CN107810013B - 用于治疗癌症的pd-1拮抗剂和艾立布林的组合 - Google Patents

用于治疗癌症的pd-1拮抗剂和艾立布林的组合 Download PDF

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CN107810013B
CN107810013B CN201680025588.3A CN201680025588A CN107810013B CN 107810013 B CN107810013 B CN 107810013B CN 201680025588 A CN201680025588 A CN 201680025588A CN 107810013 B CN107810013 B CN 107810013B
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eribulin
pembrolizumab
pharmaceutically acceptable
acceptable salt
breast cancer
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CN107810013A (zh
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J.马特随
G.阿克坦
V.克兰察
R.元
Y.富纳哈施
E.贝拉克
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Sanitary Material R&d Management Co ltd
Merck Sharp and Dohme LLC
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Merck Sharp and Dohme LLC
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
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    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39566—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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CN201680025588.3A 2015-03-04 2016-03-03 用于治疗癌症的pd-1拮抗剂和艾立布林的组合 Expired - Fee Related CN107810013B (zh)

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US201562128373P 2015-03-04 2015-03-04
US62/128373 2015-03-04
US201562264068P 2015-12-07 2015-12-07
US62/264068 2015-12-07
PCT/US2016/020734 WO2016141209A1 (en) 2015-03-04 2016-03-03 Combination of a pd-1 antagonist and eribulin for treating cancer

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CN107810013A CN107810013A (zh) 2018-03-16
CN107810013B true CN107810013B (zh) 2021-04-02

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US (1) US10945990B2 (https=)
EP (1) EP3265122B1 (https=)
JP (1) JP6951248B2 (https=)
KR (1) KR20170122810A (https=)
CN (1) CN107810013B (https=)
AU (1) AU2016226157B2 (https=)
BR (1) BR112017018872A2 (https=)
CA (1) CA2978311A1 (https=)
IL (1) IL254133B (https=)
MX (1) MX386547B (https=)
RU (1) RU2737216C2 (https=)
SG (1) SG11201706872SA (https=)
WO (1) WO2016141209A1 (https=)

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MX2017011206A (es) 2018-05-17
AU2016226157A1 (en) 2017-09-14
IL254133B (en) 2021-09-30
US10945990B2 (en) 2021-03-16
AU2016226157B2 (en) 2022-01-27
CN107810013A (zh) 2018-03-16
EP3265122A1 (en) 2018-01-10
BR112017018872A2 (pt) 2018-05-29
RU2737216C2 (ru) 2020-11-26
RU2017132877A3 (https=) 2019-08-29
JP2018508516A (ja) 2018-03-29
MX386547B (es) 2025-03-19
WO2016141209A1 (en) 2016-09-09
SG11201706872SA (en) 2017-09-28
KR20170122810A (ko) 2017-11-06
RU2017132877A (ru) 2019-04-05
IL254133A0 (en) 2017-10-31
US20180071247A1 (en) 2018-03-15
CA2978311A1 (en) 2016-09-09
EP3265122B1 (en) 2022-05-04
JP6951248B2 (ja) 2021-10-20

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