CN107802781A - 一种治疗癫痫的药物及其制备方法 - Google Patents
一种治疗癫痫的药物及其制备方法 Download PDFInfo
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Abstract
本发明提供了一种治疗癫痫的药物及其制备方法。该药物由以下重量份的成分组成:天麻20‑30份;郁金15‑25份;羚羊角10‑12份;石菖蒲8‑15份;柴胡15‑25份;蜈蚣10‑15份;桂枝10‑16份;钩藤5‑8份;珍珠母5‑8份;甘草10‑20份;辅料1‑20份。实验证明,本发明药物能够达到平肝熄风,豁痰开窍,清热定痫的功效。
Description
技术领域
本发明涉及药物及制备技术领域,特别涉及一种治疗癫痫的药物及其制备方法。
背景技术
癫痫(epilepsy)即俗称的“羊角风”或“羊癫风”,是大脑神经元突发性异常放电,导致短暂的大脑功能障碍的一种慢性疾病。据中国最新流行病学资料显示,国内癫痫的总体患病率为7.0‰,年发病率为28.8/10万,1年内有发作的活动性癫痫患病率为4.6‰。据此估计中国约有900万左右的癫痫患者,其中500~600万是活动性癫痫患者,同时每年新增加癫痫患者约40万,在中国癫痫已经成为神经科仅次于头痛的第二大常见病。
治疗癫痫往往采用西医的方法,传统医学由于见效慢往往被用作辅助治疗。吸收是影响中药疗效的一个重要因素,因此急需寻找到一种疗效好、吸收好的治疗癫痫的药物。
发明内容
本发明要解决的技术问题是针对现有技术中治疗癫痫的药物效果差且不益于吸收的问题,提供了一种治疗癫痫的药物及其制备方法。
为了解决上述技术问题,本发明提供的技术方案为:
一种治疗癫痫的药物,所述药物由以下重量份的成分组成:
天麻20-30份;郁金15-25份;羚羊角10-12份;石菖蒲8-15份;柴胡15-25份;蜈蚣10-15份;桂枝10-16份;钩藤5-8份;珍珠母5-8份;甘草10-20份;辅料1-20份。
在上述组合物中,以天麻、郁金、羚羊角、石菖蒲为君药,附以臣药柴胡、蜈蚣、桂枝、钩藤、珍珠母,佐以甘草,从而能够达到平肝熄风,豁痰开窍,清热定痫的功效。
其中天麻性甘、平。归肝经。息风止痉,平抑肝阳,祛风通络。用于小儿惊风,癫痫抽搐,破伤风,头痛眩晕,手足不遂,肢体麻木,风湿痹痛。
郁金,性辛、苦、寒。有活血止痛,行气解郁,清心凉血,利胆退黄的功效。用于胸胁刺痛,胸痹心痛,经闭痛经,乳房胀痛,热病神昏,癫痫发狂,血热吐衄,黄疸尿赤。
羚羊角味咸,性寒。归肝、心经。有平肝息风,清肝明目,散血解毒的功效。用于肝风内动,惊痫抽搐,妊娠子痫,高热痉厥,癫痫发狂,头痛眩晕,目赤翳障,温毒发斑,痈肿疮毒。
石菖蒲化湿开胃,开窍豁痰,醒神益智。用于脘痞不饥,噤口下痢,神昏癫痫,健忘耳聋。理气,活血,散风,去湿。治癫痫,痰厥,热病神昏,健忘,气闭耳聋,心胸烦闷,胃痛,腹痛,风寒湿痹,痈疽肿毒,跌打损伤。
以上四味药物的配伍及比例是本发明药物组合物的关键。作为优选,所述药物由以下重量份的成分组成:
天麻30份;郁金25份;羚羊角12份;石菖蒲10份;柴胡15份;蜈蚣15份;桂枝15份;钩藤6份;珍珠母6份;甘草15份;辅料20份。
本发明中药组合物的制剂为冻干粉剂,因此为了提高药物的口感,作为优选,在本发明的一个实施方式中,所述中药组合物还包括甜味剂和/或香味剂。
在本发明中,辅料的选择对制剂最终的疗效也起到重要作用。作为优选,所述辅料为选自甘露醇、磷酸盐、甘氨酸、赖氨酸、白蛋白、二月桂酰磷脂酰胆碱、胆固醇中的一种或几种。
本发明还提供了一种上述药物的制备方法,包括以下步骤:
步骤1)天麻、郁金、羚羊角、石菖蒲、柴胡、蜈蚣、桂枝、钩藤、珍珠母和甘草分别利用醇提法提取3~5小时,得到各自的提取物;
步骤2)将步骤1制得的提取物与辅料混合,干燥,粉粹后得到药物粉末;
步骤3)将步骤3得到的药物粉末放置在冷冻箱内,-40℃下冻结1.5~2小时,在该温度下粉碎,干燥,得到冻干粉末;
步骤4)将步骤3)得到的冻干粉末装入包装,得到所述药物。
作为优选,步骤1)所述醇提法的条件为:将所述天麻、郁金、羚羊角、石菖蒲加入5倍体积的80%乙醇提取5小时;将所述柴胡、蜈蚣、桂枝、钩藤、珍珠母和甘草加入10倍体积的65%乙醇提取8小时。
更优选地,步骤1)所述提取为回流提取,次数为3次。
作为优选,步骤3)所述冻结的时间为1.5小时。
作为优选,步骤3)所述冻干粉末的颗粒粒径为10微米以下。
本发明还提供了一种上述药物的使用方法,将所述中药组合物的粉末在50~60℃溶剂中溶解冲服。
本发明的有益效果为:
本发明以天麻、郁金、羚羊角、石菖蒲为君药,附以臣药柴胡、蜈蚣、桂枝、钩藤、珍珠母,佐以甘草,从而能够达到平肝熄风,豁痰开窍,清热定痫的功效。
具体实施方式
本发明公开了一种治疗癫痫的药物及其制备方法。本领域技术人员可以借鉴本文内容,适当改进工艺参数实现。需要特别指出的是,所有类似的替换和改动对本领域技术人员来说是显而易见的,它们都被视为包括在本发明,并且相关人员明显能在不脱离本发明内容、精神和范围的基础上对本文所述内容进行改动或适当变更与组合,来实现和应用本发明技术。
在本发明中,除非另有说明,否则本文中使用的科学和技术名词具有本领域技术人员所通常理解的含义。
为了使本领域的技术人员更好地理解本发明的技术方案,下面结合具体实施例对本发明作进一步的详细说明。
实施例1:药物组合物
所述药物由以下重量份的成分组成:
天麻30份;郁金25份;羚羊角12份;石菖蒲10份;柴胡15份;蜈蚣15份;桂枝15份;钩藤6份;珍珠母6份;甘草15份;辅料20份。
实施例2:药物组合物
所述药物由以下重量份的成分组成:
天麻20份;郁金15份;羚羊角10份;石菖蒲8份;柴胡15份;蜈蚣10份;桂枝10份;钩藤5份;珍珠母5份;甘草10份;辅料1份。
实施例3:药物组合物
所述药物由以下重量份的成分组成:
天麻30份;郁金25份;羚羊角12份;石菖蒲15份;柴胡25份;蜈蚣15份;桂枝16份;钩藤8份;珍珠母8份;甘草20份;辅料20份。
实施例4:制备实施例
取天麻30份;郁金25份;羚羊角12份;石菖蒲10份,分别洗净,分别加入5倍体积80%乙醇中,回流提取3次,每次5小时,得到各自的提取物。
取柴胡15份;蜈蚣15份;桂枝15份;钩藤6份;珍珠母6份;甘草15份,分别洗净,分别加入10倍体积65%乙醇中,回流提取3次,每次8小时,得到各自的提取物。
将上述提取物混合,再加入20份辅料,干燥,粉碎,得到药物粉末。
将上述药物粉末放置在冷冻箱内,-40℃下冻结1.5小时,在该温度下粉碎,干燥,得到冻干粉末,该冻干粉末的颗粒粒径为10微米。
将上述混合粉末装入包装,得到所述药物。
实施例5:制备实施例
取天麻20份;郁金15份;羚羊角10份;石菖蒲8份,分别洗净,分别加入5倍体积80%乙醇中,回流提取3次,每次5小时,得到各自的提取物。
取柴胡15份;蜈蚣10份;桂枝10份;钩藤5份;珍珠母5份;甘草10份,分别洗净,分别加入10倍体积65%乙醇中,回流提取3次,每次8小时,得到各自的提取物。
将上述提取物混合,再加入1份辅料,干燥,粉碎,得到药物粉末。
将上述药物粉末放置在冷冻箱内,-40℃下冻结2小时,在该温度下粉碎,干燥,得到冻干粉末,该冻干粉末的颗粒粒径为8微米。
将上述冻干粉末装入包装,得到所述药物。
实施例6:制备实施例
取天麻30份;郁金25份;羚羊角12份;石菖蒲15份,分别洗净,分别加入5倍体积80%乙醇中,回流提取3次,每次5小时,得到各自的提取物。
取柴胡25份;蜈蚣15份;桂枝16份;钩藤8份;珍珠母8份;甘草20份,分别洗净,分别加入10倍体积65%乙醇中,回流提取3次,每次8小时,得到各自的提取物。
将上述提取物混合,再加入20份辅料,干燥,粉碎,得到药物粉末。
将上述药物粉末放置在冷冻箱内,-40℃下冻结2小时,在该温度下粉碎,干燥,得到冻干粉末,该冻干粉末的颗粒粒径为8微米。
将上述冻干粉末装入包装,得到所述药物。
以上所述仅是本发明的优选实施方式,应当指出,对于本技术领域的普通技术人员来说,在不脱离本发明原理的前提下,还可以做出若干改进和润饰,这些改进和润饰也应视为本发明的保护范围。
Claims (10)
1.一种治疗癫痫的药物,其特征在于,所述药物由以下重量份的成分组成:
天麻20-30份;郁金15-25份;羚羊角10-12份;石菖蒲8-15份;柴胡15-25份;蜈蚣10-15份;桂枝10-16份;钩藤5-8份;珍珠母5-8份;甘草10-20份;辅料1-20份。
2.根据权利要求1所述的药物,其特征在于,所述药物由以下重量份的成分组成:
天麻30份;郁金25份;羚羊角12份;石菖蒲10份;柴胡15份;蜈蚣15份;桂枝15份;钩藤6份;珍珠母6份;甘草15份;辅料20份。
3.根据权利要求1所述的药物,其特征在于,所述辅料为选自甘露醇、磷酸盐、甘氨酸、赖氨酸、白蛋白、二月桂酰磷脂酰胆碱、胆固醇中的一种或几种。
4.根据权利要求1所述的药物,其特征在于,所述药物还包括甜味剂和/或香味剂。
5.一种如权利要求1-4任意一项所述的药物的制备方法,其特征在于,包括以下步骤:
步骤1)天麻、郁金、羚羊角、石菖蒲、柴胡、蜈蚣、桂枝、钩藤、珍珠母和甘草分别利用醇提法提取3~5小时,得到各自的提取物;
步骤2)将步骤1制得的提取物与辅料混合,干燥,粉粹后得到药物粉末;
步骤3)将步骤3得到的药物粉末放置在冷冻箱内,-40℃下冻结1.5~2小时,在该温度下粉碎,干燥,得到冻干粉末;
步骤4)将步骤3)得到的冻干粉末装入包装,得到所述药物。
6.根据权利要求5所述的制备方法,其特征在于,步骤1)所述醇提法的条件为:将所述天麻、郁金、羚羊角、石菖蒲加入5倍体积的80%乙醇提取5小时;将所述柴胡、蜈蚣、桂枝、钩藤、珍珠母和甘草加入10倍体积的65%乙醇提取8小时。
7.根据权利要求6所述的制备方法,其特征在于,步骤1)所述提取为回流提取,次数为3次。
8.根据权利要求5所述的制备方法,其特征在于,步骤3)所述冻结的时间为1.5小时。
9.根据权利要求5所述的制备方法,其特征在于,步骤3)所述冻干粉末的颗粒粒径为10微米以下。
10.一种如权利要求1所述的药物的使用方法,其特征在于,将所述中药组合物的粉末在50~60℃溶剂中溶解冲服。
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102343035A (zh) * | 2010-07-28 | 2012-02-08 | 陈登 | 一种治疗颠痫的中药配方 |
CN102861283A (zh) * | 2011-07-04 | 2013-01-09 | 西安千禾药业有限责任公司 | 一种用于治疗癫痫病的药物组合物及其制备方法和用途 |
CN104162005A (zh) * | 2013-05-16 | 2014-11-26 | 吕奎荣 | 一种治疗癫痫的中药 |
CN105288509A (zh) * | 2015-12-02 | 2016-02-03 | 天津太平洋制药有限公司 | 一种治疗癫痫的药物 |
-
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102343035A (zh) * | 2010-07-28 | 2012-02-08 | 陈登 | 一种治疗颠痫的中药配方 |
CN102861283A (zh) * | 2011-07-04 | 2013-01-09 | 西安千禾药业有限责任公司 | 一种用于治疗癫痫病的药物组合物及其制备方法和用途 |
CN104162005A (zh) * | 2013-05-16 | 2014-11-26 | 吕奎荣 | 一种治疗癫痫的中药 |
CN105288509A (zh) * | 2015-12-02 | 2016-02-03 | 天津太平洋制药有限公司 | 一种治疗癫痫的药物 |
Non-Patent Citations (1)
Title |
---|
容小翔: "治疗癫痫的验方", 《药膳食疗》 * |
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