CN1410063A - Embedding agent for long acting blood pressure reducing - Google Patents
Embedding agent for long acting blood pressure reducing Download PDFInfo
- Publication number
- CN1410063A CN1410063A CN 01135631 CN01135631A CN1410063A CN 1410063 A CN1410063 A CN 1410063A CN 01135631 CN01135631 CN 01135631 CN 01135631 A CN01135631 A CN 01135631A CN 1410063 A CN1410063 A CN 1410063A
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- CN
- China
- Prior art keywords
- blood pressure
- pressure reducing
- long acting
- embedding agent
- silica gel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
A long-acting implantation medicine for lowering blood prssure is composed of silica gel tube and antihypertenssive medicine. Its advantages are high long acting rate (3-5 years), high curative effect (more than 95% for primary hypertension) and no drug resistance.
Description
The invention provides a kind of embedding agent for long acting blood pressure reducing, it is that the hypertensive silica gel of clinical treatment adds pharmaceutical preparation, adopts the method for subdermal implantation, just can make the blood pressure long-term stability in normal range.
At present in the world each medical institutions' treatment hypertension and stabilizing blood pressure mainly by every day enalapril meleate keep the normal condition of blood pressure, depressor is of a great variety, once takes to make the blood pressure long-term stability.If, perhaps ignored hypertensive hazardness, or just may cause that blood pressure raises suddenly when excited and tired, cause sudden cerebral hemorrhage in case forget and take depressor, hard to guard against, cause death or deformity.
Purpose of the present invention is exactly a deficiency of avoiding above-mentioned, and a kind of embedding agent for long acting blood pressure reducing is provided, sustained release, and play the purpose of long-acting lowering and stabilizing blood pressure.A heeling-in has effectively prevented the danger of burst cerebral hemorrhage in 3-5.
Purpose of the present invention can be finished in the following manner:
Silica gel tube external diameter 2mm-2.4mm, internal diameter 1.5mm-1.9mm, long 20mm-40mm is respectively charged into indapamide 100mg-200mg in the silica gel tube, enalapril 100mg-200mg, felodipine 100mg-200mg, perindopril 100mg-200mg, pempidine 100mg-200mg, the silica gel tube two ends of various depressor are housed, with the adhesive of medical sealing, pack with medical plastic film bag then, stand-by with ethylene oxide sterilizing.
Using method: according to dissimilar hypertension, choose the silica gel tube implants of depressor, with triangular muscle place skin routine disinfection, scope 5cm-10cm, do local anesthesia with 2% lignocaine, it is subcutaneous to thrust the triangular muscle that disinfects with No. 12 puncture needles then, imbeds implants 1-2 bar subcutaneous respectively, do not make silica gel tube expose skin, get final product with adhesive bandage sealing wound then.
Action principle: silica gel tube is made just a lot of micropores, and the thickness of its wall is controlled medicine in subcutaneous burst size, and this silica gel tube is formed in subcutaneous every day of sustained release depressor 100vg, and every implants is sustained release 3 years to 5 years in vivo.By clinical trial: indapamide, enalapril, all kinds of essential hypertensions of perindopril controlled release every day 100vg may command, and be stabilized in normal range.Felodipine controlled release every day 100vg, may command plain edition essential hypertension, pempidine controlled release every day 100vg may command serious symptom essential hypertension also is stabilized in normal range.Because of subdermal implants is not subjected to the destruction of gastric juice and various digestive enzyme and the influence of food, so bioavailability is high, the medicine of trace can produce very high curative effect.For example: 1. patient Lv Wenhao: the man, 40 years old, people from Shangshui, Henan, the body obesity was suffered from essential hypertension 5 years, did not obey blood pressure 170/100mmhg before the depressor, conscious giddy, feeling of fullness in the head, companioned with headache when serious, hypomnesis.Obey 2 of Zhenju Jiangya Tablets every day, 2 of captoprils, blood pressure can be stabilized in 130/90-mmhg, reach handkerchief amine implants on April 15th, 1998 with drawing, select for use 150mg dosage to make the triangular muscle subdermal implantation, heeling-in cut out depressor after one day, second day blood pressure 130/90mmhg, the 3rd day blood pressure 120/80mmhg, so far more than 3 years since blood pressure be stabilized in 120/80mmhg to 115/75mmhg always.Other symptom that causes because of hypertension is recovery occurs without treatment also.
For example: 2. not elegant blue: the woman, 48 years old, people from Shangshui, Henan suffered from hypertension 10 years, companion's swelling pain of head, dizziness, hypomnesis is obeyed general depressor and can be reduced to normally.Have and forget for twice and to take depressor, fall in a swoon suddenly one afternoon, headache, vomiting, blood pressure 230/120mmhg through CT scan, did not find cerebral hemorrhage at that time.The blood pressure lowering of suiting the medicine to the illness is handled and is healed.This symptom in March nineteen ninety-five outbreak once, in October, 1997 once.In Ri Yong Yi Napu agent implants 150mg content October 7 in 1998, do triangular muscle subcutaneous implantation withdrawing depressor so far blood pressure stabilization sudden falling in a swoon and the hypertension symptom do not appear at 130/80mmhg-120/70mmhg.
Claims (4)
1, the hypertensive embedding agent for long acting blood pressure reducing of a kind of treatment is characterized in that being made up of silica gel tube, depressor indapamide, enalapril, perindopril, felodipine, pempidine.
2,, it is characterized in that silica gel tube sustained release dose 100vg every day, its length 20mm-40mm external diameter 2mm-2.4mm, internal diameter 1.5mm-1.9mm according to the described embedding agent for long acting blood pressure reducing of claim (1).
3, according to claim (1), every silica gel tube of the medicated powder of depressor indapamide, enalapril, perindopril, felodipine, pempidine is adorned 100mg-200mg respectively, and two ends are sealed with adhesive of medical.
4, it is characterized in that according to the described embedding agent for long acting blood pressure reducing of claim (1) (2) (3) every silica gel tube is respectively charged into the embedding agent for long acting blood pressure reducing that depressor indapamide, enalapril, perindopril, felodipine, pempidine are made.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01135631 CN1410063A (en) | 2001-10-09 | 2001-10-09 | Embedding agent for long acting blood pressure reducing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01135631 CN1410063A (en) | 2001-10-09 | 2001-10-09 | Embedding agent for long acting blood pressure reducing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1410063A true CN1410063A (en) | 2003-04-16 |
Family
ID=4673222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01135631 Pending CN1410063A (en) | 2001-10-09 | 2001-10-09 | Embedding agent for long acting blood pressure reducing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1410063A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1292747C (en) * | 2003-09-16 | 2007-01-03 | 广东省心血管病研究所 | Compound formulation for treating hypertension |
| CN1305477C (en) * | 2003-12-18 | 2007-03-21 | 袁重华 | Paint for treating benign prostate hyperplasia and its use |
| CN107753418A (en) * | 2017-11-20 | 2018-03-06 | 中国农业科学院北京畜牧兽医研究所 | Medicament slow release implants and heeling-in device |
-
2001
- 2001-10-09 CN CN 01135631 patent/CN1410063A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1292747C (en) * | 2003-09-16 | 2007-01-03 | 广东省心血管病研究所 | Compound formulation for treating hypertension |
| CN1305477C (en) * | 2003-12-18 | 2007-03-21 | 袁重华 | Paint for treating benign prostate hyperplasia and its use |
| CN107753418A (en) * | 2017-11-20 | 2018-03-06 | 中国农业科学院北京畜牧兽医研究所 | Medicament slow release implants and heeling-in device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |