CN104147606A - Biodegradable subcutaneous implant rod used for long-acting pressure reduction - Google Patents
Biodegradable subcutaneous implant rod used for long-acting pressure reduction Download PDFInfo
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- CN104147606A CN104147606A CN201410402016.5A CN201410402016A CN104147606A CN 104147606 A CN104147606 A CN 104147606A CN 201410402016 A CN201410402016 A CN 201410402016A CN 104147606 A CN104147606 A CN 104147606A
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Abstract
The invention provides a biodegradable subcutaneous implant rod used for long-acting pressure reduction. The biodegradable subcutaneous implant rod is a cylindrical implant rod prepared by mixing an antihypertensive drug with a biodegradable material--modified poly(glycerol-sebacate) which is used as a carrier. The implant rod is implanted into subcutaneous tissue of the human body after cobalt 60 irradiation sterilization; through slow degradation of modified poly(glycerol-sebacate), the drug is released, enters blood circulation and performs the effect of a pharmacological antihypertensive drug, and effective plasma concentration is guaranteed so as to achieve the purposes of long-term blood pressure reduction and blood pressure stabilization. The implant rod is totally degraded in one to two years, the drug is totally released at the same time, the implant rod turns into carbon dioxide, nitrogen, water and a few amount of glycerin which are absorbed by the human body and are then discharged out from the human body, so a treatment course of slow release administration is completed. The biodegradable subcutaneous implant rod can substantially reduce the attack rate of sudden cardio-cerebrovascular emergencies due to a patient misses a dose of a drug; and according to results of clinical verification, the biodegradable subcutaneous implant rod has an effective rate of 100% on primary hypertension adaptation diseases.
Description
Technical field
The present invention relates to a kind of long-acting blood pressure lowering slow release rod of Hypertension, a kind of biodegradation subdermal implantation for long-acting blood pressure lowering rod particularly, it is a kind ofly by the poly-decanedioic acid glycerol alcohol ester of biodegradation material modification and depressor, to be mixed and made into columniform heeling-in rod; Adopt the method implant into body of subcutaneous injection subcutaneous, because medicine is along with the poly-decanedioic acid glycerol alcohol ester degraded of modification and slowly discharge, just can reach the effect of blood pressure lowering and stabilizing blood pressure normal range.
Background technology
At present, both at home and abroad treatment and stable hypertension, mainly by every day oral blood pressure lowering medicine maintain blood pressure normal condition, blood pressure lowering is of a great variety, once take the object that can not reach blood pressure steady in a long-term, once if forget and take depressor, or ignored hypertensive harm and cut out depressor, circuitous to excited and fiercely just may cause that blood pressure raises suddenly when movable, bring out sudden cardiovascular and cerebrovascular disease, cause death or deformity.The long-term fixed patient of unstable blood pressure easily causes target organ damage.On medical market, have now a kind of implant of fatty acid, this type of medicine neither depressor, belongs to hypolipidemic, can not reach the object of blood pressure lowering and stabilizing blood pressure after use.Also have at present a kind of long-effective depressor submerged rod, because tube wall is that silicone rubber is made, after the drug release in pipe is complete, also will take out blank pipe wall, to patient, brought secondary painful.Disclosed also have a kind of long-acting subcutaneous injection bar with hypotensive medicine, and by the slow Slow release of biodegradation tube wall, tube wall is along with the time degrades, and the dosage of drug release is difficult to reach control criterion, makes blood pressure have wild effect, and its production technology is difficult for realizing.
Summary of the invention
In sum, in order to overcome the deficiency of prior art problem, the present invention develops a kind of biodegradation subdermal implantation for long-acting blood pressure lowering rod, and it is a kind ofly by the poly-decanedioic acid glycerol alcohol ester of biodegradation material modification and depressor, to be mixed and made into columniform heeling-in rod; After 60Coradiation sterilizing, implant into body is subcutaneous, gathers the slow degradation of the pure ester of decanedioic acid glycerol by modification, and medicine is also along with discharging the effect that enters blood circulation performance pharmacology depressor, guarantee effective blood drug concentration, to reach the object of long-term blood pressure lowering and stabilizing blood pressure.Heeling-in in 1 year to 2 years rod has been degraded, and medicine also releases thereupon, become carbon dioxide nitrogen, water and a small amount of glycerol by this absorption of people after, finally excrete.
For solving the problems of the technologies described above, the technical solution used in the present invention is as follows:
A kind of rod of the biodegradation subdermal implantation for long-acting blood pressure lowering, is to make by the raw material of following weight portion, and heeling-in rod comprises carrier and crude drug, wherein, carrier is the poly-pure ester of decanedioic acid glycerol of modification, and it comprises 10～30 parts of decanedioic acid, 5～20 parts of glycerol, 0.1～0.5 part of First Five-Year Plan pentanediol; The weight portion of crude drug comprises 4～12 parts of losartans, 6～18 parts of lacidipines, 1～3 part of enalapril, 1～2 part of metoprolol.
Further, described carrier is the poly-pure ester of decanedioic acid glycerol of modification, its weight portion comprises 10 parts of decanedioic acid, 5 parts of glycerol, 0.1 part of First Five-Year Plan pentanediol.
Further, the weight portion of described crude drug comprises 4 parts of losartans, 6 parts of lacidipines, 3 parts of enalaprils, 1 part of metoprolol.
Further, the diameter of the described biodegradation subdermal implantation rod for long-acting blood pressure lowering is 1～3mm, length is 20～40mm.
Production method of the present invention is:
For a production method for the biodegradation subdermal implantation rod of long-acting blood pressure lowering, by following steps, made:
The first step, carrier are the poly-pure ester of decanedioic acid glycerol of modification, its processing method is by 10～30 parts of decanedioic acid, 5～20 parts of glycerol, 0.1～0.5 part of First Five-Year Plan pentanediol is put into reactor, heat while stirring, heating-up temperature is 130～170 ℃, and when the raw material in question response still becomes ickiness, polymerization completes, be the poly-pure ester of decanedioic acid glycerol of modification, stand-by;
Second step, by 4～12 parts of crude drug losartans, 6～18 parts of lacidipines, 1～3 part of enalapril, after 1～2 part of mix homogeneously of metoprolol, remix with the poly-pure ester of decanedioic acid glycerol of modification of first step processing, after stirring, compound is injected in mould, then mould is placed in air dry oven and is heated to 100～150 ℃, be 50～100 hours heat time heating time, after the time for the treatment of reaches 50～100 hours, compound sizing in mould is cylindrical, is the biodegradation subdermal implantation rod for long-acting blood pressure lowering;
The 3rd step, mold, take out the heeling-in packing rod of sizing, and 2～3 of every bags are stand-by with Co 60 sterilizing.
using method of the present invention:
1, indication: essential hypertension, eat two kinds of following depressor and can reach normal patient.
2, be not suitable with crowd: (1) in the recent period troubles is cared flesh infarction; (2) heart organic lesion; (3) type 1 diabetes needs the insulin person that maintains blood glucose; (4) the serious sequela of cerebral infarction; (5) asthma; (6) psychosis; (7) long-term heavy drinking and cannot withdrawal person; (8) often use antirheumatic and hormone medicine; (9) to this product allergy sufferers; (10) secondary hypertension; (11) renal insufficiency person; (12) intractable hypertension, combines and takes antihypertensive drugs and cannot remain normal; (13) eat depressor medicine and occurred lower limbs edema person.
3, consumption: a time subdermal implantation is used 2～3 heeling-in rods, and the weight of every heeling-in rod is 0.2～0.3g, every heeling-in rod is 0.1～0.15g containing material medicine.
beneficial effect of the present invention:
1, the present invention has avoided liver to close elimination effect to the head of medicine, and alleviating some medicines may be to hepatotoxicity; Avoid oral drugs to gastral direct stimulation, reduced medicine to gastrointestinal side effect.
2, the present invention is that the mode spreading merely directly enters tissue fluid and blood, due to the time restriction of carrier degraded and adding of medicine, medicine is slowly discharged consistently within considerable time, significantly weakened the fluctuation of the blood drug level that the half-life because of oral drugs causes.
3, the present invention can significantly reduce the attack rate that misses drug-induced sudden cardiovascular and cerebrovascular vessel emergency case because of patient.
4, the present invention is by after 60Coradiation sterilizing, heeling-in human body is subcutaneous, the slow degradation that gathers the pure ester of decanedioic acid glycerol by modification, medicine is also along with discharging, bring into play the effect of depressor, reach the object of long-term blood pressure lowering and stabilizing blood pressure, according to the time of required degraded and the regulating action to blood pressure, the dose that change production technology and formula, adjustment are sneaked into just can be realized the object of blood pressure steady in a long-term, no side effects, safe and reliable.
5, the present invention, by clinical verification, is 100% to the effective percentage of essential hypertension indication.
the specific embodimentbelow in conjunction with embodiment, the present invention is described in further detail.
embodiment 1(by the formula of the present embodiment, can produce 110 heeling-in rods, the diameter of heeling-in rod is 3mm,, length is 40mm; The weight of every heeling-in rod is 0.3g, and every rod is 0.12g containing crude drug)
A kind of rod of the biodegradation subdermal implantation for long-acting blood pressure lowering, to make by the raw material of following weight, heeling-in rod comprises carrier and crude drug, carrier be the poly-pure ester of decanedioic acid glycerol of modification it comprise decanedioic acid 15g, glycerol 5g, First Five-Year Plan pentanediol 0.1g, crude drug comprises losartan 4g, lacidipine 6g, enalapril 2g, metoprolol 1g.
Processing method of the present invention comprises the following steps:
The first step, carrier are the poly-pure ester of decanedioic acid glycerol of modification, processing method is by decanedioic acid 15g, glycerol 5g, First Five-Year Plan, pentanediol 0.1g put into reactor, heat while stirring, heating-up temperature is 130～170 ℃, and when the raw material in question response still becomes ickiness, polymerization completes, be the poly-pure ester of decanedioic acid glycerol of modification, stand-by as carrier;
Second step, by crude drug losartan 4g, lacidipine 6 g, enalapril 2g, after metoprolol 1g mix homogeneously, remix with the poly-pure ester of decanedioic acid glycerol of modification of first step processing, after stirring, compound is injected in mould, then mould is placed in air dry oven and is heated to 100～150 ℃, be 50～100 hours heat time heating time, after the time for the treatment of reaches 50～100 hours, the compound sizing in mould is cylindrical, is the biodegradation subdermal implantation rod for long-acting blood pressure lowering;
The 3rd step, mold, take out the heeling-in packing rod of setting, and 2～3 of every bags are stand-by with Co 60 sterilizing.
embodiment 2(by the formula of the present embodiment, can produce 200 heeling-in rods, the diameter of heeling-in rod is 3mm,, length is 40mm; The weight of every heeling-in rod is 0.3g, and every rod is 0.15g containing crude drug)
A kind of rod of the biodegradation subdermal implantation for long-acting blood pressure lowering, is to make by the raw material of following weight, and heeling-in rod comprises carrier and crude drug, and carrier is the poly-pure ester of decanedioic acid glycerol of modification, and it comprises decanedioic acid 20g, glycerol 10 g, First Five-Year Plan pentanediol 0.1g; Crude drug comprises losartan 11g, lacidipine 16g, enalapril 2g, metoprolol 1g.
The processing method of the present embodiment is with embodiment 1.
implementation step of the present invention:
When 1, use is of the present invention, need support the use subdermal implantation sleeve pipe needle set: (comprise medical stainless steel trocar syringe and medical plastic nook closing member, medical stainless steel trocar syringe and medical plastic nook closing member are combined and have formed special-purpose subdermal implantation sleeve pipe needle set of the present invention).
1) the long 90mm of medical stainless steel trocar syringe, overall diameter 4 mm, interior diameter 3.8 mm, chamfer length 7 mm of cyclinder needle pointed nose, the first scale, according to needle point 11 mm, is the second scale according to the first scale 40mm, and the afterbody of medical stainless steel trocar syringe is plane, direction at the parallel pinpoint inclined plane of afterbody has an arc gap, is directed mouthful;
2) medical plastic nook closing member part: total length 9.5mm, diameter 3 mm, medical plastic nook closing member inserts effective length 8.3 mm of medical stainless steel trocar syringe, and the afterbody of medical plastic nook closing member has the handle of 12 mm length.
2, surgical operation step
1) operation receiveing person's clinostatism of making even, left (or right) hand abduction outward turning lies against on supporting plate;
2) patient be branded as, mask wear clean operating coat;
3) open sterile surgical bag, patient wears sterile gloves, with sterile gauze, cleans the Pulvis Talci on glove;
4), with 2.5% iodine tincture and 75% ethanol or use iodophor disinfection upper arm skin, spread sterilization hole towel;
5) open instrument bag and be placed in operating-table sterilization lid, check apparatus number;
6) in elbow band, 6～8cm sentences No. 5 and lengthens the capable fan-shaped infiltration anesthesia of syringe needle (bupivacaine);
7) see clearly the scale of medical stainless steel trocar syringe, with medical stainless steel trocar needle point with 25 degree angles oblique thrust subcutaneous, when prolonging subcutaneous inserting needle forward and reaching the second scale place, extract the medical plastic nook closing member in the medical stainless steel trocar, again from the afterbody of medical stainless steel sleeve bobbin syringe along putting into a heeling-in rod in syringe, with medical plastic nook closing member, be pushed to subcutaneous, while being hampered power, stop and fixing medical plastic nook closing member, retreat medical stainless steel trocar syringe to the first scale place, the needle point of medical stainless steel trocar syringe is with the outer side shifting of 15 degree angles, row thrusts subcutaneous tissue for the second time again, with method, push heeling-in rod, two heeling-in rods are 75 degree angle fan-shaped array,
8) placement of heeling-in rod is complete, extracts medical stainless steel trocar syringe and medical plastic nook closing member, with a cotton ball soaked in alcohol, pushes down pin hole, fixing with adhesive bandage.
By model case, clinical verification of the present invention is described below, by heeling-in subcutis of the present invention place, gathers the slow degradation of the pure ester of decanedioic acid glycerol by modification, medicine is also along with discharging, bring into play the effect of depressor.Reach the object of long-term blood pressure lowering and stabilizing blood pressure, according to the time of required degraded and the regulating action to blood pressure, adjust the dose of sneaking into and just can realize the object of blood pressure steady in a long-term, have no side effect, safe and reliable.Through the clinical verification to essential hypertension indication, its effective percentage is 100%.
model case
case1: Lee so-and-so, man 52 years old, Shangshui County, Henan Province, essential hypertension, medical history 10 years, blood pressure measurement systolic pressure 180 millimetress of mercury while not taking medicine at ordinary times, diastolic pressure 115 millimetress of mercury, after subdermal implantation 7 days, blood pressure stabilization is at systolic pressure 135 millimetress of mercury, diastolic pressure 85 millimetress of mercury, and heeling-in once continues normal more than 2 years.
case2: China so-and-so, female 49 years old, Shangshui County, Henan Province, essential hypertension, medical history 8 years.Blood pressure measurement systolic pressure 170 millimetress of mercury while not taking medicine at ordinary times, diastolic pressure 105 millimetress of mercury, after 7 days, blood pressure stabilization is at systolic pressure 130 millimetress of mercury for subdermal implantation, and diastolic pressure 80 millimetress of mercury, more than heeling-in once continues to maintain a year and a half.
case3: Liu so-and-so, man 50 years old, Shangshui County, Henan Province.Essential hypertension, medical history 9 years.Blood pressure measurement systolic pressure 190 millimetress of mercury while not taking medicine at ordinary times, diastolic pressure 125 millimetress of mercury, after 7 days, blood pressure stabilization is at systolic pressure 135 millimetress of mercury for subdermal implantation, and diastolic pressure 85 millimetress of mercury, more than heeling-in once continues to maintain a year and a half.
case4: Lee so-and-so, man 63 years old, Shangshui County, Henan Province, essential hypertension, medical history 12 years.Blood pressure measurement systolic pressure 180 millimetress of mercury while not taking medicine at ordinary times, diastolic pressure 110 millimetress of mercury, after 7 days, blood pressure stabilization is at systolic pressure 135 millimetress of mercury for subdermal implantation, and diastolic pressure 85 millimetress of mercury, more than heeling-in once continues to maintain two-and-a-half years.
case5: Wang, female 73 years old, Shangshui County, Henan Province, essential hypertension, medical history 25 years.Blood pressure measurement systolic pressure 190 millimetress of mercury while not taking medicine at ordinary times, diastolic pressure 100 millimetress of mercury, after 7 days, blood pressure stabilization is at systolic pressure 130 millimetress of mercury for subdermal implantation, and diastolic pressure 70 millimetress of mercury, more than heeling-in once continues to maintain two-and-a-half years.
Claims (5)
1. the biodegradation subdermal implantation for long-acting blood pressure lowering is excellent, it is characterized in that, it is to make by the raw material of following weight portion, heeling-in rod comprises carrier and crude drug, wherein carrier is the poly-pure ester of decanedioic acid glycerol of modification, it comprises 10～30 parts of decanedioic acid, 5～20 parts of glycerol, 0.1～0.5 part of First Five-Year Plan pentanediol; The weight portion of crude drug comprises 4～12 parts of losartans, 6～18 parts of lacidipines, 1～3 part of enalapril, 1～2 part of metoprolol.
2. the rod of the biodegradation subdermal implantation for long-acting blood pressure lowering according to claim 1, is characterized in that, described carrier is the poly-pure ester of decanedioic acid glycerol of modification, and its weight portion comprises 10 parts of decanedioic acid, 5 parts of glycerol, 0.1 part of First Five-Year Plan pentanediol.
3. the rod of the biodegradation subdermal implantation for long-acting blood pressure lowering according to claim 1, is characterized in that, the weight portion of described crude drug comprises 4 parts of losartans, 6 parts of lacidipines, 3 parts of enalaprils, 1 part of metoprolol.
4. the rod of the biodegradation subdermal implantation for long-acting blood pressure lowering according to claim 1, is characterized in that, the diameter of the described biodegradation subdermal implantation rod for long-acting blood pressure lowering is 1～3mm, and length is 20～40mm.
5. the rod of the biodegradation subdermal implantation for long-acting blood pressure lowering according to claim 1, is characterized in that, by following steps, is made:
The first step, carrier are the poly-pure ester of decanedioic acid glycerol of modification, its processing method is by 10～30 parts of decanedioic acid, 5～20 parts of glycerol, 0.1～0.5 part of First Five-Year Plan pentanediol is put into reactor, heat while stirring, heating-up temperature is 130～170 ℃, and when the raw material in question response still becomes ickiness, polymerization completes, be the poly-pure ester of decanedioic acid glycerol of modification, stand-by;
Second step, by 4～12 parts of crude drug losartans, 6～18 parts of lacidipines, 1～3 part of enalapril, after 1～2 part of mix homogeneously of metoprolol, remix with the poly-pure ester of decanedioic acid glycerol of modification of first step processing, after stirring, compound is injected in mould, then mould is placed in air dry oven and is heated to 100～150 ℃, be 50～100 hours heat time heating time, after the time for the treatment of reaches 50～100 hours, compound sizing in mould is cylindrical, is the biodegradation subdermal implantation rod for long-acting blood pressure lowering;
The 3rd step, mold, take out the heeling-in packing rod of sizing, and 2～3 of every bags are stand-by with Co 60 sterilizing.
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| CN201410402016.5A CN104147606B (en) | 2014-08-15 | 2014-08-15 | For the biodegradation subdermal implantation rod of long-acting blood pressure lowering |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105536076A (en) * | 2015-12-29 | 2016-05-04 | 吕汇川 | Acupuncture point subcutaneous embedment line |
| CN108743955A (en) * | 2018-06-26 | 2018-11-06 | 吕鹏威 | One kind being used for essential hypertension elastomer subdermal implantation stick |
| CN116869950A (en) * | 2023-09-07 | 2023-10-13 | 药侠谷(北京)医药文化有限公司 | Blood pressure-reducing biodegradable subcutaneous implantation rod and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2870885Y (en) * | 2005-09-20 | 2007-02-21 | 吕鹏威 | Long-effective depressor submerged rod |
| WO2007092801A2 (en) * | 2006-02-07 | 2007-08-16 | Spinalcyte, Llc | Methods and compositions for repair of cartilage using an in vivo bioreactor |
| CN101066456A (en) * | 2007-06-01 | 2007-11-07 | 哈尔滨工程大学 | Slow releasing carrier material for implanted medicine and its prepn process |
| CN101147813A (en) * | 2007-10-26 | 2008-03-26 | 哈尔滨医科大学 | Method for preparing medicine coating carrier and medicine coating blood vessel support |
-
2014
- 2014-08-15 CN CN201410402016.5A patent/CN104147606B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2870885Y (en) * | 2005-09-20 | 2007-02-21 | 吕鹏威 | Long-effective depressor submerged rod |
| WO2007092801A2 (en) * | 2006-02-07 | 2007-08-16 | Spinalcyte, Llc | Methods and compositions for repair of cartilage using an in vivo bioreactor |
| CN101066456A (en) * | 2007-06-01 | 2007-11-07 | 哈尔滨工程大学 | Slow releasing carrier material for implanted medicine and its prepn process |
| CN101147813A (en) * | 2007-10-26 | 2008-03-26 | 哈尔滨医科大学 | Method for preparing medicine coating carrier and medicine coating blood vessel support |
Non-Patent Citations (2)
| Title |
|---|
| ZHI-JIE SUN,ET AL.: "The application of poly(glycerol-sebacate) as biodegradable drug carrier", 《BIOMATETIALS》, vol. 30, 27 June 2009 (2009-06-27), pages 5209 - 5214, XP026420889 * |
| 宁卓远等: "聚癸二酸甘油酯的优化合成", 《北京理工大学学报》, vol. 31, no. 3, 31 March 2011 (2011-03-31), pages 373 - 378 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105536076A (en) * | 2015-12-29 | 2016-05-04 | 吕汇川 | Acupuncture point subcutaneous embedment line |
| CN108743955A (en) * | 2018-06-26 | 2018-11-06 | 吕鹏威 | One kind being used for essential hypertension elastomer subdermal implantation stick |
| CN116869950A (en) * | 2023-09-07 | 2023-10-13 | 药侠谷(北京)医药文化有限公司 | Blood pressure-reducing biodegradable subcutaneous implantation rod and preparation method thereof |
| CN116869950B (en) * | 2023-09-07 | 2023-11-17 | 药侠谷(北京)医药文化有限公司 | Blood pressure-reducing biodegradable subcutaneous implantation rod and preparation method thereof |
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