CN107802880A - A kind of anticoagulation conditioning liquid, its preparation method and anticoagulation sanitary napkin - Google Patents
A kind of anticoagulation conditioning liquid, its preparation method and anticoagulation sanitary napkin Download PDFInfo
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- CN107802880A CN107802880A CN201711272741.5A CN201711272741A CN107802880A CN 107802880 A CN107802880 A CN 107802880A CN 201711272741 A CN201711272741 A CN 201711272741A CN 107802880 A CN107802880 A CN 107802880A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/21—Acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/22—Lipids, fatty acids, e.g. prostaglandins, oils, fats, waxes
- A61L2300/222—Steroids, e.g. corticosteroids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
Abstract
The invention provides a kind of anticoagulation conditioning liquid, its preparation method and anticoagulation sanitary napkin, it is related to hygiene article sector.The constituent of the anticoagulation conditioning liquid includes according to the mass fraction：15 parts of sodium citrate, disodium hydrogen phosphate are 0.1 1 parts, dipotassium glycyrrhizinate is 0.1 5 parts, 0.2 5 parts of citric acid, 2 10 parts of glucose, tea polysaccharide are 0.1 2 parts, 32 75 parts of 20 40 parts of ethanol and water.It can play a part of preventing blood clotting, can keep menses script color, prevent menses blackening, moreover it is possible to effective bacteriostasis, and deodorization.The preparation method of the anticoagulation conditioning liquid is simple to operate by the way that above-mentioned constituent is well mixed, and easily realizes, obtained anticoagulation nursing liquid energy plays a part of preventing blood clotting.The anticoagulation sanitary napkin, above-mentioned anticoagulation conditioning liquid is sprayed into sanitary napkin surface and is made after volatilization.It can effectively keep the activity of isolated blood, anti-Hemostatic Oral Liquid rapid condensation.
Description
Technical field
The present invention relates to hygiene article sector, in particular to a kind of anticoagulation conditioning liquid, its preparation method and resists
Blood coagulation sanitary napkin.
Background technology
After menses are in vitro, due to the influence of the external environments such as temperature, the anticoagulant mechanism of human body is most of to isolated blood in addition
Failure, blood will inevitably condense.If timely, effective absorption can not be obtained, it will retention causes to stick in sanitary napkin surface
Paste, wet vexed sense of discomfort.And after menses are absorbed by sanitary napkin, the solidifying of small range multizone may be internally formed in sanitary napkin
Knot, reduces the subsequent absorption ability of sanitary napkin, hinders to ooze under menses, reduce the overall absorption amount of sanitary napkin, also have when measuring more
Side leakage may be caused, leak equivalent risk afterwards.
The content of the invention
The first object of the present invention is to provide a kind of anticoagulation conditioning liquid, and it can play a part of preventing blood clotting.
The second object of the present invention is to provide a kind of preparation method of anticoagulation conditioning liquid, and the preparation method is simple, behaviour
Make condition easily to realize, obtained anticoagulation nursing liquid energy plays a part of preventing blood clotting.
The third object of the present invention is to provide a kind of anticoagulation sanitary napkin, and anticoagulation conditioning liquid is applied into sanitary napkin
On, it can effectively keep the activity of isolated blood, anti-Hemostatic Oral Liquid rapid condensation.
What embodiments of the invention were realized in：
A kind of anticoagulation conditioning liquid, its constituent include according to the mass fraction：Sodium citrate 1-5 parts, disodium hydrogen phosphate
Be 0.1-5 parts for 0.1-1 parts, dipotassium glycyrrhizinate, citric acid 0.2-5 parts, glucose 2-10 parts, tea polysaccharide be 0.1-2 parts, ethanol
20-40 parts and water 32-75 parts.
A kind of preparation method of anticoagulation conditioning liquid, it includes：By part water, sodium citrate, disodium hydrogen phosphate, lemon
Acid, glucose and dipotassium glycyrrhizinate mixing, stirring form the first mixed liquor until without precipitation or crystallization, adjust pH to 5-6；
Tea polysaccharide stirring is added into the first mixed liquor again until without Precipitation, ethanol stirring is added until without Precipitation, mends
The remaining water of foot.
A kind of anticoagulation sanitary napkin, above-mentioned anticoagulation conditioning liquid is sprayed into sanitary napkin surface and is made after volatilization.
The beneficial effect of the embodiment of the present invention for example including：
Anticoagulation conditioning liquid provided in an embodiment of the present invention utilizes the sodium citrate in its constituent to clotting factor
Calcium ion in protection, and complexing blood, plays a part of preventing blood clotting.Simultaneously by disodium hydrogen phosphate and dipotassium glycyrrhizinate
Compounding use, the stimulation of disodium hydrogen phosphate effectively can be neutralized and reduced, while be also possible to prevent the mistake of disodium hydrogen phosphate
Quick reaction.Dipotassium glycyrrhizinate can accelerate absorption of the skin to sodium citrate with sodium citrate and disodium hydrogen phosphate compatibility
And increase anticoagulant effect, while the excitant of disodium hydrogen phosphate can be reduced.Further carried out using citric acid anti-oxidant
With except raw meat is deodorized, effectively suppress bacterium infection and prevent menses aoxidize blackening.Energy is provided for erythrocyte using glucose,
Citric acid can promote glucose to convert, and the also effect of color protection, further keep blood script color, and anti-Hemostatic Oral Liquid becomes
It is black.In addition, by the use of volatile ethanol as one kind in component, after can anticoagulation conditioning liquid be sprayed on sanitary napkin,
The drying of sanitary napkin is kept, comfort level is more preferably.
The preparation method of above-mentioned anticoagulation conditioning liquid provided in an embodiment of the present invention is simple, and operating condition is easily realized, system
The anticoagulation nursing liquid energy obtained plays a part of preventing blood clotting.
Anticoagulation sanitary napkin provided in an embodiment of the present invention, anticoagulation conditioning liquid is applied on sanitary napkin, can be effective
Keep the activity of isolated blood, anti-Hemostatic Oral Liquid rapid condensation.
Embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.It is unreceipted specific in embodiment
Condition person, the condition suggested according to normal condition or manufacturer are carried out.Agents useful for same or the unreceipted production firm person of instrument, it is
The conventional products that can be obtained by commercially available purchase.
Have below to a kind of anticoagulation conditioning liquid, its preparation method and the anticoagulation sanitary napkin of the embodiment of the present invention
Body explanation.
A kind of anticoagulation conditioning liquid, its constituent include according to the mass fraction：Sodium citrate 1-5 parts, disodium hydrogen phosphate
Be 0.1-5 parts for 0.1-1 parts, dipotassium glycyrrhizinate, citric acid 0.2-5 parts, glucose 2-10 parts, tea polysaccharide be 0.1-2 parts, ethanol
20-40 parts and water 32-75 parts.
Preferably, the constituent of anticoagulation conditioning liquid includes according to mass fraction meter：Sodium citrate 1-4 parts, phosphoric acid hydrogen
Disodium is 0.1-0.8 parts, dipotassium glycyrrhizinate is 0.1-3 parts, citric acid 0.2-3 parts, glucose 2-8 parts, tea polysaccharide 0.1-1
Part, ethanol 20-35 parts and water 45-75 parts.
Wherein, sodium citrate is also referred to as Chinese holly Citron acid sodium, using sodium citrate as anticoagulant in the present embodiment.Due to
In the formation of thrombokinase and later coagulation process, it is necessary to have calcium ion participation.Citric acid radical ion and calcium ion
A kind of soluble complexes for being difficult to dissociate can be formed, thus reduce calcium ion concentration in blood, blood clotting is obstructed.Lemon
Sour sodium plays a part of preventing blood clotting by the calcium ion in the protection to clotting factor, and complexing blood.
Disodium hydrogen phosphate is used as nertralizer, can neutralize the peculiar smell in menses.
Dipotassium glycyrrhizinate has anti-inflammatory, antiallergy, moisturizing and other effects, and the addition of dipotassium glycyrrhizinate can reduce conditioning liquid
To the excitant of vaginal mucosa, the safety and comfort level of sanitary napkin are improved.Because disodium hydrogen phosphate has slight stimulation,
The stimulation of disodium hydrogen phosphate effectively can be neutralized and reduce by compounding dipotassium glycyrrhizinate in the present embodiment, while can also
Prevent the allergic reaction of disodium hydrogen phosphate.Dipotassium glycyrrhizinate can accelerate skin with sodium citrate and disodium hydrogen phosphate compatibility
Skin increases the absorption of sodium citrate anticoagulant effect, while can reduce the excitant of disodium hydrogen phosphate.
Citric acid is mainly used as antioxidant and except raw meat deodorant.Contain substantial amounts of metallic element, such as iron in menses, pass through
It is oxidizable to be changed into brown after blood discharge, and then condense.In the present embodiment, oxidation resistant effect, Neng Gouyou are played by citric acid
Effect prevents menses from aoxidizing, while citric acid also has chelation, can remove the metallic element in menses.Citric acid can be prevented
The only oxidation caused by enzymatic and metal catalytic, the effect for preventing that menses from aoxidizing is further functioned as, so as to effectively suppress
Through blood coagulation.Citric acid also has the effect for suppressing bacterium, can effectively prevent bacteria breed, cause human genitals to infect, band
Carry out disease.
Wherein erythrocyte, self consumption oxygen energy supply, blood are converted into anoxemia by oxygen-enriched blood after menses are in vitro, and oxygen closes
Decreased hemoglobin, the iron ion in ferroheme porphyrin ring, which such as is oxidized at the composite factor, to be influenceed, and blood will gradually dimmed blackening.
Blood blackening, visual uncomfortable and nausea can be brought to menstruating women.In the present embodiment, the glucose in component can be supplied effectively
Isolated blood cellular energy is given, maintains haemocyte activity, blood oxygen-enriched state is maintained, effectively maintains blood script color, prevent
Blood blackening.
In addition, in the present embodiment, by citric acid and glucose compatible use, glucose provides energy, lemon for erythrocyte
Lemon acid can promote glucose to convert, and the also effect of color protection, further keep blood script color, and anti-Hemostatic Oral Liquid becomes
It is black.
Ethanol is volatile, is added to ethanol as component in anticoagulation conditioning liquid, can spray anticoagulation conditioning liquid
It is easy to volatilize at sanitary napkin surface, drying regime is in after the completion of production, improves the absorbent properties of sanitary napkin in itself, make
It is more preferable with impression.
Further, the constituent of the anticoagulation conditioning liquid in the embodiment of the present invention also includes according to mass fraction meter：
Phenoxyethanol is 1-8 parts, chlorhexidine gluconate 1-5 parts and grape fruit extract 1-5 parts.
Phenoxyethanol is a kind of colourless oily liquids, has antibiotic effect, and can be used as preservative；Gluconic acid chlorine
Oneself is fixed to have wider antimicrobial acivity, can antibacterial and sterilization, be colourless or faint yellow nearly transparent slightly sticky liquid
Body；It is odorless or almost odorless.Grape fruit extract has the function that antibacterial anti-infection, nurse tissue cell.In the present embodiment, profit
It is added to a variety of compositions with bacteriostasis antibiosis effect such as Phenoxyethanol, chlorhexidine gluconate and grape fruit extract anti-
In blood coagulation conditioning liquid, Phenoxyethanol, chlorhexidine gluconate and grape fruit extract pass through the suppression to microorganism and bacterium
Effect, can effectively prevent sanitary napkin surface colonization bacterium, cause human genitals to infect, bring disease.Phenoxyethanol, grape
The compounding of saccharic acid Chlorhexidine and grape fruit extract can be realized inhibited to various bacteria, while suppress bacterium energy
It is enough effectively to reduce menses peculiar smell, provide the user more preferable experience.
Study and find through inventor, preferably mass fraction is：Phenoxyethanol is 1-5 parts, chlorhexidine gluconate 1-3 parts
And grape fruit extract 1-3 parts.Phenoxyethanol, chlorhexidine gluconate and grape fruit extract are according to specific mass parts
Number carries out compatibility, and effect is more preferable.
Further, the constituent of the anticoagulation conditioning liquid in the embodiment of the present invention also includes according to mass fraction meter：
Vegetable active selenium 0.1-2 parts, Pheretima extract 1-2 parts and adder-wort alcohol extract 1-2 parts.
Vegetable active selenium has oxidation resistant effect.Pheretima extract has blood coagulation resisting function, can effectively extend blood coagulation
Time.
Study and find through inventor, by vegetable active selenium, Pheretima extract and adder-wort alcohol extract compounding use, plant lives
Property selenium can effectively prevent that menses from aoxidizing, and adder-wort alcohol extract and Pheretima extract compound, and can effectively extend menses setting time,
And then avoid through blood coagulation.
Preferably, vegetable active selenium 0.1-1 parts, Pheretima extract 1-1.5 parts and adder-wort alcohol extract 1-1.5 parts.
A kind of preparation method of anticoagulation conditioning liquid, it includes：
S1：Form the first mixed liquor.
By part water, sodium citrate, disodium hydrogen phosphate, citric acid, glucose and dipotassium glycyrrhizinate mix, stirring until
Without precipitation or crystallization, the first mixed liquor is formed, adjusts pH to 5-6.
It is worth noting that, water, sodium citrate, disodium hydrogen phosphate, citric acid, glucose and dipotassium glycyrrhizinate be according to
Specific step and order is added, and follow-up component is entered back into after stirring, is so advantageous to each component and is well mixed.Adjust
It is in faintly acid that section pH to 5-6, which advantageously allows whole first mixed liquor, is advantageous to keep the activity of component in anticoagulation conditioning liquid.
S2：Form the second mixed liquor.
Part water is taken, and grape fruit extract is added into the water, benzene oxygen second is added after the dissolving of grape fruit extract
Alcohol and glucose acid Chlorhexidine, it is well mixed, forms the second mixed liquor.
Grape fruit extract is highly soluble in water, by taking part water, and grape fruit extract, grape is added into the water
Shaddock extract can be evenly distributed in water, then adding Phenoxyethanol and chlorhexidine gluconate, be advantageous to grape fruit and carry
Take the mixing uniformity of thing, Phenoxyethanol and chlorhexidine gluconate.
It is worth noting that, step S2 is optional step, when being free of grape fruit extract, Phenoxyethanol and grape in component
During saccharic acid Chlorhexidine, the step can be omitted.
S3：Form the 3rd mixed liquor.
Into the second mixed liquor, interval adds Pheretima extract 1-2 parts, vegetable active selenium 0.1-2 parts and adder-wort alcohol successively
Extract 1-2 parts, interval time 3-5min；Stir, form the 3rd mixed liquor, the 3rd mixed liquor is added into the first mixed liquor
In, stir.
Pheretima extract and adder-wort alcohol extract are respectively provided with anticoagulant efficacy, in the present embodiment, by being made with vegetable active selenium
For middle bridge, Pheretima extract and adder-wort alcohol extract are compounded using its antioxidation activity, so as to effectively avoid
Through blood coagulation.
When Pheretima extract, vegetable active selenium and adder-wort alcohol extract are added into above-mentioned second mixed liquor, it may be noted that should
Pheretima extract is added in the ban, adds vegetable active selenium, is eventually adding adder-wort alcohol extract, energy is added among vegetable active selenium
Enough play a part of good bridge and regulation.
It is worth noting that, step S3 is optional step, when being free of Pheretima extract, vegetable active selenium and fist in component
When joining alcohol extract, the step can be omitted.
S4：Add tea polysaccharide and ethanol.
Tea polysaccharide stirring is added into the mixture of the first mixed liquor and the 3rd mixed liquor until without Precipitation, is added
Ethanol stirring supplies remaining water until without Precipitation.After step S2 and S3 are omitted, it can add directly into the first mixed liquor
Enter tea polysaccharide.
A kind of anticoagulation sanitary napkin, above-mentioned anticoagulation conditioning liquid is sprayed into sanitary napkin surface and is made after volatilization.Wherein,
The quantity for spray of anticoagulation conditioning liquid is 0.1-0.3g/ pieces.The volatilization time is 3-5min, and the volatilization time is fast.
It can ensure that the anticoagulant effect of every sanitary napkin reaches optimal by suitable quantity for spray, while anticoagulation is nursed
Moisture and ethanol volatilization in liquid, make the active ingredient in anticoagulation conditioning liquid retain to sanitary napkin surface, through follow-up pouch
Packaging, active ingredient can be effectively kept to be attached to sanitary napkin surface and not volatile.
Anticoagulation conditioning liquid provided in an embodiment of the present invention utilizes the sodium citrate in its constituent to clotting factor
Calcium ion in protection, and complexing blood, plays a part of preventing blood clotting.Simultaneously by disodium hydrogen phosphate and dipotassium glycyrrhizinate
Compounding use, the stimulation of disodium hydrogen phosphate effectively can be neutralized and reduced, while be also possible to prevent the mistake of disodium hydrogen phosphate
Quick reaction.Dipotassium glycyrrhizinate can accelerate absorption of the skin to sodium citrate with sodium citrate and disodium hydrogen phosphate compatibility
And increase anticoagulant effect, while the excitant of disodium hydrogen phosphate can be reduced.Further carried out using citric acid anti-oxidant
With except raw meat is deodorized, effectively suppress bacterium infection and prevent menses aoxidize blackening.Energy is provided for erythrocyte using glucose,
Citric acid can promote glucose to convert, and the also effect of color protection, further keep blood script color, and anti-Hemostatic Oral Liquid becomes
It is black.In addition, by the use of volatile ethanol as one kind in component, after can anticoagulation conditioning liquid be sprayed on sanitary napkin,
The drying of sanitary napkin is kept, comfort level is more preferably.
The preparation method of above-mentioned anticoagulation conditioning liquid provided in an embodiment of the present invention is simple, and operating condition is easily realized, system
The anticoagulation nursing liquid energy obtained plays a part of preventing blood clotting.
Anticoagulation sanitary napkin provided in an embodiment of the present invention, anticoagulation conditioning liquid is applied on sanitary napkin, can be effective
Keep the activity of isolated blood, anti-Hemostatic Oral Liquid rapid condensation.
It is further to the anticoagulation conditioning liquid, its preparation method and anticoagulation sanitary napkin of the present invention with reference to embodiments
It is illustrated.
Embodiment 1
A kind of anticoagulation conditioning liquid is present embodiments provided, its constituent includes：Sodium citrate 4g, disodium hydrogen phosphate are
0.8g, dipotassium glycyrrhizinate 3g, citric acid 3g, glucose 8g, tea polysaccharide 0.2g, ethanol 35g and water 46g.
Its preparation method is as follows：By part water, sodium citrate, disodium hydrogen phosphate, citric acid, glucose and glycyrrhizic acid two
Potassium mixes, and stirring forms the first mixed liquor until without precipitation or crystallization, adjusts pH to 5.4；Again tea is added into the first mixed liquor
Polysaccharide stirring adds ethanol stirring until without Precipitation, supplies remaining water until without Precipitation.
The present embodiment additionally provides a kind of anticoagulation sanitary napkin, by the anticoagulation conditioning liquid of above-mentioned preparation according to every 0.3g
Quantity for spray be sprayed into sanitary napkin surface, after volatilization be made.
Embodiment 2
A kind of anticoagulation conditioning liquid is present embodiments provided, its constituent includes：Sodium citrate 1g, disodium hydrogen phosphate are
0.1g, dipotassium glycyrrhizinate 0.1g, citric acid 0.2g, glucose 10g, tea polysaccharide 0.6g, ethanol 40g, water 35g, benzene oxygen second
Alcohol is 3g, chlorhexidine gluconate 5g and grape fruit extract 5g；
Its preparation method is as follows：By part water, sodium citrate, disodium hydrogen phosphate, citric acid, glucose and glycyrrhizic acid two
Potassium mixes, and stirring forms the first mixed liquor until without precipitation or crystallization, adjusts pH to 5；Part water is taken, and is added into the water
Enter grape fruit extract, add Phenoxyethanol and chlorhexidine gluconate after the dissolving of grape fruit extract, be well mixed, formed
Second mixed liquor, the second mixed liquor is added in the first mixed liquor, stirred.Tea polysaccharide stirring is added until being analysed without precipitation
Go out, add ethanol stirring until without Precipitation, supply remaining water.
The present embodiment additionally provides a kind of anticoagulation sanitary napkin, by the anticoagulation conditioning liquid of above-mentioned preparation according to every 0.1g
Quantity for spray be sprayed into sanitary napkin surface, after volatilization be made.
Embodiment 3
A kind of anticoagulation conditioning liquid is present embodiments provided, its constituent includes：Sodium citrate 5g, disodium hydrogen phosphate are
1g, dipotassium glycyrrhizinate 5g, citric acid 5g, glucose 2g, tea polysaccharide 0.1g, ethanol 20g, water 57.8g, vegetable active selenium
0.1g, Pheretima extract 2g and adder-wort alcohol extract 2g；
Its preparation method is as follows：By part water, sodium citrate, disodium hydrogen phosphate, citric acid, glucose and glycyrrhizic acid two
Potassium mixes, and stirring forms the first mixed liquor until without precipitation or crystallization, adjusts pH to 6；Into the first mixed liquor, interval adds successively
Enter Pheretima extract, vegetable active selenium and adder-wort alcohol extract, interval time 3min；Stir, add tea polysaccharide and stir
Mix until without Precipitation, add ethanol stirring until without Precipitation, supply remaining water.
The present embodiment additionally provides a kind of anticoagulation sanitary napkin, by the anticoagulation conditioning liquid of above-mentioned preparation according to every 0.2g
Quantity for spray be sprayed into sanitary napkin surface, after volatilization be made.
Embodiment 4
A kind of anticoagulation conditioning liquid is present embodiments provided, its constituent includes：Sodium citrate 3g, disodium hydrogen phosphate are
0.5g, dipotassium glycyrrhizinate 3g, citric acid 2.5g, glucose 5g, tea polysaccharide 1.2g, ethanol 30g, water 41g, Phenoxyethanol are
5g, chlorhexidine gluconate 3g and grape fruit extract 2g, vegetable active selenium 0.8g, Pheretima extract 2g and adder-wort alcohol extracting
Thing 1g.
Its preparation method is as follows：By part water, sodium citrate, disodium hydrogen phosphate, citric acid, glucose and glycyrrhizic acid two
Potassium mixes, and stirring forms the first mixed liquor until without precipitation or crystallization, adjusts pH to 5.6；Part water is taken, and into the water
Grape fruit extract is added, Phenoxyethanol and chlorhexidine gluconate is added after the dissolving of grape fruit extract, is well mixed, shape
Into the second mixed liquor, into the second mixed liquor, interval adds Pheretima extract, vegetable active selenium and adder-wort alcohol extract successively,
It is 5min every the time；Stir, form the 3rd mixed liquor, the 3rd mixed liquor is added in first mixed liquor, stirred
Mix uniformly.Tea polysaccharide stirring is added until without Precipitation, ethanol stirring is added until without Precipitation, supplies remaining
Water.
The present embodiment additionally provides a kind of anticoagulation sanitary napkin, by the anticoagulation conditioning liquid of above-mentioned preparation according to every
0.25g quantity for spray is sprayed into sanitary napkin surface, is made after volatilization.
Embodiment 5
A kind of anticoagulation conditioning liquid is present embodiments provided, its constituent includes：Sodium citrate 2g, disodium hydrogen phosphate are
0.1g, dipotassium glycyrrhizinate 2.5g, citric acid 0.2g, glucose 8g, tea polysaccharide 0.5g, ethanol 25g, water 46.7g, benzene oxygen second
Alcohol is 5g, chlorhexidine gluconate 3g and grape fruit extract 3g, vegetable active selenium 1g, Pheretima extract 1.5g and adder-wort
Alcohol extract 1.5g.
The present embodiment additionally provides a kind of anticoagulation sanitary napkin, by the anticoagulation conditioning liquid of above-mentioned preparation according to every
0.15g quantity for spray is sprayed into sanitary napkin surface, is made after volatilization.
Contrast experiment
First, anti-freezing blood test
Pure water equivalent is sprayed on the sanitary napkin surface of phase same material as blank example；
Anticoagulation sanitary napkin prepared by embodiment 1-5 is as test example 1-5；
After the anticoagulation conditioning liquid that embodiment 1 is provided dilutes 5,10,15 and 20 times, the anticoagulation nursing of equivalent is sprayed
Liquid is in sanitary napkin surface 1-4 as a comparison case；
By commercially available sanitary napkin as a comparison case 5.
Test above-mentioned blank example, test example 1-5 and comparative example 1-5 anticoagulant efficacy.
Experimental method：Blood is taken at Rabbit Heart, the safe fixed rabbit of a people, the outside of belly is upward, the hand-held infiltration of blood sampling person one
The blood sampling syringe crossed, another finger search heartbeat most strength (being normally at left border of sternum 4-5 intercostals) in rabbit anterior part of chest,
It is vertical to be pierced into intercostal space inserting needle, wait that breaking through sense is pierced into thoracic cavity, is pierced into heart vertically downward.Heart is such as pierced into, then is injected
Device vibration is uniform and stable, consistent with palmic rate, now resorption blood, and having blood to enter then proves to enter heart.
Then to the rabbit blood that equivalent is separately added on blank example, test example 1-5 and comparative example 1-5 sanitary napkins, 37 are put into
Under the conditions of DEG C, blood clotting is observed, as a result referring to table 1：
The anticoagulation function testing result of table 1.
By table 1, it is apparent that the anticoagulation conditioning liquid that the present embodiment provides can effectively prevent blood clotting, and
Anticoagulation conditioning liquid is made in mass fraction according to the component of the anticoagulation conditioning liquid provided in the present embodiment, and coagulating effectiveness is good,
Anticoagulation conditioning liquid effect after dilution gradually weakens.
2nd, properties of product detect
After anticoagulation conditioning liquid provided by the invention is sprayed at sanitary towels, after testing：Bacteriostasis property；It is antibacterial steady
It is qualitative to reach country's mark, laws and regulations requirement, meet properties of product and declare；Sanitary napkin through the spraying of anticoagulation conditioning liquid carries out skin
Allergy is tested；Vaginal mucosa irritation test meets national standard, laws and regulations requirement, meets properties of product and declares.
Table 2：Bacteriostasis property detection content and result；
Table 3：Antimicrobial stability energy detection content and result；
Table 4：Skin allergy test detection content and result；
Table 5：Vaginal mucosa irritation test detection content and result.
Specific detection content and information are as follows：
After anticoagulation conditioning liquid provided by the invention is sprayed at sanitary towels, after testing, bacteriostasis property reaches
GB15979-2002 Disposable Sanitary Accessories sanitary standard and《Disinfection technology standard》The requirement of (third edition), clearly has
Bacteriostasis efficacy, meet laws and regulations requirement.Detection content is referring to table 2：
Table 2：Bacteriostasis property detection content and result
After anticoagulation conditioning liquid provided by the invention is sprayed at sanitary towels, accelerate by constant temperature and humidity, accelerate the cycle
For 90 days at 37 DEG C, that is, period of storage was scaled as 2 years, after testing, it is disposable that antimicrobial stability can reach GB15979-2002
Using amenities sanitary standard and《Disinfection technology standard》The requirement of (third edition), meets laws and regulations requirement.Detection content referring to
Table 3：
Table 3：Antimicrobial stability energy detection content and result
After anticoagulation conditioning liquid provided by the invention is sprayed at sanitary towels, Skin allergy test is carried out, is reached
《Disinfection technology standard》The requirement of (third edition), it is extremely slight sensitization to specify the product, meets laws and regulations requirement, detection content
Referring to table 4：
Table 4：Skin allergy test detection content and result
After anticoagulation conditioning liquid provided by the invention is sprayed at sanitary towels, vaginal mucosa irritation test is carried out, is reached
Arrive《Disinfection technology standard》The requirement of (third edition), the product absence of vagina irritation on mucous membrane is specified, meet laws and regulations requirement, in detection
Hold referring to table 5：
Table 5：Vaginal mucosa irritation test detection content and result
The preferred embodiments of the present invention are these are only, are not intended to limit the invention, for those skilled in the art
For member, the present invention can have various modifications and variations.Any modification within the spirit and principles of the invention, being made,
Equivalent substitution, improvement etc., should be included in the scope of the protection.
Claims (10)
1. a kind of anticoagulation conditioning liquid, it is characterised in that its constituent includes according to the mass fraction：Sodium citrate 1-5 parts, phosphorus
Sour disodium hydrogen is 0.1-1 parts, dipotassium glycyrrhizinate is 0.1-5 parts, citric acid 0.2-5 parts, glucose 2-10 parts, tea polysaccharide 0.1-
2 parts, ethanol 20-40 parts and water 32-75 parts.
2. anticoagulation conditioning liquid according to claim 1, it is characterised in that the constituent is according to mass fraction meter bag
Include：Sodium citrate 1-4 parts, disodium hydrogen phosphate are 0.1-0.8 parts, dipotassium glycyrrhizinate is 0.1-3 parts, citric acid 0.2-3 parts, grape
Sugared 2-8 parts, tea polysaccharide are 0.1-1 parts, ethanol 20-35 parts and water 45-75 parts.
3. anticoagulation conditioning liquid according to claim 1, it is characterised in that the constituent according to mass fraction meter also
Including：Phenoxyethanol is 1-8 parts, chlorhexidine gluconate 1-5 parts and grape fruit extract 1-5 parts；
Preferably, the Phenoxyethanol is 1-5 parts, described chlorhexidine gluconate 1-3 parts and the grape fruit extract 1-3
Part.
4. according to the anticoagulation conditioning liquid described in claim any one of 1-3, it is characterised in that the constituent is according to quality
Number meter also includes：Vegetable active selenium 0.1-2 parts, Pheretima extract 1-2 parts and adder-wort alcohol extract 1-2 parts；
Preferably, described vegetable active selenium 0.1-1 parts, described Pheretima extract 1-1.5 parts and the adder-wort alcohol extract 1-1.5
Part.
5. a kind of preparation method of anticoagulation conditioning liquid as claimed in claim 1, it is characterised in that it includes：
By the part water, the sodium citrate, the disodium hydrogen phosphate, the citric acid, the glucose and described sweet
Oxalic acid dipotassium mixes, and stirring forms the first mixed liquor until without precipitation or crystallization, adjusts pH to 5-6；
The tea polysaccharide stirring is added into first mixed liquor again until without Precipitation, it is straight to add the ethanol stirring
To without Precipitation, the remaining water is supplied.
6. the preparation method of anticoagulation conditioning liquid according to claim 5, it is characterised in that to first mixed liquor
It is middle to add before the tea polysaccharide, the part water is taken, and grape fruit extract is added into the water, treat that the grape fruit carries
Take thing to add Phenoxyethanol and chlorhexidine gluconate after dissolving, be well mixed, form the second mixed liquor, described second is mixed
Liquid is added in first mixed liquor, is stirred.
7. the preparation method of anticoagulation conditioning liquid according to claim 6, it is characterised in that by second mixed liquor
Before adding in first mixed liquor, in addition into second mixed liquor successively interval add Pheretima extract 1-2 parts,
Vegetable active selenium 0.1-2 parts and adder-wort alcohol extract 1-2 parts, interval time 3-5min；Stir, form the 3rd mixing
Liquid, the 3rd mixed liquor is added in first mixed liquor, stirred.
8. a kind of anticoagulation sanitary napkin, it is characterised in that the anticoagulation conditioning liquid described in claim 1 is sprayed into sanitary napkin table
Face is made after volatilization.
9. anticoagulation sanitary napkin according to claim 8, it is characterised in that the quantity for spray of the anticoagulation conditioning liquid is
0.1-0.3g/ pieces.
10. anticoagulation sanitary napkin according to claim 8, it is characterised in that the time of the volatilization is 3-5min.
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| CN113545917A (en) * | 2021-07-23 | 2021-10-26 | 诺宸股份有限公司 | Bacteriostatic quick-absorption article and manufacturing method thereof |
| CN113876493A (en) * | 2021-11-05 | 2022-01-04 | 福建恒安集团有限公司 | Side leakage prevention sanitary towel |
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|---|---|
| CN107802880B (en) | 2021-07-16 |
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Address after: 671,000 About 100 meters east of the intersection of Xiangyun Road and Jiaochang East Road, Fengyi Town, Dali City, Dali Bai Autonomous Prefecture, Yunnan Province Patentee after: YUNNAN QINGYITANG INDUSTRIAL Co.,Ltd. Address before: 671000 bio pharmaceutical Park, Dali Innovation Industrial Park, Dali City, Dali Bai Autonomous Prefecture, Yunnan Province Patentee before: YUNNAN BAIYAO QINGYITANG INDUSTRIAL CO.,LTD. |