CN107822980A - One kind is compacted skin composition - Google Patents

One kind is compacted skin composition Download PDF

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Publication number
CN107822980A
CN107822980A CN201711242106.2A CN201711242106A CN107822980A CN 107822980 A CN107822980 A CN 107822980A CN 201711242106 A CN201711242106 A CN 201711242106A CN 107822980 A CN107822980 A CN 107822980A
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Prior art keywords
skin
composition
nmf
antioxidant
elastatinal
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Application number
CN201711242106.2A
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Chinese (zh)
Inventor
林俊浩
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Individual
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Individual
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Priority to CN201711242106.2A priority Critical patent/CN107822980A/en
Publication of CN107822980A publication Critical patent/CN107822980A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42Amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/673Vitamin B group
    • A61K8/675Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/676Ascorbic acid, i.e. vitamin C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Emergency Medicine (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

Compacted skin composition the invention discloses one kind, include the component of antioxidant, NMF, elastatinal, its elastase inhibitor mainly includes one or more of in Gentrin Knotweed P.E, quassia alkaloid, anthocyanidin.Addition antioxidant can reduce skin oxidative damage, delaying skin aging;Adding NMF can not only moisturizing, moreover it is possible to forms water lock barrier in skin surface;Addition elastatinal can effectively compact skin, increase the elasticity of skin;Acted synergistically between composition components, the effect for the skin that preferably compacts can be played, applied in cosmetics, the good skin that compacts of cosmetics, oxidation resistant effect can be assigned.

Description

One kind is compacted skin composition
Technical field
The present invention relates to cosmetic field, and in particular to one kind is compacted skin composition.
Background technology
With advancing age, the gradual aging of skin of face, skin senescence are usually expressed as skin elasticity reduction, skin wrinkle Line increases, skin roughness increases, skin moisturizing degree weakens etc..And the aging of skin of face be mainly qi and blood it is insufficient and It is clearly inadequate, ring for prevention skin senescence that moisturizer skin care is merely used caused by the deposition of toxin, in daily life The factors such as border, sunlight and pressure can all promote the aging of skin, cause skin metabolism to slow down, the collagen and bullet of skin Property tissue fibers change, and skin becomes more loose, and this image to people causes serious influence.As people live Horizontal raising, the consciousness of skin care also step up, and skin care increasingly attracts people's attention.
Occur much declaring the products with skin effect of compacting on the market at present, but the effect of publicity exaggerated, it is actual To no effect or DeGrain, misguide the consumer consumption, or even the product having with the addition of forbidden amphetamine, and can have to skin can not Inverse damage, therefore, the product for researching and developing a kind of skin that compacts of significant effect are that people are hoped.
The content of the invention
It is an object of the invention to provide a kind of composition for the skin that compacts, act synergistically, have significant anti-between composition Oxidation, the effect for the skin that compacts, and added in cosmetics, assign cosmetics good skin effect of compacting, flesh can be made Skin is more flexible.
In order to achieve the above object, the present invention provides following technical scheme:
One kind is compacted skin composition, includes the component of following mass parts:
Antioxidant 3~6
NMF 20~35
Elastatinal 12~18
Its elastase inhibitor mainly include Gentrin Knotweed P.E, quassia alkaloid, one kind in anthocyanidin or with On.
Further, described composition includes the component of following mass parts:
Antioxidant 4.2~5.8
NMF 24~31
Elastatinal 14~16
Its elastase inhibitor mainly include Gentrin Knotweed P.E, quassia alkaloid, one kind in anthocyanidin or with On.
Further, described composition includes the component of following mass parts:
Antioxidant 4.8
NMF 29
Elastatinal 15
Its elastase inhibitor mainly include Gentrin Knotweed P.E, quassia alkaloid, one kind in anthocyanidin or with On.
In addition, the antioxidant is included in Kiwi berry polysaccharide, iridin, apple polyphenol, vitamin C and its derivative It is one or more of;
The NMF includes Sodium Hyaluronate, Ampelopsis grossedentata extrat, ceramide, glycerine, collagen, Fructus Luffae extract In it is one or more of;
Composition of the present invention can be used for cosmetics, such as can be used for the product with effect of compacting as additive.
Compared with prior art, it is the device have the advantages that as follows:
(1) addition antioxidant can reduce skin oxidative damage, and delaying skin aging, Kiwi berry polysaccharide, iridin can Free radical is removed, antioxidation is effectively played and can extend to form one layer of viscoplasticity film in skin surface, skin is more stepped up Cause;
(2) adding NMF can not only moisturizing, moreover it is possible to forms water lock barrier in skin surface, Ampelopsis grossedentata extrat can suppress Hyaluronidase activity, skin moisture is maintained, skin lack of moisture is prevented, effectively plays moisture-keeping function, it is tight so as to play indirectly Cause the effect of skin;
(3) addition elastatinal can effectively compact skin, increase the elasticity of skin, and Gentrin Knotweed P.E effectively presses down Elastoser processed, suppress wrinkle of skin generation, and then play a part of crease-resistant anti-aging, anthocyanidin can safeguard skin glue Original synthesis, suppresses elastoser, is produced so as to reduce wrinkle, so as to recover the elasticity of skin, compact skin;
(4) acted synergistically between the skin composition components that compact of the invention, the effect for the skin that preferably compacts can be played, will It is applied in cosmetics, can assign the good skin that compacts of cosmetics, oxidation resistant effect.
Embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
Compact the preparation of skin composition:
4.8 grams of Kiwi berry polysaccharide, 29 grams of Ampelopsis grossedentata extrats, 15 grams of Gentrin Knotweed P.Es, 51.2 grams of deionized waters are placed in mixed In clutch, it is uniformly mixed, you can obtain the skin composition that compacts.
Embodiment 2
Compact the preparation of facial mask:
According to mass percent, 10% propane diols, 0.03% niacinamide, 8% glycerine, 15% butanediol, 3% β-Portugal are gathered Sugar, 0.05% Sodium Hyaluronate, 0.05% panthenol, 0.5% allantoin, 0.6% hexylene glycol, 0.3%EDTA disodiums, 0.3% hydroxyl Ethyl cellulose, 0.2% carbomer, 41.77% deionized water, which are added in agitated kettle, is heated with stirring to 85 DEG C, and stirring and dissolving is complete Entirely, aqueous phase is made;By 0.3% glycerine polymethacrylates, 0.8% hydrolysis Jojoba esters, 0.5%PEG-40 hydrogenation castors Sesame oil adds in agitated kettle and is heated with stirring to 85 DEG C, and oil phase is made;Under stirring, oil phase is added into aqueous phase, stirred;It is cooled to 45 DEG C, 0.1% triethanolamine is added, is stirred, added 8% and compact skin composition, 0.5% Phenoxyethanol, fully stir Cooling discharging after mixing uniformly.
Embodiment 3
The preparation for emulsion of compacting:
It is according to mass percent, 3% stearine, 4% methyl sesquistearate, 2% sorb is smooth hard Resin acid ester, 6% stearic acid, 8% stearyl alcohol, 1.5% OXYBENZONE Hybrid Heating are stirred to 85 DEG C, are produced after stirring and dissolving is complete Oil phase;8% glycerine, 0.5% allantoin, 54.6% deionized water Hybrid Heating are stirred to 85 DEG C, stirring and dissolving is afterwards completely Obtain aqueous phase;Oil phase is added in aqueous phase and stirred 30 minutes, temperature is maintained at 85 DEG C;Then 0.1% hydroxyethyl cellulose guarantor is added Temperature stirring 30 minutes;It is cooled to 42 DEG C and adds 12% compact skin composition, 0.3% Phenoxyethanol and stirs, cooling discharging.
Embodiment 4
Compact frost preparation:
According to mass percent, by 10% caprylic/capric triglyceride, 1% cetostearyl alcohol, 2% 2 cetanol phosphoric acid Ester, 2.5% white oil and 1% cyclic silicone oils heating stirring produce oil phase to 85 DEG C, and 0.5% is added into 64.6% deionized water Xanthans and 3% glycerine, and be heated with stirring to 85 DEG C and produce aqueous phase, gained oil phase is continued to stir under vacuum, then Aqueous phase is added into oil phase, and continues to stir and emulsifies, after emulsification, continues insulated and stirred 15min, hydrogen is added after being cooled to 40 DEG C Sodium oxide molybdena adjusts pH to neutrality, adds 0.2% Phenoxyethanol, 15% compacts skin composition and 0.2% essence, fully Stir.
Embodiment 5
Anti-oxidation efficacy is tested
At room temperature, in 4ml test tubes, phosphate buffer (pH 7.4) 0.5ml is sequentially added, 5 μ L 5,5- dimethyl- 1- pyrrolin-N oxides (DMP0), 250 μ L 0.1M H202, sample made from 1.5ml 0.1mM embodiments 1-4, while with It is a it is commercially available declare that with antioxidation cosmetic product or skin care item be control group, 250 μ L 3mM FeS04 solution, in 6 minutes left sides ESR detections are carried out in right injection quartz capillary.As a result such as table 1 below:
Table 1
Sequence number Embodiment 1 Embodiment 2 Embodiment 3 Embodiment 4 Control group
Clearance rate 90% 91% 93% 93% 75%
It was found from the data of upper table 1,1-4 of the embodiment of the present invention is to the clearance rate of free radical apparently higher than control group, it is seen that this The invention skin composition that compacts has very strong antioxidation activity, can remove free radical in time, effectively maintain the vigor of skin with Elasticity.
Embodiment 6
Moisture-keeping efficacy is tested
Experiment material:Some pieces of the clean glass plates of 7.5 × 7.5cm, 3M adhesive plasters, 50~500 μ l liquid-transfering guns, assay balance, Potassium acetate [KC2H3O2] saturated solution relative humidity about 60%, a ten thousandth balance, sample made from embodiment 1-4 and a Commercially available moisture-keeping cosmetics are control group.
Experimental method and testing procedure:
(1) 6 pieces of glass plate weight (M for posting 3M adhesive plasters are weighed0), record respectively, 3 pieces are blank control, and 3 pieces are sample Product are tested.
(2) take 200 μ l sample drops to be added on the glass plate for posting 3M adhesive plasters with liquid-transfering gun, the weight is weighed with assay balance M1(being accurate to 0.0001g), sample is smoothened, and glass plate is put into the drier of the constant humidity of requirement, is repeated 3 times.By its 3 pieces of blank control glass plates of remaininging are put into the drier of constant humidity together.
(3) after 4h, 8h is placed, glass plate is taken out, weighs the glass plate weight (M2), test its moisturizing rate and relatively wet Degree rate, it is immediately placed into after weighing in the drier of constant humidity.
(4) points for attention of this experiment:Smear as far as possible uniform during sample, it is impossible to have carry-over on applicator.Will Sample, which takes out, to be weighed and is put into, and a drier control is within 15min, average 1 piece of glass plate 1min.Control time It is due to that its moisture loss is very fast exposed to external environment for sample, test result can be had a strong impact on.Glass plate falls immediately after taking out Put on preprepared blank glass plate, be also upside down in the container in balance during weighing.
(5) moisturizing rate calculation formula:
Moisturizing rate=(M2–M0)/(M1–M0) × 100%
In formula:
M0:Hollow plate quality/g
M1:Glass sheet quality/g after sample-adding
M2:Quality/g after some hours is placed in drier
Test its relative humidity be 60% when 4h and 8h in moisturizing rate.Result of the test is shown in Table 2:
Table 2
It was found from the data of upper table 2, the moisturizing rate of product made from embodiment 1-4 shows the present invention apparently higher than control group The skin composition that compacts has excellent replenishing water and preserving moisture effect.
Embodiment 7
Anti-ageing efficacy test of compacting
Product prepared by embodiment 2-4 carries out clinical effect test, and its effect is assessed.Volunteer is 60 The female middle-aged of 40~50 years old or so, is divided into 3 groups, every group of 20 people;Position on probation is face's (test of half face);Method of testing:It is clean Behind face, half of face is smeared, and twice a day, is smeared one month, observation and test position are right face.Test result is as shown in table 3:
Table 3
The result of table 3 is shown, either skin density, the skin elasticity still improvement to wrinkle, is made by embodiment 1-4 The product nursing of one month, be obtained for obvious improvement substantially, anti-ageing tightening effect is notable.
Above example only illustrates embodiment of the present invention, does not have any formal limitation to the present invention;Appoint What is engaged in professional and technical personnel, all has the ability to make some changes or modification using the technology contents disclosed, turns into equivalent The equivalent embodiment of change, according to the technology of the present invention essence, simple modification, equivalent change and modification is carried out to the present invention, belonged to In the range of technical solution of the present invention.

Claims (5)

  1. The skin composition 1. one kind is compacted, it is characterised in that component includes with content:
    Antioxidant 3~6
    NMF 20~35
    Elastatinal 12~18
    It is mass parts above;
    Its elastase inhibitor mainly includes one or more of in Gentrin Knotweed P.E, quassia alkaloid, anthocyanidin.
  2. 2. composition as claimed in claim 1, it is characterised in that component includes with content:
    Antioxidant 4.2~5.8
    NMF 24~31
    Elastatinal 14~16
    It is mass parts above;
    Its elastase inhibitor mainly includes one or more of in Gentrin Knotweed P.E, quassia alkaloid, anthocyanidin.
  3. 3. composition as claimed in claim 2, it is characterised in that component includes with content:
    Antioxidant 4.8
    NMF 29
    Elastatinal 15
    It is mass parts above;
    Its elastase inhibitor mainly includes one or more of in Gentrin Knotweed P.E, quassia alkaloid, anthocyanidin.
  4. 4. the composition as described in claim any one of 1-3, it is characterised in that:
    The antioxidant include Kiwi berry polysaccharide, iridin, apple polyphenol, vitamin C and its derivative in one kind or with On;
    The NMF is included in Sodium Hyaluronate, Ampelopsis grossedentata extrat, ceramide, glycerine, collagen, Fructus Luffae extract It is one or more of.
  5. 5. the composition as described in Claims 1 to 4, it is characterised in that be used to prepare cosmetics as additive.
CN201711242106.2A 2017-11-30 2017-11-30 One kind is compacted skin composition Withdrawn CN107822980A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201711242106.2A CN107822980A (en) 2017-11-30 2017-11-30 One kind is compacted skin composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201711242106.2A CN107822980A (en) 2017-11-30 2017-11-30 One kind is compacted skin composition

Publications (1)

Publication Number Publication Date
CN107822980A true CN107822980A (en) 2018-03-23

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Country Status (1)

Country Link
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104083318A (en) * 2014-07-09 2014-10-08 广州市攸澜化妆品有限公司 Skin-whitening cosmetic and preparation method thereof
CN105748336A (en) * 2014-12-20 2016-07-13 天津裕鼎广汇科技发展有限责任公司 Plant type cosmetic

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104083318A (en) * 2014-07-09 2014-10-08 广州市攸澜化妆品有限公司 Skin-whitening cosmetic and preparation method thereof
CN105748336A (en) * 2014-12-20 2016-07-13 天津裕鼎广汇科技发展有限责任公司 Plant type cosmetic

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Application publication date: 20180323