CN105560074A - Toothpaste - Google Patents
Toothpaste Download PDFInfo
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- CN105560074A CN105560074A CN201510905606.4A CN201510905606A CN105560074A CN 105560074 A CN105560074 A CN 105560074A CN 201510905606 A CN201510905606 A CN 201510905606A CN 105560074 A CN105560074 A CN 105560074A
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- toothpaste
- agent
- hydrogen
- hydrogen water
- rich water
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to toothpaste containing hydrogen-rich water. The toothpaste has the effects of resisting oxidization, diminishing inflammation, inhibiting gum bleeding and swelling, and treating periodontal diseases. The invention discloses the toothpaste. According to the toothpaste provided by the invention, a paste body of the toothpaste contains the hydrogen-rich water with oxidization-resisting and inflammation-diminishing effects; the hydrogen-rich water is produced through a hydrogen-water machine. The toothpaste contains base materials including a friction agent, a moisture preserving agent, a foaming agent and the like, and the hydrogen-rich water; meanwhile, the toothpaste also contains auxiliary materials including aloe juice, mint oil, propolis and the like; the toothpaste not only has a tooth cleaning function and also has relatively remarkable inflammation-diminishing, swelling-eliminating and pain-alleviating, and blood-stopping functions. The toothpaste containing the hydrogen-rich water is safe to use and low in raw material cost; inflammations including periodontal tissue ulcers, swelling and pain and the like, induced by oxidization, can be remarkably inhibited.
Description
Technical field
The present invention relates to a kind of toothpaste.
Background technology
Along with the raising of people's living standard, increasing crowd suffers from periodontal, and population ages is uneven, and odontopathy brings severe jamming to daily life.Common saying is said, and " having a toothache is not disease, and pain is got up, and what an awful nuisance." periodontal is common oral disease, its symptom mainly gingival hemorrhage, swelling, ulcer, hemorrhage etc.Periodontal not only affects the health of tooth, also can relate to other organ.Bacterial component and bacterial product are diffused into neighbouring easily via periodontal ulcer area or are far apart organ, cause or aggravate Other diseases, serious harm health.The importance of visible periodontal.How effectively to treat the problem that periodontal disease becomes scientific research field concern.Therefore, need to seek a kind of stable, bactericidal antiphlogistic and the good new material of cleaning effect.Due to " illness finds its way in by the mouth ", with the use of the oral cavity nursing health products preventing periodontal, periodontal can be made progressively to obtain effectively preventing and control, and the Other diseases brought out because of oral cavity odontopathy is strangled in cradle.
At present, peroxide is added in toothpaste by main employing, and its cleaning effect is better, but due to the unstability of peroxide, shortens the service life of toothpaste.The features such as on market, existing medicated toothpaste adopts Chinese crude drug mostly, and it is long that Part of Chinese Medicinal exists growth cycle, and Regional Distribution is few, this brings certain difficulty to the production and application of toothpaste.
It is generally acknowledged that superfluous reactive oxygen species is the reason causing many diseases with the ROSburst phenomenon of some tissues, so remove the reactive oxygen species group of surplus and the treatment of organism oxidation reaction or prevention have substantial connection.
Summary of the invention
The problem that quasi-solution of the present invention is determined is to provide a kind of toothpaste, and it not only has antiinflammatory, analgesia, detumescence, anastalsis, and active component abundance, toothpaste with low cost, to have health care and treatment dual function.
For achieving the above object, the technical scheme that the present invention takes is:
A kind of toothpaste, containing rich hydrogen water in described lotion of toothpaste.
The weight ratio that described rich hydrogen water accounts for lotion of toothpaste is 40-50%.
Also containing wetting agent, flavoring agent, foaming agent, abrasivus, thickening agent, adjuvant in described lotion of toothpaste.
The weight ratio of following composition in lotion of toothpaste is:
Wetting agent 10-20%, flavouring agent 0.3-0.5%, foaming agent 1-2.5%, abrasivus 20-40%, thickening agent 1-2%, adjuvant 4-5%.
Described wetting agent is glycerol; Described flavoring agent is natural menthence; Described foaming agent is sodium lauryl sulphate; Described abrasivus is calcium carbonate powder; Described thickening agent is sodium carboxymethyl cellulose powder; Described adjuvant is propolis, Aloe juice.
Described rich hydrogen water is the pure water being dissolved with 4% hydrogen.
The juice that the volatile oil that propolis is natural propolis powder, Oleum menthae is natural peppermint stem and leaf, Aloe juice are aloes.
Rich hydrogen water in described toothpaste can effectively remove intraoral free radical, suppresses the generation of oral inflammation, removes oral cavity harmful substance, for tooth provides healthy environment, thus contributes to oral cavity health.
Hydrogen molecule amount is low, and release is fast, can freely diffuse into any position of cell.In rich hydrogen water, hydrogen relative concentration is high, can in and low concentration toxic activity oxygen.In recent years, hydrogen molecule attracts everybody concern as antioxidant.Hydrogen, when ischemia-reperfusion, can suppress sharply to consume the superoxides that oxygen produces, thus be provided with the probability of cytoprotection.Studies have reported that, in cell, the generation of the lipid peroxide that the low-concentration hydrogen of 0.6% just can hinder chain reaction to cause.Rich hydrogen water containing high concentration of hydrogen molecule can reach the effect of disease therapy by antioxidation and antiinflammatory, this obtains confirmation with it the experimenter of various diseases.Separately have research by adding phospholipid to cultured cell, whether research hydrogen has an impact to signal reception and registration.Result confirms, although hydrogen is sluggish molecule, under low consistency conditions, just can intervene lipid oxidation in free radical chain reactions system, the molecule generated thus becomes the molecule of conducted signal.
Therefore, in view of antioxidation and the anti-inflammatory effect of hydrogen, special development contains the rich hydrogen water toothpaste of hydrogen molecule, to providing Gospel for vast periodontal patient.
This invention exploits a kind of new toothpaste preventing and treating oral inflammation: rich hydrogen water toothpaste.The present invention gets kunming mice 30, set up blank group (normal group) respectively, rich hydrogen water toothpaste group, positive controls (0.05% mica filled polypropylene), proved by white mice auricle acute inflammation swelling experiment caused by xylol, compared with blank group, rich hydrogen water toothpaste significantly suppresses white mice auricle acute inflammation swelling (P<0.01) caused by dimethylbenzene.
Present invention finds the analgesic activity of rich hydrogen water toothpaste: get kunming mice 30, set up blank group (normal group) respectively, rich hydrogen water toothpaste group, positive controls (0.05% mica filled polypropylene), proved by white mice writhing assay caused by Dichlorodiphenyl Acetate, compared with blank group, rich hydrogen water toothpaste significantly suppresses white mice writhing number of times (P<0.01) caused by acetic acid.
The present invention has also found the hemostatic function of rich hydrogen water toothpaste: get kunming mice 30, set up blank group (normal group) respectively, rich hydrogen water toothpaste group, positive controls (0.05% mica filled polypropylene), checking is shown by the function test hemorrhage to suppression mechanical damage Liver of Mice, compared with blank group, rich hydrogen water toothpaste significantly suppress Liver of Mice hemorrhage (P<0.05).
Rich hydrogen water toothpaste preparation method is simple, and cost is lower, and has no side effect, and has good inflammation-diminishing function, can significantly reduce the periodontal trend occurred frequently such as toothache, dental hemorrhage, swelling and aching of gum.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described, and data involved in following table refer to weight percent hundred ratio, and the lotion of toothpaste total weight percent in embodiment 1-6 is 100.
| Composition | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 |
| Rich hydrogen water (%) | 46 | 50 | 50 | 48 | 41 | 40 |
| Glycerol (%) | 15 | 18 | 20 | 10 | 12 | 14 |
| Natural menthence (%) | 0.5 | 0.3 | 0.5 | 0.4 | 0.5 | 0.3 |
| Sodium lauryl sulphate (%) | 2 | 1.5 | 2.5 | 1 | 1.2 | 2.2 |
| Calcium carbonate powder (%) | 30 | 25 | 20 | 35 | 40 | 37.5 |
| Sodium carboxymethyl cellulose powder (%) | 2 | 1.2 | 2.0 | 1.6 | 1 | 1 |
| Propolis (%) | 2.5 | 2.0 | 2.0 | 4 | 5 | |
| Aloe juice (%) | 2 | 2 | 3.0 | 4.3 |
The preparation method of above-mentioned toothpaste is as follows:
Rich hydrogen water (hydrogen 4%), is prepared by Taishan Hospital's hydrogen biomedicine experiment center.Lotion of toothpaste can adopt conventional toothpaste preparation technology namely to can be made into: by the part by weight of above-described embodiment by abrasivus, foaming agent, wetting agent, thickening agent, flavoring agent, rich hydrogen water, auxiliary materials and mixing.First, open cream still vacuum pump processed and suck aforesaid liquid material, then open scraper, add powder, drive agitator and colloid mill, drop into flavoring agent after 50min, close colloid mill, agitator, scraper successively after 10min, except vacuum, stop vacuum pump, sampling detects.Toothpaste of the present invention with the addition of rich hydrogen water constituent, can the effective various oral inflammations that cause of inhibited oxidation stress, and stability is good, and antiinflammatory, analgesic activity are remarkable, can the generation of effectively prevention of gingivitis and periodontitis.
Natural function effect of the present invention is: because the present invention introduces rich hydrogen water composition in toothpaste raw material, the non-oxidizability of hydrogen significantly can suppress the generation of oral inflammation.Also add natural propolis, Aloe juice and Herba Menthae wet goods adjuvant in the present invention, can be used as natural flavouring and wetting agent.Propolis is described as " purple gold ", the bioactive substance contained by propolis, makes it have the effects such as antibacterial, antiinflammatory, antioxidation, suppression oral ulcer.In addition, Herba Menthae acrid in the mouth, cool in nature, gas is fragrant; Be usually used in the effect of clearing throat, anti-inflammatory analgesic, have therapeutical effect for laryngopharynx swelling and pain.Aloe has bactericidal antiphlogistic effect, and the glue liquid in Aloe has anti-treating dental ulcer, promotes wound healing and hemostatic function.
One, the functional study of toothpaste antiinflammatory, analgesia, hemostasis
(1) the antiinflammatory action research of toothpaste
30 Kun Ming mice, (18 ± 22g, 7 week age), half-and-half, adaptability was divided into 3 groups after raising 1 week to male and female at random: matched group (normal group) purchased from Tai Bang bio tech ltd, Tai'an; Rich hydrogen water toothpaste group; Positive controls (0.04% mica filled polypropylene), often organizes 10 mices.Before and after 0.05mL dimethylbenzene is applied to mouse right ear exterior feature, two sides causes inflammation, and left auricle in contrast.After causing scorching 30min, except blank group, all the other two groups are coated with corresponding toothpaste (1g/ only) at auris dextra respectively, after coating 1h, the de-neck in place puts to death mice, clean ear's medicine, beat with No. 9 card punch and get left and right ear same area auricle and weigh, subtract the heavy difference of left ear than left ear weight as auris dextra inflammation swelling using auris dextra weight, the antiinflammatory action of comparative drug, calculates swelling.
Swelling=(auris dextra weight-left ear weight)/left ear weight * 100%
(2) the analgesic activity research of toothpaste
30 Kun Ming mice, (18 ± 22g, 7 week age), half-and-half, adaptability was divided into 3 groups after raising 1 week to male and female at random: matched group (normal group) purchased from Tai Bang bio tech ltd, Tai'an; Rich hydrogen water toothpaste group; Positive controls (0.04% mica filled polypropylene), often organizes 10 mices.After mouse web portion being shaved hair (2cm*2cm) 24h, except blank group, all the other two groups are coated with toothpaste (1g/ only) in shaving a mao place, after administration 30min, all inject 0.6% glacial acetic acid solution 0.2ml, record writhing number of times in mouse writhing response latency and 30min for every, calculate analgesia percentage rate.Analgesia percentage rate (%)=(blank group writhing number of times-administration group writhing number of times)/blank group writhing number of times × 100%.
(3) the hemostatic function research of toothpaste
30 Kun Ming mice, (18 ± 22g, 7 week age), half-and-half, adaptability was divided into 3 groups after raising 1 week to male and female at random: matched group (normal group) purchased from Tai Bang bio tech ltd, Tai'an; Rich hydrogen water toothpaste group; Positive controls (0.04% mica filled polypropylene), often organizes 10 mices.Every injected in mice 30% urethane solution 0.2ml is anaesthetized, get its liver, liver cuts the long wound of 1cm, except blank group, all the other two groups are coated with different pharmaceutical toothpaste (1g/ only), external application, and start timing, every 30s observes 1 time, until wound blood no longer outflows, calculates the bleeding time (bleeding time calculating by 3min more than 3min).
(4) statistical analysis
Statistical analysis GraphPadPrismprogrammever.4.0 carries out one factor analysis of variance inspection, and result is shown as mean+SD, and P ﹤ 0.05 is for there being significant difference.
Two, result
(1) antiinflammatory action of rich hydrogen water toothpaste
As shown in Table 1, after smearing toothpaste, compare with blank group, toothpaste obviously alleviates dimethylbenzene caused group mice auricle swelling degree.Wherein, YUNNAN BAIYAO group decline 41.12%(P<0.01), rich hydrogen water toothpaste group decline 40.14%(P<0.01) and, antiphlogistic effects is remarkable.
The impact (± s) of table 1 rich hydrogen water toothpaste xylol induced mice auricle edema
Compared with blank group,
*p<0.01.
(2) analgesic activity of rich hydrogen water toothpaste
Table 2 rich hydrogen water toothpaste is on the impact (± s) of glacial acetic acid induced mice writhing response
Compared with blank group,
*p<0.01.
Body writhing test result confirms, compare with blank group, toothpaste group significantly reduces glacial acetic acid induced mice writhing number of times, significant prolongation mouse writhing incubation period.The pain suppression ratio of rich hydrogen water toothpaste and mica filled polypropylene is respectively 53.01% and 47.70%.
(3) hemostatic function of rich hydrogen water toothpaste
As shown in Table 3, toothpaste significantly suppress the mouse liver bleeding time (P<0.05), and wherein the bleeding stopping period of mica filled polypropylene and Fu Qing water toothpaste shortens 34.09% and 25.00% respectively.
Table 3 rich hydrogen water toothpaste is on the impact (± s) of the hemorrhage bleeding stopping period of mouse liver
| Group | Animal only (n) | Drug dose (only) | Bleeding stopping period (min) |
| Blank group | 10 | - | 2.20 scholar 0.54 |
| Positive controls | 10 | 1g/ only | 1.45 scholar 0.24 * |
| Rich hydrogen water toothpaste group | 10 | 1g/ only | 1.65 scholar 1.26 * |
Compared with blank group,
*p<0.05.
Claims (7)
1. a toothpaste, is characterized in that: containing rich hydrogen water in described lotion of toothpaste.
2. toothpaste according to claim 1, is characterized in that: the weight ratio that described rich hydrogen water accounts for lotion of toothpaste is 40-50%.
3. toothpaste according to claim 1, is characterized in that, described rich hydrogen water is the pure water being dissolved with 4% hydrogen.
4. toothpaste according to claim 1, is characterized in that: also containing wetting agent, flavoring agent, foaming agent, abrasivus, thickening agent, adjuvant in described lotion of toothpaste.
5. toothpaste according to claim 4, is characterized in that: the weight ratio of following composition in lotion of toothpaste is:
Wetting agent 10-20%,
Flavoring agent 0.3-0.5%,
Foaming agent 1-2.5%,
Abrasivus 20-40%,
Thickening agent 1-2%,
Adjuvant 4-5%.
6. the toothpaste according to claim 4 or 5, is characterized in that:
Described wetting agent is glycerol; Described flavoring agent is natural menthence; Described foaming agent is sodium lauryl sulphate; Described abrasivus is calcium carbonate powder; Described thickening agent is sodium carboxymethyl cellulose powder; Described adjuvant is propolis, Aloe juice.
7. toothpaste according to claim 6, is characterized in that, the juice that the volatile oil that propolis is natural propolis powder, Oleum menthae is natural peppermint stem and leaf, Aloe juice are aloes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510905606.4A CN105560074A (en) | 2015-12-10 | 2015-12-10 | Toothpaste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510905606.4A CN105560074A (en) | 2015-12-10 | 2015-12-10 | Toothpaste |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105560074A true CN105560074A (en) | 2016-05-11 |
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ID=55871102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510905606.4A Pending CN105560074A (en) | 2015-12-10 | 2015-12-10 | Toothpaste |
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| Country | Link |
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| CN (1) | CN105560074A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105919902A (en) * | 2016-06-29 | 2016-09-07 | 江苏开源康达医疗器械有限公司 | Gargle for relieving thirst, wetting throat and resisting bacteria and preparation method thereof |
| CN111434329A (en) * | 2019-01-11 | 2020-07-21 | 薪火炙药(北京)科技有限公司 | Antibacterial anti-inflammatory health-care toothpaste containing pepper extract |
| CN112915052A (en) * | 2020-11-06 | 2021-06-08 | 北京明宣生物技术有限公司 | Whitening pure plant nano-silver healthy oral toothpaste and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1171929A (en) * | 1996-07-30 | 1998-02-04 | 程文显 | Health-care and whitening toothpaste |
| CN204779001U (en) * | 2015-06-25 | 2015-11-18 | 姜宁 | Hydrogen -rich water directly drinks machine |
-
2015
- 2015-12-10 CN CN201510905606.4A patent/CN105560074A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1171929A (en) * | 1996-07-30 | 1998-02-04 | 程文显 | Health-care and whitening toothpaste |
| CN204779001U (en) * | 2015-06-25 | 2015-11-18 | 姜宁 | Hydrogen -rich water directly drinks machine |
Non-Patent Citations (1)
| Title |
|---|
| 中国食品报: "《中国食品报网》", 7 July 2015 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105919902A (en) * | 2016-06-29 | 2016-09-07 | 江苏开源康达医疗器械有限公司 | Gargle for relieving thirst, wetting throat and resisting bacteria and preparation method thereof |
| CN111434329A (en) * | 2019-01-11 | 2020-07-21 | 薪火炙药(北京)科技有限公司 | Antibacterial anti-inflammatory health-care toothpaste containing pepper extract |
| CN112915052A (en) * | 2020-11-06 | 2021-06-08 | 北京明宣生物技术有限公司 | Whitening pure plant nano-silver healthy oral toothpaste and preparation method thereof |
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Application publication date: 20160511 |
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