CN107789433A - 一种用于治疗糖尿病肾病的中药配方及其制备方法 - Google Patents

一种用于治疗糖尿病肾病的中药配方及其制备方法 Download PDF

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CN107789433A
CN107789433A CN201710893319.5A CN201710893319A CN107789433A CN 107789433 A CN107789433 A CN 107789433A CN 201710893319 A CN201710893319 A CN 201710893319A CN 107789433 A CN107789433 A CN 107789433A
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贾文浩
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Abstract

本发明公开了一种用于治疗糖尿病肾病的中药配方，按重量份数是包括以下中药成分：西洋参10g，枸杞子30g，黄芪50g，生地黄15g，益母草15g，丹参15g，地龙15g，大黄10g，黄连10g，榛花10g。本发明中药组合物的制备和使用方法：先用冷水浸泡50~60分钟，加水量超过药物3~5厘米，在汤药沸腾以前用武火(大火），沸腾以后改用文火（小火），使汤药微微沸腾，头煎35分钟左右，二煎30分钟左右即可，然后把两次煎好的汤药混合在一起，早晚各服1次，每天1剂，7剂为1疗程，需要用药4‑6疗程。

Description

一种用于治疗糖尿病肾病的中药配方及其制备方法
技术领域
本发明属于中药组合物，具体地说，是涉及一种用于治疗糖尿病肾病的中药配方及其制备方法。
背景技术
糖尿病肾病是糖尿病病人最重要的合并症之一。我国的发病率亦呈上升趋势，目前已成为终末期肾脏病的第二位原因，仅次于各种肾小球肾炎。由于其存在复杂的代谢紊乱，一旦发展到终末期肾脏病，往往比其他肾脏疾病的治疗更加棘手，因此及时防治对于延缓糖尿病肾病的意义重大。中医学认为：糖尿病肾病乃糖尿病日久伤阴耗气，阴损及阳，气阴两虚，阴阳两虚，久病入络，痰浊、邪热、血瘀、气郁互相胶结，形成“微型症瘕”，使肾体受损，肾用失司所致。临床糖尿病肾病阶段，由于肾元受伤，气化不行，浊毒内生，浊毒可更伤肾元，耗伤气血，阻滞气机升降出入，最终可表现为尿毒症“关格”危候。治疗则当重视化浊解毒，以保护肾功能为要务。糖尿病肾病在前期蛋白尿期失治后很容易发展到肾功能不全、尿毒症阶段，导致体内大量“毒素”积聚。
“毒损肾络”是糖尿病肾病的病机核心，消渴之病位波及五脏、胃及三焦，尤以肺、胃、肾为主，气虚、气郁、痰凝、血瘀等因素在不同的阶段都可能为主要矛盾，要灵活对待，而根据其特点及不同的阶段，灵活地处理“毒”与“阴虚”的关系是辨证的关键，尤以滋阴清热、益气养阴、活血化瘀、健脾益肾为论治的准绳。
本发明用于治疗糖尿病肾病的中药配方及制备方法，针对糖尿病肾病病因病机，降低空腹血糖，餐后2小时血糖及糖化红蛋白，调整脂代谢，降低胆固醇及三酰甘油，改善肾功能及减少蛋白尿。
发明内容
本发明的目的是解决现有技术上的问题，特提供了一种效果明显、食用安全的治疗糖尿病肾病的中药配方及制备方法。
为了实现上述发明目的，本发明制成该药物有效成分的原料组成及其重量配比为：西洋参10g，枸杞子30g，黄芪50g，生地黄15g，益母草15g，丹参15g，地龙15g，大黄10g，黄连10g，榛花10g。
本发明中药组合物的制备和使用方法：先用冷水浸泡50~60分钟，加水量超过药物3~5厘米，在汤药沸腾以前用武火(大火），沸腾以后改用文火（小火），使汤药微微沸腾，头煎35分钟左右，二煎30分钟左右即可，然后把两次煎好的汤药混合在一起，早晚各服1次，每天1剂，7剂为1疗程，需要用药4-6疗程。
发明用于治疗糖尿病肾病的中药配方，选择天然药物，针对糖尿病肾病病因病机，各味药材各具其效，互相协调，黄芪、生地黄、西洋参、枸杞子益气健脾补肾，阴津得补正气得复，体现治病求本、益肾保肾之法；大黄、黄连、榛花具解毒保肾，祛瘀化湿通络之功；丹参、地龙、益母草活血通络解毒。诸药合用，滋而不腻，补而不滞，解毒而不寒，化瘀通络而不伤正，标本兼治，相辅相成。
具体实施方式
实施例1：一种治疗糖尿病肾病的中药配方及制备方法，按重量份数包括以下中药成分：西洋参10g，枸杞子30g，黄芪50g，生地黄15g，益母草15g，丹参15g，地龙15g，大黄10g，黄连10g，榛花10g。
实施例2：如果患者水肿，在上述组分中加车前10g，茯苓12g，泽泻7g。
实施例3：如果患者夜尿频多，在上述组分中加芡实12g，金樱子12g，浮小麦10g。
实施例4：如果患者舌苔黄腻，有湿热之象，在上述组分中加二妙散15g。
实施例5：如果患者蛋白尿，在上述组分中加蝉蜕12g，白僵蚕7g。
先用冷水浸泡50~60分钟，加水量超过药物3~5厘米，在汤药沸腾以前用武火(大火），沸腾以后改用文火（小火），使汤药微微沸腾，头煎35分钟左右，二煎30分钟左右即可，然后把两次煎好的汤药混合在一起，早晚各服1次，每天1剂，7剂为1疗程，需要用药4-6疗程。
以下通过实用例来阐明本发明所述用于糖尿病肾病的中药配方的临床治疗效果。
1、临床资料
男8例,女13例。年龄30-75岁,平均年龄51岁,病程<5年者4例,病程在5-10年者10例,病程在10-20年者5例,病程>20年者2例。 21例糖尿病肾病患者症见：头重晕蒙恶心呕吐，水肿，尿少尿闭，口苦而粘，或口中有尿味，苔腻或垢等，脉滑。
2、疗效标准
显效：临床症状明显减轻，空腹血糖降低，肾功能改善，蛋白尿减少；
无效：临床症状无明显减轻、加重。
3、治疗结果
21例糖尿病肾病患者治疗2～4疗程后，治疗显效18例，无效3例。治疗总有效率为85％。
典型案例：
崔某，女，62岁，患者自述患糖尿病20余年，近期尿频而量多，倦怠乏力，长期服用各种降糖药物，空腹血糖基本稳定在8~11mmol/L之间，但近来因服药不规则，血糖数次波动，空腹最高至21mmol/L，并于半年前起尿中偶出现蛋白（++），伴随出现腰酸痛，夜尿频繁，严重时一夜需起7~8次，尿时混浊，以治心烦不寐，渐感疲劳纳呆，双肢无力消瘦，口干不欲饮，舌暗红，苔白微黄而腻，脉沉滑。刻诊：糖尿病肾病，辨证为脾肾亏虚、气阴两虚、热毒内兼瘀浊内阻，治宜益气养阴、通络解毒，服用本发明配方7剂，每日1剂，水煎分2次服用。二诊：服药至4剂时尿频大减，至1周时即已减到1夜2次，腰酸痛、心烦乏力等症状缓解，血糖降至9mmol/L，继服14剂，血糖降至8.1mmol/L，尿糖降至（+），继服上方服用近2个月，血糖和尿糖恢复正常，自觉症状基本消失，后逐渐减少西药服用量，并改服左归丸长期维持良好。

Claims (6)

1.一种用于治疗糖尿病肾病的中药配方，其特征在于：该中药配方按重量份数包括以下中药成分：西洋参10g，枸杞子30g，黄芪50g，生地黄15g，益母草15g，丹参15g，地龙15g，大黄10g，黄连10g，榛花10g。
2.如权利要求1所述的用于治疗糖尿病肾病的中药配方，其特征在于：该中药配方还包括车前10g，茯苓12g，泽泻7g。
3.如权利要求1所述的用于治疗糖尿病肾病的中药配方，其特征在于：该中药配方还包括芡实12g，金樱子12g，浮小麦10g。
4.如权利要求1所述的用于治疗糖尿病肾病的中药配方，其特征在于：该中药配方还包括二妙散15g。
5.如权利要求1所述的用于治疗糖尿病肾病的中药配方，其特征在于：该中药配方还包括蝉蜕12g，白僵蚕7g。
6.如权利要求1所述的用于治疗糖尿病肾病的中药配方的制备方法，其特征在于：先用冷水浸泡50~60分钟，加水量超过药物3~5厘米，在汤药沸腾以前用武火(大火），沸腾以后改用文火（小火），使汤药微微沸腾，头煎35分钟左右，二煎30分钟左右即可，然后把两次煎好的汤药混合在一起，早晚各服1次，每天1剂，7剂为1疗程，需要用药4-6疗程。
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