CN107753144A - Hand-held liquid aerosol lung delivery apparatus - Google Patents
Hand-held liquid aerosol lung delivery apparatus Download PDFInfo
- Publication number
- CN107753144A CN107753144A CN201610686497.6A CN201610686497A CN107753144A CN 107753144 A CN107753144 A CN 107753144A CN 201610686497 A CN201610686497 A CN 201610686497A CN 107753144 A CN107753144 A CN 107753144A
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- Prior art keywords
- delivery tube
- hand
- liquid aerosol
- tube
- held liquid
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- 210000004072 lung Anatomy 0.000 title claims abstract description 34
- 239000008263 liquid aerosol Substances 0.000 title claims abstract description 29
- 241001465754 Metazoa Species 0.000 claims abstract description 32
- 238000002347 injection Methods 0.000 claims abstract description 22
- 239000007924 injection Substances 0.000 claims abstract description 22
- 239000012530 fluid Substances 0.000 claims abstract description 16
- 239000007788 liquid Substances 0.000 claims abstract description 8
- 238000004891 communication Methods 0.000 claims abstract description 4
- 239000007921 spray Substances 0.000 claims description 16
- 239000011159 matrix material Substances 0.000 claims description 14
- 239000011521 glass Substances 0.000 claims description 5
- 229910052710 silicon Inorganic materials 0.000 claims description 5
- 239000010703 silicon Substances 0.000 claims description 5
- 229910001220 stainless steel Inorganic materials 0.000 claims description 3
- 239000010935 stainless steel Substances 0.000 claims description 3
- 238000005253 cladding Methods 0.000 claims description 2
- 239000003595 mist Substances 0.000 claims description 2
- 239000000443 aerosol Substances 0.000 abstract description 13
- 238000004445 quantitative analysis Methods 0.000 abstract description 4
- 238000004088 simulation Methods 0.000 abstract description 3
- 239000000523 sample Substances 0.000 description 22
- 238000000034 method Methods 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 4
- 230000029058 respiratory gaseous exchange Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 201000005202 lung cancer Diseases 0.000 description 2
- 208000020816 lung neoplasm Diseases 0.000 description 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
- 201000003883 Cystic fibrosis Diseases 0.000 description 1
- 206010014561 Emphysema Diseases 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 241000009328 Perro Species 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 208000008128 pulmonary tuberculosis Diseases 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a kind of hand-held liquid aerosol lung delivery apparatus.The device includes：Syringe, it has the injection tube for being used for containing liquid sample and the piston being arranged in injection tube；Delivery tube, its inlet communication is in the outlet of injection tube, and the port of export of delivery tube is configured to insert animal tracheae；And sprayer unit, sprayer unit are installed on the port of export of delivery tube, it is configured to, when piston promotes the fluid sample in injection tube to move to animal tracheae, make fluid sample be atomized into aerosol at the port of export of delivery tube.The hand-held liquid aerosol lung delivery apparatus of the present invention can make the device be directly inserted into animal pipe aerosol occurs again by delivery tube and sprayer unit, sample is set effectively to be delivered to animal lung, especially, sample is to enter in the form of an aerosol in animal body, its real simulation human body daily suction condition.In addition, the accurate quantitative analysis to the actual inhalation dose of animal can be realized by syringe.
Description
Technical field
The present invention relates to aerosol generation technique field, more particularly to a kind of straight cutting are molten in animal tracheal strips generation liquid gas
The hand-held liquid aerosol lung delivery apparatus of glue.
Background technology
With the increase of human breathing tract disease and lung cancer morbidity rate, inhalable material is cured to harm caused by health
Hair is paid close attention to.In recent years, scientific research personnel has carried out largely on agricultural chemicals, chemicals, medicine, cosmetics and environmental contaminants
Animal toxicity on inhalation Deng material is tested to evaluate its security, such as investigates it to lung cancer, pulmonary emphysema, pulmonary tuberculosis, pneumonia, heavy breathing
The influence of the disease incidences such as asthma, chronic obstructive pulmonary disease and cystic fibrosis.The conventional two methods of suction experiment at present are animal mouth respectively
Nasal inhalation method and animal tracheal instillation method.Although the application of both approaches is wider, there is also many problems.For example,
The problem of mouth and nose inhalation is present has sample consumption big, it is difficult to which it is accurately fixed that the actual inhalation dose of animal to may be inhaled thing is carried out
Amount, the effective rate of utilization of sample is relatively low, and expensive equipment composition is complicated, and tracheal instillation method be difficult to daily couple of people of simulation can
The actual breathing state of inhaled material.
The content of the invention
It is contemplated that overcome at least one defect of existing suction experiment, there is provided a kind of hand-held liquid aerosol lung is passed
Device is sent, it can be inserted directly into the pipe of experimental animal and liquid aersol occurs again, and sample can be realized to animal lung
Effective delivering, animal can realize accurate quantitative analysis to the actual inhalation dose of sample, while such a contaminating mode simulates human body
Actual breathing state to may be inhaled thing.
Therefore, the invention provides a kind of hand-held liquid aerosol lung delivery apparatus, it includes：
Syringe, it has the injection tube for being used for containing liquid sample and the piston being arranged in the injection tube；
Delivery tube, the inlet communication of the delivery tube is in the outlet of the injection tube, and the port of export of the delivery tube is matched somebody with somebody
It is set to insertion animal tracheae；With
Sprayer unit, the sprayer unit are installed on the port of export of the delivery tube, are configured to promote institute in the piston
State fluid sample in injection tube to the animal tracheae move when, fluid sample is atomized at the port of export of the delivery tube
Into aerosol.
Further, the sprayer unit includes air deflector and nozzle, and the air deflector has dispensing passage, and is arranged at
In the delivery tube, the cross-sectional area of the dispensing passage is less than the cross-sectional area of the delivery tube Internal periphery；
The nozzle has spray orifice, and is arranged in the delivery tube, with the fluid sample to flowing out the dispensing passage
It is atomized.
Further, the air deflector also has cylindrical matrix, and the cylindrical matrix contacts with the inwall of the delivery tube
Against, and the dispensing passage is the spiral groove to be formed on the perisporium of the cylindrical matrix.
Further, the spray orifice is tapered hole or bellmouth, and the aperture of its port of export is less than the aperture of its entrance point.
Further, the aperture of the entrance point of the spray orifice is the 3/4 to 1 of the internal diameter of the delivery tube.
Further, the length of the cylindrical matrix is 380 to 420 microns, and external diameter is 290 to 310 microns；The spiral
The width of shape groove is 85 to 95 microns.
Further, the distance between the entrance point of the spray orifice and the air deflector are the 1/ of the internal diameter of the delivery tube
4 to 2 times.
Further, the delivery tube is rectilinear tubes, or the delivery tube include two intersect it is straight in 100 ° to 150 °
Spool section.
Further, the edge of the port of export of the delivery tube has fillet.
Further, hand-held liquid aerosol lung delivery apparatus also includes connector, connects the syringe and described
Delivery tube；And
The injection tube includes accurate high-boron-silicon glass pipe, and the accurate high-boron-silicon glass pipe outer cladding it is stainless
Steel sheel.
The hand-held liquid aerosol lung delivery apparatus of the present invention relies on delivery tube and the spray inside delivery tube
Mist device can make the device be directly inserted into animal pipe aerosol occurs again, makes sample effectively be delivered to animal lung
Portion, especially, sample are to enter in the form of an aerosol in animal body, its real simulation human body daily suction condition.And
And by syringe, especially precision syringe, the accurate quantitative analysis to the actual inhalation dose of animal can be achieved.
Brief description of the drawings
Some specific embodiments of the present invention are described in detail by way of example, and not by way of limitation with reference to the accompanying drawings hereinafter.
Identical reference denotes same or similar part or part in accompanying drawing.It should be appreciated by those skilled in the art that these
What accompanying drawing was not necessarily drawn to scale.In accompanying drawing：
Fig. 1 is the schematic diagram according to the hand-held liquid aerosol lung delivery apparatus of one embodiment of the invention；
Fig. 2 is the schematic partial cross-sectional view of the delivery tube and sprayer unit shown in Fig. 1.
Embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below in conjunction with accompanying drawing to specific real
Example is applied to be described in detail.
Fig. 1 is the schematic diagram according to the hand-held liquid aerosol lung delivery apparatus of one embodiment of the invention,
Fig. 2 is the schematic partial cross-sectional view of the delivery tube shown in Fig. 1.As depicted in figs. 1 and 2, the embodiments of the invention provide one kind
Hand-held liquid aerosol lung delivery apparatus.The hand-held liquid aerosol lung delivery apparatus includes syringe 10, delivery tube 20
With sprayer unit 30.Syringe 10 has the injection tube 11 for being used for containing liquid sample and the piston being arranged in injection tube 11
12.Piston 12 can be band push-rod piston.The inlet communication of delivery tube 20 is in the outlet of injection tube 11, and the port of export of delivery tube 20
It is configured to insert animal tracheal strips.Sprayer unit 30 is installed on the port of export of delivery tube 20, is configured to promote to inject in piston 12
Cylinder 11 in fluid sample to animal tracheae move when, fluid sample is atomized into aerosol at the port of export of delivery tube 20.
When in use, syringe 10 is built with liquid to be delivered for the hand-held liquid aerosol lung delivery apparatus of the present invention
Sample, delivery tube 20 is inserted into animal pipe, the piston 12 of pushing syringe 10, gas is formed in the port of export of delivery tube 20
Colloidal sol, so that sample to be delivered is sucked by animal in the form of an aerosol.The present apparatus is applicable not only to drug sample, such as medical medicine
Product, apply also for health products, agricultural chemicals, chemicals, cosmetics and environmental contaminants (such as PM2.5, PM10) inhalable chemicals.
In addition, the hand-held liquid aerosol lung delivery apparatus is hand-held, manual operation is simple in construction, small volume, easy to use.
In some embodiments of the invention, in order to accurately control sample size, can be set on the injection tube of syringe 10
It is equipped with scale.Alternatively, the design range for the syringe 10 that the hand-held liquid aerosol lung delivery apparatus uses has 300
Microlitre, the model such as 400 microlitres and 500 microlitres, in different experiments, to select the syringe of different model to carry out, it is ensured that right
The actual inhalation dose of animal realizes accurate quantitative analysis.Further, to ensure the intensity and precision of syringe 10 in the present apparatus, note
The injection tube 11 of emitter 10 can be made up of the Stainless Steel Shell that high-boron-silicon glass pipe and its outer surface are coated with.
For the ease of the demand of actual experiment, for different animals, sprayer unit 30 is preferentially arranged at delivery tube 20
Inside, and delivery tube 20 is rectilinear tubes or is made up of two intersections in 100 ° to 150 ° of straight line pipeline section that angle is typically selected
With 120 °, 125 ° etc..Delivery tube 20 may be designed as random length, and the external diameter of delivery tube can be 300 to 350 microns, so that
The hand-held liquid aerosol lung delivery apparatus of the present invention is applicable to the toys such as mouse, rat, rabbit, dog and horse or big dynamic
Lung's aerosol delivery of thing.Further, to reduce damage of the delivery tube 20 into animal tracheae insertion process to tracheae, pass
Fillet 21 can be had by sending the edge of the port of export of pipe 20.
In some embodiments of the invention, as shown in Fig. 2 sprayer unit 30 includes air deflector 31 and nozzle 32.Water conservancy diversion
Device 31 has dispensing passage 311, and is arranged in delivery tube 20, and the cross-sectional area of dispensing passage 311 is less than the lubrication groove of delivery tube 20
Wide cross-sectional area.The effect of air deflector 31 is fluid sample is entered animal tracheal strips dispersedly.Nozzle 32 has spray
Hole 321, and being arranged in delivery tube 20, to be atomized to the dispersed ground fluid sample for flowing out dispensing passage 311 and then
Dispersed geogas aerosol is formed to be sucked by animal.Especially, the fluid sample for guarantee outflow dispensing passage 311 is disperseed equal
It is even, in order to be sufficiently accurate it may be desired to be arranged at intervals between the entrance point and air deflector 31 of spray orifice 321.Preferably, the entrance point and air deflector of spray orifice 321
The distance between 31 can be 1/4 to 2 times of the internal diameter of delivery tube 20.
In some embodiments of the invention, air deflector 31 also has cylindrical matrix 312, cylindrical matrix 312 and delivery tube
20 inwall is contacted against, i.e. the external diameter of cylindrical matrix 312 is approximately the same as or slightly larger than or the slightly smaller than internal diameter of delivery tube 20, and point
Passage 311 is dissipated to form the spiral groove on the perisporium of cylindrical matrix 312 so that fluid sample spirally enters nozzle
32 and then it is atomized into aerosol.
Specifically, in this embodiment, the length of cylindrical matrix 312 is 380 to 420 microns, and a diameter of 290 to 310 is micro-
Rice.The width of spiral groove is 85 to 95 microns, and depth is 40 to 50 microns, and helical angle can be 10 ° to 40 °, groove type
Can be triangular groove, deep-slotted chip breaker, rectangular channel or dovetail groove etc..For example, the Design of length of cylindrical matrix 312 is 400 microns, it is a diameter of
300 microns, spiral groove is wide 90 microns, deep 45 microns, and helical angle is 20 °.
To be further speeded up the fluid sample into nozzle 32 and uniform atomizing, in some embodiments of the present invention
In, spray orifice 312 is designed as tapered hole or bellmouth, and the aperture of its port of export is less than the aperture of its entrance point.For example, spray orifice
The aperture of 312 entrance point is generally the 3/4 to 1 of the internal diameter of delivery tube 20.Preferably, spray orifice 321 is bellmouth and spray orifice 321
Entrance point aperture and delivery tube 20 internal diameter it is roughly equal.
In some embodiments of the invention, hand-held liquid aerosol lung delivery apparatus also includes connector 40, is used for
Connect syringe 10 and delivery tube 20 so that delivery tube 20, which can disassemble, to be conveniently replaceable and clean.Use in the present invention
Connector 40 may include a portion and cap, cap is arranged at the one end in a portion, and mounting hole is provided with cap.Delivery tube 20
Entrance point be mountable in the mounting hole of cap.The outlet of injection tube 11 can be out of, cylinder portion other end insertion connector 40.
The joint efficiency of delivery tube 20 and injection tube 11 is significantly improved using connector 40, and then improves conventional efficient.
The hand-held liquid aerosol lung delivery apparatus of the embodiment of the present invention when in use, can show connector from injection tube
11 pull up, and syringe 10 sucks fluid sample；Then connector 40 is installed on injection tube 11；Then piston 12 is promoted to move,
Drain the gas in delivery tube；Then delivery tube 20 is inserted into animal tracheae, promotes piston 12, start to make animal suction hand that this is held
Aerosol caused by formula liquid aersol lung delivery apparatus.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, any improvements and modifications made also should be regarded as the protection of the present invention
Scope.
Claims (10)
- A kind of 1. hand-held liquid aerosol lung delivery apparatus, it is characterised in that including：Syringe, it has the injection tube for being used for containing liquid sample and the piston being arranged in the injection tube；Delivery tube, the inlet communication of the delivery tube is in the outlet of the injection tube, and the port of export of the delivery tube is configured to Insert animal tracheal strips；WithSprayer unit, the sprayer unit are installed on the port of export of the delivery tube, are configured to promote the note in the piston Fluid sample in shooting cylinder to the animal tracheae move when, fluid sample is atomized into gas at the port of export of the delivery tube Colloidal sol.
- 2. hand-held liquid aerosol lung delivery apparatus according to claim 1, it is characterised in that the sprayer unit bag Include：Air deflector, there is dispensing passage, and be arranged in the delivery tube, the cross-sectional area of the dispensing passage is less than described pass Send the cross-sectional area of pipe Internal periphery；WithNozzle, it has spray orifice, and is arranged in the delivery tube, to carry out mist to the fluid sample for flowing out the dispensing passage Change.
- 3. hand-held liquid aerosol lung delivery apparatus according to claim 2, it is characterised in thatThe air deflector also has cylindrical matrix, and the cylindrical matrix and the inwall of the delivery tube contact against, and described point Scattered passage is the spiral groove to be formed on the perisporium of the cylindrical matrix.
- 4. hand-held liquid aerosol lung delivery apparatus according to claim 2, it is characterised in thatThe spray orifice is tapered hole or bellmouth, and the aperture of its port of export is less than the aperture of its entrance point.
- 5. hand-held liquid aerosol lung delivery apparatus according to claim 4, it is characterised in thatThe aperture of the entrance point of the spray orifice is the 3/4 to 1 of the internal diameter of the delivery tube.
- 6. hand-held liquid aerosol lung delivery apparatus according to claim 3, it is characterised in thatThe length of the cylindrical matrix is 380 to 420 microns, and external diameter is 290 to 310 microns；The width of the spiral groove is 85 to 95 microns.
- 7. hand-held liquid aerosol lung delivery apparatus according to claim 2, it is characterised in thatThe distance between the entrance point of the spray orifice and the air deflector are 1/4 to 2 times of the internal diameter of the delivery tube.
- 8. hand-held liquid aerosol lung delivery apparatus according to claim 1, it is characterised in thatThe delivery tube is rectilinear tubes, orThe delivery tube includes two straight line pipeline sections intersected in 100 ° to 150 °.
- 9. hand-held liquid aerosol lung delivery apparatus according to claim 1, it is characterised in thatThe edge of the port of export of the delivery tube has fillet.
- 10. hand-held liquid aerosol lung delivery apparatus according to claim 1, it is characterised in that also including connector, Connect the syringe and the delivery tube；AndThe injection tube includes accurate high-boron-silicon glass pipe, and the stainless steel case that the accurate high-boron-silicon glass pipe outer cladding Body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610686497.6A CN107753144A (en) | 2016-08-18 | 2016-08-18 | Hand-held liquid aerosol lung delivery apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610686497.6A CN107753144A (en) | 2016-08-18 | 2016-08-18 | Hand-held liquid aerosol lung delivery apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107753144A true CN107753144A (en) | 2018-03-06 |
Family
ID=61262461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610686497.6A Pending CN107753144A (en) | 2016-08-18 | 2016-08-18 | Hand-held liquid aerosol lung delivery apparatus |
Country Status (1)
| Country | Link |
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| CN (1) | CN107753144A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108392498A (en) * | 2018-05-24 | 2018-08-14 | 中国人民解放军军事科学院军事医学研究院 | Mouse model is immunized in the bacterium attenuated live vaccine liquid aersol lung delivering of cloth Shandong |
| CN108668998A (en) * | 2018-04-20 | 2018-10-19 | 中国人民解放军军事科学院军事医学研究院 | Staphylococcal enterotoxin B aerosol lung delivers the preparation method of infecting mouse model |
| CN110141660A (en) * | 2018-03-29 | 2019-08-20 | 中国人民解放军军事科学院军事医学研究院 | Plague bacillus F1 vaccine liquid aersol lung delivers immune mouse model |
| CN110151793A (en) * | 2018-03-29 | 2019-08-23 | 中国人民解放军军事科学院军事医学研究院 | Plague bacillus liquid aersol lung delivers infecting mouse model |
| CN110354147A (en) * | 2018-03-26 | 2019-10-22 | 中国人民解放军军事科学院军事医学研究院 | The preparation method of brucella liquid aersol lung delivering infecting mouse model |
| CN110584828A (en) * | 2019-10-31 | 2019-12-20 | 中国人民解放军陆军军医大学第一附属医院 | Atomizing bronchus toxicant exposure device under bronchofiberscope guide |
| CN111359061A (en) * | 2020-03-13 | 2020-07-03 | 北京控制工程研究所 | Miniature whirl nozzle structure of lung delivery device |
| CN115918608A (en) * | 2023-02-02 | 2023-04-07 | 中国人民解放军军事科学院军事医学研究院 | Construction method and application of hand-held aerosol inhalation stenotrophomonas maltophilia mouse lung infection model |
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| DE817222C (en) * | 1949-01-14 | 1951-10-15 | Hugo Tafelmaier | Atomizing nozzle and method of making a slot therein |
| SU1358969A1 (en) * | 1986-03-24 | 1987-12-15 | Войсковая часть 27177 | Sprayer |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110354147A (en) * | 2018-03-26 | 2019-10-22 | 中国人民解放军军事科学院军事医学研究院 | The preparation method of brucella liquid aersol lung delivering infecting mouse model |
| CN110141660A (en) * | 2018-03-29 | 2019-08-20 | 中国人民解放军军事科学院军事医学研究院 | Plague bacillus F1 vaccine liquid aersol lung delivers immune mouse model |
| CN110151793A (en) * | 2018-03-29 | 2019-08-23 | 中国人民解放军军事科学院军事医学研究院 | Plague bacillus liquid aersol lung delivers infecting mouse model |
| CN108668998A (en) * | 2018-04-20 | 2018-10-19 | 中国人民解放军军事科学院军事医学研究院 | Staphylococcal enterotoxin B aerosol lung delivers the preparation method of infecting mouse model |
| CN108392498A (en) * | 2018-05-24 | 2018-08-14 | 中国人民解放军军事科学院军事医学研究院 | Mouse model is immunized in the bacterium attenuated live vaccine liquid aersol lung delivering of cloth Shandong |
| CN110584828A (en) * | 2019-10-31 | 2019-12-20 | 中国人民解放军陆军军医大学第一附属医院 | Atomizing bronchus toxicant exposure device under bronchofiberscope guide |
| CN111359061A (en) * | 2020-03-13 | 2020-07-03 | 北京控制工程研究所 | Miniature whirl nozzle structure of lung delivery device |
| CN115918608A (en) * | 2023-02-02 | 2023-04-07 | 中国人民解放军军事科学院军事医学研究院 | Construction method and application of hand-held aerosol inhalation stenotrophomonas maltophilia mouse lung infection model |
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