CN107812132A

CN107812132A - A kind of medicine for treating acne and preparation method thereof

Info

Publication number: CN107812132A
Application number: CN201711154201.7A
Authority: CN
Inventors: 李江; 刘自平
Original assignee: Guizhou Xinlong Medical Hall Hospital Ltd
Current assignee: Guizhou Xinlong Medical Hall Hospital Ltd
Priority date: 2017-08-28
Filing date: 2017-11-20
Publication date: 2018-03-20

Abstract

The invention discloses a kind of medicine for treating acne and preparation method thereof, the medicine is mainly made by the coptis, Honeysuckle flower, chrysanthemum indicum, dandelion, Chinese violet, the fruit of Chinese wolfberry, the red sage root, kuh-seng, moutan bark, coix seed, rheum officinale, the root of kudzu vine, radix scutellariae, the root bark of white mulberry and borneol.The medicine has the effect of clearing heat-fire removing toxic substances, activating blood circulation and reducing swelling dissipating bind.Available for acne is treated, have no toxic side effect.

Description

A kind of medicine for treating acne and preparation method thereof

Technical field

The present invention relates to a kind of medicine for treating acne and preparation method thereof, belong to the field of medicine technology.

Background technology

Acne is a kind of chronic dermatosis for betiding pilosebaceous follicle, is mainly in the skin such as Head And Face, neck, shirtfront back The abundant position of adipose gland.The main clinical manifestation of acne is：Blackhead, Whiteheads, inflamed papules, fester, easily form color Plain calmness, pore are thick or even scar sample damages, and influence beauty, severe patient can cause to disfeature, and the great heart is caused to young man Manage pressure and mental suffering.Because of acne category persistent ailment class disease, easily recurrence, being currently used in the medicine for the treatment of acne has oral class and outer With two kinds of class, although these medicines have the effect of certain to acne, thorough cure rate is very low and costly, often It can only play a part of taking stopgap measures, it is impossible to play the purpose effected a permanent cure.

The content of the invention

It is an object of the present invention to provide a kind of medicine for treating acne and preparation method thereof.The medicine has heat-clearing Purging intense heat and detonicating, the effect of activating blood circulation and reducing swelling dissipating bind.Available for acne is treated, have no toxic side effect.

In order to solve the above technical problems, the present invention is realized using following technical scheme：A kind of medicine for treating acne, by weight Measure part to calculate, mainly by coptis 1-5 parts, Honeysuckle flower 6-15 parts, chrysanthemum indicum 9-15 parts, dandelion 10-15 parts, Chinese violet 15- 30 parts, fruit of Chinese wolfberry 6-12 parts, red sage root 10-15 parts, kuh-seng 4.5-9 parts, moutan bark 6-12 parts, coix seed 9-30 parts, rheum officinale 3-15 Part, root of kudzu vine 10-15 parts, radix scutellariae 3-10 parts, root bark of white mulberry 6-12 and borneol 0.15-0.3 parts are made.

In the medicine of foregoing treatment acne, calculate by weight, mainly by coptis 1-5 parts, Honeysuckle flower 6-15 parts, mother chrysanthemum Flower 9-15 parts, dandelion 10-15 parts, Chinese violet 15-30 parts, fruit of Chinese wolfberry 6-12 parts, red sage root 10-15 parts, kuh-seng 4.5-9 parts, Moutan bark 6-12 parts, coix seed 9-30 parts, rheum officinale 3-15 parts, root of kudzu vine 10-15 parts, radix scutellariae 3-10 parts, root bark of white mulberry 6-12 and borneol 0.15-0.3 parts are made.

In the medicine of foregoing treatment acne, calculate by weight, mainly by 5 parts of the coptis, 12 parts of Honeysuckle flower, chrysanthemum indicum 12 Part, 12 parts of dandelion, 12 parts of Chinese violet, 10 parts of the fruit of Chinese wolfberry, 12 parts of the red sage root, 9 parts of kuh-seng, 12 parts of moutan bark, 12 parts of coix seed, 0.3 part of 15 parts of rheum officinale, 10 parts of the root of kudzu vine, 10 parts of radix scutellariae, 10 parts of the root bark of white mulberry and borneol are made.

A kind of preparation method of the medicine of aforementioned therapies acne, takes said medicine, can add auxiliary material, can also be not added with auxiliary Material, according to common process, is made pharmaceutical preparation.

In the preparation method of the medicine of aforementioned therapies acne, the pharmaceutical preparation is gel, ointment or patch.

In the preparation method of the medicine of aforementioned therapies acne, the gel so makes：Above medicine is taken, is ground into thick Particle, the ethanol that the 1-3 times of concentration measured is 40%, closed placement 15min to 6h after mixing are added, until medicinal powder fully expands, filled Cylinder, exhaust, 24-48 hours are impregnated, after carrying out diacolation by 1000g medicinal materials outflow l-3mL per minute, collect liquid to medicinal material weight 4 times of amounts when stop diafiltration, dregs pressing, take pressed liquor to merge with percolate, decoction insufficient total amount is 5 times of medicinal material weight Amount, then 5 times of amounts that 40% ethanol complements to medicinal material weight are added, are slowly added to the carbomer with total amount of liquid 0.5-1.5%, Bian Jia Enter side quickly to stir, stand overnight, it is even mixed to add total amount of liquid 1.5%-2% triethanolamine, mixes, you can.

In the preparation method of the medicine of aforementioned therapies acne, the ointment so makes：Above medicine is taken, is ground into thick Particle, the ethanol that the 1-3 times of concentration measured is 40-50%, closed placement 15min to 6h after mixing are added, until medicinal powder is fully swollen It is swollen, fitted tube, exhaust, 24-48 hours are impregnated, after carrying out diacolation by 1000g medicinal materials outflow l-3mL per minute, collect liquid to medicine Stop diafiltration during 4 times of amounts of material weight, dregs pressing, take pressed liquor to merge with percolate, it is relatively close when being condensed into 60-70 DEG C The thick paste for 1.32-1.35 is spent, takes the amount of being made 6-8% sorbierite and 7-9% glycerine, adds in above-mentioned thick paste, is heated to 80- 85 DEG C make dissolving；It is another take the amount of being made 7-9% stearic acid, 6-8% tristearin, 2-4% yellow petroleum jelly, 8-9% poly- sorb fat 80, 1-3% lanolin and 0.5-1.5% sucrose stearate are heated to 80-85 DEG C, make melting, and above two solution is mixed into breast Change 10-20 minutes, 80-85 DEG C of insulation 25-35 minute, add the amount of being made 0.5-0.7% benzoic acid and 0.1-0.2% oxybenzene second Ester mixes, filling, produces.

In the preparation method of the medicine of aforementioned therapies acne, the paste so makes：Above medicine is taken, is ground into thick Grain, the ethanol that the 1-3 times of concentration measured is 40-50%, closed placement 15min to 6h after mixing are added, until medicinal powder fully expands, Fitted tube, exhaust, 24-48 hours are impregnated, after carrying out diacolation by 1000g medicinal materials outflow l-3mL per minute, collect liquid to medicinal material weight Stop diafiltration during 4 times of amounts of amount, dregs pressing, take pressed liquor to merge with percolate, when being condensed into 60-70 DEG C, relative density is 1.32-1.35 thick paste, separately take thick paste amount 40-60% rubber, 40-60% rosin, 5-15% vaseline and 15-25% sheep Hair fat heating melting, adds above-mentioned clear cream, and thick paste amount 10-20% glycerine and 55-65% zinc oxide mix 15-30 Minute, spice is obtained, will mount material respectively, and medical mylar and spice are fitted into patch spreading equipment, roll, after shaping, Cutting, dispense, seal, packaging, produce.

Medicine of the present invention is mainly by the coptis, Honeysuckle flower, chrysanthemum indicum, dandelion, Chinese violet, the fruit of Chinese wolfberry, the red sage root, hardship Ginseng, moutan bark, coix seed, rheum officinale, the root of kudzu vine, radix scutellariae, the root bark of white mulberry and borneol are made.Wherein, the coptis,（Scientific name： Coptischinensis Franch.）, heat-clearing and damp-drying drug, purging intense heat and detonicating.For damp and hot feeling of fullness, acid regurgitation, rush down dysentery, jaundice, height are vomitted Hot coma, heart-fire hyperactivity, dysphoria and insomnia, blood-head tells nosebleed, hot eyes, toothache, quench one's thirst, carbuncle swells furunculosis；Control eczema, wet sore, duct outside Suppurate.It is burning hot that prepared RHIZOMA COPTIDIS with vino is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For hot eyes, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach anti-vomiting.Mutually tied for fever and chills, in damp and hot Resistance, feeling of fullness vomiting.The easypro liver anti-vomiting of cornel coptis.For liver-stomach disharmony, acid regurgitation is vomitted.Honeysuckle flower is just entitled：Wild rice gland honeysuckle Lonicerahypoglauca Lonicera confusas Loniceraconfusa, version in 2010《Chinese Pharmacopoeia》To honeysuckle and grey felt hair Honeysuckle carries out a point row, and wherein honeysuckle is listed in the unique medicine source plant resource of honeysuckle, and largeflower-like honeysuckle flower is collected in Honeysuckle flower.It is right Honeysuckle（Honeysuckle）The property of medicine be described as：[nature and flavor and channel tropism] is sweet, trembles with fear.Return lung, the heart, stomach.[function is with curing mainly] heat-clearing solution Poison, dispelling wind and heat from the body.For carbuncle swells furunculosis, larynx numbness, erysipelas, toxic-heat and blood stasis, anemopyretic cold, warm morbidity.As Chinese department of traditional Chinese medicine As the famous expert of institute, doctoral advisor Zhou Chaofan professors are described：" NF is to treat as to Honeysuckle flower and honeysuckle Benevolence, be equivalent, is without what difference.Moreover "《Chinese Pharmacopoeia》Between 28 years before version in 2005, honeysuckle and ash Felt hairy honeysuckle is applied in tcm clinical makees honeysuckle application with same always in traditional Chinese medical science medicament, and its clinical effectiveness obtains with agent efficacy Obtained the accreditation of medical expert, patient and pharmacy corporation.Chrysanthemum indicum（Scientific name：Dendranthemaindicum）For composite family for many years Raw herbaceous plant, bitter, pungent, cool, clearing heat and detoxicating, wind-dispelling heat-dissipating, dissipate the stasis of blood, improving eyesight, hypotensive.Prevent and treat epidemic cerebrospinal film Inflammation, prevention influenza, flu, treatment hypertension, hepatitis, dysentery, carbuncle furuncle treatment sore have positive effect.The immersion liquid of chrysanthemum indicum It is also highly effective to killing wriggler and fly maggot.Dandelion（Classification system：Taraxacummongolicum Hand.-Mazz.）Chrysanthemum Section, Dandelion herbaceos perennial.Nature and flavor：Bitter sweet, tremble with fear.Channel tropism：Enter liver, stomach.Major function：It is clearing heat and detoxicating, diuresis Dissipating bind.Control acute mastitis, adenolymphitis, scrofula, boil poisonous soreness, acute conjunctivitis, cold, fever, acute tonsillitis, urgency Property bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infections.Chinese violet（Scientific name：Viola philippica）, bitter, it is pungent, It is cold.The thoughts of returning home, lung channel.With clearing heat and detoxicating, cool blood detumescence, the effect of clearing heat and promoting diuresis, furunculosis, carbuncle swells, scrofula, jaundice, dysentery are cured mainly Disease, diarrhoea, hot eyes, larynx numbness, venomous snake bite.Matrimony vine is people to Lyciums such as commodity matrimony vine, plant lycium barbarum, Chinese matrimony vines The general designation of lower species.Nature and flavor：The fruit of Chinese wolfberry：It is sweet, put down.Folium lycii：It is bitter, sweet；It is cool in nature.Function：The fruit of Chinese wolfberry：Nourishing the liver, nourshing kidney, moistening lung. Folium lycii：Qi-restoratives strengthening the essence, heat-clearing improving eyesight.The red sage root, Chinese medicine name.For labiate red sage root Salvia miltiorrhizaBge. Dry root and rhizome.It is inducing meastruation to relieve menalgia with promoting blood circulation, relieving restlessness that clears away heart-fire, the effect of cool blood to disappear carbuncle.For chest impediment and cardialgia, gastral cavity Abdomen hypochondriac pain, the accumulation of lump in the abdomen lump in the abdomen, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhoea Amenorrhea, sore swell and ache curative.Kuh-seng, Chinese medicine name.For beans The dry root of section's plant kuh-seng, it is bitter, trembles with fear.There are heat-clearing and damp-drying drug, desinsection, the work(of diuresis.For hot dysentery, have blood in stool, jaundice renal shutdown is red Under leukorrhea, swelling of vulva pruritus vulvae, eczema, wet sore, pruitus, mange leprosy, trichomonas vaginitis is controlled outside.Moutan bark, also known as it is male The root bark of tree peony, Chinese medicine name.For ranunculaceae peony dry root skin.《Compendium of Materia Medica》：" nourishing Yin and falling fire, solution spot poison, throat, leads to small Have blood in stool stagnant.It is cold in nature, bitter；It is cool；It is slightly cold.The thoughts of returning home；Liver；Kidney；Lung channel.Coix seed, Chinese medicine name.For grass Job's tears Coixlacryma-jobiL.var.mayuen (Roman.) Stapf dry mature kernal.It is sweet, light, it is cool in nature.Returns spleen, stomach, Lung channel.Favourable water penetration is wet, invigorating the spleen to arrest diarrhea, eliminating impediment, apocenosis, the effect of detoxicating and resolving a mass.For oedema, tinea pedis, difficult urination, spleen Empty diarrhea, arthritis with fixed pain caused by dampness contraction, lung carbuncle, acute appendicitis；The diseases such as wart, cancerous swelling.Rheum officinale, Rheum palmatum L., it is a variety of polygonaceae rheum officinales The perennial plant of category is collectively referred to as, bitter, trembles with fear.Returns spleen, stomach, large intestine, liver, pericardium channel.【Function is with curing mainly】Heat and toxic materials clearing away, heat-clearing are rushed down Fire, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow, removing dampness through diuresis and removing jaundice.Stagnated constipation for real heat, blood-head tells nosebleed, hot eyes pharynx swelling, carbuncle swells furunculosis, intestines Carbuncle is suffered from abdominal pain, blood stasis closed, postpartum stasis, traumatic injury, damp-heat dysentery, jaundice, stranguria, oedema；Externally treating burns and scalds.Wine is big Huang is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.For hot eyes pharynx swelling, gingivitis.Prepared RADIX ET RHIZOMA RHEI, which rushes down, exerts oneself to delay, purging intense heat and detonicating.For fiery poison sore Ulcer.Charred RADIX ET RHIZOMA RHEI cooling blood and removing stasis stops blooding.There is stasis of blood haemorrhage for blood-head.The root of kudzu vine, Chinese medicine name.For the dry root of legume pueraria lobata, It is sweet, pungent, it is cool in nature.Attach to the lung and stomach meridians.Bring down a fever, promoting eruption, promote the production of body fluid to quench thirst with expelling pathogenic factors from muscles and skin, the effect of Shengyang Zhixie.Sent out for exterior syndrome Heat, stiff nape and back, measles without adequate eruption, pyreticosis is thirsty, and the deficiency of Yin is quenched one's thirst, and heat is purged heat the disease such as dysentery, splenasthenic diarrhea.Radix scutellariae（Classification system： Scutellariabaicalensis Georgi）, root is used as medicine, bitter, cold in nature, there is heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, antiabortive And other effects.Cure mainly warm heat disease, the infection of the upper respiratory tract, cough with lung heat, neonatal jaundice caused by dampness-heat, pneumonia, dysentery, hemoptysis, hot eyes, movement of the foetus not The diseases such as peace, hypertension, carbuncle swells furuncle sore.The root bark of white mulberry is moraceae plants mulberry (Classification system：Morus alba L.) dry root Skin.Acted on anti-inflammatory, antibacterial and hypotensive etc..

We's card is gathered, contamination skin forms by internal organs intrinsic heat fiery poison knots more by ulcerative carbuncle serious case of furuncle.Partially visible red and swollen heat pain. Honeysuckle flower is sweet, cold, return lung, the heart, stomach, clearing heat and detoxicating, dissipation carbuncle swells, is monarch drug in a prescription for carbuncle swells furunculosis, toxic-heat and blood stasis etc..It is wild Chrysanthemum enters Liver Channel, the fire of special clearing liver courage, matches with Honeysuckle flower, is apt to clearing up the qi system knot；Dandelion, Chinese violet have clearing heat and detoxicating Work(, be ulcerative carbuncle serious case of furuncle key medicine；Dandelion and can promoting diuresis for stranguria, rush down the damp and hot of lower Jiao, match with Chinese violet, it is kind to purify the blood point Thermojunction；The coptis is bitter, cold, heat-clearing and damp-drying drug, purging intense heat and detonicating；Rheum officinale is clearing heat and detoxicating, defaecation lead it is stagnant, can broken stasis of blood simultaneously " with rush down Dai Qing " plus The work(to expel the heat-evil again；Five medicines share and play clearing heat for detumescence dissipating bind altogether, the work(of purging intense heat and detonicating, are altogether ministerial drug.Radix scutellariae is bitter, cold, strengthens the coptis Heat-clearing and damp-drying drug, the work(of purging intense heat and detonicating；Coix seed, the root of kudzu vine both can dispersing swelling and dissipating binds, the high power rushed down of rheum officinale can be delayed again；Fruit of Chinese wolfberry enriching yin； The red sage root, moutan bark enter the heart, Liver Channel, promoting blood circulation, with solar heat protection and blood knot；The root bark of white mulberry, the kuh-seng inducing diuresis for removing edema with regulating fluid apssage； For adjutant.Borneol is pungent, bitter, is slightly cold, and fragrance is walked to alter, and each medicine is exercised on priming and is guided drugs to illness station, to make medicine.All medicines share, altogether into clear Hot purging intense heat and detonicating, the agent of activating blood circulation and reducing swelling dissipating bind.

Experimental example pharmacological evaluation

1 material

1.1 experimental animal：Kunming mouse 20, rabbit 20, male and female dual-purpose, body weight 2.5-3.0kg

1.2 Experimental agents：Medicine of the present invention（Prepared by embodiment 1）, scaly tetter ointment（It is commercially available）.

2 methods and result

The influence of 2.1 pairs of mouse tail epidermis models

Mouse is randomly divided into 2 groups, i.e. present invention group and psoriasis group, every group 10, every group of mouse tail is sooner or later each to smear one 0.5g is administered in secondary medicine, every mouse every time, and successive administration is put to death mouse, taken with scalpel away from root of the tail about 2.0cm after 15 days Locate the strip of skin of back one, section, scale is observed one by one to each sample under an optical microscope, sees whether epidermis has stratum granulosum Formed.Every scale has the rows of Granulosa cells person of connection, is referred to as the scale for having stratum granulosum.Calculate and do not have 100 scales In have the scale of stratum granulosum, be compared, and make statistics of science.

The influence result of 2.2 pairs of mouse tail epidermis models

Tables 1 and 2 is shown in data record and processing.

Each rat-tail scale stratum granulosum of table 1 forms number

Group	Stratum granulosum forms number in every 100 scales
		Psoriasis group	15 14 19 14 13 20 18 20 17 16
Of the present invention group	17 20 13 22 18 15 15 25 19 20

The data statistics result of table 2

Group	Number of animals	M±d
			Psoriasis group	10	16.61±2.90
Of the present invention group	10	18.40±4.55^*

Note：Compared with psoriasis group, * P>0.5.

It can be drawn by data above, medicine of the present invention has therapeutic action to acne, and curative effect is compared with scaly tetter ointment, nothing Significant difference.

The influence of 2.3 pairs of rabbit ear Acne Models

2.3.1 method

At every ear inboard ear tube opening of rabbit two in the range of 1.5cm*1.5cm, trimerization acetic acid is being applied daily 1 time, every every time Ear dosage 0.3g, continuous 2 weeks.

After 2 weeks after visual inspection rabbit ear inside skin, rabbit is randomly divided into 2 groups, i.e. present invention group and psoriasis group, Every group 10, present invention group smears medicine of the present invention, and only, psoriasis group smears scaly tetter ointment to 0.5g/, and 0.5g/ is only.

2.3.2 result

It is very thin and soft to visually observe rabbit ear before processing, thereon visible capillary, the arrangement of ear opening follicular orifice Neatly, after trichloroacetic acid is smeared one week, ear thickness increase, it is hardened, follicular orifice has black keratotic plug：After coating 2 weeks, it is seen that coating Place's follicular orifice substantially has black keratotic plug, and in blackhead shape, follicular orifice is grand to draw papulosquamous, whole ear rough surface.

Present invention group and psoriasis group are visually observed, it is found that two groups of part hair follicle keratotic plugs are reduced, part keratotic plug is lost after coming off The hair follicle of pitting is stayed, papule, which flattens, to tail off.

It follows that medicine of the present invention has therapeutic action to acne.

Beneficial effect：Medicine of the present invention has the effect of clearing heat-fire removing toxic substances, activating blood circulation and reducing swelling dissipating bind.Available for treating Acne, have no toxic side effect.

Embodiment：

Invention is further described with reference to embodiment, but is not intended as the foundation limited the present invention.

Embodiment 1.

Formula：Coptis 5kg, Honeysuckle flower 12kg, chrysanthemum indicum 12kg, dandelion 12kg, Chinese violet 12kg, fruit of Chinese wolfberry 10kg, pellet Join 12kg, kuh-seng 9kg, moutan bark 12kg, coix seed 12kg, rheum officinale 15kg, root of kudzu vine 10kg, radix scutellariae 10kg, root bark of white mulberry 10kg and Borneol 0.3kg.

Technique：Above medicine is taken, is ground into coarse granule, the concentration for adding 2 times of amounts is 40% ethanol, closed after mixing to put 3h is put, until medicinal powder fully expands, fitted tube, exhaust, is impregnated 35 hours, diacolation is carried out by 1000g medicinal materials outflow 2mL per minute Afterwards, stop diafiltration when collecting liquid to 4 times of medicinal material weight amounts, dregs pressing, take pressed liquor to merge with percolate, decoction total amount 5 times of amounts for medicinal material weight are supplied, then adds 5 times of amounts that 40% ethanol complements to medicinal material weight, is slowly added to and total amount of liquid 1% Carbomer, quickly stir, stand overnight when adding, it is even mixed to add the triethanolamine of total amount of liquid 1.6%, mixes, produces Gel.

Usage and dosage:Affected part is applied to, each 4-6h is applied 1 time.

Embodiment 2.

Technique：Above medicine is taken, is ground into coarse granule, the concentration for adding 2 times of amounts is 45% ethanol, closed after mixing to put 3h is put, until medicinal powder fully expands, fitted tube, exhaust, is impregnated 35 hours, diacolation is carried out by 1000g medicinal materials outflow 3mL per minute Afterwards, stop diafiltration when collecting liquid to 4 times of medicinal material weight amounts, dregs pressing, take pressed liquor to merge with percolate, be condensed into At 60-70 DEG C, relative density is 1.32-1.35 thick paste, takes the sorbierite of the amount of being made 7% and 8% glycerine, adds above-mentioned thick paste In, being heated to 80-85 DEG C makes dissolving；Another stearic acid, 7% tristearin, 3% yellow petroleum jelly, the 8% poly- sorb for taking the amount of being made 8% The lanolin and 1% sucrose stearate of fat 80,2% are heated to 80-85 DEG C, make melting, by above two solution mixing and emulsifying 15 minutes, 80-85 DEG C was incubated 30 minutes, and the benzoic acid and 0.15% ethyl hydroxy benzoate for adding the amount of being made 0.6% mix, filling, i.e., .

Usage and dosage:Affected part is applied to, each 4-6h is applied 1 time.

Embodiment 3.

Formula：Coptis 5kg, Honeysuckle flower 12kg, chrysanthemum indicum 12kg, dandelion 12kg, Chinese violet 12kg, the fruit of Chinese wolfberry 10kg, red sage root 12kg, kuh-seng 9kg, moutan bark 12kg, coix seed 12kg, rheum officinale 15kg, root of kudzu vine 10kg, radix scutellariae 10kg, the root bark of white mulberry 10kg and borneol 0.3kg.

Technique：Above medicine is taken, is ground into coarse granule, the concentration for adding 2 times of amounts is 45% ethanol, closed after mixing to put 6h is put, until medicinal powder fully expands, fitted tube, exhaust, is impregnated 48 hours, diacolation is carried out by 1000g medicinal materials outflow 3mL per minute Afterwards, stop diafiltration when collecting liquid to 4 times of medicinal material weight amounts, dregs pressing, take pressed liquor to merge with percolate, be condensed into At 60-70 DEG C, relative density is 1.32-1.35 thick paste, separately takes the rubber, 60% rosin, 15% vaseline of thick paste amount 60% Lanolin with 25% heats melting, adds above-mentioned clear cream, and the mixing of the glycerine of thick paste amount 20% and 55-65% zinc oxide is stirred Mix 30 minutes, obtain spice, will mount material respectively, and medical mylar and spice are fitted into patch spreading equipment, roll, shaping Afterwards, cut, dispense, seal, packaging, produce patch.

Usage and dosage：It is affixed on affected part, daily 1-2 patches.

Claims

A kind of 1. medicine for treating acne, it is characterised in that：Calculate by weight, mainly by coptis 1-5 parts, Honeysuckle flower 6-15 Part, chrysanthemum indicum 9-15 parts, dandelion 10-15 parts, Chinese violet 15-30 parts, fruit of Chinese wolfberry 6-12 parts, red sage root 10-15 parts, kuh-seng 4.5-9 parts, moutan bark 6-12 parts, coix seed 9-30 parts, rheum officinale 3-15 parts, root of kudzu vine 10-15 parts, radix scutellariae 3-10 parts, root bark of white mulberry 6- 12 and borneol 0.15-0.3 parts be made.
2. the medicine for the treatment of acne as claimed in claim 1, it is characterised in that：Calculate by weight, mainly by coptis 1-5 Part, Honeysuckle flower 6-15 parts, chrysanthemum indicum 9-15 parts, dandelion 10-15 parts, Chinese violet 15-30 parts, fruit of Chinese wolfberry 6-12 parts, the red sage root 10-15 parts, kuh-seng 4.5-9 parts, moutan bark 6-12 parts, coix seed 9-30 parts, rheum officinale 3-15 parts, root of kudzu vine 10-15 parts, radix scutellariae 3-10 Part, root bark of white mulberry 6-12 and borneol 0.15-0.3 parts are made.
3. the medicine for the treatment of acne as claimed in claim 2, it is characterised in that：Calculate by weight, mainly by 5 parts of the coptis, It is 12 parts of Honeysuckle flower, 12 parts of chrysanthemum indicum, 12 parts of dandelion, 12 parts of Chinese violet, 10 parts of the fruit of Chinese wolfberry, 12 parts of the red sage root, 9 parts of kuh-seng, male 0.3 part of 12 parts of the root bark of tree peony, 12 parts of coix seed, 15 parts of rheum officinale, 10 parts of the root of kudzu vine, 10 parts of radix scutellariae, 10 parts of the root bark of white mulberry and borneol are made.
A kind of 4. preparation method for the medicine that acne is treated as any one of claim 1-3, it is characterised in that：Take above-mentioned Medicine, auxiliary material can be added, auxiliary material can also be not added with, according to common process, pharmaceutical preparation is made.
5. the preparation method of the medicine for the treatment of acne as claimed in claim 4, it is characterised in that：The pharmaceutical preparation is gel Agent, ointment or patch.
6. the preparation method of the medicine for the treatment of acne as claimed in claim 5, it is characterised in that：The gel is so made Make：Above medicine is taken, is ground into coarse granule, adds the ethanol that the 1-3 times of concentration measured is 40%, closed placement 15min is extremely after mixing 6h, fitted tube, exhaust, 24-48 hours are impregnated, after carrying out diacolation by 1000g medicinal materials outflow l-3mL per minute, collect liquid to medicine Stop diafiltration during 4 times of amounts of material weight, dregs pressing, take pressed liquor to merge with percolate, decoction total amount is supplied as medicinal material weight 5 times of amounts, then add 40% ethanol and complement to 5 times of medicinal material weight amounts, be slowly added to the card ripple with total amount of liquid 0.5-1.5% Nurse, quickly stir, stand overnight when adding, it is even mixed to add total amount of liquid 1.5%-2% triethanolamine, mixes, you can.
7. the preparation method of the medicine for the treatment of acne as claimed in claim 5, it is characterised in that：The ointment is so made Make：Above medicine is taken, is ground into coarse granule, adds the ethanol that the 1-3 times of concentration measured is 40-50%, closed placement after mixing 15min to 6h, fitted tube, exhaust, 24-48 hours are impregnated, after carrying out diacolation by 1000g medicinal materials outflow l-3mL per minute, collection liquid Stop diafiltration during body to 4 times of medicinal material weight amounts, dregs pressing, take pressed liquor to merge with percolate, when being condensed into 60-70 DEG C, Relative density is 1.32-1.35 thick paste, takes the amount of being made 6-8% sorbierite and 7-9% glycerine, adds in above-mentioned thick paste, add Hot to 80-85 DEG C makes dissolving；Separately take the amount of being made 7-9% stearic acid, 6-8% tristearin, 2-4% yellow petroleum jelly, 8-9% poly- mountain The sucrose stearate of pears fat 80,1-3% lanolin and 0.5-1.5% is heated to 80-85 DEG C, makes melting, and above two is molten Liquid mixing and emulsifying 10-20 minutes, 80-85 DEG C of insulation 25-35 minute, the addition amount of being made 0.5-0.7% benzoic acid and 0.1-0.2% Ethyl hydroxy benzoate mix, it is filling, produce.
8. the preparation method of the medicine for the treatment of acne as claimed in claim 5, it is characterised in that：The paste so makes： Above medicine is taken, is ground into coarse granule, adds the ethanol that the 1-3 times of concentration measured is 40-50%, closed placement 15min is extremely after mixing 6h, fitted tube, exhaust, 24-48 hours are impregnated, after carrying out diacolation by 1000g medicinal materials outflow l-3mL per minute, collect liquid to medicine Stop diafiltration during 4 times of amounts of material weight, dregs pressing, take pressed liquor to merge with percolate, it is relatively close when being condensed into 60-70 DEG C The thick paste for 1.32-1.35 is spent, separately takes thick paste amount 40-60% rubber, 40-60% rosin, 5-15% vaseline and 15-25% Lanolin heating melting, add above-mentioned clear cream, and thick paste amount 10-20% glycerine and 55-65% zinc oxide mix 15-30 minutes, spice is obtained, will mount material respectively, and medical mylar and spice are fitted into patch spreading equipment, roll, into After shape, cut, dispense, seal, packaging, produce.