CN107753418A - Medicament slow release implants and heeling-in device - Google Patents
Medicament slow release implants and heeling-in device Download PDFInfo
- Publication number
- CN107753418A CN107753418A CN201711155594.3A CN201711155594A CN107753418A CN 107753418 A CN107753418 A CN 107753418A CN 201711155594 A CN201711155594 A CN 201711155594A CN 107753418 A CN107753418 A CN 107753418A
- Authority
- CN
- China
- Prior art keywords
- slow release
- medicine
- medicament slow
- silicone tube
- release implants
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
Abstract
The invention discloses medicament slow release implants and its heeling-in device, the medicament slow release implants is in capsule shape, it is made up of medicine, laboratory level silicone tube and medical solidification adhesive, the medicine is placed in the silicone tube, the silicone tube both ends open is sealed with the solidification adhesive, and the medicine is controlled by silicone tube surface micropore footpath and is sustained.The heeling-in device of the present invention includes hollow bushing and pushes away medicine nook closing member, for the medicament slow release implants in animal body or described in subdermal implantation.Medicament slow release implants provided by the invention has the advantages such as the sustained release phase is long, release is stable, and heeling-in device making and use method is simple and easy, has significant technical advantage and scientific research value.
Description
Technical field
The present invention relates to biomedicine technical field, specifically, is related to medicament slow release implants and heeling-in device.
Background technology
Estrogen is a kind of steroid hormone, mainly by ovarian secretion.In mammal, estrogen is main before puberty
If promote and maintain the development of secondary sex characters；After sexal maturity, estrogen mainly adjust jenny hypothalamus, hypophysis, ovary,
The physiological activity of placenta and genital tract etc., tremendous influence is produced to the breeding activity of animal.
At present, in life science research, by studying it the methods of estrogen heeling-in to animals' reproduction physiology
The effect of activity is widely adopted.However, because animal is oral or injection hormonal stability is poor, effective acting time is short, and
Release concentration is uncontrollable, is difficult fully to excavate its effect in life process under study for action.In addition, the past is due to heeling-in side
Animal wound is excessive when the limitation of method causes heeling-in, gently then infects, heavy then cause animal dead, causes huge economic losses.
In order to solve the above problems, stability and long-term effect that estrogen is discharged after heeling-in in animal body are improved, and
The science of heeling-in method, needs a kind of sustained release agent that can be used for subcutaneous estrogen heeling-in of exploitation badly and heeling-in device, maximum can
The destabilizing factor and economic loss that reduce during estrogen heeling-in of energy.
The content of the invention
It is an object of the invention to provide medicament slow release implants and heeling-in device.
In order to realize the object of the invention, medicament slow release implants of the invention, the medicament slow release implants is in capsule shape,
It is made up of medicine, laboratory level silicone tube and medical solidification adhesive, the medicine is placed in the silicone tube, the silicone tube
Both ends open is sealed with the solidification adhesive.
The surface micropore footpath of silicone tube of the present invention is 0.5 ± 0.02 μm, and the medicine is by silicone tube surface micropore control
System sustained release.
3.35 ± 0.30mm of internal diameter of silicone tube of the present invention, 4.65 ± 0.30mm of external diameter, the length of the silicone tube
Cut as needed, explosive payload is 2.09 ± 0.18mg/cm in silicone tube3。
Solidification adhesive of the present invention is medical silicone or polysiloxanes (such as the transparent medical silicone of A types), room temperature bar
0.02 ± 0.003g bonding implants both ends are taken under part respectively.
Medicine of the present invention includes hormone medicine, preferably estrogen, more preferably 17- β estradiol.
Medicament slow release implants of the present invention is used for (muscle) or subdermal implantation in animal body.
The medicament slow release implants of the present invention can be prepared in accordance with the following methods：Silicone tube is cut to required length
Degree, Single port is sealed with solidification adhesive, loads medicine in pipe after to be bonded dose of solidification, it is then another with solidification adhesive closure
Single port.
The present invention also provides a kind of heeling-in device, for medicament slow release implants in animal body or described in subdermal implantation, institute
Stating heeling-in device includes hollow bushing and pushes away medicine nook closing member, and nook closing member is in sleeve pipe, and nook closing member can slide along internal surface of sleeve pipe.
Wherein, the hollow bushing is used to accommodate the medicament slow release implants；
It is easy to be pierced into animal skin, one end is blunt end, is easy to patient to operate for tip in the described medicine nook closing member one end that pushes away.
Foregoing heeling-in device, the length of the hollow bushing is L0, the length for pushing away medicine nook closing member is L1, wherein L1Than
L0Big more than 10mm；The diameter of the nook closing member and the internal diameter size of described sleeve pipe match.
Foregoing heeling-in device, the tip (needle point) for pushing away medicine nook closing member is cone, and (i.e. cone is high for tip length
Degree) it is 5mm.
The heeling-in device of the present invention, wherein hollow bushing and to push away medicine nook closing member be stainless steel.
In the specific embodiment of the present invention, carry out in accordance with the following steps：
1. subcutaneous estrogen sustained-release implant taking, bonded by 17- β estradiol, laboratory level silicone tube and medical cold curing
Agent etc. forms, and implants is 0.5 ± 0.02 μm by silicone tube surface micropore footpath, controls estrogen slow release speed, above each component
It can be bought from pharmaceuticals.
2. 3.35 ± 0.30mm of internal diameter of silicone tube, 4.65 ± 0.30mm of external diameter, length 1.50cm, silicone tube inner estrogen
Measure as 2.09 ± 0.18mg/cm3, centered position includes estrogen powder in silicone tube, and left and right ends are sealed by adhesive of medical
Mouthful.Wherein, adhesive of medical (the transparent medical silicone of A types) is purchased from Dow corning company (goods number：
000000000001019821)。
3. the preparation method of estrogen sustained-release implant taking, silicone tube is cut to required length first, uses cold curing
Adhesive seals one end port, loads estrogen in pipe after to be bonded dose of solidification, then closes another port.
4. the heeling-in device of estrogen sustained-release implant taking, including hollow bushing (internal diameter 6mm, external diameter 6.50mm), nook closing member is (straight
Footpath 5.50mm, nook closing member length is than set pipe range 15mm, the long 5mm of needle point), nook closing member one end is tip, is easy to be pierced into animal skin, one end
For blunt end, it is easy to patient to operate.
5. by heeling-in fixation of animal it is good after, 5mm wounds are cut at subdermal implantation with scalpel, nook closing member is penetrated into needle tubing simultaneously
Wound is pierced into, then needle tubing is stayed in subcutaneously, takes out nook closing member.
6. ready estrogen sustained-release implant taking in step 3 is put into needle tubing, it is sent to subcutaneously, is taken out with nook closing member
Sleeve pipe, sew up a wound, sterilize.
Compared with prior art, the present invention has advantages below：
Medicament slow release implants provided by the invention has the advantages such as the sustained release phase is long, release is stable, and manufacturing process is not
Complexity, it can be mass, large-scale use；In addition, heeling-in device making and use method is simple and easy, material easily obtains, into
This is relatively low, has significant technical advantage and scientific research value.
Brief description of the drawings
Fig. 1 is the structural representation of estrogen sustained-release implant taking (A) and silicone tube heeling-in device (B) in the embodiment of the present invention 1
Figure, wherein 1 and 4 be adhesive of medical sealing end；2 be the estrogen powder in silicone tube；3 be silicone tube；5 be hollow bushing, 6
To push away medicine nook closing member, 7 be needle point, and 8 be nook closing member blunt end.
Fig. 2 is that estrogen sustained-release implant taking makes figure in the embodiment of the present invention 1, and wherein A is silicone tube, and B is single-ended sealing
Length be 2cm silicone tube, C be sealing two ends effective length 1.5cm estrogen sustained-release implant taking finished product, wherein effectively
Length refers to the silica gel length of tube of charge segment in silicone tube.
Fig. 3 is estrogen heeling-in device finished figure in the embodiment of the present invention 1, and wherein A is the group injected nook closing member after sleeve pipe
Dress figure, B is the split schematic diagram after nook closing member is extracted out of sleeve pipe.
Embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.Unless otherwise specified, embodiment
In the conventional meanses that are well known to those skilled in the art of used technological means, raw materials used is commercial goods.
The sheep subcutaneous estrogen sustained-release implant taking of embodiment 1 and heeling-in device
Now so that sheep estrogen is sustained heeling-in as an example, with reference to figure 1 and Fig. 2, it is described in conjunction with the embodiments as follows：
1. subcutaneous estrogen sustained-release implant taking, bonded by 17- β estradiol, laboratory level silicone tube and medical cold curing
The part such as agent forms, and implants is by 0.5 ± 0.02 μm of silicone tube surface micropore footpath control estrogen slow release speed.
2. silicone tube, is cut to by as shown in Figure 1A, the present embodiment used silica gel bore 3.5mm, external diameter 5.5mm first
2cm, Single port is sealed with adhesive of medical (the transparent medical silicone of A types), loads estrogen, silicon in pipe after to be bonded dose of solidification
Sebific duct inner estrogen amount is 2.09 ± 0.18mg/cm3, then close another port, complete estrogen implants making (Fig. 2,
A-C)。
3. Figure 1B is the heeling-in schematic device of estrogen sustained-release implant taking, including hollow bushing (internal diameter 6mm, external diameter
6.5mm, length 8cm), nook closing member (diameter 5.5mm, than hollow sleeve pipe range 15mm), nook closing member one end is sophisticated (the long 5mm of needle point), just
In being pierced into animal skin, one end is blunt end, is easy to patient to operate (Fig. 3, A and B).
4. by heeling-in fixation of animal it is good after, 5mm wounds are cut at subdermal implantation with scalpel, nook closing member is penetrated into sleeve pipe simultaneously
Wound is pierced into, then sleeve pipe is stayed in subcutaneously, takes out nook closing member.
5. ready estrogen sustained-release implant taking in step 3 is put into sleeve pipe, it is sent to subcutaneously, is taken out with nook closing member
Sleeve pipe, sew up a wound, sterilize.
Although above the present invention is described in detail with a general description of the specific embodiments,
On the basis of the present invention, it can be modified or improved, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements, belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (10)
1. medicament slow release implants, it is characterised in that the medicament slow release implants is in capsule shape, by medicine, laboratory level silicon
Sebific duct and medical solidification adhesive composition, the medicine is placed in the silicone tube, and the silicone tube both ends open is with described solid
Change adhesive to seal.
2. medicament slow release implants according to claim 1, it is characterised in that the surface micropore footpath of the silicone tube is
0.5 ± 0.02 μm, the medicine is controlled by silicone tube surface micropore and is sustained.
3. medicament slow release implants according to claim 1, it is characterised in that the internal diameter 3.35 of the silicone tube ±
0.30mm, 4.65 ± 0.30mm of external diameter, the length of the silicone tube are cut as needed, in silicone tube explosive payload be 2.09 ±
0.18mg/cm3。
4. medicament slow release implants according to claim 1, it is characterised in that it is described solidification adhesive be medical silicone or
Polysiloxanes.
5. medicament slow release implants according to claim 1, it is characterised in that the medicine includes hormone medicine, excellent
Select estrogen, more preferably 17- β estradiol.
6. according to the medicament slow release implants described in claim any one of 1-5, it is characterised in that the medicament slow release implants
For in animal body or subdermal implantation.
7. the preparation method of any one of the claim 1-6 medicament slow release implants, it is characterised in that be cut to silicone tube
Required length, Single port is sealed with solidification adhesive, loads medicine in pipe after to be bonded dose of solidification, then with solidification adhesive
Close another port.
8. heeling-in device, for the medicament slow release implants in animal body or described in subdermal implantation claim any one of 1-6, its
It is characterised by, the heeling-in device includes hollow bushing and pushes away medicine nook closing member, and nook closing member is in sleeve pipe, and nook closing member can be along in sleeve pipe
Wall slides；
Wherein, the hollow bushing is used to accommodate the medicament slow release implants；
It is easy to be pierced into animal skin, one end is blunt end, is easy to patient to operate for tip in the described medicine nook closing member one end that pushes away.
9. heeling-in device according to claim 8, it is characterised in that the length of the hollow bushing is L0, it is described to push away medicine pin
The length of core is L1, wherein L1Compare L0Big more than 10mm；The diameter of the nook closing member and the internal diameter size of described sleeve pipe match；
The tip for pushing away medicine nook closing member is cone, tip length 5mm.
10. heeling-in device according to claim 8 or claim 9, it is characterised in that the hollow bushing and to push away medicine nook closing member be not
Rust steel material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711155594.3A CN107753418A (en) | 2017-11-20 | 2017-11-20 | Medicament slow release implants and heeling-in device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711155594.3A CN107753418A (en) | 2017-11-20 | 2017-11-20 | Medicament slow release implants and heeling-in device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107753418A true CN107753418A (en) | 2018-03-06 |
Family
ID=61278472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711155594.3A Pending CN107753418A (en) | 2017-11-20 | 2017-11-20 | Medicament slow release implants and heeling-in device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107753418A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10912933B2 (en) | 2014-08-19 | 2021-02-09 | The Regents Of The University Of California | Implants for localized drug delivery and methods of use thereof |
| CN112569457A (en) * | 2020-12-10 | 2021-03-30 | 北京大学第三医院（北京大学第三临床医学院） | Continuous drug delivery bag tube system |
| US11173291B2 (en) | 2020-03-20 | 2021-11-16 | The Regents Of The University Of California | Implantable drug delivery devices for localized drug delivery |
| US11338119B2 (en) | 2020-03-20 | 2022-05-24 | The Regents Of The University Of California | Implantable drug delivery devices for localized drug delivery |
| US11344526B2 (en) | 2020-03-20 | 2022-05-31 | The Regents Of The University Of California | Implantable drug delivery devices for localized drug delivery |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10912933B2 (en) | 2014-08-19 | 2021-02-09 | The Regents Of The University Of California | Implants for localized drug delivery and methods of use thereof |
| US11324935B2 (en) | 2014-08-19 | 2022-05-10 | The Regents Of The University Of California | Implants for localized drug delivery and methods of use thereof |
| US11918770B2 (en) | 2014-08-19 | 2024-03-05 | The Regents Of The University Of California | Implants for localized drug delivery and methods of use thereof |
| US11173291B2 (en) | 2020-03-20 | 2021-11-16 | The Regents Of The University Of California | Implantable drug delivery devices for localized drug delivery |
| US11338119B2 (en) | 2020-03-20 | 2022-05-24 | The Regents Of The University Of California | Implantable drug delivery devices for localized drug delivery |
| US11344526B2 (en) | 2020-03-20 | 2022-05-31 | The Regents Of The University Of California | Implantable drug delivery devices for localized drug delivery |
| CN112569457A (en) * | 2020-12-10 | 2021-03-30 | 北京大学第三医院（北京大学第三临床医学院） | Continuous drug delivery bag tube system |
| CN112569457B (en) * | 2020-12-10 | 2024-02-13 | 北京大学第三医院（北京大学第三临床医学院） | Continuous administration cyst tube system |
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