CN102974025B - A kind of one-off cervix dilator with medicine film - Google Patents
A kind of one-off cervix dilator with medicine film Download PDFInfo
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- CN102974025B CN102974025B CN201210532882.7A CN201210532882A CN102974025B CN 102974025 B CN102974025 B CN 102974025B CN 201210532882 A CN201210532882 A CN 201210532882A CN 102974025 B CN102974025 B CN 102974025B
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- 238000000034 method Methods 0.000 claims description 28
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- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 description 1
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
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- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
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- 229960002023 chloroprocaine Drugs 0.000 description 1
- VDANGULDQQJODZ-UHFFFAOYSA-N chloroprocaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1Cl VDANGULDQQJODZ-UHFFFAOYSA-N 0.000 description 1
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- 229960004288 levobupivacaine Drugs 0.000 description 1
- LEBVLXFERQHONN-INIZCTEOSA-N levobupivacaine Chemical compound CCCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-INIZCTEOSA-N 0.000 description 1
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- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
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- 229960002372 tetracaine Drugs 0.000 description 1
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
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Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides a kind of one-off cervix dilator with medicine film and preparation method thereof, this cervical dilator is attached with the medicine film of local anaesthetics, medicine film swelling dissolving under body temperature during use, drug release in medicine film out, and absorbed by cervical mucosal, the pain of reduction of patient, reduces the generation of untoward reaction.This cervical dilator is easy to use, and preparation technology is simple and easy to do, and involved pharmaceutic adjuvant is all easy to buy and cost is lower, has good Social benefit and economic benefit.
Description
Technical field
The present invention relates to the medical apparatus and instruments of the cervix dilating that a kind of department of obstetrics and gynecology often use clinically, be specifically related to a kind of one-off cervix dilator with medicine film.
Background technology
Usually need during intrauterine surgical to carry out cervical dilatation, to facilitate inspection and the treatment of doctor.Current cervical dilator is widely used in department of obstetrics and gynecology clinical operation, as artificial abortion, hysteroscopy, placement and taking-up intrauterine device, diagnostic curettage etc.
Existing cervical dilatation apparatus kind is a lot, and conventional is one-off cervix dilator clinically, is made up of one group of diameter dilator bar from fine to coarse, its diameter of section is constant, during use, due to the special physiological function that cervical orifice shrinks, must by the dilator bar that diameter is thinner, continuous replacing is till reaching requirement, and its deficiency is, repeatedly inserts dilator bar, patient suffering is larger, the easy generation feared state of mind, and operation is more loaded down with trivial details, also easily causes cross infection.Use gelatin rod in addition, gelatin rod needs within 24 hours, just to reach required cervix uteri mouth width, and operating time is long, and patient susceptible contaminates.
In addition Chinese patent ZL201020124138.X discloses a kind of replacement-free dilating bar, during use, barred body front end is inserted in cervix uteri mouth, then swivel bolt slowly, promote expansion gear progressively to advance, the barred body of cervix uteri port part is expanded gradually, progressively makes cervix uteri mouth open, after reaching requirement, barred body is extracted out, avoid the injury repeatedly changed dilator bar and patient body is caused.
Chinese patent ZL200620009381.0 discloses a kind of swelling formula palace neck spreader, be made up of conduit, thin film air bag, inflation/deflation air bag, sebific duct, thin film air bag is fixed wtih around catheter proximal end outer wall, catheter proximal end tube wall is provided with multiple air-filled pore communicated with thin film air bag inner chamber, and inflation/deflation air bag is connected on the rear end of conduit by glue pipe socket load.By inflation, make thin film air bag external diameter thicker, cervical orifice is also extended.
Chinese patent ZL200820017137.8 openly knows clearly a kind of expansion type Uterus expanding stick for drug injection, first record the length of cervix uteri in use, by push rod, the barred body in trocar sheath is pushed in cervix uteri mouth, with by the infusion of medicine in hollow ram afterbody plastic bottle body at barred body, remove trocar sheath and push rod, the liquid that barred body is met containing analgesic drug product slowly can expand, and the analgesic drug product in barred body also can discharge and pass through mucosal absorption, play the effect that palace is expanded in analgesia, and patient can not agonize.The undeclared barred body material of this patent, when meeting the liquid containing analgesic drug product, barred body speed of expansion is indefinite, and expanding the palace time may be longer.
Chinese patent ZL201020632911.3 discloses a kind of cervical dilator with anesthetis storage chamber, comprise main body, rotating adjustment ring, tensioner ring, anesthetis storage chamber is provided with in the inside of main body, the flexible of tensioner ring is regulated by rotating adjustment ring, promote the push rod in anesthesia storage chamber, release anesthetis simultaneously.
Although mechanically expand cervix uteri mouth with airing form above-mentioned, easy and simple to handle, alleviate the workload of doctor, this mode is difficult to the size of suitable control cervical dilatation apparatus, can cause patient pain, and the expansion palace time is longer.
Without the women that plan is conceived, operation is feared owing to worrying pain, many women wish to adopt painless surgical operation by pregnant women especially for the first time, and the generation of pain in artificial abortion and Induced abortion syndrome, cause vagal excitation because cervix uteri when expansion official, suction palace and uterus are subject to mechanical irritation, discharge a large amount of acetylcholine, caused by cardiovascular effect.There is bradycardia, cardiac arrhythmia, blood pressure drops, pale complexion, perspiration, dizziness, uncomfortable in chest, even faint and twitch.These and anemia of pregnant woman's psychentonia, cervical dilatation, tractive can not be tolerated and cross high negative pressure and have direct relation.
In order to alleviate patient suffering, general needs while cervix dilating carries out local anesthesia to patient clinically, and doctor often injects lignocaine, adds medical expense and operation easier.Also carry out local anesthesia after having doctor to infiltrate lignocaine with medical cotton ball, but the method dosage is inaccurate, has certain risk that untoward reaction occurs.
Lignocaine belongs to acyl Ammonia local anaesthetics, have rapid-action, penetrance is strong, disperse is wide, to the feature such as the main organs function of anemia of pregnant woman is harmless, the generation of the other nerve block anesthesia cervix uteri capable of blocking of temporary dwelling palace neck and the impulsion of palace somesthesia teleneuron and spreading out of, and reduce vagal excitation, alleviate the stimulation to uterus and cervix uteri due to tractive and expansion to play analgesia and reduce the generation of Induced abortion syndrome, reduce intraoperative hemorrhage, shorten operating time, simple to operate, safety, do not affect uterine contraction again, and undergo surgery under making operation receiveing person's situation that local is painless at Consciousness.
Use during lignocaine and should be noted that injection pumpback depletion of blood can inject, namely vein can not be injected, in order to avoid have an impact to central nervous system and cardiovascular system, emphasize that local anaesthetics eliminates in blood than mode by measurement simultaneously, its half-life and original blood drug level have nothing to do, increase drug level or increase dose all can not in proportion extra-inning's anaesthetic maintain time.
When carrying out Therapeutic Abortion, use analgesia, reducing operation receiveing person painful, is the problem that current doctors should pay attention to, but the basic hospital and the community sanitary institute that are not having condition to carry out general anesthesia painless surgical operation, but receive very large puzzlement.In order to alleviate the misery of patient, the generation of prevention artificial abortion combined reaction, applies the capable paracervical block anesthesia of 2% lignocaine, is the analgesia that basic hospital artificial abortion is commonly used, satisfactory effect.
Summary of the invention
The present invention relates to a kind of one-off cervix dilator with lignocaine medicine film, the lignocaine medicine film containing effective dose is attached on suitable one-off cervix dilator, medicine film swelling thawing discharge medicine under body temperature during use.Lignocaine is soon effective, and penetration into tissue is good, and action time is short, can block the conduction of various neural impulse.Cervical canal local anesthesia cervix uteri capable of blocking and palace somesthesia teleneuron impulsion generation and spread out of, and reduce vagus nerve, the conduction of impulse of excitation, thus alleviate because tractive and expansion are to uterus and Cervical stimulation, play analgesic activity, and lax uterine smooth muscle, makes cervical dilatation.
The object of this invention is to provide a kind of cervical dilator with medicine film, solve in prior art for cervical dilatation time because repeatedly inserting cervical dilator, the problem that patient suffering is larger, is characterized in that described cervical dilator comprises one-off cervix dilator and lignocaine medicine film.One-off cervix dilator of the present invention is 5-7 cervical dilator, the pharmaceutic adjuvant that lidocaine hydrochloride containing effective dose in described lignocaine medicine film and pharmacy are suitable for, in described lignocaine medicine film, the consumption of lidocaine hydrochloride is 4mg ~ 40mg/.
Another object of the present invention is exactly containing water-soluble high-molecular material in medicine film, this water-soluble high-molecular material is met water and can be dissolved rapidly, the good film of one deck lubricity is formed on surface, cervical dilator tip, thus enable dilator insert cervix uteri mouth more smoothly, reduce the misery of patient to greatest extent, and once.
One-off cervix dilator with medicine film of the present invention, is characterized in that described local anaesthetics comprises lignocaine, chloroprocaine, procaine, bupivacaine, levobupivacaine, tetracaine, ropivacaine and salt thereof.
The described one-off cervix dilator with medicine film of the present invention, is characterized in that described local anaesthetics is lignocaine or its hydrochlorate.
The described one-off cervix dilator with medicine film of the present invention, is characterized in that the consumption of lidocaine hydrochloride in described lignocaine medicine film is 4mg ~ 40mg.
The described one-off cervix dilator with medicine film of the present invention, it is characterized in that described water-soluble high-molecular compound comprises sodium alginate, sodium carboxymethyl cellulose, the one in methylcellulose, hydroxypropyl cellulose, CP, Polyethylene Glycol and polyoxyethylene stearate (40) ester or its mixture.
Polyethylene Glycol has another name called polymer, the polyethylene glycol oxide (PEO-LS) of α-hydrogen-ω-hydroxyl (oxygen-1,2-second two base).Mean molecule quantity about 200 at least 6000 the general name of ethylene glycol high polymer.
The described one-off cervix dilator with medicine film of the present invention, is characterized in that described water-soluble high-molecular compound consumption is 30% ~ 80% of medicine film weight.
The described one-off cervix dilator with medicine film of the present invention, is characterized in that contained PEG-4000, polyoxyethylene stearate (40) ester in described medicine film.
One-off cervix dilator with lignocaine medicine film of the present invention, is characterized in that preparation process comprises the steps:
Take polymer substance in prescription, after lidocaine hydrochloride is dissolved in water, add PEG-4000, the mixing of polyoxyethylene stearate (40) ester, after water-bath 40 DEG C-50 DEG C stirs 10 minutes, use dips technique, cervical dilator is inserted into about 5cm height in above-mentioned solution, takes out cold air drying molding.
One-off cervix dilator with lignocaine medicine film of the present invention in use, the swelling dissolving under body temperature of medicine film on cervical dilator, drug release in medicine film out, and pass through mucosal absorption, play analgesia, expand the effect in palace, simple to operation, alleviate the misery of patient, alleviate medical and nursing work person works amount, reduce operation cost.And preparation technology is simple and easy to do, involved pharmaceutic adjuvant is all easy to buy and cost is lower, has good Social benefit and economic benefit.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described, but the present invention is not limited to these embodiments.
Embodiment 1
Specific operation process: after taking PEG-4000, polyoxyethylene stearate (40) ester water-bath 60 DEG C of meltings, add lidocaine hydrochloride insulated and stirred after 10 minutes, use dips technique, cervical dilator is inserted into about 5cm height in upper solution, takes out cold air drying molding, a skim for smooth in appearance, toughness is bad, more crisp, uniformity is not so good, is limited to about 3 minutes when dissolving.
Embodiment 2
Specific operation process: take sodium alginate, after lidocaine hydrochloride is dissolved in water, add PEG-4000, the mixing of polyoxyethylene stearate (40) ester, after water-bath 40 DEG C stirs 10 minutes, use dips technique, cervical dilator is inserted into about 5cm height in upper solution, takes out cold air drying molding, smooth in appearance, good toughness, is limited to about 1 minute when dissolving.
Embodiment 3
Specific operation process: take sodium alginate, after lidocaine hydrochloride is dissolved in water, add PEG-4000, S-40 water-bath again in 40 DEG C of mixing, insulated and stirred is after 10 minutes, use dips technique, cervical dilator is inserted into about 5cm height in upper solution, takes out cold air drying molding, smooth in appearance, good toughness, is limited to about 1 minute when dissolving.
Embodiment 4:
Specific operation process: take sodium alginate, after lidocaine hydrochloride is dissolved in water, add PEG-4000, the mixing of polyoxyethylene stearate (40) ester, after water-bath 40 DEG C stirs 10 minutes, use dips technique, cervical dilator is inserted into about 5cm height in upper solution, takes out cold air drying molding, smooth in appearance, good toughness, is limited to about 1 minute when dissolving.
Embodiment 5:
Specific operation process: take xanthan gum, after lidocaine hydrochloride is dissolved in water, add PEG-4000, the mixing of polyoxyethylene stearate (40) ester, after water-bath 40 DEG C stirs 10 minutes, use dips technique, cervical dilator is inserted into about 5cm height in upper solution, takes out cold air drying molding, smooth in appearance, good toughness, is limited to about 1 minute when dissolving.
Embodiment 6:
Specific operation process: take PVP, after lidocaine hydrochloride is dissolved in water, add PEG-4000, the mixing of polyoxyethylene stearate (40) ester, after water-bath 40 DEG C stirs 10 minutes, use dips technique, cervical dilator is inserted into about 5cm height in upper solution, takes out cold air drying molding, smooth in appearance, good toughness, is limited to about 1 minute when dissolving.
Embodiment 7:
Specific operation process: take methylcellulose, after lidocaine hydrochloride is dissolved in water, add PEG-4000, the mixing of polyoxyethylene stearate (40) ester, after water-bath 40 DEG C stirs 10 minutes, use dips technique, cervical dilator is inserted into about 5cm height in upper solution, takes out cold air drying molding, smooth in appearance, good toughness, is limited to about 1 minute when dissolving.
Embodiment 8:
Specific operation process: take crosslinked acrylic resin, after lidocaine hydrochloride is dissolved in water, add PEG-4000, the mixing of polyoxyethylene stearate (40) ester, after water-bath 40 DEG C stirs 10 minutes, use dips technique, cervical dilator is inserted into about 5cm height in upper solution, takes out cold air drying molding, smooth in appearance, good toughness, is limited to about 1 minute when dissolving.
Embodiment 9:
Specific operation process: take sodium carboxymethyl cellulose, after lidocaine hydrochloride is dissolved in water, add PEG-4000, the mixing of polyoxyethylene stearate (40) ester, after water-bath 40 DEG C stirs 10 minutes, use dips technique, cervical dilator is inserted into about 5cm height in upper solution, takes out cold air drying molding, smooth in appearance, good toughness, is limited to about 1 minute when dissolving.
Claims (8)
1. the preparation technology with the disposable uterine-expanding rod of lignocaine medicine film, it is characterized in that: take 0.6g sodium alginate, after 12g lidocaine hydrochloride adds 47.4g water dissolution, add 30g PEG-4000, the mixing of 30g polyoxyethylene stearate (40) ester, after water-bath 40 DEG C stirs 10 minutes, use picks technique, cervical dilator is stained with and is inserted into about 5cm height in upper solution, take out cold air drying molding, make 10 finished products.
2. the preparation technology with the disposable uterine-expanding rod of lignocaine medicine film, it is characterized in that: take 0.7g sodium alginate, after 40g lidocaine hydrochloride adds 59.3g water dissolution, add 20g PEG-4000,30g polyoxyethylene stearate (40) ester water-bath again in 40 DEG C of mixing, insulated and stirred is after 10 minutes, use picks technique, cervical dilator is stained with and is inserted into about 5cm height in upper solution, take out cold air drying molding, make 10 finished products.
3. the preparation technology with the disposable uterine-expanding rod of lignocaine medicine film, it is characterized in that: take 3g hydroxypropyl methylcellulose, after 12g lidocaine hydrochloride adds 55g water dissolution, add 30g PEG-4000, the mixing of 20g polyoxyethylene stearate (40) ester, after water-bath 40 DEG C stirs 10 minutes, use picks technique, cervical dilator is stained with and is inserted into about 5cm height in upper solution, take out cold air drying molding, make 10 finished products.
4. the preparation technology with the disposable uterine-expanding rod of lignocaine medicine film, it is characterized in that: take 0.8g xanthan gum, after 12g lidocaine hydrochloride adds 42.2g water dissolution, add 30g PEG-4000, the mixing of 35g polyoxyethylene stearate (40) ester, after water-bath 40 DEG C stirs 10 minutes, use picks technique, cervical dilator is stained with and is inserted into about 5cm height in upper solution, take out cold air drying molding, make 10 finished products.
5. the preparation technology with the disposable uterine-expanding rod of lignocaine medicine film, it is characterized in that: take 6g PVP, after 12g lidocaine hydrochloride adds 48g water dissolution, add 24g PEG-4000, the mixing of 30g polyoxyethylene stearate (40) ester, after water-bath 40 DEG C stirs 10 minutes, use picks technique, cervical dilator is stained with and is inserted into about 5cm height in upper solution, take out cold air drying molding, make 10 finished products.
6. the preparation technology with the disposable uterine-expanding rod of lignocaine medicine film, it is characterized in that: take 3g methylcellulose, after 12g lidocaine hydrochloride adds 49g water dissolution, add 32g PEG-4000, the mixing of 24g polyoxyethylene stearate (40) ester, after water-bath 40 DEG C stirs 10 minutes, use picks technique, cervical dilator is stained with and is inserted into about 5cm height in upper solution, take out cold air drying molding, make 10 finished products.
7. the preparation technology with the disposable uterine-expanding rod of lignocaine medicine film, it is characterized in that: take 0.4g crosslinked acrylic resin, after 12g lidocaine hydrochloride adds 52.6g water dissolution, add 25g PEG-4000, the mixing of 30g polyoxyethylene stearate (40) ester, after water-bath 40 DEG C stirs 10 minutes, use picks technique, cervical dilator is stained with and is inserted into about 5cm height in upper solution, take out cold air drying molding, make 10 finished products.
8. the preparation technology with the disposable uterine-expanding rod of lignocaine medicine film, it is characterized in that: take 0.6g sodium carboxymethyl cellulose, after 12g lidocaine hydrochloride adds 47.4g water dissolution, add 30g PEG-4000, the mixing of 30g polyoxyethylene stearate (40) ester, after water-bath 40 DEG C stirs 10 minutes, use picks technique, cervical dilator is stained with and is inserted into about 5cm height in upper solution, take out cold air drying molding, make 10 finished products.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201210532882.7A CN102974025B (en) | 2012-12-11 | 2012-12-11 | A kind of one-off cervix dilator with medicine film |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210532882.7A CN102974025B (en) | 2012-12-11 | 2012-12-11 | A kind of one-off cervix dilator with medicine film |
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| CN102974025A CN102974025A (en) | 2013-03-20 |
| CN102974025B true CN102974025B (en) | 2015-09-30 |
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| CN201210532882.7A Expired - Fee Related CN102974025B (en) | 2012-12-11 | 2012-12-11 | A kind of one-off cervix dilator with medicine film |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104434885A (en) * | 2014-11-12 | 2015-03-25 | 天津大学 | Water-soluble polymeric membrane capable of quickly releasing drugs and preparation method thereof |
| CN107198814A (en) * | 2016-03-18 | 2017-09-26 | 天津和杰医疗器械有限公司 | Disposable pastille cervical dilator bar |
| CN112773317A (en) * | 2020-12-25 | 2021-05-11 | 深圳市人民医院 | Soft hysteroscope guiding device |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1091041A (en) * | 1993-12-04 | 1994-08-24 | 中国人民解放军优生优育研究中心 | Analgesic dilator for cervix and production technology thereof |
| CN1846703A (en) * | 2006-02-13 | 2006-10-18 | 程定超 | Vagina administration mifepristone prepn and its composition and prepn process |
| CN101116762A (en) * | 2006-07-31 | 2008-02-06 | 何东方 | Disposable active cervical dilator bar |
| CN101357121A (en) * | 2008-09-03 | 2009-02-04 | 宋信平 | Preparation of arilin slow-release medicine-membrane for tooth |
-
2012
- 2012-12-11 CN CN201210532882.7A patent/CN102974025B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1091041A (en) * | 1993-12-04 | 1994-08-24 | 中国人民解放军优生优育研究中心 | Analgesic dilator for cervix and production technology thereof |
| CN1846703A (en) * | 2006-02-13 | 2006-10-18 | 程定超 | Vagina administration mifepristone prepn and its composition and prepn process |
| CN101116762A (en) * | 2006-07-31 | 2008-02-06 | 何东方 | Disposable active cervical dilator bar |
| CN101357121A (en) * | 2008-09-03 | 2009-02-04 | 宋信平 | Preparation of arilin slow-release medicine-membrane for tooth |
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| CN102974025A (en) | 2013-03-20 |
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