CN107737173A - 一种治疗糖尿病周围神经病变的中药配方及其制备方法 - Google Patents

一种治疗糖尿病周围神经病变的中药配方及其制备方法 Download PDF

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CN107737173A
CN107737173A CN201710893274.1A CN201710893274A CN107737173A CN 107737173 A CN107737173 A CN 107737173A CN 201710893274 A CN201710893274 A CN 201710893274A CN 107737173 A CN107737173 A CN 107737173A
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贾文浩
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Abstract

本发明公开了一种治疗糖尿病周围神经病变的中药配方，按重量份数是包括以下中药成分：生黄芪30g，陈皮10g，鸡血藤15g，当归12g，川芎10g，川牛膝12g，赤白芍30g，桃仁10g，红花10g，地龙12g，土鳖虫12g。本发明中药组合物的制备和使用方法：取中药原料置于煎锅中，第一次加入中药原料重量5～7倍的水，加热至沸腾后煎煮30～40分钟；第二次加入中药原料重量3～4倍的水，煎煮25～30分钟；第三次加入中药原料重量3～4倍的水，煎煮25～30分钟，三次药液混合再过滤得1剂。每日1剂，每日3次温服，10天为1个疗程。

Description

一种治疗糖尿病周围神经病变的中药配方及其制备方法
技术领域
本发明属于中药组合物，具体地说，是涉及一种治疗糖尿病周围神经病变的中药配方及其制备方法。
背景技术
糖尿病周围神经病变（DPN）为常见的糖尿病并发症之一，主要表现为肢体远端对称性疼痛、麻木、发凉、肿胀、感觉异常等，早期感觉过敏，后期感觉减退甚则消失。被后世医家归于“痹证”“萎证”“血痹”“脚气”等范畴。
从临床症状分析，糖尿病并发症均属本虚标实之证，所谓本虚是指阴虚→气阴两虚→阴阳俱虚的病机发展过程；所谓标实是正气虚弱、气血运行阻滞而致的淤血、痰浊等有形之邪。糖尿病周围神经病变是因消渴日久，气血耗伤，甚者阴阳俱虚，气血无力推动血行，而致内生瘀血，阻滞脉络，或肾阳虚，气化失职，致内生湿邪而易外感寒湿，阻于络脉而成。故将其主要病机归结为气虚血瘀阻络和阳虚寒湿阻络两种。
本发明用于治疗糖尿病周围神经病变的中药配方及其制备方法，针对糖尿病周围神经病变病因病机，以补阳还五汤为基本方，益气活血，主治气虚血瘀证，加入少量理气、养血之品，既养血又活血，达到标本兼治的目的。
发明内容
本发明的目的是解决现有技术上的问题，特提供了一种效果明显、食用安全的治疗糖尿病周围神经病变的中药配方及其制备方法。
为了实现上述发明目的，本发明制成该药物有效成分的原料组成及其重量配比为：生黄芪30g，陈皮10g，鸡血藤15g，当归12g，川芎10g，川牛膝12g，赤白芍30g，桃仁10g，红花10g，地龙12g，土鳖虫12g。
本发明中药组合物的制备和使用方法：取中药原料置于煎锅中，第一次加入中药原料 重量5～7倍的水，加热至沸腾后煎煮30～40分钟；第二次加入中药原料重量3～4倍的水， 煎煮25～30分钟；第三次加入中药原料重量3～4倍的水， 煎煮25～30分钟，三次药液混合再过滤得1剂。每日1剂，每日3次温服，10天为1个疗程。
发明用于治疗糖尿病周围神经病变的中药配方，选择天然药物，针对糖尿病周围神经病变病因病机，各味药材各具其效，互相协调，生黄芪补益中气，陈皮理气和中，鸡血藤、当归养血活血，川芎、川牛膝、赤白芍、桃仁、红花活血化瘀，地龙、土鳖虫取其血肉有情之品，活血通络。诸药共用，共奏益气、养血、活血之功效。
具体实施方式
实施例1：一种治疗糖尿病周围神经病变的中药配方，按重量份数包括以下中药成分：生黄芪30g，陈皮10g，鸡血藤15g，当归12g，川芎10g，川牛膝12g，赤白芍30g，桃仁10g，红花10g，地龙12g，土鳖虫12g。
实施例2：如果患者畏寒肢冷，在上述组分中加仙灵脾15g，葫芦巴12g，桂枝12g，吴茱萸10g，附片10g。
实施例3：如果患者疼痛明显，属热症，在上述组分中赤白芍改为白芍并重用，加生甘草12g，徐长卿12g。
实施例4：如果患者属寒证，在上述组分中加桂枝12g，制川草乌（先煎1小时）12g，细辛10g。
实施例5：如果患者有灼热感且伴有阴虚，在上述组分中去当归，加玄参15g，丹皮15g。
取中药原料置于煎锅中，第一次加入中药原料 重量5～7倍的水，加热至沸腾后煎煮30～40分钟；第二次加入中药原料重量3～4倍的水， 煎煮25～30分钟；第三次加入中药原料重量3～4倍的水， 煎煮25～30分钟，三次药液混合再过滤得1剂。每日1剂，每日3次温服，10天为1个疗程。
以下通过实用例来阐明本发明所述用于治疗糖尿病周围神经病变的中药配方的临床治疗效果。
1、临床资料
50例糖尿病周围神经病变患者，患者年龄40-80之间，符合“《中医病证诊断疗效标准》(国家中医药管理局颁布)”中的糖尿病诊断标准，症见肢体麻木不仁，困倦乏力，以下肢为甚，活动后好转，或伴肢凉疼痛，入夜疼痛加剧，舌质淡红略暗或有瘀斑，苔薄白，脉细无力。
2、疗效标准
显效：临床症状明显减轻，肢体活动基本正常，疼痛减轻；
无效：临床症状无明显减轻、或加重。
3、治疗结果
50例糖尿病周围神经病变患者治疗2～3疗程后，，治疗显效42例，无效8例。治疗总有效率为84％。
典型案例：
周某，男，76岁，糖尿病病史20余年，长期服用二甲双胍0.5g，每日3次；3个月前加用阿卡波糖50mg，每日3次。检测空腹血糖波动于9~12mmol/L，餐后2小时血糖10~15mmol/L。刻诊：双下肢麻木，无疼痛发凉，视物模糊，无口渴多饮消瘦症状，纳眠可，二便调，舌体胖边有齿痕色淡红有瘀斑，苔薄白，脉细涩，中医辨证：气血不足夹瘀证，服用本发明配方10剂，常规控制血糖。二诊：服用后，双下肢麻木症状明显改善，继服10剂，并配合甲钴胺片0.5mg，每日3次，巩固疗效。出院后两周随访，患者双下肢麻木基本消失。

Claims (6)

1.一种治疗糖尿病周围神经病变的中药配方，其特征在于：该中药配方按重量份数包括以下中药成分：生黄芪30g，陈皮10g，鸡血藤15g，当归12g，川芎10g，川牛膝12g，赤白芍30g，桃仁10g，红花10g，地龙12g，土鳖虫12g。
2.如权利要求1所述的治疗糖尿病周围神经病变的中药配方，其特征在于：该中药配方还包括仙灵脾15g，葫芦巴12g，桂枝12g，吴茱萸10g，附片10g。
3.如权利要求1所述的治疗糖尿病周围神经病变的中药配方，其特征在于：该中药配方还包括生甘草12g，徐长卿12g。
4.如权利要求1所述的治疗糖尿病周围神经病变的中药配方，其特征在于：该中药配方还包括桂枝12g，制川草乌（先煎1小时）12g，细辛10g。
5.如权利要求1所述的治疗糖尿病周围神经病变的中药配方，其特征在于：该中药配方还包括玄参15g，丹皮15g。
6.如权利要求1所述的治疗糖尿病周围神经病变的中药配方的制备方法，其特征在于：取中药原料置于煎锅中，第一次加入中药原料 重量5～7倍的水，加热至沸腾后煎煮30～40分钟；第二次加入中药原料重量3～4倍的水， 煎煮25～30分钟；第三次加入中药原料重量3～4倍的水， 煎煮25～30分钟，三次药液混合再过滤得1剂，每日1剂，每日3次温服，10天为1个疗程。
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114699452A (zh) * 2022-03-18 2022-07-05 中国中医科学院西苑医院 一种治疗糖尿病周围神经病变的中药组合物、其制备方法和用途

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114699452A (zh) * 2022-03-18 2022-07-05 中国中医科学院西苑医院 一种治疗糖尿病周围神经病变的中药组合物、其制备方法和用途
CN114699452B (zh) * 2022-03-18 2023-07-21 中国中医科学院西苑医院 一种治疗糖尿病周围神经病变的中药组合物、其制备方法和用途

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