g、合欢皮160g、柏子仁160g、夜交藤220g、灵芝160g。
典型病例
经临床诊断治疗心肌缺血及心悸怔忡病证患者共930例，年龄为55岁以上的540例，只有390例为55岁以下。930例患者中痊愈的705例，有效的225例，总有效率达100%。

Claims (3)

1.一种治疗心肌缺血及心悸怔忡病证的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
党参150～260g、白芍100～220g、当归80～160g、陈皮30～130g、香附80～160g、郁金30～120g、山茱萸（去核）60～120g、生黄芪100～660g、西洋参30～70g、山药150～320g、肉桂20～60g、甘草30～150g、石菖蒲30～70g、安息香3～18g、杜仲60～160g、远志50～160g、熟地黄100～350g、何首乌100～220g、沙参100～160g、茯苓100～160g、石斛60～160g、玉竹60～120g、天门冬60～160g、酸枣仁100～260g、丹参80～160g、红花50～120g、桃仁80～160g、川芎50～120g、神曲100～160g、麦芽100～160g、人参30～160g、白术30～160g、苏合香3～10g、冰片2～5g、蟾酥1.5～3g、生地黄9～16g、牡蛎150～360g、合欢皮100～160g、柏子仁100～160g、夜交藤100～220g、灵芝100～160g。
2.根据权利要求1所述的治疗心肌缺血及心悸怔忡病证的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
党参170～230g、白芍115～190g、当归90～140g、陈皮40～115g、香附90～140g、郁金40～105g、山茱萸（去核）70～105g、生黄芪115～560g、西洋参40～60g、山药170～280g、肉桂30～50g、甘草40～135g、石菖蒲40～60g、安息香6～16g、杜仲70～140g、远志60～140g、熟地黄115～300g、何首乌115～200g、沙参115～140g、茯苓115～140g、石斛70～140g、玉竹70～105g、天门冬70～140g、酸枣仁115～230g、丹参90～140g、红花60～105g、桃仁90～140g、川芎60～105g、神曲115～140g、麦芽115～140g、人参40～140g、白术40～140g、苏合香5～9g、冰片3～4.5g、蟾酥1.8～2.5g、生地黄10～14g、牡蛎170～320g、合欢皮115～140g、柏子仁115～140g、夜交藤115～200g、灵芝115～140g。
3.根据权利要求1至2所述的治疗心肌缺血及心悸怔忡病证的丸剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
党参200g、白芍165g、当归120g、陈皮100g、香附120g、郁金90g、山茱萸（去核）90g、生黄芪480g、西洋参50g、山药250g、肉桂40g、甘草115g、石菖蒲50g、安息香14g、杜仲120g、远志120g、熟地黄260g、何首乌170g、沙参120g、茯苓120g、石斛120g、玉竹95g、天门冬120g、酸枣仁200g、丹参120g、红花95g、桃仁120g、川芎95g、神曲120g、麦芽120g、人参120g、白术120g、苏合香8g、冰片4g、蟾酥2g、生地黄12g、牡蛎280g、合欢皮120g、柏子仁120g、夜交藤170g、灵芝120g。
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