CN107744587A - A kind of sea cucumber wine for improving cardiovascular function and preparation method thereof - Google Patents
A kind of sea cucumber wine for improving cardiovascular function and preparation method thereof Download PDFInfo
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- CN107744587A CN107744587A CN201710824171.XA CN201710824171A CN107744587A CN 107744587 A CN107744587 A CN 107744587A CN 201710824171 A CN201710824171 A CN 201710824171A CN 107744587 A CN107744587 A CN 107744587A
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
- C12G3/00—Preparation of other alcoholic beverages
- C12G3/04—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The present invention relates to sea cucumber field of deep, more particularly to a kind of sea cucumber wine for improving cardiovascular function and preparation method thereof.The sea cucumber wine of the present invention for improving cardiovascular function, raw material include：Base liquor, sea cucumber peptide liquid, Chinese medicine extract, the Chinese medicine extract raw material include：Cordyceps sinensis, ganoderma lucidum, matrimony vine, Poria cocos, hawthorn, the Radix Astragali, the red sage root.This sea cucumber has preferable adjuvant treatment effect to cardiovascular patient with regard in good taste.
Description
Technical field
The present invention relates to sea cucumber field of deep, more particularly to a kind of sea cucumber wine for improving cardiovascular function and its preparation side
Method.
Background technology
Sea cucumber, it is one of eight big treasure of the world, it is equally celebrated for their achievements with ginseng, bird's nest, shark's fin.According to《A Supplement to the Compendium of Materia Medica》Described in：
Sea cucumber, sweet-salty, kidney tonifying, benefiting quintessence take the photograph urine, and impotence, its warm-natured benefit, sufficient enemy's ginseng, therefore named sea cucumber are treated in establishing-Yang.Modern study table
Bright, sea cucumber has very big benefit to the people that has a heart disease.HF-reducing blood lipid, suppress blood clotting, hypertension, high blood
Fat, coronary heart disease, hepatitis and in, the elderly, adhere to beche-de-mer for a long time, to improve cardiovascular function have good result.
Do not have a sea cucumber wine for improving cardiovascular function on the market at present.
The content of the invention
Improve the sea cucumber wine of cardiovascular function it is an object of the invention to provide a kind of, while provide its preparation method.
To solve above technical problem, the technical solution adopted by the present invention is：
The sea cucumber wine of the present invention for improving cardiovascular function, raw material include：Base liquor, sea cucumber peptide liquid, Chinese medicine extract,
The Chinese medicine extract raw material includes：Cordyceps sinensis, ganoderma lucidum, matrimony vine, Poria cocos, hawthorn, the Radix Astragali, the red sage root.
Preferably, it is made up of the component of following parts by weight：
Sea cucumber peptide 10~20wt% of liquid, 1~20wt% of Chinese medicine extract, remaining is base liquor；
The base liquor is the grain original plasm wine of more than 60 ° of alcoholic strength.
Preferably, the Chinese medicine extract is prepared from the following raw materials in parts by weight：
The preparation method of the sea cucumber wine of the present invention for improving cardiovascular function, step include the system of Chinese medicine extract
It is standby：
1) cordyceps sinensis, ganoderma lucidum, matrimony vine, Poria cocos, hawthorn, the Radix Astragali, the red sage root are mixed, soaked 3-4 days with base liquor, centre is stirred
Mix 6-8 times；
2) heating is boiled, and flow back 3~6h, cools down, and filtering, obtains extracts of Chinese herbal medicine.
Preferably, step also includes the preparation of sea cucumber peptide liquid：
Fresh sea cucumber processing is clean, crushed, add base liquor, heating, add boiling to boil, cool, add compound egg
White enzyme, mix, digest, filtering, obtain sea cucumber peptide liquid.
Preferably, in the preparation process of sea cucumber peptide liquid：The addition of base liquor is the 50wt% of sea cucumber weight.
Preferably, in the preparation process of sea cucumber peptide liquid：Heating-up temperature is 75~80 DEG C, heat time 20min.
Preferably, in the preparation process of sea cucumber peptide liquid：The addition of water is 2 times of base liquor and sea cucumber gross weight.
Preferably, in the preparation process of sea cucumber peptide liquid：The addition of compound protease is the 1.0wt%- of sea cucumber weight
1.5wt%, hydrolysis temperature are 40-50 DEG C, enzymolysis time 2h.
Preferably, step is also included sea cucumber peptide liquid, Chinese medicine extract, base liquor, is proportionally blent, at normal temperatures
Store at least three moon.
Sea cucumber has very big benefit to the people that has a heart disease.HF-reducing blood lipid, suppression blood clotting, hypertension,
High fat of blood, coronary heart disease, hepatitis and in, the elderly, adhere to beche-de-mer for a long time, have good effect to alleviating illness and treatment
Fruit.
Cordyceps sinensis can work under cell excitement state, and excitement L-type passage calcium, L-type passage calcium are mainly distributed
In skeletal muscle and cardiac muscle, its function is regulation and control excitation-contraction coupling.Cordyceps sinensis Aqueous extracts can promote cardiac muscle cell's Ca2+ influx, and then touch
Myocardium excitation and contraction are sent out, makes SA node and chamber ganglion cell excited, so as to play its positive heart myodyamia effect；Cordyceps sinensis has obvious
Reducing blood lipid effect, while cardiac muscle nutritional blood flow can be increased, there is decreasing heart rate and of short duration antihypertensive effect.
Ganoderma lucidum, which can increase the total CBF and can of coronary artery, increases myocardium blood capillary flow, improves Myocardial Microcirculation, and reduce the heart
Myocardial oxygen consumption, GL-B have antithrombotic and anticoagulant effect, suppress platelet aggregation, improve blood viscosity and confrontation blood
Bolt is formed.
Poria cocos has enhancing to shrink, accelerates heart rate function.
Hawthorn can reduce serum cholesterol and the ester of glycerine three, effectively prevent and treat atherosclerosis；Hawthorn can also pass through enhancing
Myocardial contractive power, increase cardiac output, expansion of coronary artery, increase coronary blood flow, reduction myocardial oxygen consumption etc. play
Cardiac stimulant and the anginal effect of prevention.In addition, the general flavone in hawthorn plays the role of to expand blood vessel and lasting buck.
The Radix Astragali has cardiotonic, increases heart contraction amplitude, output quantity increase, to poisoning or Fatigue failure heart
Effect becomes apparent.Astragalus polyose can resist acute myocardial ischemia caused by posterior pituitary rope.
The red sage root：Strengthen myocardial contractive power, improve cardiac function, do not increase myocardial oxygen consumption；Coronary artery is expanded, increases myocardium blood
Flow；Expand peripheral vascular, blood flow increase；Cerebral blood flow (CBF) declines；Improve plasmin activity；Extend bleeding and cotting time；Suppress blood
Platelet is assembled.
Compared with prior art, the invention has the advantages that：This sea cucumber is with regard in good taste, to cardiovascular patient
With preferable adjuvant treatment effect.
Embodiment
Technical solution of the present invention is described in detail with reference to specific embodiment.
Embodiment 1
(1) preparation of sea cucumber peptide liquid
Fresh sea cucumber processing is clean, crushed.Add relative sea cucumber and crush liquid product 50%, temperature is at 40 DEG C
Grain original plasm wine, the alcoholic strength of grain original plasm wine is 68 °, after being heated to 75 DEG C, 30 minutes, adds sea cucumber and grain original plasm wine is total
The water that 2 times of weight is mixed to form solution, and heating is boiled 20 minutes, is cooled to 50 DEG C, adds sea cucumber weight 1.5wt% compound egg
White enzyme, mixing mix, and after 2h, are heated to 100 DEG C of progress enzyme deactivations.It is separated by filtration, obtains sea cucumber peptide liquid.
(2) preparation of Chinese medicine extract
From the Chinese medicine of following parts by weight：
Cordyceps sinensis, ganoderma lucidum, matrimony vine, Poria cocos, hawthorn, the Radix Astragali, the red sage root are mixed, solvent is from the grain that alcoholic strength is 68 °
Original plasm wine is eaten, is soaked 3 days, intermediate agitation 7 times, heating is boiled, and flow back 3h, cools down, and filtering, obtains extracts of Chinese herbal medicine.
(3) the extracts of Chinese herbal medicine mixing that the sea cucumber peptide liquid and step (2) obtained step (1) obtains, adds grain wine
Blent so that alcoholic strength reaches 30 °, stores 3 months at normal temperatures, and filtering is canned.
Embodiment 2
(1) preparation of sea cucumber peptide liquid
Fresh sea cucumber processing is clean, crushed.Add relative sea cucumber and crush liquid product 50%, temperature is at 40 DEG C
Grain original plasm wine, the alcoholic strength of grain original plasm wine is 68 °, after being heated to 80 DEG C, 30 minutes, adds sea cucumber and grain original plasm wine is total
The water that 2 times of weight is mixed to form solution, and heating is boiled 20 minutes, is cooled to 40 DEG C, adds sea cucumber weight 1wt% compound proteins
Enzyme, mixing mix, and after 2h, are heated to 100 DEG C of progress enzyme deactivations.It is separated by filtration, obtains sea cucumber peptide liquid.
(2) preparation of Chinese medicine extract
From the Chinese medicine of following parts by weight：
Cordyceps sinensis, ganoderma lucidum, matrimony vine, Poria cocos, hawthorn, the Radix Astragali, the red sage root are mixed, solvent is from the grain that alcoholic strength is 68 °
Original plasm wine is eaten, is soaked 4 days, intermediate agitation 8 times, heating is boiled, and flow back 6h, cools down, and filtering, obtains extracts of Chinese herbal medicine.
(3) the extracts of Chinese herbal medicine mixing that the sea cucumber peptide liquid and step (2) obtained step (1) obtains, adds grain wine
Blent so that alcoholic strength reaches 30 °, stores 3 months at normal temperatures, and filtering is canned.
Embodiment 3
(1) preparation of sea cucumber peptide liquid
Fresh sea cucumber processing is clean, crushed.Add relative sea cucumber and crush liquid product 50%, temperature is at 40 DEG C
Grain original plasm wine, the alcoholic strength of grain original plasm wine is 68 °, after being heated to 80 DEG C, 30 minutes, adds sea cucumber and grain original plasm wine is total
The water that 2 times of weight is mixed to form solution, and heating is boiled 20 minutes, is cooled to 45 DEG C, adds sea cucumber weight 1.3wt% compound proteins
Enzyme, mixing mix, and after 2h, are heated to 100 DEG C of progress enzyme deactivations.It is separated by filtration, obtains sea cucumber peptide liquid.
(2) preparation of Chinese medicine extract
From the Chinese medicine of following parts by weight：
Cordyceps sinensis, ganoderma lucidum, matrimony vine, Poria cocos, hawthorn, the Radix Astragali, the red sage root are mixed, solvent is from the grain that alcoholic strength is 68 °
Original plasm wine is eaten, is soaked 4 days, intermediate agitation 8 times, heating is boiled, and flow back 5h, cools down, and filtering, obtains extracts of Chinese herbal medicine.
(3) the extracts of Chinese herbal medicine mixing that the sea cucumber peptide liquid and step (2) obtained step (1) obtains, adds grain wine
Blent so that alcoholic strength reaches 30 °, stores 3 months at normal temperatures, and filtering is canned.
Claims (10)
1. a kind of sea cucumber wine for improving cardiovascular function, it is characterised in that raw material includes：Base liquor, sea cucumber peptide liquid, traditional Chinese medicine extraction
Liquid,
The Chinese medicine extract raw material includes：Cordyceps sinensis, ganoderma lucidum, matrimony vine, Poria cocos, hawthorn, the Radix Astragali, the red sage root.
2. the sea cucumber wine according to claim 1 for improving cardiovascular function, it is characterised in that by the group of following parts by weight
It is grouped into：
Sea cucumber peptide 10~20wt% of liquid, 1~20wt% of Chinese medicine extract, remaining is base liquor；
The base liquor is the grain original plasm wine of more than 60 ° of alcoholic strength.
3. it is according to claim 1 improve cardiovascular function sea cucumber wine, it is characterised in that the Chinese medicine extract by with
The raw material of lower parts by weight is made：
4. the preparation method of the sea cucumber wine of the improvement cardiovascular function described in a kind of claim 1, it is characterised in that step includes
The preparation of Chinese medicine extract：
1) cordyceps sinensis, ganoderma lucidum, matrimony vine, Poria cocos, hawthorn, the Radix Astragali, the red sage root are mixed, soaked 3-4 days with base liquor, intermediate agitation 6-
8 times；
2) heating is boiled, and flow back 3~6h, cools down, and filtering, obtains extracts of Chinese herbal medicine.
5. the preparation method of the sea cucumber wine according to claim 4 for improving cardiovascular function, it is characterised in that step is also wrapped
Include the preparation of sea cucumber peptide liquid：
Fresh sea cucumber processing is clean, crushed, add base liquor, heating, add boiling to boil, cool, add compound protease,
Mix, digest, filtering, obtain sea cucumber peptide liquid.
6. the preparation method of the sea cucumber wine according to claim 5 for improving cardiovascular function, it is characterised in that sea cucumber peptide liquid
Preparation process in：The addition of base liquor is the 50wt% of sea cucumber weight.
7. the preparation method of the sea cucumber wine according to claim 5 for improving cardiovascular function, it is characterised in that sea cucumber peptide liquid
Preparation process in：Heating-up temperature is 75~80 DEG C, heat time 20min.
8. the preparation method of the sea cucumber wine according to claim 5 for improving cardiovascular function, it is characterised in that sea cucumber peptide liquid
Preparation process in：The addition of water is 2 times of base liquor and sea cucumber gross weight.
9. the preparation method of the sea cucumber wine according to claim 5 for improving cardiovascular function, it is characterised in that sea cucumber peptide liquid
Preparation process in：The addition of compound protease is the 1.0wt%-1.5wt% of sea cucumber weight, and hydrolysis temperature is 40-50 DEG C,
Enzymolysis time is 2h.
10. according to the preparation method of the sea cucumber wine of improvement cardiovascular function according to claim 4, it is characterised in that step
Suddenly also include sea cucumber peptide liquid, Chinese medicine extract, base liquor, proportionally blent, store at least three moon at normal temperatures.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710824171.XA CN107744587A (en) | 2017-09-13 | 2017-09-13 | A kind of sea cucumber wine for improving cardiovascular function and preparation method thereof |
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| CN201710824171.XA CN107744587A (en) | 2017-09-13 | 2017-09-13 | A kind of sea cucumber wine for improving cardiovascular function and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113831994A (en) * | 2020-06-24 | 2021-12-24 | 青岛越群生物科技有限公司 | Wind-dispelling spleen-tonifying sea cucumber wine and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113831994A (en) * | 2020-06-24 | 2021-12-24 | 青岛越群生物科技有限公司 | Wind-dispelling spleen-tonifying sea cucumber wine and preparation method thereof |
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