CN107753775A - A kind of chrysanthemum composition and its application - Google Patents
A kind of chrysanthemum composition and its application Download PDFInfo
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- CN107753775A CN107753775A CN201710878982.8A CN201710878982A CN107753775A CN 107753775 A CN107753775 A CN 107753775A CN 201710878982 A CN201710878982 A CN 201710878982A CN 107753775 A CN107753775 A CN 107753775A
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- chrysanthemum
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- taurine
- chrysanthemum composition
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A kind of chrysanthemum composition, it is made up of the raw material of following parts by weight：5~15 parts of chrysanthemum extract, 2~5 parts of Wheat Grass Powder, 3~10 parts of taurine.Application of the above-mentioned chrysanthemum composition in antifatigue.Each raw material of chrysanthemum composition of the present invention is taken, by pharmacy conventional method, customary adjuvant is added, clinically acceptable preparation, preferred tablet, granule, effervescent tablet is made.The present invention prepares a kind of chrysanthemum composition using chrysanthemum extract, Wheat Grass Powder, taurine as active ingredient, by scientific and reasonable collocation.The chrysanthemum composition of the present invention can significantly extend the mice burden swimming time, reduce tiring exercises mice serum lactic acid content, reduce tiring exercises mice serum urea nitrogen content, improve tiring exercises mouse hepatic glycogen content, there is remarkable effect in terms of body fatigue resistance is improved, available for antifatigue effect medicine in terms of application.
Description
Technical field
The invention belongs to field of traditional Chinese, and in particular to a kind of chrysanthemum composition and its application.
Background technology
Fatigue is modern society's common problem, both unhealthy status, also non-disease conditions, referred to as inferior health shape
State.One global sex inventory of the World Health Organization is bright, and the people of true health only accounts for 5%, and the people with disease accounts for 20%, and 75%
People be in sub-health state.In the patient age that Fatigue Clinic is gone to a doctor mostly at 20~40 years old, with the young people of 30 years old or so
Common, M-F is suitable.These patients are well-educated intellectual mostly, also there is successfully businessman, enterprise boss.
To find out its cause, more fast with rhythm of life, life is irregular, and work, learning pressure are big, ponder over relevant with brain, stress etc..It is tired
Labor or inferior health are lived to people, the influence and its high rate of work so that increasingly prominent to the demand of its effective prevention measure
It is aobvious.
At present, for clinical symptoms such as battle-weary or caused sleep-disorder and fatigues, general widely used sleep medicine,
Or the antianxiety drug such as benzodiazepine classes thing be used for alleviate and treat, but these medicines again because have certain side effect with
Drug dependence and limit its use range.Although people also can often use some nourishing tonics or vitamin E etc. anti-oxidant
Agent is used to improve fatigue state, although these methods really have certain help for alleviation or on organism fatigue is recovered, simultaneously
It is not most appropriate solution method, therefore clinically with greater need for nervous battle-weary to improve by alleviating, reaches improvement
Sleep quality and anti-uneasy and promotion fatigue recovery action effect.
Due to the unique theoretical system of the traditional Chinese medical science, the personalized medicines thought of diagnosis and treatment, and abundant intervention means, make
Obtain traditional Chinese medicine has advantageous advantage in terms of medical treatment fatigue and inferior health.
The content of the invention
It is an object of the invention to provide a kind of chrysanthemum composition and its application.
To achieve the above object, the present invention adopts the following technical scheme that：
A kind of chrysanthemum composition, it is made up of 5~15 parts of chrysanthemum extract, 2~5 parts of Wheat Grass Powder, 3~10 parts of taurine.
Preferably, the chrysanthemum composition is made up of the raw material of following parts by weight：10 parts of chrysanthemum extract, Wheat Grass Powder 3
Part, 5 parts of taurine.
Further, the chrysanthemum extract can obtain according to the following steps：
（1）The chrysanthemum that bud is complete, is gone rotten without stalk leaf, nothing is selected, is cleaned, 90 DEG C -95 DEG C of water is added and soaks 30 ~ 60min, use
Filtered through gauze obtains chrysanthemum liquid；
（2）To step（1）90 DEG C -95 DEG C of water is added in the filter residue of filtering and soaks 30 ~ 60min, chrysanthemum liquid is obtained with filtered through gauze；
（3）Combining step（1）And step（2）Chrysanthemum liquid, be cooled to room temperature, filtrate is dense with 65 ~ 75 DEG C of vacuum of Rotary Evaporators
5 times of contracting, concentrate is centrifuged, the freeze-dried freeze-dried powder that chrysanthemum extract is made of supernatant, produced.
The step（1）The mass ratio of reclaimed water and chrysanthemum is 40: 1；The step（2）The mass ratio of reclaimed water and filter residue is 40
∶1；The step（3）Middle freeze-drying refers to dry 36 hours at -40 DEG C.
Application of the above-mentioned chrysanthemum composition in anti-fatigue medicament is prepared.
Each raw material is taken in proportion, after being well mixed, by pharmacy conventional method, is added customary adjuvant, is made and clinically connects
Tablet, granule or the effervescent tablet received.
The advantage of product of the present invention is：The selected medicinal and edible Chinese medicine chrysanthemum extract of the present invention and there are excellent health functions
Wheat seedling powder, taurine be active ingredient, by the reasonable compatibility of above material, prepare a kind of chrysanthemum composition.Tried through animal
Test proves with clinical test, and chrysanthemum composition has remarkable effect in terms of body fatigue resistance is improved.Chrysanthemum composition and its system
Agent can significantly extend the mice burden swimming time, reduce tiring exercises mice serum lactic acid content, reduce tiring exercises mouse blood
Clear urea nitrogen content, improve tiring exercises mouse hepatic glycogen content.Shown with 68 chronic fatigue syndrome patient clinical trials,
Chrysanthemum composition can the effective symptom such as reduction of patient stress, insomnia and dreamful sleep, fatigue and weak, it is efficient up to more than 95%.Therefore
Available in terms of the medicine for preparing antifatigue effect.
Chrysanthemum is composite family herbaceos perennial, is one of parts of generic medicinal plants of Chinese tradition.Recorded according to ancient books, chrysanthemum taste
Sweetness and bitterness, cold nature；There is scattered wind heat-clearing, clear liver and improve vision and detoxicating, relieving inflammation etc. acts on.Modern pharmacology research shows that chrysanthemum has anti-
The multiple pharmacological effect such as bacterium, anti-inflammatory, anti-oxidant, vasodilator.It can speculate that chrysanthemum has according to the effect of chrysanthemum vasodilator and promote blood
Circulation, reduce the effect such as accumulation, fatigue-relieving of body acidic metabolite under fatigue state.
Wheat Grass Powder rich in chlorophyll, carrotene, protein, essential amino acid, vitamin, active ferment, mineral matter,
The natural nutrients such as cellulose.Ferroheme structure in chlorophyll and blood of human body contained by Wheat Grass Powder is extremely similar, so, it is small
Wheat seedling powder contributes to ferroheme to act on, and can promote the transport of internal oxygen and the exclusion of cellular waste；In addition, Wheat Grass Powder is inclined
Alkalescence, body acid-base value (pH value) can be balanced, alleviate fatigue problem caused by acidic metabolic waste excessively gives people.
Taurine is a kind of sulfur-containing amino acid simple in construction in animal body, has cardioprotection, antifatigue effect, often quilt
As nutrition fortifier, in fatigue resistant health food.
The present invention is prepared a kind of using chrysanthemum extract, Wheat Grass Powder, taurine as active ingredient by scientific and reasonable collocation
Chrysanthemum composition.The chrysanthemum composition of the present invention can significantly extend the mice burden swimming time, reduce tiring exercises mice serum
Lactic acid content, tiring exercises mice serum urea nitrogen content is reduced, improve tiring exercises mouse hepatic glycogen content, improving body
Antifatigue aspect has remarkable effect, available for antifatigue effect medicine in terms of application.
For the present invention according to the principle of integration of drinking and medicinal herbs, basis derive from common food, the nontoxic pair and not in Clinical practice
Good action, can be long-term use of.
Embodiment
Technical scheme is described in detail below by specific embodiment and test example.
Embodiment 1
The preparation of chrysanthemum extract：
The chrysanthemum that selection bud is complete, is gone rotten without stalk leaf, nothing, with clear water rinsed clean, the pure water of 90 DEG C of addition（Water: chrysanthemum
=40: 1）40min is soaked, chrysanthemum liquid is obtained with 4 layers of filtered through gauze, then adds 90 DEG C pure into the filter residue after filtering again
Water（Water: filter residue=40: 1）40min is soaked, two chrysanthemum liquid are obtained with 4 layers of filtered through gauze, chrysanthemum liquid merges twice, is cooled to room
Temperature.Chrysanthemum liquid after merging is concentrated in vacuo 5 times for 70 DEG C with Rotary Evaporators, and concentrate is centrifuged, takes supernatant at -40 DEG C
The freeze-dried powder of chrysanthemum extract, standby (per 10g extracts equivalent to 200g chrysanthemums crude drug) is made in freeze-drying 36h.
The preparation of the chrysanthemum composition granule of embodiment 2：
After freeze-dried powder 360g, Wheat Grass Powder 100g, the taurine 200g of chrysanthemum extract made from Example 1 are mixed, add
Appropriate amount of starch, dextrin, glucose stir obtained elastic suitable, soft or hard appropriate softwood, extrusion granulator, dry at 50~60 DEG C
Dry 5~6 hours, particle after drying is put to room temperature, cross 18 mesh sieve whole grains, obtain dry particl, bag distribution packaging, every bag
10g, every bag of 4.5~5.0g containing chrysanthemum composition.
Oral above-mentioned chrysanthemum composition granule, daily once in the morning and once at night, 1 bag every time.It is within 4 weeks a course for the treatment of, general 1~2
The individual course for the treatment of is effective, can cure substantially within 2 months~6 months.
The preparation of the chrysanthemum composition tablet of embodiment 3：
After freeze-dried powder 360g, Wheat Grass Powder 140g, the taurine 180g of chrysanthemum extract made from Example 1 are mixed, add
Appropriate amount of starch, dextrin, magnesium stearate, wet grain are mixed and made into by tabletting machine, piece weight 1.0g, every contains chrysanthemum composition
0.45~0.50g.
Oral above-mentioned chrysanthemum composition tablet, daily once in the morning and once at night, 5~10 every time.It is within 4 weeks a course for the treatment of, general 1~
2 courses for the treatment of are effective, can cure substantially within 2 months~6 months.
The preparation of the chrysanthemum composition effervescent tablet of embodiment 4：
The freeze-dried powder 200g of chrysanthemum extract made from Example 1, Wheat Grass Powder 60g, taurine 100g, citric acid 300g,
Sodium acid carbonate 300g, PEG6000 50g, Aspartame 50g, maltodextrin 440g, weigh medicine and auxiliary material, and each raw and auxiliary material is equal
It is standby to cross 80 mesh sieves.Medicine, citric acid are well mixed, and add appropriate maltodextrin, are granulated to obtain sour grain with comminutor, are crossed 12 mesh
Sieve； NaHCO3, PEG6000, Aspartame, remaining maltodextrin mix, be granulated to obtain alkali grain with method.Particle is done in 45 DEG C of air blast
After dry 4 h, with 14 mesh sieve whole grains.Gained acid grain, alkali grain are well mixed with talcum powder, magnesium stearate, tabletting 1000, obtained
Finished product.Every weight 1.5g, every 0.36g containing chrysanthemum composition.
Oral above-mentioned chrysanthemum composition effervescent tablet, daily once in the morning and once at night, 5~10 every time.It is within 4 weeks a course for the treatment of, general 1
~2 courses for the treatment of are effective, can cure substantially within 2 months~6 months.
Beneficial effects of the present invention are proved below by experimental example.Chrysanthemum extract group and chrysanthemum group in following each experimental examples
The chrysanthemum extract that compound group is related to is the freeze-dried powder of chrysanthemum extract.
The chrysanthemum composition of experimental example 1. is tested on mice burden swimming to be influenceed
Experimental animal：SPF level Kunming mouses, male and female half and half, 20 ± 2g of body weight, drinking-water of freely ingesting, 23-27 DEG C of room temperature, phase
To humidity 55-65%, aeration-drying, peace and quiet, 12 hours periodicity of illuminations..
Experimental design and packet：Normal Kunming healthy mice is randomly divided into blank control group, chrysanthemum extract group, wheat seedling
Powder group, taurine group, chrysanthemum composition group（Chrysanthemum extract, Wheat Grass Powder and taurine mix by weight the ︰ 5 of 10 ︰ 3, directly
Gastric infusion, similarly hereinafter）, every group 12.Each administration group gastric infusion（200 mg/kg）, 1 time a day, continuous 2 weeks；Blank control
Group was with isometric distilled water alternative medicine gavage, 1 time a day, continuous 2 weeks.
Swimming with a load attached to the body is tested：After last dose 30min, by the galvanized wire of rat-tail root load body weight 5%, mouse is put in trip
Swimming case（80 cm×60 cm×60 cm）Went swimming, the depth of water are not less than 30 cm, water temperature（25±1）DEG C, record mouse is swum certainly
Start to be shown in Table 1 to the time of death, i.e. mice burden swimming time, concrete outcome.
Influence of the chrysanthemum composition of table 1. to the mice burden swimming time（± s, n=12）
Note：Compared with control group* P<0.05,** P<0.01
Table 1 is shown：Each experimental group can extend the mice burden swimming time, and wherein chrysanthemum composition group significantly extends the trip of mouse
Swim the time（P＜ 0.01）, compared with blank control group, significant difference.Result of the test shows chrysanthemum composition at antifatigue aspect
Than the single medicine treatment more remarkable treatment effect before combination.
Influence of the chrysanthemum composition of experimental example 2. to mouse blood lactase acid
Experimental animal：With experiment 1
Experimental design and packet：With experiment 1
Tired mouse Serum lactic acid content measure：After last dose 30min, each group mouse 2% body weight galvanized wire of heavy burden, water temperature 30
DEG C, swum 30 min, picks up and dries, and eyeball blood sampling is plucked after 15 min of peace and quiet, is added anti-freezing, centrifugation, is separated serum.Used by program
Spectrophotometric determination blood lactase acid, concrete outcome are shown in Table 2.
Influence of the chrysanthemum composition of table 2. to mice serum lactic acid（± s, n=12）
Note：Compared with control group* P<0.05
Table 2 is shown：Each experimental mice Serum lactic acid content is below blank control group, and chrysanthemum composition group can significantly reduce swimming
The content of mouse blood lactase acid afterwards（P＜ 0.05）, each single medicine treatment group DeGrain.Before showing chrysanthemum composition and combining
Single medicine treatment have it is significantly different, can cooperate with improve body fatigue resistance effect.
Influence of the chrysanthemum composition of experimental example 3. to mice serum urea nitrogen
Experimental animal：With experiment 1
Experimental design and packet：With experiment 1
Tired mouse blood urea nitrogen assay：30 min after last dose, the min of each group mouse not swimming with a load attached to the body 30, water temperature
30℃.Pull out and dry, pluck eyeball blood sampling, survey serum urea nitrogen with semi-automatic biochemical analyzer, concrete outcome is shown in Table 3.
Influence of the chrysanthemum composition of table 3. to mice serum urea nitrogen（±s）
Note：Compared with control group,* P<0.05
Serum urea nitrogen is the end-product of protein metabolism, body serum urea nitrogen content with work and the increase of exercise load and
Increase, body is poorer to load performance, and serum urea nitrogen increase is more obvious.Table 3 is shown：Compared with blank control group, chrysanthemum
Flower composition group can significantly reduce the content of mice serum urea nitrogen after swimming, significant difference（P＜ 0.05）, chrysanthemum extract
Though group, wheat seedling powder group and taurine group can also reduce the content of mice serum urea nitrogen after swimming, difference is not notable, illustrates chrysanthemum
Flower composition group antifatigue effect effect is obvious compared with one-component.
Influence of the chrysanthemum composition of experimental example 4. to mouse hepatic glycogen
Experimental animal：With experiment 1
Experimental design and packet：With experiment 1
The measure of mouse hepatic glycogen：30 min after last dose, the min of each group mouse not swimming with a load attached to the body 60,30 DEG C of water temperature.Drag for
Rise and put to death immediately, liver is taken after being dissected in ice face, blotted after frost physiological saline rinsing with filter paper, add 5wt% trichlorine vinegar
After acid solution 4mL, 15 min of homogenate 1min, 3000 rpt/min centrifugation liver muscle glycogen, tool are tested according to kit operating instruction
Body the results are shown in Table 4.
Influence of the chrysanthemum composition of table 4. to mouse hepatic glycogen（± s, n=12）
Note：Compared with control group,* P<0.05
Table 4 is shown：Chrysanthemum composition group hepatic glycogen content and the obvious increase of blank control group, significant difference（P＜
0.05）, illustrate that chrysanthemum composition can dramatically increase experimental animal liver glycogen reserves amount, reaching antifatigue purpose for body provides
Sufficient energy.
Clinical data
1st, case selection：With in 68 chronic fatigue syndrome patients, man 38, female 30, max age 56 years old is minimum
23 years old age, the course of disease 3 months to 2 years.
2nd, diagnostic criteria：Stress, insomnia and dreamful sleep, agitation, poor appetite, palpitaition, dizziness, fatigue and weak, notice
Do not concentrate, decrease of memory is slow in reacting.
3rd, treatment method：Present composition particle made from oral embodiment 2, daily once in the morning and once at night, every time 5~
10 grams, warm water delivery service after meal.4 weeks are a course for the treatment of, and general 1~2 course for the treatment of is effective, can cure substantially within 2 months~6 months.
4th, efficacy determination：
（1）Cure, clinical symptoms（The symptom mentioned in above-mentioned diagnostic criteria）It is basic to disappear；
（2）Effective, the cardinal symptom such as stress, insomnia and dreamful sleep, agitation, tiredness eliminates；
（3）It is invalid, it is preceding without significant change with treating.
5th, result：Pharmaceutical preparation of the present invention is taken, can take effect within general 2 weeks~3 weeks, there is obvious effect after one month.
Take after two months, healing 20, effective 45, invalid 3, it is efficient up to more than 95%.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent
The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that：Its according to
The technical scheme described in foregoing embodiments can so be modified, either which part or all technical characteristic are entered
Row equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology
The scope of scheme.
Claims (6)
1. a kind of chrysanthemum composition, it is characterised in that be made up of the raw material of following parts by weight：5~15 parts of chrysanthemum extract, wheat
2~5 parts of seedling powder, 3~10 parts of taurine.
2. chrysanthemum composition according to claim 1, it is characterised in that be made up of the raw material of following parts by weight：Chrysanthemum carries
Take 10 parts of thing, 3 parts of Wheat Grass Powder, 5 parts of taurine.
3. chrysanthemum composition according to claim 1 or 2, it is characterised in that the chrysanthemum extract can be according to the following steps
Obtain：
（1）Select bud it is complete, without stalk leaf, without mildew and rot chrysanthemum, clean, add 90 DEG C~95 DEG C-water soak 30 ~ 60min,
Chrysanthemum liquid is obtained with filtered through gauze；
（2）To step（1）90 DEG C -95 DEG C of water is added in the filter residue of filtering and soaks 30 ~ 60min, chrysanthemum liquid is obtained with filtered through gauze；
（3）Combining step（1）And step（2）Chrysanthemum liquid, be cooled to room temperature, be concentrated in vacuo 5 times, concentrate is centrifuged,
The freeze-dried freeze-dried powder that chrysanthemum extract is made of supernatant, is produced.
4. chrysanthemum composition according to claim 3, it is characterised in that the step（1）The mass ratio of reclaimed water and chrysanthemum
For 40: 1；The step（2）The mass ratio of reclaimed water and filter residue is 40: 1；The step（3）Middle freeze-drying refers to dry at -40 DEG C
Dry 36 hours.
5. application of the chrysanthemum composition described in claim 1 or 2 in anti-fatigue medicament is prepared.
6. application of the chrysanthemum composition according to claim 5 in anti-fatigue medicament is prepared, it is characterised in that in proportion
Each raw material is taken, after being well mixed, by pharmacy conventional method, customary adjuvant is added, the tablet clinically received, granule is made
Or effervescent tablet.
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| US20050058730A1 (en) * | 2003-09-15 | 2005-03-17 | Xushan Wan | Compositions and methods for preventing or treating eyestrain |
| CN105146656A (en) * | 2015-09-07 | 2015-12-16 | 王保红 | Drink composition containing L-carnitine and plant extracts as well as preparation method and application of drink composition |
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| CN110637949A (en) * | 2019-09-24 | 2020-01-03 | 曹杰 | Freshly squeezed fruit juice |
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