A kind of one-off cervix dilator with the medicine film
Technical field
The present invention relates to the medical apparatus and instruments that cervix dilating that a kind of department of obstetrics and gynecology often use is clinically used, be specifically related to a kind of one-off cervix dilator with the medicine film.
Background technology
Usually need to carry out cervical dilatation during intrauterine surgical, with inspection and the treatment that makes things convenient for the doctor.Cervical dilator is widely used in the department of obstetrics and gynecology clinical operation at present, such as artificial abortion, hysteroscopy, placement and taking-up intrauterine device, diagnostic curettage etc.
Existing cervical dilatation is a lot of with the apparatus kind, and commonly used is one-off cervix dilator clinically, is comprised of one group of diameter dilator bar from fine to coarse, its diameter of section is constant, during use, because the special physiological function that cervical orifice shrinks, must be begun by the thinner dilator bar of diameter, constantly change until reach till the requirement, its deficiency is, repeatedly inserts dilator bar, the patient suffering is larger, easily produce the feared state of mind, and operation is more loaded down with trivial details, also causes easily cross infection.Use in addition the gelatin rod, the gelatin rod needed 24 hours just can reach required cervix uteri mouth width, and operating time is long, patient's easy infection.
Chinese patent ZL201020124138.X discloses a kind of replacement-free dilating bar in addition, during use, the barred body front end is inserted in the cervix uteri mouth, then slowly swivel bolt, promote expansion gear and progressively advance, the barred body of cervix uteri port part is expanded gradually, the cervix uteri mouth is opened, after reaching requirement barred body is extracted out, avoided repeatedly changing the injury that dilator bar causes patient body.
Chinese patent ZL200620009381.0 discloses a kind of swelling formula palace neck spreader, formed by conduit, thin film air bag, inflation/deflation air bag, sebific duct, around the catheter proximal end outer wall, be fixed wtih the thin film air bag, be provided with a plurality of air-filled pores that communicate with thin film air bag inner chamber at the catheter proximal end tube wall, inflation/deflation air bag is connected on the rear end of conduit by the glue pipe socket load.By inflation, make the chap of thin film air bag external diameter, cervical orifice is also extended.
Chinese patent ZL200820017137.8 a kind of expansion type Uterus expanding stick for drug injection of openly knowing clearly, record first in use the length of cervix uteri, by push rod the barred body in the trocar sheath is pushed in the cervix uteri mouth, with being about to infusion of medicine in the hollow ram afterbody plastic bottle body at barred body, remove trocar sheath and push rod, barred body is met the liquid that contains analgesic drug product and slowly can be expanded, and the analgesic drug product in the barred body also can discharge and absorb by mucosa, play analgesia and expand the effect in palace, and the patient can not agonize.The undeclared barred body material of this patent, the barred body speed of expansion is indefinite when chance contains the liquid of analgesic drug product, and expanding the palace time may be longer.
Chinese patent ZL201020632911.3 discloses a kind of cervical dilator with the anesthetis storage chamber, comprise main body, rotating adjustment ring, tensioner ring, be provided with the anesthetis storage chamber in the inside of main body, regulate the flexible of tensioner ring by rotating adjustment ring, promote simultaneously the push rod in the anesthesia storage chamber, discharge anesthetis.
Although above-mentioned with mechanical system and airing form expansion cervix uteri mouth, easy and simple to handle, alleviated doctor's workload, this mode is difficult to the size of suitable control cervical dilatation apparatus, can cause patient's pain, and the expansion palace time is longer.
Without the conceived women of plan, fear operation owing to worrying pain, many women are subjected to pregnant women to wish to adopt painless surgical operation especially for the first time, and the syndromic generation of the pain in the artificial abortion and artificial abortion, because the expansion official, cervix uteri and uterus are subject to mechanical irritation and cause vagal excitation when inhaling the palace, discharge a large amount of acetylcholine, due to cardiovascular effect.Bradycardia, cardiac arrhythmia, blood pressure drops, pale complexion, perspiration, dizziness, uncomfortable in chest occur, even faint and twitch.These and anemia of pregnant woman's psychentonia, can not tolerate cervical dilatation, tractive and cross high negative pressure direct relation is arranged.
In order to alleviate the patient suffering, generally in cervix dilating, need to carry out local anesthesia to the patient clinically, the doctor often injects lignocaine, has increased medical expense and operation easier.Carry out local anesthesia after also having the doctor to infiltrate lignocaine with medical cotton ball, but the method dosage is inaccurate, and the risk of certain generation untoward reaction is arranged.
Lignocaine belongs to acyl Ammonia local anaesthetics, have rapid-action, penetrance is strong, disperse is wide, to the characteristics such as anemia of pregnant woman's main organs function is harmless, the generation of the other nerve block anesthesia cervix uteri capable of blocking of temporary dwelling palace neck and the impulsion of palace somesthesia teleneuron and spreading out of, and minimizing vagal excitation, alleviate because tractive and expansion are played analgesia and reduced the syndromic generation of artificial abortion the stimulation of uterus and cervix uteri, reduce intraoperative hemorrhage, shorten operating time, simple to operate, safety, do not affect again uterine contraction, and make the operation receiveing person at Consciousness and undergo surgery under the local painless situation.
Should be noted when using lignocaine that injection pumpback depletion of blood can inject, namely can not annotate people's vein, in order to avoid central nervous system and cardiovascular system are exerted an influence, emphasize that simultaneously local anaesthetics is to eliminate than mode by weighing in blood, its half-life and original blood drug level are irrelevant, increase drug level or increase equal extra-inning anaesthetic time of keeping in proportion of dose.
When carrying out Therapeutic Abortion, use the analgesia, it is painful to reduce the operation receiveing person, is the problem that current doctors should pay attention to, but there not being condition to carry out basic hospital and the community sanitary institute of general anesthesia painless surgical operation, but has been subject to very large puzzlement.In order to alleviate patient's misery, the capable paracervical block anesthesia of 2% lignocaine is used in the generation of prevention artificial abortion combined reaction, is basic hospital artificial abortion analgesia commonly used, satisfactory effect.
Summary of the invention
The present invention relates to a kind of one-off cervix dilator with lignocaine medicine film, the lignocaine medicine film that will contain effective dosage is attached on the suitable one-off cervix dilator, and medicine film swelling under body temperature is melted and the release medicine during use.The lignocaine produce effects is fast, and tissue penetration is good, and action time is short, can block the conduction of various neural impulses.The generation of cervical canal local anesthesia cervix uteri capable of blocking and palace somesthesia teleneuron impulsion and spreading out of, and minimizing vagus nerve, the conduction of impulse of excitation, thereby alleviate because tractive and the expansion to uterus and Cervical stimulation, play analgesic activity, and lax uterine smooth muscle makes cervical dilatation.
The purpose of this invention is to provide a kind of cervical dilator with the medicine film, solved when being cervical dilatation in the prior art because repeatedly inserting cervical dilator, the problem that the patient suffering is larger is characterized in that described cervical dilator comprises one-off cervix dilator and lignocaine medicine film.One-off cervix dilator of the present invention is the 5-7 cervical dilator, contain lidocaine hydrochloride and the applicable pharmaceutic adjuvant of pharmacy of effective dose in the described lignocaine medicine film, the consumption of lidocaine hydrochloride is 4mg~40mg/ in the described lignocaine medicine film.
Another object of the present invention is exactly to contain water-soluble high-molecular material in the medicine film, this water-soluble high-molecular material is met water and can be dissolved rapidly, form the good film of one deck lubricity on surface, cervical dilator tip, thereby make dilator can insert more smoothly the cervix uteri mouth, reduce to greatest extent patient's misery, and once get final product.
One-off cervix dilator with the medicine film of the present invention is characterized in that described local anaesthetics comprises lignocaine, chloroprocaine, procaine, bupivacaine, levobupivacaine, tetracaine, ropivacaine and salt thereof.
Described one-off cervix dilator with the medicine film of the present invention is characterized in that described local anaesthetics is lignocaine or its hydrochlorate.
Described one-off cervix dilator with the medicine film of the present invention is characterized in that the consumption of lidocaine hydrochloride in the described lignocaine medicine film is 4mg~40mg.
Described one-off cervix dilator with the medicine film of the present invention, it is characterized in that described water-soluble high-molecular compound comprises sodium alginate, sodium carboxymethyl cellulose, a kind of or its mixture in methylcellulose, hydroxypropyl cellulose, CP, Polyethylene Glycol and polyoxyethylene stearate (40) ester.
Polyethylene Glycol has another name called polymer, the polyethylene glycol oxide (PEO-LS) of α-hydrogen-ω-hydroxyl (oxygen-1,2-second two bases).Mean molecule quantity in the general name of about 200 at least 6000 ethylene glycol high polymer.
Described one-off cervix dilator with the medicine film of the present invention is characterized in that described water-soluble high-molecular compound consumption is 30%~80% of medicine film weight.
Described one-off cervix dilator with the medicine film of the present invention is characterized in that contained PEG-4000 in the described medicine film, polyoxyethylene stearate (40) ester.
One-off cervix dilator with lignocaine medicine film of the present invention is characterized in that preparation process comprises the steps:
After taking by weighing polymer substance in the prescription, lidocaine hydrochloride and being dissolved in water, add PEG-4000, the mixing of polyoxyethylene stearate (40) ester, after 40 ℃-50 ℃ of water-baths are stirred 10 minutes, use picks technique, cervical dilator is stained with is inserted into about 5cm height in the mentioned solution, take out the cold air drying molding.
One-off cervix dilator with lignocaine medicine film of the present invention in use, medicine film on the cervical dilator is the swelling dissolving under body temperature, drug release in the medicine film out, and absorb by mucosa, the effect of play analgesia, expanding the palace, simple to operation, alleviate patient's misery, alleviate medical and nursing work personnel workload, reduce the operation cost.And preparation technology is simple and easy to do, related pharmaceutic adjuvant all be easy to buy and cost lower, have good Social benefit and economic benefit.
The specific embodiment
The present invention will be further described below in conjunction with embodiment, but the present invention is not limited to these embodiment.
Embodiment 1
Specific operation process: after taking by weighing PEG-4000,60 ℃ of meltings of polyoxyethylene stearate (40) ester water-bath, add the lidocaine hydrochloride insulated and stirred after 10 minutes, use picks technique, cervical dilator is inserted into about 5cm height in the upper solution, takes out the cold air drying molding, the skim of smooth in appearance, toughness is bad, more crisp, uniformity is not so good, is limited to when dissolving about 3 minutes.
Embodiment 2
Specific operation process: after taking by weighing sodium alginate, lidocaine hydrochloride and being dissolved in water, add PEG-4000, the mixing of polyoxyethylene stearate (40) ester, after 40 ℃ of water-baths are stirred 10 minutes, use picks technique, cervical dilator is stained with is inserted into about 5cm height in the upper solution, take out the cold air drying molding, smooth in appearance, good toughness was limited to when dissolving about 1 minute.
Embodiment 3
Specific operation process: after taking by weighing sodium alginate, lidocaine hydrochloride and being dissolved in water, add again PEG-4000, S-40 water-bath in 40 ℃ of mixing, after the insulated and stirred 10 minutes, use picks technique, cervical dilator is stained with is inserted into about 5cm height in the upper solution, take out the cold air drying molding, smooth in appearance, good toughness was limited to when dissolving about 1 minute.
Embodiment 4:
Specific operation process: after taking by weighing sodium alginate, lidocaine hydrochloride and being dissolved in water, add PEG-4000, the mixing of polyoxyethylene stearate (40) ester, after 40 ℃ of water-baths are stirred 10 minutes, use picks technique, cervical dilator is stained with is inserted into about 5cm height in the upper solution, take out the cold air drying molding, smooth in appearance, good toughness was limited to when dissolving about 1 minute.
Embodiment 5:
Specific operation process: after taking by weighing xanthan gum, lidocaine hydrochloride and being dissolved in water, add PEG-4000, the mixing of polyoxyethylene stearate (40) ester, after 40 ℃ of water-baths are stirred 10 minutes, use picks technique, cervical dilator is stained with is inserted into about 5cm height in the upper solution, take out the cold air drying molding, smooth in appearance, good toughness was limited to when dissolving about 1 minute.
Embodiment 6:
Specific operation process: after taking by weighing PVP, lidocaine hydrochloride and being dissolved in water, add PEG-4000, the mixing of polyoxyethylene stearate (40) ester, after 40 ℃ of water-baths are stirred 10 minutes, use picks technique, cervical dilator is stained with is inserted into about 5cm height in the upper solution, take out the cold air drying molding, smooth in appearance, good toughness was limited to when dissolving about 1 minute.Embodiment 7:
Specific operation process: after taking by weighing methylcellulose, lidocaine hydrochloride and being dissolved in water, add PEG-4000, the mixing of polyoxyethylene stearate (40) ester, after 40 ℃ of water-baths are stirred 10 minutes, use picks technique, cervical dilator is stained with is inserted into about 5cm height in the upper solution, take out the cold air drying molding, smooth in appearance, good toughness was limited to when dissolving about 1 minute.
Embodiment 8:
Specific operation process: after taking by weighing crosslinked acrylic resin, lidocaine hydrochloride and being dissolved in water, add PEG-4000, the mixing of polyoxyethylene stearate (40) ester, after 40 ℃ of water-baths are stirred 10 minutes, use picks technique, cervical dilator is stained with is inserted into about 5cm height in the upper solution, take out the cold air drying molding, smooth in appearance, good toughness was limited to when dissolving about 1 minute.
Embodiment 9:
Specific operation process: after taking by weighing sodium carboxymethyl cellulose, lidocaine hydrochloride and being dissolved in water, add PEG-4000, the mixing of polyoxyethylene stearate (40) ester, after 40 ℃ of water-baths are stirred 10 minutes, use picks technique, cervical dilator is stained with is inserted into about 5cm height in the upper solution, take out the cold air drying molding, smooth in appearance, good toughness was limited to when dissolving about 1 minute.