CN107822981A - A kind of crease-resistant moisture-keeping composition of eye - Google Patents

A kind of crease-resistant moisture-keeping composition of eye Download PDF

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Publication number
CN107822981A
CN107822981A CN201711243810.XA CN201711243810A CN107822981A CN 107822981 A CN107822981 A CN 107822981A CN 201711243810 A CN201711243810 A CN 201711243810A CN 107822981 A CN107822981 A CN 107822981A
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composition
eye
crease
moisture
keeping
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CN201711243810.XA
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林俊浩
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/005—Preparations for sensitive skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10—General cosmetic use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses a kind of crease-resistant moisture-keeping composition of eye, including NMF, anti wrinkling agent, antioxidant, anti-allergic agent, and wherein anti wrinkling agent is the one or more in micromolecular collagen polypeptide, prepared rehmannia root polysaccharide, Gentrin Knotweed P.E, lupulus extract.Addition anti wrinkling agent can be effectively increased the elasticity of skin；Addition NMF has good water lock water retention, and moisturizing ingredient contributes to keratoderma to keep normal moisture in dry air；Addition antioxidant agent can effectively remove free radical, reduce oxidative damage, acted synergistically between composition, composition is had efficient moisture-keeping crease-shedding effect, and be applied in eye product, eye skin can be made more to moisten, high resilience.

Description

A kind of crease-resistant moisture-keeping composition of eye
Technical field
The present invention relates to cosmetic field, and in particular to a kind of crease-resistant moisture-keeping composition of eye.
Background technology
The time of people's eye is increasingly longer, along with life stress is big, the factor such as irregular of working and resting, livid ring around eye, pouch All tend to become younger with wrinkle, turned into the headache of many young woman.In addition, air-conditioning, environmental pollution, Seasonal conversion band The temperature change and pressure come, and skin senescence, metabolism such as slow down at the factor can all cause skin water loss, make skin thick Rough, dim mute, the dry line of formation, trigger many skin problems, so skin needs frequent replenishing water and preserving moisture.And eye skin be human body most Thin skin, while be the most frequent position of activity again, but also be to pull the most place of skin number in making up, if nursing is not When, it is very easy to grow wrinkle, and once grow and be difficult to disappear, while the easy chromogenesis precipitation of eye, grow livid ring around eye Deng influenceing face.
Eye product is various on the market at present, but majority is all containing a large amount of chemical substances, it is well known that many changes It is to have certain toxicity to learn substances on human, if selection is improper to will result in immeasurable infringement, therefore, crease-resistant moisturizing class Eye product security and effectiveness be valued by people, people are also contemplated that safety, the product of significant effect emerges.
The content of the invention
It is an object of the invention to provide a kind of crease-resistant moisture-keeping composition of eye, and applied in cosmetics, played Significant crease-resistant, moisture-keeping function.
To achieve the above object, the present invention provides following technical scheme：
A kind of crease-resistant moisture-keeping composition of eye, include the component of following parts by weight：
Wherein anti wrinkling agent is in micromolecular collagen polypeptide, prepared rehmannia root polysaccharide, Gentrin Knotweed P.E, lupulus extract It is one or more.
Further, described composition includes the component of following parts by weight：
Wherein anti wrinkling agent is in micromolecular collagen polypeptide, prepared rehmannia root polysaccharide, Gentrin Knotweed P.E, lupulus extract It is one or more.
Further, described composition includes the component of following parts by weight：
Wherein anti wrinkling agent is in micromolecular collagen polypeptide, prepared rehmannia root polysaccharide, Gentrin Knotweed P.E, lupulus extract It is one or more.
In addition, the NMF is included in ceramide, propane diols, hyaluronic acid, mineral oil, amino acid, glucan It is one or more kinds of；
The antioxidant includes one in vitamin E and its derivative, persimmon leaf polyphenol, skunk bush polysaccharide, ascorbic acid Kind or more than one.
Described anti-allergic agent is pot marigold extract.
Composition of the present invention can be used for cosmetics, such as can be used for moisture-keeping crease-shedding class product as additive.
Compared with prior art, it is the device have the advantages that as follows：
(1) addition anti wrinkling agent can be effectively increased the elasticity of skin, and micromolecular collagen polypeptide can pass through skin surface Into inside, promote cell growth, Gentrin Knotweed P.E can suppress elastase activity, there is crease-resistant effect；
(2) addition NMF has good water lock water retention, and moisturizing ingredient contributes to keratoderma dry Normal moisture is kept in air, prevents that moisture content of skin is too low and produces the symptom such as crowfoot cracks, skin is more moistened, Pick up crease-resistant effect；
(3) antioxidant is added, skunk bush polysaccharide has stronger removing free radical, and persimmon leaf polyphenol has stronger antioxygen Change acts on, and skin oxidative damage is reduced, so as to play crease-resistant effect.
(4) composition of the invention is natural, safety, is acted synergistically between composition, has efficient moisture-keeping crease-shedding effect, by it Apply in eye product, eye skin can be made more to moisten, high resilience.
Embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The preparation of the crease-resistant moisture-keeping composition of eye：
2.5 grams of micromolecular collagen polypeptides, 3.5 grams of Gentrin Knotweed P.Es, 1 gram of skunk bush polysaccharide, 2.5 grams of persimmon leafs are more 1.5 grams, 88 grams phenol, 2.5 grams of glucans, pot marigold extract deionized waters are placed in blender, are uniformly mixed, you can To the described crease-resistant moisture-keeping composition of eye.
Embodiment 2
The preparation of eye cream：
According to mass percent, by 65.67% deionized water, 0.08% xanthans, 0.2% acryloyldimethyl taurine Ammonium, 1.5% acetyl chitosamine and the mixing of 2.5% niacinamide, agitating and heating are warming up to 85 DEG C, obtain aqueous phase；By 6% cetearyl alcohol Alcohol, 4% cetanol ethylhexoate, 1.5% stearine, 2%PEG-100 stearates, 3% palm acid ethyl oneself Ester, 2% dimethyl silicone polymer, 1.2% Butyrospermum parkii fruit fat, the mixing of 0.15% tocopherol acetate, agitating and heating are warming up to 85 DEG C, obtain oil phase；Oil phase is added in aqueous phase, 20min is stirred and makes emulsifying mixture, homogeneous 5min after emulsification is completed；Drop For temperature to 75 DEG C, vacuum defoams 60min；Wait to cool to less than 40 DEG C, add the crease-resistant moisture-keeping composition of 10% eye and 0.2% benzene oxygen Ethanol stirs, and produces eye cream.
Embodiment 3
The preparation of eye emulsions：
It is according to mass percent, 3% stearine, 4% methyl sesquistearate, 2% sorb is smooth hard Resin acid ester, 6% stearic acid, 8% stearyl alcohol, 1.5% OXYBENZONE Hybrid Heating are stirred to 85 DEG C, are produced after stirring and dissolving is complete Oil phase；8% glycerine, 0.5% allantoin, 56.6% deionized water Hybrid Heating are stirred to 85 DEG C, stirring and dissolving is afterwards completely Obtain aqueous phase；Oil phase is added in aqueous phase and stirred 30 minutes, temperature is maintained at 85 DEG C；Then 0.1% hydroxyethyl cellulose guarantor is added Temperature stirring 30 minutes；It is cooled to the crease-resistant moisture-keeping composition of 42 DEG C of 10% eyes of addition, 0.3% Phenoxyethanol stirs, cooling Discharging.
Embodiment 4
Moistening effect is tested
First, test philosophy
According to cosmetic composition moisture absorption, the difference of performance of keeping humidity, different moisturizing agent molecules to the active force of hydrone not Together, it is different with the ability of moisture is kept to absorb moisture.Oil content has sealing process to moisture, can prevent scattering and disappearing for moisture.Moisture absorption is made It is firmly big, it is strong to water molecules power, absorb and the amount of holding moisture is also bigger, closure is good, moisture loss It is few.The biomaterial of cuticula, epidermis etc. is imitated using adhesive tape, cosmetics are coated with adhesive tape, simulates answering for actual cosmetics Use situation.It is of poor quality before and after weighing sample placement after certain time under conditions of constant temperature and humidity, obtain the damage of sample size Lose, the effect of moisturizing ingredient moisturizing can be calculated.
2nd, experiment purpose
By contrast, the crease-resistant moisture-keeping composition of eye made from assay embodiment 1, eye cream made from embodiment 2 is real Apply the moistening effect of eye emulsions made from example 3 and a commercially available eye moisture-keeping cosmetics (control group).
3rd, experiment material
Some pieces of the clean glass plates of 7.5 × 7.5cm, 3M adhesive plasters, 50~500 μ l liquid-transfering guns, assay balance, potassium acetate [KC2H3O2] saturated solution relative humidity about 60%, a ten thousandth balance.
4th, experimental method and testing procedure
(1) 6 pieces of glass plate weight (M for posting 3M adhesive plasters are weighed0), record respectively, 3 pieces are blank control, and 3 pieces are sample Experiment.
(2) take 200 μ l sample drops to be added on the glass plate for posting 3M adhesive plasters with liquid-transfering gun, the weight is weighed with assay balance M1(being accurate to 0.0001g), sample is smoothened, and glass plate is put into the drier of the constant humidity of requirement, is repeated 3 times.By its 3 pieces of blank control glass plates of remaininging are put into the drier of constant humidity together.
(3) after 4h, 8h is placed, glass plate is taken out, weighs the glass plate weight (M2), test its moisturizing rate and relatively wet Degree rate, it is immediately placed into after weighing in the drier of constant humidity.
(4) points for attention of this experiment：Smear as far as possible uniform during sample, it is impossible to have carry-over on applicator.Will Sample, which takes out, to be weighed and is put into, and a drier control is within 15min, average 1 piece of glass plate 1min.Control time is Due to sample, exposed to external environment, its moisture loss is very fast, can have a strong impact on test result.Glass plate is inverted immediately after taking out Also it is upside down in the container in balance on preprepared blank glass plate, during weighing.
(5) moisturizing rate calculation formula：
Moisturizing rate=(M2–M0)/(M1–M0) × 100%
In formula：
M0：Hollow plate quality/g
M1：Glass sheet quality/g after sample-adding
M2：Quality/g after some hours is placed in drier
Test its relative humidity be 60% when 4h and 8h in moisturizing rate.
5th, experimental result
As a result referring to table 1.
Table 1
Time/h Embodiment 1 Embodiment 2 Embodiment 3 Control group
4 46.35 43.41 44.56 31.28
8 46.18 43.46 44.42 31.13
As known from Table 1, the crease-resistant moisture-keeping composition of eye of the present invention and eye cream, the eye emulsions of preparation have preferable moisturizing Effect, control group is significantly better than, shows that the crease-resistant moisture-keeping composition of eye of the present invention is applied to that in cosmetics significant benefit can be played Water moistening effect.
Embodiment 5
Crease-resistant moisture-keeping efficacy evaluation
Detection results on probation are carried out to the embodiment 1-3 products prepared, while are declared with a commercially available with good anti- The eye cosmetic of wrinkle moisture-keeping efficacy is control group.Test object：Each experimental group is 20 women (25-50 year)；Test section Domain：Eye；Use：Twice daily, persistently using 4 weeks；Test event：Skin elasticity, skin water are tender, wrinkle depth (crow's feet Region).Result on trial see the table below 2.
Table 2
By the visible embodiment 1-3 skin elasticities of table 2, water is tender and wrinkle depth improves obvious number and is significantly more than control Group, illustrate the crease-resistant moisture-keeping composition of eye of the present invention and obtained cosmetics be significantly improved skin elasticity, skin water it is tender and The effect of wrinkle depth.
Above example only shows several embodiments of the present invention, therefore its description is more specific and detailed, but can not be And it is interpreted as the limitation scope to patent of the present invention.It should be noted that：It is any to be engaged in professional and technical personnel, all have the ability Using the technology contents having revealed that, some are made to it and changes or modifies, turns into the equivalent embodiment of equivalent variations.According to this hair Bright technical spirit, simple modification, equivalent change and modification is carried out to the present invention, belonged in the range of technical solution of the present invention.

Claims (5)

1. a kind of crease-resistant moisture-keeping composition of eye, it is characterised in that contain following components and content：
It is parts by weight above；
Wherein anti wrinkling agent is one kind in micromolecular collagen polypeptide, prepared rehmannia root polysaccharide, Gentrin Knotweed P.E, lupulus extract It is or a variety of.
2. composition as claimed in claim 1, it is characterised in that contain following components and content：
It is parts by weight above；
Wherein anti wrinkling agent is one kind in micromolecular collagen polypeptide, prepared rehmannia root polysaccharide, Gentrin Knotweed P.E, lupulus extract It is or a variety of.
3. composition as claimed in claim 2, it is characterised in that component and content：
It is parts by weight above；
Wherein anti wrinkling agent is one kind in micromolecular collagen polypeptide, prepared rehmannia root polysaccharide, Gentrin Knotweed P.E, lupulus extract It is or a variety of.
4. the composition as described in claim any one of 1-3, it is characterised in that：
The NMF includes ceramide, propane diols, hyaluronic acid, mineral oil, amino acid, one kind or one kind in glucan More than；
The antioxidant include vitamin E and its derivative, persimmon leaf polyphenol, skunk bush polysaccharide, one kind in ascorbic acid or More than one；
The anti-sensitizer is pot marigold extract.
5. the composition as described in Claims 1 to 4, it is characterised in that the composition is used for moisture-keeping crease-shedding as additive Class product.
CN201711243810.XA 2017-11-30 2017-11-30 A kind of crease-resistant moisture-keeping composition of eye Withdrawn CN107822981A (en)

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Application Number Priority Date Filing Date Title
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109044906A (en) * 2018-08-28 2018-12-21 广州皓雨投资有限公司 A kind of moisturizing is releived anti-wrinkle composition, facial mask and preparation method thereof
CN112006929A (en) * 2020-08-26 2020-12-01 湖南神农国油生态农业发展有限公司 Traditional Chinese medicine eye cream capable of relieving pouch and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106176450A (en) * 2016-08-26 2016-12-07 施协均 A kind of plant biological source nanospray nursing eye glue and preparation method thereof
CN106580798A (en) * 2016-12-30 2017-04-26 广州科盈化妆品有限公司 All-in-one eye cream and preparation method

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106176450A (en) * 2016-08-26 2016-12-07 施协均 A kind of plant biological source nanospray nursing eye glue and preparation method thereof
CN106580798A (en) * 2016-12-30 2017-04-26 广州科盈化妆品有限公司 All-in-one eye cream and preparation method

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109044906A (en) * 2018-08-28 2018-12-21 广州皓雨投资有限公司 A kind of moisturizing is releived anti-wrinkle composition, facial mask and preparation method thereof
CN112006929A (en) * 2020-08-26 2020-12-01 湖南神农国油生态农业发展有限公司 Traditional Chinese medicine eye cream capable of relieving pouch and preparation method thereof

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Application publication date: 20180323