CN107789616A - 一种含麦胚白蛋白的口服液及其制备方法 - Google Patents
一种含麦胚白蛋白的口服液及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种含麦胚白蛋白的口服液,由麦胚白蛋白、白花蛇舌草、半边莲、半枝莲、当归、川芎、白芍、阿胶、龙眼肉、龙舌草、牛黄、蜂王浆、甜味剂组成。本发明的含麦胚白蛋白的口服液是一款方便携带的,简单便捷的具有医疗辅助功能的口服液,大大减少了传播某些已知和未知病原体的潜在风险,给人体提供必要的氨基酸,且该口服液起到补益心血、活血行气、祛风止痛等辅助治疗效果,将麦胚白蛋白和各种具有补气血功能的当归、川芎、白芍、阿胶、龙眼肉和具有清热消毒功能的龙舌草和牛黄混合,添加具有提高免疫力和抗肿瘤活性的白花蛇舌草、蜂王浆,并添加天然甜味剂,增加口服液的口感。
Description
技术领域
本发明涉及一种口服液,尤其是涉及一种含麦胚白蛋白的口服液及其制备方法。
背景技术
人血白蛋白,用于治疗(1)失血创伤、烧伤引起的休克;(2)脑水肿及损伤引起的烦压升高;(3)肝硬化及肾病引起的水肿或腹水;(4)低蛋白血症的防治;(4)新生儿高胆红素血症;(4)用于心肺分流术、烧伤的辅助治疗、血液透析的辅助治疗和成人呼吸窘迫综合征。然而,由于人血白蛋白仍存在传播某些已知和未知病原体的潜在风险。
小麦胚芽又称麦芽粉、胚芽,金黄色颗粒状。麦芽是小麦发芽及生长的器官之一,约占整个麦粒的 2.5%,含丰富的维他命E、B1及蛋白质,营养价值非常的高。胚芽是小麦生命的根源,是小麦中营养价值最高的部分。小麦胚芽的蛋白质含量高达30%左右,它含有人体必需的8种氨基酸,占总氨基酸的34.7%。特别是在氨基酸中,蛋氨酸占2%,组氨酸占2.5%,小麦胚芽蛋白是一种优质的完全蛋白。
小麦胚芽各种蛋白质中,白蛋白(又称清蛋白)评分最高,具有最高的蛋白质效率比(PER)、体外消化率(IVPD)和较好的氨基酸组成,是一种优质蛋白。刁大鹏等在小麦胚芽清蛋白提取工艺及分子量测定了清蛋白分子量分布为分子量分别为10.47、14.45、20.89、26.92、38.02、52.48、85.11ku。Bahrle指出,麦胚经蛋白质组学分析,麦胚白蛋白有应激蛋白(HSP70、LEA1 protein 、WSI18 protein、Cold regulated protein、Eukaryotictranslation initiation factor 4B1、Salt tolerant correlative protein)、抑制肝癌蛋白(5a2 protein)、二聚体泛素(Dimeric ubiquitin)、类甜蛋白(Thaumatin-likeprotein)、晚胚胎发生丰富蛋白(late embryogenesis abundant protein)、抗菌蛋白(Wheatwin-1)、转录共激活剂(Multiprotein bridging factor)、甘油醛-3-磷酸脱氢酶(Glyceraldehyde-3-phosphate dehydrogenase)、丝氨酸蛋白酶抑制剂(Serpin-N3.7)及未表征蛋白。
15-30份、半边莲15-30份、半枝莲15-30份、当归4-8份、川芎 5-10份、白芍 5-10份、阿胶3-6份、龙眼肉3-6份、龙舌草3-6份、牛黄3-6份、蜂王浆10-14份。
白花蛇舌草,成药味苦、淡,性寒。有清热解毒、消痛散结、利尿除湿功效。在临床实践中,发现白花蛇舌草若配伍得当,有活血行气之功效;半边莲含多种生物碱,有清热解毒、利尿消肿之效,临床应用治毒蛇咬伤、肝硬化腹水、晚期血吸虫病腹水、阑尾炎功等;半支莲全草入药,含多种维生素、微量元素及氨基酸等成分,有具有清热解毒、活血祛瘀、消肿止痛、抗癌等功能;龙舌草治哮喘,咳嗽,水肿,汤火伤,痈肿;牛黄具有清热解毒、消肿散湿之功能;当归、川芎、白芍 、阿胶、龙眼肉、蜂王浆有补气养血、提高免疫力功能。
上述中草药经提取配合麦胚白蛋白使用,具有补益心血、活血行气、祛风止痛之功效、作为人血白蛋白的生物类似药,用于辅助医疗,则很好的解决了上述问题,设计一种含麦胚白蛋白的口服液,大大减少了传播某些已知和未知病原体的潜在风险,给人体提供必要的氨基酸,且该口服液起到补益心血、活血行气、祛风止痛等辅助治疗效果。
发明内容
本发明的目的是提供一种含麦胚白蛋白的口服液及其制备方法,给人体提供必要的氨基酸,且该口服液起到补益心血、活血行气、祛风止痛等辅助治疗效果,保障了人们的健康。
一种含麦胚白蛋白的口服液,包括如下重量份的原料:麦胚白蛋白30-62份、白花蛇舌草15-30份、半边莲15-30份、半枝莲15-30份、当归4-8份、川芎 5-10份、白芍 5-10份、阿胶3-6份、龙眼肉3-6份、龙舌草3-6份、牛黄3-6份、蜂王浆10-14份、甜味剂2-4份。
优选的,包括如下重量份的原料麦胚白蛋白47份、白花蛇舌草20份、半边莲20份、半枝莲20份、当归6份、川芎8份、白芍8份、阿胶4份、龙眼肉4份、龙舌草4份、牛黄4份、蜂王浆12份、甜味剂3份。
优选的,所述甜味剂由蜂蜜2份、麦芽糖5份和甘草2份混合搅拌而制。
优选的,包括如下步骤:
(1)按照白花蛇舌草20份、半边莲20份、半枝莲20份、当归6份、川芎8份、白芍8份、阿胶4份、龙眼肉4份、龙舌草4份、牛黄4份、蜂王浆12份、甜味剂3份的配比称取相应的原料;
(2)将称取的原料粉碎并混合,得到混合料,过80目筛;
(3)将所述混合料放入42℃的蒸馏水中浸泡,再降温至25℃并保温,保温结束后得到所述混合料的水提液和混合料的水提渣;
(4)将所述混合料的水提液、混合料的水提渣、肉苁蓉醇提液和乙醇混合,得到固液混合物;
(5)所述固液混合物常温封闭自然陈化,35天后进行固液分离,得到混合渣和混合液;
(6)静置,除去所述上清液中的乙醇,用水稀释后得到口服液。
优选的,所述步骤(3)中浸泡时间为5h,所述步骤(3)保温时间为3h;
所述步骤(4)乙醇的的体积百分含量为75%,添加量为5%;
所述步骤(5)中固液混合物常温封闭自然陈化35天,每5天均匀搅拌一次;
所述混合液静置时间为20h,采用旋转薄膜蒸发器除去上清液中的乙醇,得到溶液,加入麦胚白蛋白47份,用蒸馏水稀释溶液得到稀释溶液;其中,蒸馏水和溶液的体积比为45:1。
本发明的有益效果是:本发明含麦胚白蛋白的口服液是一款方便携带的,简单便捷的具有医疗辅助功能的口服液,大大减少了传播某些已知和未知病原体的潜在风险,给人体提供必要的氨基酸,且该口服液起到补益心血、活血行气、祛风止痛等辅助治疗效果;将麦胚白蛋白和各种具有补气血功能的当归、川芎、白芍、阿胶、龙眼肉和具有活血行气、消痛散结功能的龙舌草和牛黄混合,添加具有清热解毒、提高免疫力功能的半边莲、半枝莲、蜂王浆,并添加由蜂蜜、麦芽糖和甘草混合搅拌而制的天然甜味剂,增加口服液的口感;各类中药按君臣佐使合理配比,改变传统高温煎煮方式中温温和提取,辅以自然陈化,中药活性更高,提取方法更加简便可行。
具体实施方式
下面结合实施例对本发明做进一步描述:
实施例1
一种含麦胚白蛋白的口服液,包括如下重量份的原料:麦胚白蛋白30-62份、白花蛇舌草23份、半边莲23份、半枝莲23份、当归4-8份、川芎5-10份、白芍5-10份、阿胶3-6份、龙眼肉3-6份、龙舌草3-6份、牛黄3-6份、蜂王浆10-14份、甜味剂2-4份。
优选的,包括如下重量份的原料:麦胚白蛋白47份、白花蛇舌草23份、半边莲23份、半枝莲23份、当归6份、川芎8份、白芍8份、阿胶4份、龙眼肉4份、龙舌草4份、牛黄4份、蜂王浆12份、甜味剂3份。
优选的,甜味剂由蜂蜜2份、麦芽糖5份和甘草2份混合搅拌而制。
优选的,包括如下步骤:
(1)按照白花蛇舌草23份、半边莲23份、半枝莲23份、当归6份、川芎8份、白芍8份、阿胶4份、龙眼肉4份、龙舌草4份、牛黄4份、蜂王浆12份、甜味剂3份的配比称取相应的原料;
(2)将称取的原料粉碎并混合,得到混合料,过80目筛;
(3)将混合料放入42℃的蒸馏水中浸泡,再降温至25℃并保温,保温结束后得到混合料的水提液和混合料的水提渣;
(4)将混合料的水提液、混合料的水提渣乙醇混合,得到固液混合物;
(5)固液混合物常温封闭自然陈化,35天后进行固液分离,得到混合渣和混合液;
(6)静置,除去上清液中的乙醇,用水稀释后得到口服液。
优选的,步骤(3)中浸泡时间为5h,步骤(3)保温时间为3h;
步骤(4)中乙醇的的体积百分含量为75%,添加量为5%;
步骤(5)中固液混合物常温封闭自然陈化35天,每5天均匀搅拌一次;
混合液静置时间为20h,采用旋转薄膜蒸发器除去上清液中的乙醇,得到溶液,加入麦胚白蛋白47份,用蒸馏水稀释溶液得到稀释溶液;其中,蒸馏水和溶液的体积比为45:1。
实施例2
一种含麦胚白蛋白的口服液,包括如下重量份的原料:麦胚白蛋白30-62份、白花蛇舌草15-30份、半边莲15-30份、半枝莲15-30份、当归4-8份、川芎5-10份、白芍5-10份、阿胶3-6份、龙眼肉3-6份、龙舌草3-6份、牛黄3-6份、蜂王浆10-14份、甜味剂2-4份。
优选的,包括如下重量份的原料:麦胚白蛋白62份、白花蛇舌草30份、半边莲30份、半枝莲15份、当归5份、川芎5份、白芍5份、阿胶3份、龙眼肉3份、龙舌草3份、牛黄3份、蜂王浆10份、甜味剂2份。
优选的,甜味剂由蜂蜜、麦芽糖和甘草混合搅拌而制。
优选的,包括如下步骤:
(1)按照白花蛇舌草30份、半边莲30份、半枝莲15份、当归5份、川芎5份、白芍5份、阿胶3份、龙眼肉3份、龙舌草3份、牛黄3份、蜂王浆10份、甜味剂2份的配比称取相应的原料;
(2)将称取的原料粉碎并混合,得到混合料,过80目筛;
(3)将混合料放入42℃的蒸馏水中浸泡,再降温至25℃并保温,保温结束后得到混合料的水提液和混合料的水提渣;
(4)将混合料的水提液、混合料的水提渣和乙醇混合,得到固液混合物;
(5)固液混合物常温封闭自然陈化,35天后进行固液分离,得到混合渣和混合液;
(6)静置,除去上清液中的乙醇,用水稀释后得到口服液。
优选的,步骤(3)中浸泡时间为5h,步骤(3)保温时间为3h;
步骤(4)乙醇的的体积百分含量为75%,添加量为5%;
步骤(5)中固液混合物常温封闭自然陈化35天,每5天均匀搅拌一次;
混合液静置时间为20h,采用旋转薄膜蒸发器除去上清液中的乙醇,得到溶液,加入麦胚白蛋白47份,用蒸馏水稀释溶液得到稀释溶液;其中,蒸馏水和溶液的体积比为45:1。
实施例3
一种含麦胚白蛋白的口服液,包括如下重量份的原料:麦胚白蛋白30-62份、白花蛇舌草15-30份、半边莲15-30份、半枝莲15-30份、当归4-8份、川芎5-10份、白芍5-10份、阿胶3-6份、龙眼肉3-6份、龙舌草3-6份、牛黄3-6份、蜂王浆10-14份、甜味剂2-4份。
优选的,包括如下重量份的原料:麦胚白蛋白30份、白花蛇舌草15份、半边莲15份、半枝莲30份、当归8份、川芎10份、白芍10份、阿胶6份、龙眼肉6份、龙舌草6份、牛黄6份、蜂王浆14份、甜味剂4份。
优选的,甜味剂由蜂蜜、麦芽糖和甘草混合搅拌而制。
优选的,包括如下步骤
(1)按照白花蛇舌草15份、半边莲15份、半枝莲30份、当归8份、川芎10份、白芍10份、阿胶6份、龙眼肉6份、龙舌草6份、牛黄6份、蜂王浆14份、甜味剂4份的配比称取相应的原料;
(2)将称取的原料粉碎并混合,得到混合料,过80目筛;
(3)将混合料放入42℃的蒸馏水中浸泡,再降温至25℃并保温,保温结束后得到混合料的水提液和混合料的水提渣;
(4)将混合料的水提液、混合料的水提渣和乙醇混合,得到固液混合物;
(5)固液混合物常温封闭自然陈化,35天后进行固液分离,得到混合渣和混合液;
(6)静置,除去上清液中的乙醇,用水稀释后得到口服液。
优选的,步骤(3)中浸泡时间为5h,步骤(3)保温时间为3h;
步骤(4)中乙醇的的体积百分含量为75%,添加量为5%;
步骤(5)中固液混合物常温封闭自然陈化放置35天,每5天均匀搅拌一次;
混合液静置时间为20h,采用旋转薄膜蒸发器除去上清液中的乙醇,得到溶液,加入麦胚白蛋白30份,用蒸馏水稀释溶液得到稀释溶液;其中,蒸馏水和溶液的体积比为45:1。
以上所述仅为本发明的一种实施例,并不限制本发明,凡采用等同替换或等效变换的方式所获得的技术方案,均落在本发明的保护范围内。
Claims (5)
1.一种含麦胚白蛋白的口服液,其特征在于,包括如下重量份的原料:麦胚白蛋白30-62份、白花蛇舌草15-30份、半边莲15-30份、半枝莲15-30份、当归4-8份、川芎5-10份、白芍5-10份、阿胶3-6份、龙眼肉3-6份、龙舌草3-6份、牛黄3-6份、蜂王浆10-14份、甜味剂2-4份。
2.根据权利要求书1所述的一种含麦胚白蛋白的口服液,其特征在于,包括如下重量份的原料:麦胚白蛋白47份、白花蛇舌草20份、半边莲20份、半枝莲20份、当归6份、川芎8份、白芍8份、阿胶4份、龙眼肉4份、龙舌草4份、牛黄4份、蜂王浆12份、甜味剂3份。
3.根据权利要求书2所述的一种含麦胚白蛋白的口服液,其特征在于,所述甜味剂由蜂蜜2份、麦芽糖5份和甘草2份混合搅拌而制。
4.根据权利要求书3所述的一种含麦胚白蛋白的口服液的制备方法,其特征在于,包括如下步骤:
(1)按照白花蛇舌草20份、半边莲20份、半枝莲20份、当归6份、川芎8份、白芍8份、阿胶4份、龙眼肉4份、龙舌草4份、牛黄4份、蜂王浆12份、甜味剂3份的配比称取相应的原料;
(2)将称取的原料粉碎并混合,得到混合料,过80目筛;
(3)将所述混合料放入42℃的蒸馏水中浸泡,再降温至25℃并保温,保温结束后得到所述混合料的水提液和混合料的水提渣;
(4)将所述混合料的水提液、混合料的水提渣和乙醇混合,得到固液混合物;
(5)所述固液混合物常温封闭自然陈化,35天后进行固液分离,得到混合渣和混合液;
(6)静置,除去所述上清液中的乙醇,加入麦胚白蛋白47份,用水稀释后得到口服液。
5.根据权利要求书4所述的一种含麦胚白蛋白的口服液的制备方法,其特征在于,所述步骤(3)中浸泡时间为5h,所述步骤(3)保温时间为3h;
所述步骤(4)中乙醇的的体积百分含量为75%,添加量为5%;
所述步骤(5)中固液混合物常温封闭自然陈化35天,每5天均匀搅拌一次;
所述混合液静置时间为20h,采用旋转薄膜蒸发器除去上清液中的乙醇,得到溶液,加入麦胚白蛋白47份,用蒸馏水稀释溶液得到稀释溶液;其中,蒸馏水和溶液的体积比为45:1。
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