CN201410196Y - Quantitative aerial fog inhalation device - Google Patents
Quantitative aerial fog inhalation device Download PDFInfo
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- CN201410196Y CN201410196Y CN2009200739535U CN200920073953U CN201410196Y CN 201410196 Y CN201410196 Y CN 201410196Y CN 2009200739535 U CN2009200739535 U CN 2009200739535U CN 200920073953 U CN200920073953 U CN 200920073953U CN 201410196 Y CN201410196 Y CN 201410196Y
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- valve body
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- measuring glass
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Abstract
The utility model discloses a quantitative aerial fog inhalation device which can be used reversely and has constant spray amount at every time as well as safe and simple operation. A quantitative spraying device is arranged at the end of the bottle opening of a bottle body and comprises a fixed cover, a valve body, a quantitative cup and a valve core, wherein the fixed cover is fixed on the bottle opening; the valve body and the quantitative cup are contained in the fixed cover; one end of the valve core is penetrated through an inner gasket and stretches out of the fixed cover, and the otherend thereof is connected on the valve body by a spring in a push-against way; one end of the valve core stretching out of the fixed cover is provided with a hollow valve core outlet; one metering hole is communicated with the valve core outlet; one end of the valve body is connected with the inner gasket in a push-against way and is clamped and fixed on the fixed cover; a first break-over passagecapable of controlling communicating is arranged between the other end of the valve core and the valve body; the quantitative cup is sheathed on the valve body and is connected with the bottle body in a sealing way by an outer gasket; and a second break-over passage used for communicating with the valve body is arranged on the quantitative cup.
Description
Technical field
This utility model relates to a kind of suction class doser, and especially a kind of quantitative aerosol sucks class administration speed and send device.
Background technology
The breathing of adopting at present sucks the class administering mode, because administering mode directly arrives diseased region with drug delivery, and can produce the therapeutical effect of part or whole body, is therefore used greatly clinically.This administering mode can be avoided oral administration destroyed and damage that the duplicate injection administration causes to the patient in gastrointestinal, and drug effect reduces the negative interaction of medicine to parts of body directly, fast.
In breathing suction class administering mode, thereby the research of drug delivery to whole body performance therapeutical effect is subjected to paying close attention to widely by pulmonary, the existing small-molecule drug of medicine of research has macromolecular drug again, and wherein the pulmonary administration research and development of polypeptide and protein drug gets the fastest.In recent years, along with understanding in depth to diseases such as pulmonary function and asthma, emphysema, chronic obstructive pulmonary disease and cystic fibrosises, it has been recognized that inhalation is the comparatively simple and effective route of administration of the above-mentioned disease of treatment, can reduce untoward reaction greatly.Compare with other route of administration, it is greatly long-pending that pulmonary administration has sorbent surface, the characteristics that the absorption site blood flow enriches and avoids liver first-pass effect, and pulmonary has, and enzymatic activity is lower, the epithelium barrier is thin and the permeability advantages of higher, in addition, it can also reduce the distribution of medicine in its hetero-organization.But the deposition behavior that the suction particle enters behind the human body will directly influence pharmaceutically-active performance, and therefore, the deposition behavior of research particle after entering respiratory tract is the key of pulmonary administration performance curative effect.
It is reported that calendar year 2001 whole world pulmonary administration system drug market sales volume reaches 8,400,000,000 dollars, expectation will increase with 13% compound annual growth rate.Along with biotechnology and engineered development, make increasing polypeptide and protein drug be applied to clinical treatment, the application of pulmonary administration system in this type of drug research is many, and development is also than comparatively fast, and each big drugmaker of the world gets involved the developmental research of pulmonary administration preparation one after another.
Existing pulmonary inhalation mode generally is that the form by spray is injected to medicinal liquid in patient's the oral cavity, enter patient pulmonary then, the greatest problem that this spray pattern exists can not realize dosed administration exactly, each straying quatity all is at random, thereby the size of uncontrollable straying quatity can't realize the quantitative control to medicinal liquid.
The utility model content
In order to overcome the deficiency that can't realize quantitatively controlling medicinal liquid in the prior art, this utility model provides a kind of can be inverted use, the quantitative aerosol inhalation device of the constant and simple and safe operation of each straying quatity homogeneous.
The technical scheme that its technical problem that solves this utility model adopts is:
A kind of quantitative aerosol inhalation device, bottleneck end at a bottle is provided with a certain amount of sprayer unit, described quantitative sprayer unit comprises that one is fixed on the fixed cap on the bottleneck, one is installed with valve body and the Measuring glass in fixed cap, one spool, described spool one end passes an inner washer and stretches out from fixed cap, the other end is connected on the valve body by a spring, the end that described spool stretches out fixed cap is provided with the spool outlet of a hollow, one dip hatch is connected with this spool outlet, described valve body one end butt inner washer also is fixed on the fixed cap, be provided with first conductive channel of a may command conducting between the described spool other end and the valve body, described Measuring glass is set on the valve body and by an outer washer and bottle and is tightly connected, and described Measuring glass is provided with second conductive channel of carrying out conducting with valve body.
Further, second conductive channel on the described Measuring glass is the groove that is provided with on the Measuring glass wall of cup, and described groove extends to form a conductive channel from wall of cup at the bottom of cup.
Further, one, two or three grooves are set on the wall of cup of described Measuring glass
Further, the described spool other end is provided with the gradient that can keep sealing between spool and valve body.
Further, described quantitative sprayer unit is provided with a three-phase toucher that is used to change spray direction.
In this utility model device, be full of the liquid that has certain pressure in the bottle, after this bottle inversion, liquid enters Measuring glass in the bottle, capacity in the Measuring glass is quantitative, and second conductive channel of liquid from quantitative wall of cup enters into valve body, first conductive channel conducting this moment, because dip hatch also is in the fixed cap top this moment, therefore liquid can't spray in the bottle; When pressing bottom spool, spool moves down, dip hatch moves to the fixed cap below, make the outlet of valve body and spool keep conducting state, simultaneously, the other end of spool compression spring, the other end of spool is provided with certain slope, first conductive channel when spool moves down like this and between the valve body will keep sealing state, and from the ejection of spool exit, the liquid of ejection just in time is quantitative liquid in the Measuring glass to the intravital liquid of valve by dip hatch.After the liquid ejection, the compression spring pops up, spool is upwards promoted, dip hatch will move to the top of fixed cap once more like this, make valve body keep sealing state, and moving up along with spool, first conductive channel conducting once more between the spool other end and the valve body, the intravital compressed liquid of bottle enters into valve body by second conductive channel on the Measuring glass, first conductive channel, the capacity that enters in the valve body still is that Measuring glass is quantitative equally, when pressing bottom spool, once sprays once more, so repeatedly, the medicinal liquid capacity of each ejection all is certain.
This utility model device is to be inverted to use, another effect of Measuring glass just is after the intravital liquid of bottle uses a period of time to tail off, when especially being lower than the height of Measuring glass, because the inlet of Measuring glass is at the bottle body and bottleneck place, the intravital liquid of bottle enters by second conductive channel, first conductive channel from the Measuring glass inlet and enters into valve body, have only when the intravital liquid height of bottle just can't feed liquor when being lower than the bottleneck inlet, and substantially do not had residual medicinal liquid in the bottle this moment, it is residual that thereby assurance can not cause, the waste medicinal liquid.
The characteristics of this patent are
(1), this device can be inverted and use so that the patient is passed to pulmonary through the oral cavity;
(2), each straying quatity quantitatively and strict homogeneity of determining whenever to press once, promptly emitted dose difference limit meansigma methods is controlled at standard discharge rate ± 20%;
(3), the droplet size that enters pulmonary is carried out strictness control by the three-phase toucher;
(4), liquid annual slip is controlled at 1.5% with interior (national Specification annual slip is controlled in 3.5%) in this shelf bottle.
Description of drawings
Below in conjunction with drawings and Examples this utility model is further specified;
Fig. 1 is this utility model overall structure sketch map;
Fig. 2 is the structural representation after the spool of the quantitative sprayer unit of Fig. 1 is pressed;
Fig. 3 is the structural representation of Measuring glass of the present utility model;
Fig. 4 is the structural representation of three-phase toucher of the present utility model;
Fig. 5 is the three-dimensional structure diagram of Fig. 4 three-phase toucher.
The number in the figure explanation:
1. spool, 2. fixed cap, 3. inner washer, 4. valve body, 5. outer washer, 6. Measuring glass,
7. spring, 8. first conductive channel, 9. bottle, 10. three-phase toucher, the outlet of 11. spools,
12. dip hatch, 13. second conductive channel, the outlet of 14. three-phase touchers
The specific embodiment
As Fig. 1 is this utility model overall structure sketch map; A kind of quantitative aerosol inhalation device, bottleneck end at a bottle 9 is provided with a certain amount of sprayer unit, quantitatively sprayer unit comprises that one is fixed on the fixed cap 2 on the bottleneck, one is installed with valve body 4 and the Measuring glass 6 in fixed cap 2, one spool 1, spool 1 one ends pass an inner washer 3 and stretch out from fixed cap 2, the other end is connected on the valve body 4 by a spring 7, the end that spool 1 stretches out fixed cap 2 is provided with the spool outlet 11 of a hollow, one dip hatch 12 is connected with this spool outlet 11, valve body 4 one end butt inner washers 3 also are fixed on the fixed cap 2, be provided with first conductive channel 8 of a may command conducting between spool 1 other end and the valve body 4, spool 1 other end is provided with certain gradient, like this, when spool 1 moves down, spool 1 will be inserted in the valve body 4, Measuring glass 6 is set on the valve body 4 and by an outer washer 5 and is tightly connected with bottle 9, and Measuring glass 6 is provided with second conductive channel 13 of carrying out conducting with valve body 4.
As shown in Figure 3, the groove of second conductive channel 13 on the Measuring glass 6 for being provided with on the Measuring glass wall of cup, groove extends to form a conductive channel from wall of cup at the bottom of cup.Actually add man-hour, one, two or three grooves can be set on the Measuring glass, can become between each groove etc. branch arrange or not five equilibrium arrange.
As Fig. 4, shown in Figure 5, quantitatively sprayer unit is provided with a three-phase toucher 10 that is used to change spray direction, bottle 1 is inserted in the three-phase toucher 10, after pressing three-phase toucher 10, turn to from three-phase toucher outlet 14 ejections after the atomizing of liquid through three-phase toucher 10 of spool outlet 11.
As shown in Figure 1 and Figure 2, in this utility model device, be full of the liquid that has certain pressure in the bottle 9, after these bottle 9 inversions, liquid enter Measuring glass 6 in the bottle 9, and the capacity in the Measuring glass 6 are quantitative, second conductive channel 13 of liquid from Measuring glass 6 walls enters into valve body 4, first conductive channel, 8 conductings this moment, because dip hatch also is in fixed cap 2 tops 12 this moments, therefore liquid can't spray in the bottle; When the shake-up of pressing three-phase toucher 10, when promptly being equivalent to push spool 1, spool 1 moves down, dip hatch 12 moves to fixed cap 2 belows, make valve body 4 and spool 1 outlet keep conducting state, as shown in Figure 2, simultaneously, the other end compression spring 7 of spool 1, the other end of spool 1 is provided with certain slope, first conductive channel 8 when spool 1 moves down like this and between the valve body 4 will keep sealing state, and the guiding that the liquid in the valve body 4 exports 11 ejections and prolonging three-phase toucher 10 from spool by dip hatch 12 is from three-phase toucher outlet 14 ejections, and the liquid of ejection just in time is quantitative liquid in the Measuring glass 6.After the liquid ejection, compression spring 7 pops up, spool 1 is upwards promoted, dip hatch 12 will move to the top of fixed cap 2 once more like this, make valve body 4 keep sealing state, and moving up along with spool 1, first conductive channel 8 conducting once more between spool 1 other end and the valve body 4, compressed liquid in the bottle 9 is by second conductive channel 13 on the Measuring glass 6, first conductive channel 8 enters into valve body 4, the capacity that enters in the valve body 4 still is that Measuring glass 6 is quantitative equally, when pressing bottom spool 1, once sprays once more, so repeatedly, the medicinal liquid capacity of each ejection all is certain.
Concerning patent device, slip is to embody the important indicator of aerosol sealing.Slip is closely related to the particle diameter of whenever pressing drug content, content uniformity, ejection medicine/droplet.Slip is the important inspection item of stability experiment.Under the certain situation of identical experiment condition and container and valve system, medicine slip before the deadline is directly related with loading amount.Thereby the slip of checking medicine in stability experiment is very necessary, patent device year slip be strict controlled in 1.5% with interior (national Specification annual slip is controlled in 3.5%), obviously the sealing property of patent device is better.Emitted dose difference limit meansigma methods will be controlled at standard discharge rate ± 15% with interior (emitted dose difference limit meansigma methods national standard is controlled in standard discharge rate ± 20%)
Because when chemical spray goes out bottle, may be in " dead space " deposition or the delay of valve system, cause a part of medicine to spray, the medicine of ejection may (be assembled at the nozzle place as drug particles because of size, shape and the dosage form factor of nozzle in addition, bigger particle studded electrostatic interaction between nozzle place, granule etc.), also make the part drug residue at the nozzle place, and can't be sucked by the patient, drug residue for these positions, apparatus of the present invention have perfectly solved this difficult problem, make every bottle of feed liquid residual quantity be controlled in the 1.5g.
Patent device also has following advantage simultaneously:
(1) no intestines and stomach degradation;
(2) no liver first-pass effect;
(3) drug absorption is rapid, and is rapid-action after the administration;
(4) bioavilability of macromolecular drug can be by the improve that should be used for of sorbefacient or additive method;
(5) small-molecule drug is particularly useful for respiratory tract and directly inhales people or spray people administration; Directly enter the body circulation after the drug absorption, reach The purpose of whole body therapeutic;
(6) can be used for the water-soluble big medicine that intestines and stomach are difficult to absorb; Good patient compliance is specially adapted to former need and annotates for a long time Penetrate the patient for the treatment of;
(7) play the local medicine that acts on, dosage obviously reduces, and toxic and side effect is little.
Claims (5)
1, a kind of quantitative aerosol inhalation device is provided with a certain amount of sprayer unit at the bottleneck end of a bottle, and described quantitative sprayer unit comprises that one is fixed on fixed cap, on the bottleneck and is installed with valve body in fixed cap and Measuring glass, a spool, it is characterized in that:
Described spool one end passes an inner washer and stretches out from fixed cap, the other end is connected on the valve body by a spring, the end that described spool stretches out fixed cap is provided with the spool outlet of a hollow, one dip hatch is connected with this spool outlet, described valve body one end butt inner washer also is fixed on the fixed cap, be provided with first conductive channel of a may command conducting between the described spool other end and the valve body, described Measuring glass is set on the valve body and by an outer washer and bottle and is tightly connected, and described Measuring glass is provided with second conductive channel with the valve body conducting.
2, quantitative aerosol inhalation device according to claim 1, it is characterized in that: second conductive channel on the described Measuring glass is the groove that is provided with on the Measuring glass wall of cup, described groove extends to form a conductive channel from wall of cup at the bottom of cup.
3, quantitative aerosol inhalation device according to claim 2 is characterized in that: one, two or three grooves are set on the wall of cup of described Measuring glass.
4, quantitative aerosol inhalation device according to claim 1 is characterized in that: the described spool other end is provided with the gradient that can keep sealing between spool and valve body.
5, quantitative aerosol inhalation device according to claim 1 is characterized in that: described quantitative sprayer unit is provided with a three-phase toucher that is used to change spray direction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009200739535U CN201410196Y (en) | 2009-05-25 | 2009-05-25 | Quantitative aerial fog inhalation device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009200739535U CN201410196Y (en) | 2009-05-25 | 2009-05-25 | Quantitative aerial fog inhalation device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201410196Y true CN201410196Y (en) | 2010-02-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009200739535U Expired - Fee Related CN201410196Y (en) | 2009-05-25 | 2009-05-25 | Quantitative aerial fog inhalation device |
Country Status (1)
| Country | Link |
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| CN (1) | CN201410196Y (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104258489A (en) * | 2014-10-10 | 2015-01-07 | 济南高达信息技术有限公司 | Quantitative sprayer for powder drugs |
| CN104379452A (en) * | 2012-06-07 | 2015-02-25 | 和谐医疗有限公司 | Improvements in or relating to dispensing valves |
| CN105092786A (en) * | 2015-07-23 | 2015-11-25 | 上海化工研究院 | Oppositely-impacting quantitative atomization drug delivery apparatus |
| CN106620973A (en) * | 2017-02-13 | 2017-05-10 | 上海华瑞气雾剂有限公司 | Inverted rationed aerosol valve |
| CN109701147A (en) * | 2018-11-16 | 2019-05-03 | 常州市第一人民医院 | A kind of wet watering can of limitation limit time timing |
| CN111298250A (en) * | 2020-03-25 | 2020-06-19 | 吴红燕 | Quantitative atomizing device based on intermittent absorption |
-
2009
- 2009-05-25 CN CN2009200739535U patent/CN201410196Y/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104379452A (en) * | 2012-06-07 | 2015-02-25 | 和谐医疗有限公司 | Improvements in or relating to dispensing valves |
| CN104379452B (en) * | 2012-06-07 | 2017-04-19 | 和谐医疗有限公司 | Improvements in or relating to dispensing valves |
| CN104258489A (en) * | 2014-10-10 | 2015-01-07 | 济南高达信息技术有限公司 | Quantitative sprayer for powder drugs |
| CN105092786A (en) * | 2015-07-23 | 2015-11-25 | 上海化工研究院 | Oppositely-impacting quantitative atomization drug delivery apparatus |
| CN106620973A (en) * | 2017-02-13 | 2017-05-10 | 上海华瑞气雾剂有限公司 | Inverted rationed aerosol valve |
| CN109701147A (en) * | 2018-11-16 | 2019-05-03 | 常州市第一人民医院 | A kind of wet watering can of limitation limit time timing |
| CN109701147B (en) * | 2018-11-16 | 2023-08-18 | 常州市第一人民医院 | Wet watering can with limited quantity and time |
| CN111298250A (en) * | 2020-03-25 | 2020-06-19 | 吴红燕 | Quantitative atomizing device based on intermittent absorption |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100224 Termination date: 20140525 |