CN1078082C - Medicinal composite for acne and preparing method thereof - Google Patents

Abstract

The present invention relates to a drug composition for treating whelk and a preparation method thereof. The drug composition contains chinensis, skullcap, pieplant, red sage root, synthetic bovine bezoar, cimetidine, chloramphenicol, 5% nipagin solution and ethanol. The preparation method comprises the steps that firstly, the Chinese medicinal plants infused with the conventional method are crushed into fine powder, and the fine powder is mixed evenly with the cimetidine to obtain an oral preparation; secondly, the chloramphenicol is added to the 70% ethanol to be dissolved; then the nipagin solution is added and filtrated; finally, the filtrate is added with enough 70% ethanol. The drug composition has the advantages of no toxic or side effect and no anaphylaxis; 1000 odd cases of patients are treated by the drug composition by clinical application; the cure rate is 98%, and the effective rate is 100%; the disease does not relapse after the patients are healed.

Description

Medicine of one cover treatment comedo and preparation method thereof

The present invention relates to Chinese medicine composition, particularly a cover is treated medicine of comedo and preparation method thereof, comedo is acne of youth again, is a kind of pilosebaceous chronic inflammatory disease, good sending out in face, chest and back shows as blackhead, pimple, pustule, infringements such as cyst, primary disease are a kind of multi-pathogenesis diseases, often think increasing owing to androgen and metabolite thereof, sebaceous gland activity is strengthened, or hair follicle leaks head keratinization process and strengthens, or its cell membrane densification thickens difficult drop-off, or the rising of free fat in the sebum, or hair follicle endoparasitism propionibacterium acnes, or inherited genetic factors and the interior trace element deficiency of body etc.

The traditional Chinese medical science to the acne record very early, claim that as " case gold mirror surgery heart method " on the books in " element is asked the vital QI of the body connecting with natural QI human relations " primary disease is " rosacea caused by lung-wind ", this card is formed by the lung meridian heat in blood, and every in the face nose, plays broken pimple, shape such as broomcorn millet bits red complexion swell and ache, break out white lead juice, the traditional Chinese medical science also has the primary disease of title to be " acne vulgaris ", " acne vulgaris " or " whelk ", the primary disease cause of disease is the unclear outer wind heat that is subjected to of lung qi, or eating and drinking without temperance surfeit delicious food savoury, upward steaming of stomach-heat also can be menoxenia, stasis of blood stagnation-derived fever etc., the traditional Chinese medical science thinks that acne is flourishing outer being subjected to due to the ailment said due to cold or exposure of interior-heat, and interior-heat can be divided into lung-heat, heat in blood again, liver-heat, the branch of interior-heat caused by deficiency of YIN.Skin lesion such as pustule belong to wind heat, scorchingly hot due to, acne cystica, inflammatory symptoms such as polymerism seat skin ulcer are not obvious.Chronic process is an erythema multiforme, the disease of cold sore, and and for example the cicatrix acne can be because of caused by energy stagnation and blood stasis.

Primary disease is seen the 15-30 youth of both sexes in year more, begin to occur the age of erythra at present, the city can be in 10-12 year, the rural area is many in 14-15 year, and circuitous prolonging do not healed, outbreak repeatedly, the time heavy when light, the time heavy when light, make facial a lot of scraggly little cicatrixes that occur, influence attractive in appearance, stress is very big in teenager especially, and all day is worried for the goose pimples of face, so that the normal studying and living of influence, in face of others, be ashamed of seeing the people, influence the healthy development of health normal physiological, even marriage and life behind the influence adult, about 40% of young sum accounted for according to present incomplete statistics sickness rate.

The domestic medicine that does not also have to effect a radical cure at present primary disease.Existing medicine, as " acne king ", " Benzoyl Peroxide ", " Sha Laina pox angle cream ", " clear pox cream " etc., what have can only play prophylactic action, and the usefulness that has back has in a few days been come out again at once, make that people's medicine is used very much, " pox " also as before, cure the symptoms, not the disease, do not reach the purpose of radical cure.

The purpose of this invention is to provide a cover cure rate height, can effect a radical cure the medicine of comedo fully.

Another object of the present invention provides a kind of preparation method of medicine of above-mentioned treatment comedo.

Comprise oral formulations and external preparation in the medicine of treatment comedo of the present invention, contain Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, artificial Calculus Bovis, cimetidine in the described oral formulations, contain chloromycetin, 5% nipalgin liquid and 70% ethanol in the described external preparation.

Wherein, described Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, the parts by weight proportioning of artificial Calculus Bovis, cimetidine is:

Rhizoma Coptidis 30-80 part Radix Scutellariae 20-70 part Radix Et Rhizoma Rhei 20-70 part

The described chloromycetin of Radix Salviae Miltiorrhizae 20-70 part artificial Calculus Bovis 5-30 part cimetidine 30-80 part, 5% nipalgin liquid and 70%

Alcoholic acid parts by weight proportioning is:

0.5 part of 70% ethanol 85-99 of chloromycetin 0.5-2 part 5% nipalgin liquid part

The preparation method of the medicine of treatment comedo of the present invention comprises and will be ground into fine powder with the good Chinese crude drug of conventional method infusion, promptly gets oral formulations with the cimetidine mix homogeneously; After getting catilan and being added in 70% ethanol dissolving, add nipalgin again, filter and fill up 70% ethanol in proportion in the rear filtrate and get final product.

Described Rhizoma Coptidis is the Ranunculaceae herbaceos perennial, and Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall rhizome, root hair and leaf, autumn excavate, and the stock of 5-7 is removed floral leaf, fibrous root, and drying is given birth to and is used or stir-fry; Meridian distribution of property and flavor: bitter cold, GUIXIN, liver, stomach, large intestine channel; Function: heat clearing and damp drying, eliminating fire and detoxication.Because of acne has the branch of lung-heat, heat in blood, liver-heat, dark and damp interior-heat, so with its clearing away liver-fire, gastric heat, eliminating heart-fire, separate pyretic toxicity income medicine.

Described Radix Scutellariae is the Labiatae herbaceos perennial, the root main product of Radix Scutellariae in Hebei, ground such as Shanxi, the Inner Mongol, Henan and Shaanxi, maximum with Shanxi output, it is best in quality that produce the Chengde, residual stem is excavated, removed to spring and autumn, fibrous root, dries; Meridian distribution of property and flavor: bitter cold, return lung, gallbladder, stomach, large intestine channel.Effect: heat clearing and damp drying, eliminating fire and detoxication, arresting bleeding and miscarriage prevention.

The traditional Chinese medical science thinks that acne is formed by the lung meridian heat in blood, and the cause of disease is that lung qi is unclear, is subjected to wind heat outward, or eating and drinking without temperance, upward steaming of stomach-heat, and the interior-heat flag is contained, and is subjected to due to the ailment said due to cold or exposure outward.

Described Radix Et Rhizoma Rhei, another name general, Radix Et Rhizoma Rhei, bright and beautiful stricture of vagina are Polygonaceae herbaceos perennial sorrel, big especially big Huang of Tang or Rheum officinale, main product is in Qinghai, Gansu and other places, and the Rheum officinale medical material claims RADIX ET RHIZOMA RHEI OFFICILALIS, be produced in Sichuan, autumn Mo, stem and leaf was withered, or the inferior spring excavate before germinateing and remove fibrous root, scrape off crust, be cut into lobe or section, rope is worn bunchiness, drying or convection drying, and life is with wine stir-fry, parch to black or make ripe usefulness; The nature and flavor problem: bitter cold, return spleen, stomach, large intestine, liver, heart channel; Effect: heat and toxic materials clearing away, clearing away heat-fire, detoxifcation, blood circulation promoting and blood stasis dispelling; Be used for bleeding due to blood-heat, get the property of its bitter cold sedimentation, make that let out below inflammation scorching can also blood circulation promoting and blood stasis dispelling.

Described Radix Salviae Miltiorrhizae is called and is Radix Salviae Miltiorrhizae, is the root of Labiatae herbaceos perennial Radix Salviae Miltiorrhizae, all there is production in most of area, the whole nation, main product in Hebei, ground such as Anhui, Jiangsu, Sichuan, excavate autumn and remove stem and leaf, clean earth, run through the back section and dry, give birth to and use or wine paper money; Meridian distribution of property and flavor: bitter, be slightly cold, GUIXIN, pericardium, Liver Channel; Effect: blood circulation promoting and blood stasis dispelling, forgive blood disappear the pain, nourishing blood to tranquillize the mind.

Described artificial Calculus Bovis is the cholelithiasis of bovid, and minority is the calculus in the cystic duct, claims natural Calculus Bovis, the title artificial Calculus Bovis who is processed through extraction by Fel Bovis seu Bubali or Fel Sus domestica; Meridian distribution of property and flavor: bitter, cool, return through liver, heart channel; Effect: heat-clearing and toxic substances removing, endogenous wind stopping relieves the pain, waking up the patient from unconsciousness by dissipating phlegm.

Described cimetidine is a colourless crystallization, and fusing point 141-142 ℃, water soluble, solution ph are 9.3, and the dissolubility degree increases in weighing apparatus acid, and solution can be stablized a week at least when room temperature PH9.0; Be the H2-of a histamine receptor blocking agent, can suppress the histamine pentapeptide, gastrin stimulates the gastric acid secretion that causes, also can be used for treating herpes zoster, closely questions anti-agent as androgen again recently, can also enhancing human body immunity power.Catilan is a broad ectrum antibiotic, and is effective to the infection that comedo causes.

Described external preparation is colourless or little yellow transparent liquid.

This cover medicine is controlled pyretic toxicity and is contained, is full of vehement in three warmers, the pathogenic fire, the absurd row of forcing blood, thermal burn channels, excessive skin, stagnant heat is steamed and is smoked outer rising, disease sees that haematemesis knob blood or retention of damp-heat in the interior form yellow pox feeling of stuffiness in chest dysphoria with smothery sensation, or red-hot upper punch and cause conjunctival congestion and swollen aphtha of the mouth and tongue or pain is swollen, furunculosis is seen irritable feverish sensation of chest and heart, constipation with dry stool mostly is heat and stops up due to the muscle.Though it is many that this pharmaceutical composition is controlled disease; but the cause of disease is one; promptly be the endogenous fire excessive noxious heat, be full of three warmers, thus be monarch with the Rhizoma Coptidis removing pathogen in the heart, the double fire that rushes down middle Jiao; the fire of the Radix Scutellariae lung heat clearing diarrhea of heat type part of the body cavity above the diaphragm housing the heart and lungs is a minister; Radix Et Rhizoma Rhei has strengthens the merit that pathogenic fire purging expels the heat-evil, rushing down the Dai Qingwei assistant, artificial Calculus Bovis, Radix Salviae Miltiorrhizae have invigorate blood circulation, the merit of blood stasis removing removing heat from blood, the pain that disappears nourishing blood to tranquillize the mind is messenger drug; add and use the Western medicine cimetidine, closely question the effect of antiandrogen and enhancing human body immunity power with it.All medicines share the common Qin, and have pathogenic fire purging and expel the heat-evil, promoting blood circulation and cooling blood, antiandrogen is closely questioned in the blood stasis removing detoxifcation, the effect of nourishing blood to tranquillize the mind, its disease is from disappearing; Particularly the nontoxic nothing of this pharmaceutical composition is paid reaction, does not have irritated symptom, through clinical practice, the treatment patient 1000 surplus example, cure rate 98%, effective percentage 100%, non-relapse after healing.

Usage and consumption: 2 times/day 2/time

The smelting standard that heals is that symptomatology disappears; Effectively obviously improve for symptom.

The course of treatment: one week of medication is a course of treatment.

The clinical case choosing is plucked:

Example 1, Puyang County Qu Cun township local police station: Liu * * male 26 years old, suffer from acne cystica for many years, tcm diagnosis and treatment is not good enough through giving washout effect for oral administration, take multiple medicines such as Western medicine and externally used paste, all there is not positive effect, facial both sides buccal and angle of mandible place cyst join together, and the pharmaceutical composition that uses treatment comedo of the present invention is after one course of treatment, and 70% disappears.Serve on three courses of treatment, symptomatology disappears, and cures and follows up a case by regular visits to so far not recurrence.

Example 2, municipal public security bureau 110 command centres, Lee * * male 36 years old, suffer from pustular acne for many years, once went to a doctor in the whole nation several known to name hospital department of dermatologry, through department of dermatologry expert diagnosis and treatment, it is invalid to award oral administration and externally Chinese medicine and western medicine and commercially available some unguentum or cream, facially cleans and take the pharmaceutical composition of treatment comedo of the present invention after one course of treatment through giving, facial rash all disappears, logotype two courses of treatment of end recurrence so far again.

Example 3, the reporter Wu of east society of family * * woman 25 years old, facial shirtfront, back, blackhead thorn powder sample acne are for many years, at city's hospital dermatology department, skin liver section of institute of traditional Chinese medicine, prescription on individual diagnosis, Chinese medicine and western medicine washout effect for oral administration is not good enough, after giving the affected part and cleaning, take a kind of pharmaceutical composition for the treatment of comedo of the present invention and preparation method thereof, erythra all disappears and takes off after one week, and back logotype is cured for two courses of treatment, so far recurrence.

Further describe the present invention below in conjunction with embodiment

Embodiment

The medicine of one cover treatment comedo, it comprises oral formulations and external preparation, and described oral formulations contains Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, artificial Calculus Bovis, cimetidine, and described external preparation contains chloromycetin, 5% nipalgin liquid and 70% ethanol.Wherein, the parts by weight proportioning of described Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, artificial Calculus Bovis, cimetidine is:

40 parts of 40 parts of Radix Et Rhizoma Rhei of 50 parts of Radix Scutellariaes of Rhizoma Coptidis

50 parts of 20 portions of cimetidine of 40 parts of artificial Calculus Boviss of Radix Salviae Miltiorrhizae

Described chloromycetin, 5% nipalgin liquid and 70% alcoholic acid parts by weight proportioning are:

98.5 parts of 0.5 part of 70% ethanol of 1 part of 5% nipalgin liquid of chloromycetin

The preparation method of the medicine of treatment comedo of the present invention comprises and will be ground into fine powder with the good Chinese crude drug of conventional method infusion, promptly gets oral capsule with cimetidine mix homogeneously rear packing; After extracting chloromycetin is added on and dissolves in 70% ethanol, add nipalgin dissolving after-filtration again, add 70% ethanol in the filtrate in proportion and get final product.

Claims (2)

1, the medicine of a cover treatment comedo; it is characterized in that comprising oral formulations and external preparation; described oral formulations is by Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, artificial Calculus Bovis, cimetidine, and described external preparation is made up of chloromycetin, 5% nipalgin liquid and 70% ethanol

Wherein, in the oral formulations; the parts by weight proportioning of each composition is: 30-80 parts of Rhizoma Coptidis, 20-70 parts of Radix Scutellariaes, 20-70 parts of Radix Et Rhizoma Rhei, 20-70 parts of Radix Salviae Miltiorrhizaes, 5-30 parts of artificial Calculus Boviss, cimetidine 30-80, the parts by weight proportioning of each composition is in the described external preparation: 0.5-2 parts in chloromycetin, 0.5 part of 5% nipalgin liquid, 85-99 parts of 70% ethanol.

2, the preparation method of medicine as claimed in claim 1 is characterized in that comprising that the Chinese crude drug with cooking with conventional method is ground into fine powder, promptly gets oral formulations with the cimetidine mix homogeneously; Get and add nipalgin again after catilan is added in 70% ethanol dissolving, filter and fill up 70% ethanol in proportion in the rear filtrate and get final product.