CN107753147A - Hand-held dry powder aerosol lung delivery apparatus - Google Patents
Hand-held dry powder aerosol lung delivery apparatus Download PDFInfo
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- CN107753147A CN107753147A CN201610685625.5A CN201610685625A CN107753147A CN 107753147 A CN107753147 A CN 107753147A CN 201610685625 A CN201610685625 A CN 201610685625A CN 107753147 A CN107753147 A CN 107753147A
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- dry powder
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- 239000000843 powder Substances 0.000 title claims abstract description 94
- 239000000443 aerosol Substances 0.000 title claims abstract description 56
- 210000004072 lung Anatomy 0.000 title claims abstract description 33
- 238000002347 injection Methods 0.000 claims abstract description 36
- 239000007924 injection Substances 0.000 claims abstract description 36
- 241001465754 Metazoa Species 0.000 claims abstract description 29
- 238000009423 ventilation Methods 0.000 claims description 35
- 241001149930 Protura <class> Species 0.000 claims description 6
- 239000011521 glass Substances 0.000 claims description 4
- 230000002093 peripheral effect Effects 0.000 claims description 4
- 229910052710 silicon Inorganic materials 0.000 claims description 4
- 239000010703 silicon Substances 0.000 claims description 4
- 229910001220 stainless steel Inorganic materials 0.000 claims description 3
- 239000010935 stainless steel Substances 0.000 claims description 3
- 238000005253 cladding Methods 0.000 claims description 2
- 238000004445 quantitative analysis Methods 0.000 abstract description 4
- 238000004088 simulation Methods 0.000 abstract description 4
- 238000000034 method Methods 0.000 description 6
- 230000029058 respiratory gaseous exchange Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 201000005202 lung cancer Diseases 0.000 description 2
- 208000020816 lung neoplasm Diseases 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000002685 pulmonary effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
- 201000003883 Cystic fibrosis Diseases 0.000 description 1
- 206010014561 Emphysema Diseases 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000009328 Perro Species 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 239000008263 liquid aerosol Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 208000008128 pulmonary tuberculosis Diseases 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
- A61D7/04—Devices for anaesthetising animals by gases or vapours; Inhaling devices
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a kind of hand-held dry powder aerosol lung delivery apparatus, it includes：Gas supply part 10, it has syringe 11, and gas supply part 10 is configured with the air outflow gas supply part 10 in the injection tube of the piston pushing syringe 11 of syringe 11, to provide air stream；Generating unit 20, gas supply part 10 is connected to, is configured to receive air stream, and make to move with air stream under the driving at least partially in air stream of its interior dry powder and diffuse to form dry powder aerosol；With delivery portion 30, delivery portion 30 has delivery tube 31, and the entrance point of delivery tube 31 is connected to generating unit 20, and to receive dry powder aerosol, the port of export of delivery tube 31 is configured to insert animal tracheal strips, to deliver dry powder aerosol to animal tracheal strips.The hand-held dry powder aerosol lung delivery apparatus real simulation daily suction condition of human body and can carry out accurate quantitative analysis to the actual inhalation dose of animal, be tested especially suitable for suction.
Description
Technical field
The present invention relates to aerosol generation technique field, more particularly to a kind of straight cutting are molten in animal tracheal strips generation dry powder gas
The hand-held dry powder aerosol lung delivery apparatus of glue.
Background technology
With the increase of human breathing tract disease and lung cancer morbidity rate, inhalable material is cured to harm caused by health
Hair is paid close attention to.In recent years, scientific research personnel has carried out largely on agricultural chemicals, chemicals, medicine, cosmetics and environmental contaminants
Animal toxicity on inhalation Deng material is tested to evaluate its security, such as investigates it to lung cancer, pulmonary emphysema, pulmonary tuberculosis, pneumonia, heavy breathing
The influence of the disease incidences such as asthma, chronic obstructive pulmonary disease and cystic fibrosis.The conventional two methods of suction experiment at present are animal mouth respectively
Nasal inhalation method and animal tracheal instillation method.Although the application of both approaches is wider, there is also many problems.For example,
The problem of mouth and nose inhalation is present has sample consumption big, it is difficult to which it is accurately fixed that the actual inhalation dose of animal to may be inhaled thing is carried out
Amount, the effective rate of utilization of sample is relatively low, and expensive equipment composition is complicated, and tracheal instillation method be difficult to daily couple of people of simulation can
The actual breathing state of inhaled material.
The content of the invention
It is contemplated that overcome at least one defect of existing suction experiment, there is provided a kind of hand-held dry powder aerosol lung is passed
Device is sent, it can be inserted directly into the pipe of experimental animal and dry powder aerosol occurs again, and sample can be realized to animal lung
Effective delivering, animal can realize accurate quantitative analysis to the actual inhalation dose of sample, while such a contaminating mode simulates human body
Actual breathing state to may be inhaled thing.
Therefore, the invention provides a kind of hand-held dry powder aerosol lung delivery apparatus, it includes：
Gas supply part, it has syringe, and the gas supply part is configured with the piston promotion note of the syringe
Air in the injection tube of emitter flows out the gas supply part, to provide air stream；
Generating unit, be connected to the gas supply part, be configured to receive the air stream, and make its interior dry powder at least partially in
The air stream is moved with air stream under driving and diffuses to form dry powder aerosol；With
Delivery portion, the delivery portion have delivery tube, and the entrance point of the delivery tube is connected to the generating unit, to receive
The dry powder aerosol, the port of export of the delivery tube are configured to insert animal tracheal strips, to be delivered to the animal tracheal strips
The dry powder aerosol.
Further, the flow direction of air stream described in the generating unit interior edge successively and coaxially define dry powder chamber,
Accelerating cavity and scattered chamber；
The dry powder chamber is the conical cavity that extension is inwardly tapered from the entrance point of the generating unit；
The accelerating cavity includes connecting the Connectivity Section of the dry powder chamber and to connect the scattered chamber and cross section be rectangle
Tapered cavity section, and the outlet of the tapered cavity section is in slot-shaped；
The scattered chamber is along the tapered conical cavity in the flow direction of the air stream.
Further, the generating unit includes：
Housing, its one end have the dry powder chamber, and its other end has accommodating chamber；
Accelerate cavity, be installed in the accommodating chamber, there is the accelerating cavity in it；
Distribution cavity, it is installed in the accommodating chamber, there is the scattered chamber in it.
Further, the gas supply part is configured to make the speed of the air stream of the outflow gas supply part to have vertically
In the velocity component of the axis direction of the dry powder chamber.
Further, the gas supply part also includes air interchanger, and described air interchanger one end is connected to the syringe, separately
One end is connected to the generating unit, and
The air interchanger is configured to：
Become hour in the injection cylinder pressure, outside air is entered via it in the injection tube；And
When the injection cylinder pressure becomes big, the air in the injection tube is set to enter the generating unit via it.
Further, the air interchanger includes：
Ventilation pipe, its one end is connected to the syringe, and its other end is connected to the generating unit, has along its length in it
The ventilation lumen of direction extension is spent, the air intlet for connecting the ventilation lumen is offered on its perisporium；
First check valve, it is installed at the air intlet, is configured to become hour in the injection cylinder pressure, makes the external world
Air enters in the injection tube via it；And
Second check valve, it is installed in the ventilation lumen, is configured to, when the injection cylinder pressure becomes big, make the note
Air in shooting cylinder enters the generating unit via it.
Further, the ventilation lumen includes being connected to the ventilation section of the injection tube and is connected to going out for the generating unit
Mouth section, the diameter of the outlet section are more than the diameter of the ventilation section；
Second check valve is installed on the intersection of the ventilation section and the outlet section, and the second check valve bag
Closing cap is included, the diameter of the ventilation section is had a diameter larger than, less than the diameter of the outlet section；And
The entrance point of the generating unit inserts the outlet section of the ventilation lumen.
Further, the generating unit also includes fixing pipe, and its one end is plugged in or be threadingly attached to the receiving
The end of chamber, and mohs tapered bore of the opening towards the delivery portion is defined in it；
The delivery portion also includes Mohs conehead, is installed in the delivery tube, and the Mohs conehead inserts the Mohs
Taper hole, the delivery portion is installed on the generating unit.
Further, the outer peripheral face of the port of export of the delivery tube is the flow direction elder generation flaring along the dry powder aerosol
Tapered curved surface afterwards.
Further, the delivery tube is rectilinear tubes, or the delivery tube include two intersect it is straight in 100 ° to 150 °
Spool section；
The injection tube includes accurate high-boron-silicon glass pipe, and the accurate high-boron-silicon glass pipe outer cladding it is stainless
Steel sheel.
The hand-held dry powder aerosol lung delivery apparatus of the present invention can make the dress by gas supply part, generating unit and delivery portion
Put and be directly inserted into animal pipe dry powder aerosol occurs again, sample is effectively delivered to animal lung.Especially, occur
The sample powder of the dry powder intracavitary in portion is entered in the form of an aerosol in animal body and all by pulmonary absorption, its real simulation
Human body daily suction condition and accurate quantitative analysis can be carried out to the actual inhalation dose of animal, it is real especially suitable for suction
Test.
Brief description of the drawings
Some specific embodiments of the present invention are described in detail by way of example, and not by way of limitation with reference to the accompanying drawings hereinafter.
Identical reference denotes same or similar part or part in accompanying drawing.It should be appreciated by those skilled in the art that these
What accompanying drawing was not necessarily drawn to scale.In accompanying drawing：
Fig. 1 is the schematic diagram according to the hand-held dry powder aerosol lung delivery apparatus of one embodiment of the invention；
Fig. 2 is the schematic explosive view of hand-held dry powder aerosol lung delivery apparatus shown in Fig. 1；
Fig. 3 is the schematic cross sectional views of hand-held dry powder aerosol lung delivery apparatus shown in Fig. 1；
Fig. 4 is the schematic expanded view at A in Fig. 3.
Embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below in conjunction with accompanying drawing to specific real
Example is applied to be described in detail.
Fig. 1 is the schematic diagram according to the hand-held dry powder aerosol lung delivery apparatus of one embodiment of the invention.
Shown in such as Fig. 1 and referring to figs. 2 to Fig. 4, the embodiments of the invention provide a kind of hand-held dry powder aerosol lung delivery apparatus, the hand
Holding formula dry powder aerosol lung delivery apparatus includes gas supply part 10, generating unit 20 and delivery portion 30.Specifically, gas supply part 10 has note
Emitter 11, and gas supply part 10 is configured with the air outflow supply in the injection tube of the piston pushing syringe 11 of syringe 11
Portion 10, to provide air stream.Generating unit 20 is connected to gas supply part 10, is configured to receive the air stream from syringe 11, and make
Moved under being driven at least partially in air stream of the dry powder accommodated in generating unit 20 with air stream and diffuse to form dry powder
Aerosol.Delivery portion 30 has delivery tube 31, and the entrance point of delivery tube 31 is connected to generating unit 20, to receive dry powder aerosol,
The port of export of delivery tube 31 is configured to insert animal tracheal strips, to deliver dry powder aerosol.
The hand-held dry powder aerosol lung delivery apparatus of the present invention when in use, accommodates in the syringe 11 of gas supply part 10
Pure air, the piston of pushing syringe 11 form one air stream, and air stream enters generating unit 20, in the effect of air stream
Under, the sample powder (i.e. dry powder) accommodated in generating unit 20 is carried, rolls, spread, and ultimately forms dry powder aerosol.Dry powder
Aerosol enters in the delivery tube 31 of delivery portion 30, because delivery tube 31 has inserted animal pipe, then dry powder aerosol
Animal tracheal strips are then delivered to by it and then all by the pulmonary absorption of animal.
The hand-held dry powder aerosol lung delivery apparatus of the embodiment of the present invention relies on gas supply part 10, generating unit 20 and delivery portion
30 can make the device be directly inserted into animal pipe occurs dry powder aerosol again, sample is effectively delivered to animal lung
Portion.Especially, the sample powder of the dry powder intracavitary of generating unit 20 is entered in the form of an aerosol in animal body and all by lung
Portion absorbs, and its real simulation human body daily suction condition and can carry out accurate quantitative analysis to the actual inhalation dose of animal.
Moreover, the sample powder of the present apparatus not only includes drug sample, the Medicines of powder, in addition to health care are such as made
Product, agricultural chemicals, chemicals, cosmetics and environmental contaminants (such as PM2.5, PM10) inhalable particles/powder.In addition, this is hand-held
Formula dry powder aerosol lung delivery apparatus is hand-held, manual operation, simple in construction, small volume, easy to use.
In some embodiments of the invention, the flow direction of the interior edge air stream of generating unit 20 defines successively and coaxially
Dry powder chamber, accelerating cavity and scattered chamber.Dry powder chamber is the conical cavity that extension is inwardly tapered from the entrance point of generating unit 20, in order to dry
The receiving of powder and dry powder are carried by air stream.Accelerating cavity includes the Connectivity Section of connection dry powder chamber and connected disperseing chamber and cross section and being
Rectangular tapered cavity section, and the outlet of tapered cavity section is in slot-shaped.The Connectivity Section of dry powder chamber can be cylinder.Scattered chamber is edge
The tapered conical cavity in the flow direction of air stream.The special construction of the inner chamber body of generating unit 20, can make accommodated sample powder (i.e.
Dry powder) it is carried, roll, spreads well, form the aerosol of even concentration.
Specifically, in some embodiments of the embodiment, generating unit 20 may include housing 21, accelerate cavity 22 and divide
Dissipate cavity 23.One end of housing 21 has dry powder chamber, and the other end has accommodating chamber.Cavity 22 is accelerated to be installed in accommodating chamber, its
It is interior that there is accelerating cavity.Distribution cavity 23 is installed in accommodating chamber, and it is interior with scattered chamber.Accelerate cavity 22 and distribution cavity 23
Outer peripheral face is cylinder, can be manufactured using injection molding process.
In some alternative embodiments of the embodiment, generating unit 20 may also comprise housing, accelerate cavity and disperse
Cavity.However, one end of housing has Connectivity Section and the accommodating chamber of dry powder chamber and accelerating cavity.Only limited in accelerating cavity body
It is rectangular tapered cavity section that the connection of accelerating cavity, which disperses chamber and cross section,.There is scattered chamber in distribution cavity.In the embodiment
Other alternative embodiments in, generating unit 20 may include that housing, first accelerate cavity, second to accelerate cavity and scattered chamber
Body.One end of housing has dry powder chamber, and the other end has accommodating chamber.The Connectivity Section of accelerating cavity is limited in first accelerating cavity body,
The scattered chamber of connection and cross section that accelerating cavity is limited in second accelerating cavity body are rectangular tapered cavity section.Have in distribution cavity
There is scattered chamber.
In some embodiments of the invention, it may also include ventilation for the ease of air inlet in injection tube, gas supply part 10
Device 12, its one end are connected to syringe 11, and the other end is connected to generating unit 20.The effect of air interchanger 12 is to work as injection tube
When interior pressure diminishes, outside air is set to enter via it in injection tube；When injection cylinder pressure becomes big, make the sky in injection tube
Gas enters generating unit 20 via it.In other words, when pulling back the piston rod of syringe 11, outside air can fill via ventilation
12 are put to enter in injection tube and then lay in air；When pushing ahead the piston rod of syringe 11, air in injection tube can be through
Generating unit 20 is entered by air interchanger 12 to provide source of the gas to form dry powder aerosol.The and so on piston of push-and-pull syringe 11
Bar is to complete the release of air and deposit, so as to which dry powder aerosol sustainably occur.
Air interchanger 12 may include take a breath pipe 121, the first check valve 122 and the second check valve 123.The one of ventilation pipe 121
End is connected to syringe 11, and its other end is connected to generating unit 20, has the ventilation lumen extended along its length, its week in it
The air intlet of connection ventilation lumen is offered on wall.First check valve 122 is installed at air intlet, is configured in injection tube
Pressure becomes hour, outside air is entered via it in injection tube.Second check valve 123 is installed in ventilation lumen, is configured to
When injection cylinder pressure becomes big, the air in injection tube is set to enter generating unit 20 via it.
Homogeneous dry powder aerosol is formed to make the sample powder in generating unit 20 be uniformly dispersed, in some realities of the present invention
Apply in example, the speed that gas supply part 10 is configured to make the air stream of outflow gas supply part 10 is with the axis direction perpendicular to dry powder chamber
Velocity component.That is, the air stream of outflow gas supply part 10 forms roughly annular or/spiral shell in the presence of gas supply part 10
Annular/helical flow of shape is revolved, is compared with straight air flow, annular/helical flow is easier to the sample in generating unit 20
Product powder is rolled, spread and then forms more homogeneous dry powder aerosol.
For example, ventilation lumen includes being connected to the ventilation section of injection tube and is connected to the outlet section of generating unit 20, outlet section
Diameter is more than the diameter of ventilation section.That is, ventilation lumen has step surface.Second check valve 123 is installed on ventilation section and gone out
The intersection of mouth section, and the second check valve 123 includes closing cap, has a diameter larger than the diameter of ventilation section, it is straight less than outlet section
Footpath.When needing to close the second check valve 123, the closing cap of the second check valve 123 can contact against with step surface.When the second list
After being opened to valve 123, air stream can collide closing cap and be changed so as to flow to, after collide the outlet section internal perisporium of ventilation lumen
On, form annular airflow or helical flow.
Moreover, in this embodiment, the outlet section of the entrance point insertion ventilation lumen of generating unit 20, specifically, make housing 21
With dry powder chamber one end insertion ventilation lumen outlet section.The speed for the air stream that outflow gas supply part 10 can be made so is set
Velocity component with the axis direction perpendicular to dry powder chamber, that is to say, that can make annular airflow or helical flow roll it is dry
The sample powder of powder intracavitary.
In some embodiments of the invention, generating unit 20 also includes fixing pipe 24, and its one end is plugged in or passed through screw thread
The end of the accommodating chamber of housing 21 is connected to, and mohs tapered bore of the opening towards delivery portion 30 is defined in it.Delivery portion 30 is also
Including Mohs conehead 32, it is installed in delivery tube 31, Mohs conehead 32 inserts mohs tapered bore, and delivery portion 30 is installed on into generation
Portion 20.
Further, to ensure the intensity and precision of syringe 11 in the present apparatus, the injection tube of syringe 11 can be by high boron
The Stainless Steel Shell composition that silica glass tube and its outer surface are coated with.The piston of syringe 11 may include piston portion and push rod portion.
For the ease of the demand of actual experiment, for different animals, delivery tube 31 is rectilinear tubes or intersected by two
Formed in 100 ° to 150 ° of straight line pipeline sections, angle typically selects 120 °, 125 ° etc..Delivery tube 31 may be designed as random length,
The external diameter of delivery tube 31 can be 300 to 350 microns, so that the hand-held liquid aerosol lung delivery apparatus of the present invention can fit
For the toys such as mouse, rat, rabbit, dog and horse or lung's aerosol delivery of big animal.Further, delivered to reduce
Pipe 31 inserts the damage in withdrawal process to tracheae to animal tracheae, and the outer peripheral face of the port of export of delivery tube 31 is molten along dry powder gas
Tapered curved surface after the flow direction elder generation flaring of glue.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, any improvements and modifications made also should be regarded as the protection of the present invention
Scope.
Claims (10)
- A kind of 1. hand-held dry powder aerosol lung delivery apparatus, it is characterised in that including：Gas supply part, it has syringe, and the gas supply part is configured with the piston promotion syringe of the syringe Injection tube in air flow out the gas supply part, to provide air stream；Generating unit, be connected to the gas supply part, be configured to receive the air stream, and make its interior dry powder at least partially in described Air stream is moved with air stream under driving and diffuses to form dry powder aerosol；WithDelivery portion, the delivery portion have delivery tube, and the entrance point of the delivery tube is connected to the generating unit, with described in reception Dry powder aerosol, the port of export of the delivery tube are configured to insert animal tracheal strips, with to described in animal tracheal strips delivering Dry powder aerosol.
- 2. hand-held dry powder aerosol lung delivery apparatus according to claim 1, it is characterised in thatThe flow direction of air stream described in the generating unit interior edge defines successively and coaxially dry powder chamber, accelerating cavity and scattered Chamber；The dry powder chamber is the conical cavity that extension is inwardly tapered from the entrance point of the generating unit；The accelerating cavity include connecting the Connectivity Section of the dry powder chamber and connect the scattered chamber and cross section be it is rectangular gradually Contracting chamber section, and the outlet of the tapered cavity section is in slot-shaped；The scattered chamber is along the tapered conical cavity in the flow direction of the air stream.
- 3. hand-held dry powder aerosol lung delivery apparatus according to claim 2, it is characterised in that the generating unit bag Include：Housing, its one end have the dry powder chamber, and its other end has accommodating chamber；Accelerate cavity, be installed in the accommodating chamber, there is the accelerating cavity in it；Distribution cavity, it is installed in the accommodating chamber, there is the scattered chamber in it.
- 4. hand-held dry powder aerosol lung delivery apparatus according to claim 2, it is characterised in thatThe gas supply part is configured to make the speed of the air stream of the outflow gas supply part to have perpendicular to the dry powder chamber Axis direction velocity component.
- 5. hand-held dry powder aerosol lung delivery apparatus according to claim 1, it is characterised in thatThe gas supply part also includes air interchanger, and described air interchanger one end is connected to the syringe, and the other end is connected to institute Generating unit is stated, andThe air interchanger is configured to：Become hour in the injection cylinder pressure, outside air is entered via it in the injection tube；AndWhen the injection cylinder pressure becomes big, the air in the injection tube is set to enter the generating unit via it.
- 6. hand-held dry powder aerosol lung delivery apparatus according to claim 5, it is characterised in that the air interchanger bag Include：Ventilation pipe, its one end are connected to the syringe, and its other end is connected to the generating unit, and it is interior with side along its length To the ventilation lumen of extension, the air intlet for connecting the ventilation lumen is offered on its perisporium；First check valve, it is installed at the air intlet, is configured to become hour in the injection cylinder pressure, makes outside air Enter via it in the injection tube；AndSecond check valve, it is installed in the ventilation lumen, is configured to, when the injection cylinder pressure becomes big, make the injection tube Interior air enters the generating unit via it.
- 7. hand-held dry powder aerosol lung delivery apparatus according to claim 6, it is characterised in thatThe ventilation lumen includes being connected to the ventilation section of the injection tube and is connected to the outlet section of the generating unit, the outlet The diameter of section is more than the diameter of the ventilation section；Second check valve is installed on the intersection of the ventilation section and the outlet section, and second check valve includes envelope Lid is closed, the diameter of the ventilation section is had a diameter larger than, less than the diameter of the outlet section；AndThe entrance point of the generating unit inserts the outlet section of the ventilation lumen.
- 8. hand-held dry powder aerosol lung delivery apparatus according to claim 3, it is characterised in thatThe generating unit also includes fixing pipe, and its one end is plugged in or be threadingly attached to the end of the accommodating chamber, and its Inside define mohs tapered bore of the opening towards the delivery portion；The delivery portion also includes Mohs conehead, is installed in the delivery tube, and the Mohs conehead inserts the mohs tapered bore, So that the delivery portion is installed on into the generating unit.
- 9. hand-held dry powder aerosol lung delivery apparatus according to claim 1, it is characterised in that the delivery tube goes out The outer peripheral face at mouth end is along curved surface tapered after the flow direction elder generation flaring of the dry powder aerosol.
- 10. hand-held dry powder aerosol lung delivery apparatus according to claim 1, it is characterised in thatThe delivery tube is rectilinear tubes, or the delivery tube includes two straight line pipeline sections intersected in 100 ° to 150 °；The injection tube includes accurate high-boron-silicon glass pipe, and the stainless steel case that the accurate high-boron-silicon glass pipe outer cladding Body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610685625.5A CN107753147A (en) | 2016-08-18 | 2016-08-18 | Hand-held dry powder aerosol lung delivery apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610685625.5A CN107753147A (en) | 2016-08-18 | 2016-08-18 | Hand-held dry powder aerosol lung delivery apparatus |
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| Publication Number | Publication Date |
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| CN107753147A true CN107753147A (en) | 2018-03-06 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610685625.5A Pending CN107753147A (en) | 2016-08-18 | 2016-08-18 | Hand-held dry powder aerosol lung delivery apparatus |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114229484A (en) * | 2021-12-20 | 2022-03-25 | 杭州绿洁环境科技股份有限公司 | Dry powder aerosol generator |
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| CN105749386A (en) * | 2015-03-21 | 2016-07-13 | 深圳百美酶生物医药科技有限公司 | Hand-operated dry powder inhaler and application in curing diabetes |
| WO2016115379A1 (en) * | 2015-01-14 | 2016-07-21 | Respira Therapeutics, Inc. | Powder dispersion methods and devices |
| CN206414365U (en) * | 2016-08-18 | 2017-08-18 | 中国人民解放军军事医学科学院微生物流行病研究所 | Hand-held dry powder aerosol lung delivery apparatus |
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| CN1920096A (en) * | 2005-08-24 | 2007-02-28 | 兄弟工业株式会社 | Film forming apparatus and jetting nozzle |
| CN201847994U (en) * | 2010-07-14 | 2011-06-01 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | Tracheal cannula experimental facility |
| WO2016115379A1 (en) * | 2015-01-14 | 2016-07-21 | Respira Therapeutics, Inc. | Powder dispersion methods and devices |
| CN105749386A (en) * | 2015-03-21 | 2016-07-13 | 深圳百美酶生物医药科技有限公司 | Hand-operated dry powder inhaler and application in curing diabetes |
| CN206414365U (en) * | 2016-08-18 | 2017-08-18 | 中国人民解放军军事医学科学院微生物流行病研究所 | Hand-held dry powder aerosol lung delivery apparatus |
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| CN114229484A (en) * | 2021-12-20 | 2022-03-25 | 杭州绿洁环境科技股份有限公司 | Dry powder aerosol generator |
| CN114229484B (en) * | 2021-12-20 | 2023-05-16 | 杭州绿洁科技股份有限公司 | Dry powder aerosol generator |
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