CN206414361U - Hand-held liquid aerosol lung delivery apparatus - Google Patents
Hand-held liquid aerosol lung delivery apparatus Download PDFInfo
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- CN206414361U CN206414361U CN201620900551.8U CN201620900551U CN206414361U CN 206414361 U CN206414361 U CN 206414361U CN 201620900551 U CN201620900551 U CN 201620900551U CN 206414361 U CN206414361 U CN 206414361U
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Abstract
The utility model provides a kind of hand-held liquid aerosol lung delivery apparatus.The device includes：Syringe, it has the injection tube and the piston being arranged in injection tube for containing liquid sample；Delivery tube, its inlet communication is configured to insert animal tracheae in the outlet of injection tube, and the port of export of delivery tube；And sprayer unit, sprayer unit is installed on the port of export of delivery tube, is configured to, when piston promotes the fluid sample in injection tube to move to animal tracheae, make fluid sample be atomized into aerosol at the port of export of delivery tube.Hand-held liquid aerosol lung delivery apparatus of the present utility model can make the device be directly inserted into animal pipe aerosol occurs again by delivery tube and sprayer unit, sample is set effectively to be delivered to animal lung, especially, sample is to enter in the form of an aerosol in animal body, and it truly simulates the daily suction condition of human body.In addition, the accurate quantitative analysis to the actual inhalation dose of animal can be realized by syringe.
Description
Technical field
The utility model is related to aerosol generation technique field, more particularly in animal tracheal strips liquid occurs for a kind of straight cutting
The hand-held liquid aerosol lung delivery apparatus of aerosol.
Background technology
With the increase of human breathing tract disease and lung cancer morbidity rate, the harm that inhalable material is produced to health is cured
Hair is paid close attention to.In recent years, scientific research personnel has carried out substantial amounts of on agricultural chemicals, chemicals, medicine, cosmetics and environmental contaminants
Animal toxicity on inhalation Deng material is tested to evaluate its security, for example, investigate it to lung cancer, pulmonary emphysema, pulmonary tuberculosis, pneumonia, heavy breathing
Breathe heavily, the influence of the disease incidence such as chronic obstructive pulmonary disease and cystic fibrosis.The conventional two methods of suction experiment at present are animal mouthful respectively
Nasal inhalation method and animal tracheal instillation method.Although the application of both approaches is wider, there is also many problems.For example,
The problem of mouth and nose inhalation is present has sample consumption big, it is difficult to which it is accurately fixed that the actual inhalation dose of animal that may be inhaled thing is carried out
Amount, the effective rate of utilization of sample is relatively low, and expensive equipment composition is complicated, and be difficult to simulate daily couple of people can for tracheal instillation method
The actual breathing state of inhaled material.
Utility model content
The utility model is intended to overcome at least one defect of existing suction experiment, and there is provided a kind of hand-held liquid aerosol
Liquid aersol occurs again for lung delivery apparatus, its pipe that can be inserted directly into experimental animal, and sample can be realized to animal
Effective delivering of lung, animal can realize accurate quantitative analysis to the actual inhalation dose of sample, while such a contaminating mode is simulated
Actual breathing state of the human body to inhalable thing.
Therefore, the utility model provides a kind of hand-held liquid aerosol lung delivery apparatus, it includes：
Syringe, it has the injection tube and the piston being arranged in the injection tube for containing liquid sample；
Delivery tube, the inlet communication of the delivery tube is matched somebody with somebody in the outlet of the injection tube, and the port of export of the delivery tube
It is set to insertion animal tracheae；With
Sprayer unit, the sprayer unit is installed on the port of export of the delivery tube, is configured to promote institute in the piston
State fluid sample in injection tube to the animal tracheae move when, fluid sample is atomized at the port of export of the delivery tube
Into aerosol.
Further, the sprayer unit includes air deflector and nozzle, and the air deflector has dispensing passage, and is arranged at
In the delivery tube, the cross-sectional area of the dispensing passage is less than the cross-sectional area of the delivery tube Internal periphery；
The nozzle has spray orifice, and is arranged in the delivery tube, with the fluid sample to flowing out the dispensing passage
It is atomized.
Further, the air deflector also has cylindrical matrix, and the cylindrical matrix is contacted with the inwall of the delivery tube
Against, and the dispensing passage is the spiral groove to be formed on the perisporium of the cylindrical matrix.
Further, the spray orifice be tapered hole or bellmouth, and its port of export aperture be less than its entrance point aperture.
Further, the aperture of the entrance point of the spray orifice is the 3/4 to 1 of the internal diameter of the delivery tube.
Further, the length of the cylindrical matrix is 380 to 420 microns, and external diameter is 290 to 310 microns；The spiral
The width of shape groove is 85 to 95 microns.
Further, the distance between the entrance point of the spray orifice and the air deflector are the 1/ of the internal diameter of the delivery tube
4 to 2 times.
Further, the delivery tube is rectilinear tubes, or the delivery tube include two intersect in 100 ° to 150 ° it is straight
Spool section.
Further, the edge of the port of export of the delivery tube has fillet.
Further, hand-held liquid aerosol lung delivery apparatus also includes connector, connects the syringe and described
Delivery tube；And
The injection tube includes accurate high-boron-silicon glass pipe, and the accurate high-boron-silicon glass pipe outer cladding it is stainless
Steel sheel.
Hand-held liquid aerosol lung delivery apparatus of the present utility model is by delivery tube and inside delivery tube
Sprayer unit the device can be made to be directly inserted into animal pipe aerosol occurs again, makes sample effectively be delivered to animal
Lung, especially, sample are to enter in the form of an aerosol in animal body, and it truly simulates the daily suction condition of human body.
Moreover, by syringe, especially precision syringe, the accurate quantitative analysis to the actual inhalation dose of animal can be achieved.
Brief description of the drawings
It is described in detail by way of example, and not by way of limitation with reference to the accompanying drawings hereinafter more of the present utility model specific real
Apply example.Identical reference denotes same or similar part or part in accompanying drawing.It should be appreciated by those skilled in the art that
What these accompanying drawings were not necessarily drawn to scale.In accompanying drawing：
Fig. 1 is the schematic structure of the hand-held liquid aerosol lung delivery apparatus according to the utility model one embodiment
Figure；
Fig. 2 is the delivery tube and the schematic partial cross-sectional view of sprayer unit shown in Fig. 1.
Embodiment
To make the purpose, technical scheme and advantage of the utility model embodiment clearer, below in conjunction with accompanying drawing to tool
Body embodiment is described in detail.
Fig. 1 is the schematic structure of the hand-held liquid aerosol lung delivery apparatus according to the utility model one embodiment
Figure, Fig. 2 is the schematic partial cross-sectional view of the delivery tube shown in Fig. 1.As depicted in figs. 1 and 2, the utility model embodiment is provided
A kind of hand-held liquid aerosol lung delivery apparatus.The hand-held liquid aerosol lung delivery apparatus includes syringe 10, passs
Send pipe 20 and sprayer unit 30.Syringe 10 has the injection tube 11 for being used for containing liquid sample and is arranged in injection tube 11
Piston 12.Piston 12 can be band push-rod piston.The inlet communication of delivery tube 20 is in the outlet of injection tube 11, and delivery tube 20 goes out
Mouth end is configured to insert animal tracheal strips.Sprayer unit 30 is installed on the port of export of delivery tube 20, is configured to promote in piston 12
Fluid sample in injection tube 11 to animal tracheae move when, fluid sample is atomized into gas at the port of export of delivery tube 20 molten
Glue.
When in use, syringe 10 is built with to be delivered for hand-held liquid aerosol lung delivery apparatus of the present utility model
Fluid sample, animal pipe, the piston 12 of pushing syringe 10, in the port of export shape of delivery tube 20 are inserted by delivery tube 20
Into aerosol, so that sample to be delivered is sucked by animal in the form of an aerosol.The present apparatus is applicable not only to drug sample, such as cures
Medicine is treated, health products, agricultural chemicals, chemicals, cosmetics and environmental contaminants (such as PM2.5, PM10) inhalableization is applied also for
Learn thing.In addition, the hand-held liquid aerosol lung delivery apparatus is hand-held, artificial operation, is used simple in construction, small volume
It is convenient.
In some embodiments of the present utility model, controlled in order to accurate on sample size, the injection tube of syringe 10
It is settable to have scale.Alternatively, the design range for the syringe 10 that the hand-held liquid aerosol lung delivery apparatus is used
There are the models such as 300 microlitres, 400 microlitres and 500 microlitres, so that in different experiments, the syringe of selection different model is carried out, really
Guarantor realizes accurate quantitative analysis to the actual inhalation dose of animal.Further, it is the intensity and essence of syringe 10 in the guarantee present apparatus
Degree, the Stainless Steel Shell that the injection tube 11 of syringe 10 can be coated with by high-boron-silicon glass pipe and its outer surface is constituted.
For the ease of the demand of actual experiment, for different animals, sprayer unit 30 is preferentially arranged at delivery tube 20
Inside, and delivery tube 20 is rectilinear tubes or is made up of two intersections in 100 ° to 150 ° of straight line pipeline section that angle is typically selected
With 120 °, 125 ° etc..Delivery tube 20 may be designed as random length, and the external diameter of delivery tube can be 300 to 350 microns, so that
Hand-held liquid aerosol lung delivery apparatus of the present utility model be applicable to the toys such as mouse, rat, rabbit, dog and horse or
Lung's aerosol delivery of big animal.Further, the damage for reduction delivery tube 20 into animal tracheae insertion process to tracheae
Wound, the edge of the port of export of delivery tube 20 can have fillet 21.
In some embodiments of the present utility model, as shown in Fig. 2 sprayer unit 30 includes air deflector 31 and nozzle 32.
Air deflector 31 has dispensing passage 311, and is arranged in delivery tube 20, and the cross-sectional area of dispensing passage 311 is less than delivery tube 20
The cross-sectional area of Internal periphery.The effect of air deflector 31 is fluid sample is entered animal tracheal strips dispersedly.Nozzle 32 has
There is spray orifice 321, and be arranged in delivery tube 20, to be atomized to the dispersed ground fluid sample for flowing out dispensing passage 311
And then the dispersed geogas aerosol of formation is sucked by animal.Especially, the fluid sample for guarantee outflow dispensing passage 311 is divided
Dissipate uniform, in order to be sufficiently accurate it may be desired to be arranged at intervals between the entrance point and air deflector 31 of spray orifice 321.Preferably, the entrance point of spray orifice 321 is with leading
The distance between stream device 31 can be 1/4 to 2 times of the internal diameter of delivery tube 20.
In some embodiments of the present utility model, air deflector 31 also has cylindrical matrix 312, and cylindrical matrix 312 is with passing
The inwall of pipe 20 is sent to contact against, i.e. the external diameter of cylindrical matrix 312 is approximately the same as or slightly larger than or the slightly smaller than internal diameter of delivery tube 20,
And spiral groove of the dispensing passage 311 for formation on the perisporium of cylindrical matrix 312 so that fluid sample spirally enters
Nozzle 32 and then it is atomized into aerosol.
Specifically, in this embodiment, the length of cylindrical matrix 312 is 380 to 420 microns, and a diameter of 290 to 310 is micro-
Rice.The width of spiral groove is 85 to 95 microns, and depth is 40 to 50 microns, and helical angle can be 10 ° to 40 °, groove type
Can be triangular groove, deep-slotted chip breaker, rectangular channel or dovetail groove etc..For example, the Design of length of cylindrical matrix 312 is 400 microns, it is a diameter of
300 microns, spiral groove is wide 90 microns, deep 45 microns, and helical angle is 20 °.
To make the fluid sample into nozzle 32 be further speeded up and uniform atomizing, in some realities of the present utility model
Apply in example, spray orifice 312 is designed as tapered hole or bellmouth, and aperture of the aperture less than its entrance point of its port of export.For example, spray
The aperture of the entrance point in hole 312 is generally the 3/4 to 1 of the internal diameter of delivery tube 20.Preferably, spray orifice 321 is bellmouth and spray orifice
321 entrance point aperture and the internal diameter of delivery tube 20 are roughly equal.
In some embodiments of the present utility model, hand-held liquid aerosol lung delivery apparatus also includes connector 40,
For connecting syringe 10 and delivery tube 20 so that delivery tube 20, which can be disassembled, to be conveniently replaceable and clean.It is new in this practicality
The connector 40 used in type may include a portion and cap, and cap is arranged at the one end in a portion, and mounting hole is provided with cap.
The entrance point of delivery tube 20 is mountable in the mounting hole of cap.The outlet of injection tube 11 can insert connection from the other end in cylinder portion
In first 40.The joint efficiency of delivery tube 20 and injection tube 11 is significantly improved using connector 40, and then improves conventional efficient.
The hand-held liquid aerosol lung delivery apparatus of the utility model embodiment when in use, can show connector from note
Shooting cylinder 11 is pulled up, the suction fluid sample of syringe 10；Then connector 40 is installed on injection tube 11；Then piston 12 is promoted to move
It is dynamic, drain the gas in delivery tube；Then delivery tube 20 is inserted into animal tracheae, promotes piston 12, start to make animal suck hand
This holds the aerosol of formula liquid aersol lung delivery apparatus generation.
Described above is only preferred embodiment of the present utility model, it is noted that for the common skill of the art
For art personnel, on the premise of the utility model principle is not departed from, any improvements and modifications made also should be regarded as this reality
With new protection domain.
Claims (10)
1. a kind of hand-held liquid aerosol lung delivery apparatus, it is characterised in that including：
Syringe, it has the injection tube and the piston being arranged in the injection tube for containing liquid sample；
Delivery tube, the inlet communication of the delivery tube is configured in the outlet of the injection tube, and the port of export of the delivery tube
Insert animal tracheal strips；With
Sprayer unit, the sprayer unit is installed on the port of export of the delivery tube, is configured to promote the note in the piston
Fluid sample in shooting cylinder to the animal tracheae move when, fluid sample is atomized into gas at the port of export of the delivery tube
Colloidal sol.
2. hand-held liquid aerosol lung delivery apparatus according to claim 1, it is characterised in that the sprayer unit bag
Include：
Air deflector, with dispensing passage, and is arranged in the delivery tube, and the cross-sectional area of the dispensing passage is less than described pass
Send the cross-sectional area of pipe Internal periphery；With
Nozzle, it has spray orifice, and is arranged in the delivery tube, to carry out mist to the fluid sample for flowing out the dispensing passage
Change.
3. hand-held liquid aerosol lung delivery apparatus according to claim 2, it is characterised in that
The air deflector also has cylindrical matrix, and the cylindrical matrix and the inwall of the delivery tube are contacted against, and described point
Scattered passage is the spiral groove to be formed on the perisporium of the cylindrical matrix.
4. hand-held liquid aerosol lung delivery apparatus according to claim 2, it is characterised in that
The spray orifice be tapered hole or bellmouth, and its port of export aperture be less than its entrance point aperture.
5. hand-held liquid aerosol lung delivery apparatus according to claim 4, it is characterised in that
The aperture of the entrance point of the spray orifice is the 3/4 to 1 of the internal diameter of the delivery tube.
6. hand-held liquid aerosol lung delivery apparatus according to claim 3, it is characterised in that
The length of the cylindrical matrix is 380 to 420 microns, and external diameter is 290 to 310 microns；
The width of the spiral groove is 85 to 95 microns.
7. hand-held liquid aerosol lung delivery apparatus according to claim 2, it is characterised in that
The distance between the entrance point of the spray orifice and the air deflector are 1/4 to 2 times of the internal diameter of the delivery tube.
8. hand-held liquid aerosol lung delivery apparatus according to claim 1, it is characterised in that
The delivery tube is rectilinear tubes, or
The delivery tube includes two straight line pipeline sections intersected in 100 ° to 150 °.
9. hand-held liquid aerosol lung delivery apparatus according to claim 1, it is characterised in that
The edge of the port of export of the delivery tube has fillet.
10. hand-held liquid aerosol lung delivery apparatus according to claim 1, it is characterised in that also including connector,
Connect the syringe and the delivery tube；And
The injection tube includes accurate high-boron-silicon glass pipe, and the stainless steel case that the accurate high-boron-silicon glass pipe outer cladding
Body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620900551.8U CN206414361U (en) | 2016-08-18 | 2016-08-18 | Hand-held liquid aerosol lung delivery apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620900551.8U CN206414361U (en) | 2016-08-18 | 2016-08-18 | Hand-held liquid aerosol lung delivery apparatus |
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| Publication Number | Publication Date |
|---|---|
| CN206414361U true CN206414361U (en) | 2017-08-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201620900551.8U Active CN206414361U (en) | 2016-08-18 | 2016-08-18 | Hand-held liquid aerosol lung delivery apparatus |
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| CN (1) | CN206414361U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107753144A (en) * | 2016-08-18 | 2018-03-06 | 中国人民解放军军事医学科学院微生物流行病研究所 | Hand-held liquid aerosol lung delivery apparatus |
-
2016
- 2016-08-18 CN CN201620900551.8U patent/CN206414361U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107753144A (en) * | 2016-08-18 | 2018-03-06 | 中国人民解放军军事医学科学院微生物流行病研究所 | Hand-held liquid aerosol lung delivery apparatus |
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