CN107744140A - 一种预消化型全营养液及其制备方法 - Google Patents
一种预消化型全营养液及其制备方法 Download PDFInfo
- Publication number
- CN107744140A CN107744140A CN201711075108.7A CN201711075108A CN107744140A CN 107744140 A CN107744140 A CN 107744140A CN 201711075108 A CN201711075108 A CN 201711075108A CN 107744140 A CN107744140 A CN 107744140A
- Authority
- CN
- China
- Prior art keywords
- predigestion
- pancebrin
- type
- vitamin
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000003921 oil Substances 0.000 claims abstract description 18
- 235000019198 oils Nutrition 0.000 claims abstract description 18
- 235000015097 nutrients Nutrition 0.000 claims abstract description 17
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 11
- 239000011707 mineral Substances 0.000 claims abstract description 11
- 229940088594 vitamin Drugs 0.000 claims abstract description 11
- 229930003231 vitamin Natural products 0.000 claims abstract description 11
- 235000013343 vitamin Nutrition 0.000 claims abstract description 11
- 239000011782 vitamin Substances 0.000 claims abstract description 11
- 150000003722 vitamin derivatives Chemical class 0.000 claims abstract description 11
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 7
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 7
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 7
- 239000003381 stabilizer Substances 0.000 claims abstract description 7
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 7
- 239000008158 vegetable oil Substances 0.000 claims abstract description 7
- 150000001875 compounds Chemical class 0.000 claims abstract description 5
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 5
- 239000012071 phase Substances 0.000 claims description 18
- 230000001954 sterilising effect Effects 0.000 claims description 17
- 238000011049 filling Methods 0.000 claims description 15
- 238000003756 stirring Methods 0.000 claims description 15
- 102000004169 proteins and genes Human genes 0.000 claims description 14
- 108090000623 proteins and genes Proteins 0.000 claims description 14
- 238000013329 compounding Methods 0.000 claims description 12
- 238000004659 sterilization and disinfection Methods 0.000 claims description 12
- 239000008346 aqueous phase Substances 0.000 claims description 9
- 230000003301 hydrolyzing effect Effects 0.000 claims description 9
- 244000068988 Glycine max Species 0.000 claims description 6
- 235000010469 Glycine max Nutrition 0.000 claims description 6
- 239000011521 glass Substances 0.000 claims description 6
- 238000010008 shearing Methods 0.000 claims description 6
- 238000003860 storage Methods 0.000 claims description 6
- 210000000481 breast Anatomy 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 4
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 4
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 4
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 4
- 235000004347 Perilla Nutrition 0.000 claims description 4
- 244000124853 Perilla frutescens Species 0.000 claims description 4
- 239000002285 corn oil Substances 0.000 claims description 4
- 235000005687 corn oil Nutrition 0.000 claims description 4
- 235000019197 fats Nutrition 0.000 claims description 4
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 4
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 4
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 4
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 4
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 4
- 229920001285 xanthan gum Polymers 0.000 claims description 4
- 235000019482 Palm oil Nutrition 0.000 claims description 3
- 108010079058 casein hydrolysate Proteins 0.000 claims description 3
- 239000003240 coconut oil Substances 0.000 claims description 3
- 235000019864 coconut oil Nutrition 0.000 claims description 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 3
- 238000004945 emulsification Methods 0.000 claims description 3
- 239000000194 fatty acid Substances 0.000 claims description 3
- 229930195729 fatty acid Natural products 0.000 claims description 3
- -1 fatty acid ester Chemical class 0.000 claims description 3
- 230000007062 hydrolysis Effects 0.000 claims description 3
- 238000006460 hydrolysis reaction Methods 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 239000011777 magnesium Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 239000002540 palm oil Substances 0.000 claims description 3
- 239000003549 soybean oil Substances 0.000 claims description 3
- 235000012424 soybean oil Nutrition 0.000 claims description 3
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 2
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 2
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 2
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 2
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 2
- 235000019484 Rapeseed oil Nutrition 0.000 claims description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 2
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 2
- 229930003779 Vitamin B12 Natural products 0.000 claims description 2
- 229930003471 Vitamin B2 Natural products 0.000 claims description 2
- 229930003316 Vitamin D Natural products 0.000 claims description 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 2
- 229930003448 Vitamin K Natural products 0.000 claims description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 2
- 229960002685 biotin Drugs 0.000 claims description 2
- 235000020958 biotin Nutrition 0.000 claims description 2
- 239000011616 biotin Substances 0.000 claims description 2
- 239000011575 calcium Substances 0.000 claims description 2
- 229910052791 calcium Inorganic materials 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims description 2
- 229910052802 copper Inorganic materials 0.000 claims description 2
- 239000010949 copper Substances 0.000 claims description 2
- 229960000304 folic acid Drugs 0.000 claims description 2
- 235000019152 folic acid Nutrition 0.000 claims description 2
- 239000011724 folic acid Substances 0.000 claims description 2
- 229910052742 iron Inorganic materials 0.000 claims description 2
- 235000020778 linoleic acid Nutrition 0.000 claims description 2
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims description 2
- 229910052749 magnesium Inorganic materials 0.000 claims description 2
- 229960003512 nicotinic acid Drugs 0.000 claims description 2
- 235000001968 nicotinic acid Nutrition 0.000 claims description 2
- 239000011664 nicotinic acid Substances 0.000 claims description 2
- 229940055726 pantothenic acid Drugs 0.000 claims description 2
- 235000019161 pantothenic acid Nutrition 0.000 claims description 2
- 239000011713 pantothenic acid Substances 0.000 claims description 2
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims description 2
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 2
- 229960002477 riboflavin Drugs 0.000 claims description 2
- 239000011669 selenium Substances 0.000 claims description 2
- 229910052711 selenium Inorganic materials 0.000 claims description 2
- 239000002195 soluble material Substances 0.000 claims description 2
- 235000013311 vegetables Nutrition 0.000 claims description 2
- 235000019163 vitamin B12 Nutrition 0.000 claims description 2
- 239000011715 vitamin B12 Substances 0.000 claims description 2
- 235000019164 vitamin B2 Nutrition 0.000 claims description 2
- 239000011716 vitamin B2 Substances 0.000 claims description 2
- 235000019158 vitamin B6 Nutrition 0.000 claims description 2
- 239000011726 vitamin B6 Substances 0.000 claims description 2
- 235000019166 vitamin D Nutrition 0.000 claims description 2
- 239000011710 vitamin D Substances 0.000 claims description 2
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 2
- 235000019168 vitamin K Nutrition 0.000 claims description 2
- 239000011712 vitamin K Substances 0.000 claims description 2
- 150000003721 vitamin K derivatives Chemical class 0.000 claims description 2
- 229940011671 vitamin b6 Drugs 0.000 claims description 2
- 229940046008 vitamin d Drugs 0.000 claims description 2
- 229940046010 vitamin k Drugs 0.000 claims description 2
- 239000011701 zinc Substances 0.000 claims description 2
- 229910052725 zinc Inorganic materials 0.000 claims description 2
- 102000004407 Lactalbumin Human genes 0.000 claims 1
- 108090000942 Lactalbumin Proteins 0.000 claims 1
- 235000009508 confectionery Nutrition 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 235000013305 food Nutrition 0.000 abstract description 2
- 230000006920 protein precipitation Effects 0.000 abstract description 2
- 235000016709 nutrition Nutrition 0.000 description 12
- 238000000034 method Methods 0.000 description 6
- 230000000968 intestinal effect Effects 0.000 description 5
- 210000000936 intestine Anatomy 0.000 description 5
- 230000035764 nutrition Effects 0.000 description 5
- 238000002192 cholecystectomy Methods 0.000 description 4
- 230000000050 nutritive effect Effects 0.000 description 4
- 230000002980 postoperative effect Effects 0.000 description 4
- 239000013049 sediment Substances 0.000 description 4
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 3
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 3
- 235000010489 acacia gum Nutrition 0.000 description 3
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000005189 flocculation Methods 0.000 description 3
- 230000016615 flocculation Effects 0.000 description 3
- 229940083466 soybean lecithin Drugs 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 102000009027 Albumins Human genes 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 206010016946 Food allergy Diseases 0.000 description 2
- 206010025476 Malabsorption Diseases 0.000 description 2
- 208000004155 Malabsorption Syndromes Diseases 0.000 description 2
- 206010033645 Pancreatitis Diseases 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 201000001352 cholecystitis Diseases 0.000 description 2
- 238000007457 cholecystostomy Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000000232 gallbladder Anatomy 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 238000005191 phase separation Methods 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- 208000000197 Acute Cholecystitis Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 206010008614 Cholecystitis acute Diseases 0.000 description 1
- 206010008617 Cholecystitis chronic Diseases 0.000 description 1
- 208000004845 Cholecystolithiasis Diseases 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 208000022072 Gallbladder Neoplasms Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- UEZVMMHDMIWARA-UHFFFAOYSA-N Metaphosphoric acid Chemical compound OP(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-N 0.000 description 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
- 102000015636 Oligopeptides Human genes 0.000 description 1
- 108010038807 Oligopeptides Proteins 0.000 description 1
- 102000007584 Prealbumin Human genes 0.000 description 1
- 108010071690 Prealbumin Proteins 0.000 description 1
- 102000002070 Transferrins Human genes 0.000 description 1
- 108010015865 Transferrins Proteins 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003451 Vitamin B1 Natural products 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 201000001883 cholelithiasis Diseases 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 201000010175 gallbladder cancer Diseases 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- 235000011082 potassium citrates Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pediatric Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
一种预消化型全营养液及其制备方法，属于医用食品加工领域。目的在于提供一种pH接近中性，不存在配伍禁忌，保质期较长且保质期内不会出现相分离和沉淀现象的预消化型全营养液。该预消化型全营养液，每升营养液中干物质含量为：水解蛋白质20‑60g，植物油8‑18g，麦芽糊精150‑300g，复配维生素0.2‑1g，复配矿物质0.2‑1.0g，乳化剂1‑10g，稳定剂1‑5g。该预消化型全营养液pH为6.5‑7.5，接近中性，不存在配伍禁忌，保质期长，且在保质期内不会出现水油两相分层和蛋白质沉淀现象，应用范围广。
Description
技术领域
本发明属于医用食品加工领域，尤其涉及预消化型全营养液及其制备方法。
背景技术
预消化型全营养液一般针对术前准备及术后营养支持，胃肠道吸收障碍、胰腺炎、炎性肠炎、蛋白质过敏等患者，其目的是为患者提供机体代谢所需的营养素，其配方宜选用易于消化吸收的脂肪来源，增加产品的耐受性并减少胃肠道负担，避免刺激胰腺，从而为患者提供充足的营养支持，辅助机体疾病后修复。
适合的底物配比、加工处理温度、体系pH及离子强度是影响营养液体系稳定性的关键性因素，尽管现有生产工艺方法可以得到均相的整蛋白型肠内营养液（一般整蛋白肠内营养液pH=6.4-6.8），但该型营养液普遍存在长时间静置后出现水油两相相分离及蛋白沉淀的现象，一般情况下，这种现象不会对产品的营养质量或功效产生负面影响，但是在临床营养医师或患者心目中可能对产品的质量和可接受程度产生负面印象。
预消化型全营养液因原料分子更小，在一定的离子强度及热处理（保证产品无菌）条件下相互之间的反应相对于整蛋白全营养液更为容易、剧烈，加剧水油两相分离。中性pH时获得均相全营养液难度更大。
目前临床应用的预消化型全营养产品以粉剂形式为主，使用之前需要加水重新配制，液体产品只有荷兰纽迪西亚公司的产品“百普力”，但该产品的pH=4，在临床使用过程中易与整蛋白型的肠内营养液（一般整蛋白肠内营养液pH=6.4-6.8）发生反应，产生絮状或块状沉淀物，存在配伍禁忌，另外营养液的pH=4也限制了该产品在肠造瘘患者中的应用。
我国的专利中也有类似营养液产品，如专利号201310327448.X，但该专利所得产品并非全营养产品，蛋白质来源也只有部分来源于大豆寡肽，没有额外添加矿物质离子，不用考虑离子强度对营养液体系稳定性的影响，这样产品制备工艺相对简单，而且该产品的保质期短，只有6个月，而目前市场现有产品的保质期普遍为12个月。
发明内容
本发明旨在提供一种pH接近中性，不存在配伍禁忌，保质期较长且保质期内不会出现相分离和沉淀现象的预消化型全营养液。
本发明提供一种预消化型全营养液，每升营养液中的干物质含量为：水解蛋白质20-60g，植物油8-18g，麦芽糊精150-300g，复配维生素0.2-1.0g复配矿物质0.2-1.0g，乳化剂1-10g，稳定剂1-5g。
所述预消化型全营养液的pH为6.5-7.5。
所述复配维生素为维生素A6000-8500IU/g,维生素D700-1100IU/g，维生素 E12-20mg/g，维生素K0.3-0.5mg/g，维生素B18-12mg/g，维生素B27-10 mg/g，维生素B66-9mg/g，维生素B1213.5-19.5mcg/g，维生素C100-200mg/g,泛酸 8-12mg/g，生物素0.15-0.3mg/g，叶酸0.25-0.5mg/g，烟酸20-30mg/g。
所述复配矿物质为铁20-35mg/g，锌20-30mg/g，钙200-400mg/g，镁100-300 mg/g，铜1.5-2.0mg/g，硒0.1-0.2mg/g。
所述水解蛋白质来源于水解乳清蛋白、水解酪蛋白或水解大豆蛋白中的一种或几种。
优选地，所述水解蛋白质来源于上述物质深度水解的2-3肽。
所述植物油脂肪中的中链甘油三酯含量≥30%总脂肪，亚油酸供能占总能量的2-4%，在上述条件下，所述植物油来源于玉米油、大豆油、椰子油、棕榈油、菜籽油、紫苏油、中链甘油三酯中的一种或几种的复配。
所述乳化剂来源于亲水亲油平衡值HLB＜10的单硬脂酸甘油酯、聚甘油脂肪酸酯和磷脂中的一种或几种。
所述稳定剂来源于阿拉伯胶、微晶纤维素、黄原胶的一种或几种。
本发明还提供上述预消化型全营养液的制备方法，包括如下步骤：
（1）配制料液：先将水溶性物料加60-80℃纯水搅拌溶解形成均匀分散的水相，再将脂溶性物料加60-80℃纯水搅拌经高速剪切乳化，条件为5000-20000r/min,5-15min，溶解形成均匀分散的油相，最后将水相及油相混合剪切，条件为5000-20000r/min,5-15min，并搅拌除去泡沫，调整混合液pH=6.5-7之间；
（2）将配制好的混合液经高压均质，条件为30-100MPa,5-15min后冷却至30℃暂存于储料罐中；
（3）将均质冷却后的混合液在自动灌装线灌装于输液用玻璃瓶中；
（4）将灌装后的产品置于旋转式蒸汽灭菌釜中灭菌，灭菌温度为121-137℃，灭菌时间为3-20min。
上述制备方法中水溶性物料为水解蛋白质、麦芽糊精、复配维生素、复配矿物质和稳定剂，脂溶性物料为植物油和乳化剂。
本发明具有如下有益效果：
该预消化型全营养液的pH为6.5-7.5，接近中性，营养全面均衡，在临床应用过程中不存在配伍禁忌；
该预消化型全营养液保质期较一般肠内营养液（保质期一般12个月）长6个月，储存时间久，且在保质期内不会出现水油两相分层和蛋白质沉淀现象；
该预消化型全营养液适于术前准备及术后营养支持，胃肠道吸收障碍、胰腺炎、炎性肠炎、蛋白质过敏等患者的饮食替代或者营养补充，应用范围广。
具体实施方式
下面通过给出的具体实施例对本发明做进一步说明，但不作为对本发明的限定。
实施例1
以每升营养液中的干物质含量计，将市售的水解大豆蛋白25g，水解水清蛋白25g,麦芽糊精250g，复配维生素1.2g，复配矿物质0.5g，柠檬酸钾0.2g，微晶纤维素0.2g,阿拉伯胶0.15g加60-80℃纯水搅拌溶解形成均匀分散的水相，再将玉米油9g，椰子油9g,单甘脂1.8g，聚甘油脂肪酸酯1.8g，大豆磷脂6.2g，加60-80℃纯水搅拌，经高速剪切乳（8000r/min,7min）形成均匀分散的油相，再将水相及油相混合剪切（8000r/min,7min），并搅拌除去泡沫，调整混合液pH=6.7；再将配制的好的混合液经高压均质(50MPa,10min)后冷却至30℃左右暂存于储料罐中；然后将均质冷却后的混合液在自动灌装线灌装于输液用玻璃瓶中，最后将灌装后的产品置于旋转式蒸汽灭菌釜中灭菌，灭菌温度为121℃，灭菌时间为20min，即得到成品预消化全营养液。
经检测该成品pH=6.55，在室温下保存能够保存12个月以上状态稳定，不发生水油两相分离及蛋白质絮凝沉淀，产品为商业无菌，其它各营养指标也均符合国家相应标准要求。
实施例2
以每升营养液中的干物质含量计，将市售的水解大豆蛋白20g，水解酪蛋白10g,水解乳清蛋白10g，麦芽糊精280g，复配维生素1.2g，复配矿物质0.5g，六偏磷酸钠0.35g，黄原胶0.25g,阿拉伯胶0.15g加60-80℃纯水搅拌溶解形成均匀分散的水相，再将大豆油9g，中链甘油三酯6g,紫苏油3g,单甘脂1.5g，大豆磷脂7.5g，加60-80℃纯水搅拌，经高速剪切乳（10000r/min,5min）形成均匀分散的油相，再将水相及油相混合剪切（10000r/min,5min），并搅拌除去泡沫，调整混合液pH=7；再将配制的好的混合液经高压均质(60MPa,10min)后冷却至30℃左右暂存于储料罐中；然后将均质冷却后的混合液在自动灌装线灌装于输液用玻璃瓶中，最后将灌装后的产品置于旋转式蒸汽灭菌釜中灭菌，灭菌温度为121℃，灭菌时间为15min，即得到成品预消化全营养液。
经检测该成品pH=6.8，在室温下保存能够保存12个月以上状态稳定，不发生水油两相分离及蛋白质絮凝沉淀，产品为商业无菌，其它各营养指标也均符合国家相应标准要求。
实施例3
以每升营养液中的干物质含量计，将市售的水解大豆蛋白40g，麦芽糊精280g，复配维生素1.2g，复配矿物质0.5g，六偏磷酸0.35g，黄原胶0.25g,微晶纤维素0.2g加60-80℃纯水搅拌溶解形成均匀分散的水相，再将玉米油9g，棕榈油6g,紫苏油3g,单甘脂1.5g，大豆磷脂7.5g，加60-80℃纯水搅拌，经高速剪切乳（10000r/min,5min）形成均匀分散的油相，再将水相及油相混合剪切（10000r/min,5min），并搅拌除去泡沫，调整混合液pH=7；再将配制的好的混合液经高压均质(60MPa,10min)后冷却至30℃左右暂存于储料罐中；然后将均质冷却后的混合液在自动灌装线灌装于输液用玻璃瓶中，最后将灌装后的产品置于旋转式蒸汽灭菌釜中灭菌，灭菌温度为137℃，灭菌时间为180s，即得到成品预消化全营养液。
经检测该成品pH=6.76，在室温下保存能够保存12个月以上状态稳定，不发生水油两相分离及蛋白质絮凝沉淀，产品为商业无菌，其它各营养指标也均符合国家相应标准要求。
实施例4
应用例：筛选胆囊切除术后患者共132例，男74例，女58例，年龄63-88岁（平均72.3岁），病种包括胆囊结石76例，急性胆囊炎（非结石性）21例，慢性胆囊炎（非结石性）18例，胆囊息肉9例，胆囊癌6例，胆囊外伤2例。观察组采用本发明制备的预消化型肠内营养液实行术后早期肠内营养支持的患者73例，对照组为进行市售的常规肠内营养支持的患者，共59例，两组患者的病因及年龄构成无显著差异。观察组中37例进行常规的胆囊切除术，32例小切口胆囊切除术，4例行胆囊造口术；对照组59例中，33例进行常规的胆囊切除术，22例小切口胆囊切除术，4例行胆囊造口术。两组患者各种术式所占比例相似，术后其他治疗手段也相同，两者对比其营养指标的疗效结果如表1所示，表2为术后并发症发生率及切口愈伤时间的对比结果。
表1
从表1营养支持的结果可以看出，观察组采用预消化型肠内营养液实行术后早期肠内营养支持后，体重、皮褶厚度、体质指数增高，但与对照组无显著性差异；血清总蛋白、血红蛋白、转铁蛋白有所改善，也无明显差异；但前白蛋白明显增高，有显著性差异（P＜0.05），视黄醇结合蛋白也明显增高。
表2
从表2可以看出，观察组的并发症要明显低于对照组，切口愈合时间也明显短于对照组。
以上内容是结合具体的实施方式对本发明所做的进一步详细说明，不能认定本发明的具体实施只局限于这些说明。对于本发明所属技术领域的普通技术人员来说，在不脱离本发明构思的前提下，还可以做出若干简单推演或替换，都应当视为属于本发明的保护范围。
Claims (10)
1. 一种预消化型全营养液，其特征在于每升营养液中的干物质含量为：水解蛋白质20- 60g，植物油8-18g，麦芽糊精150-300g，复配维生素0.2-1.0g，复配矿物质0.2-1.0g，乳化剂 1-10g，稳定剂1-5g。
2. 根据权利要求1所述的预消化型全营养液，其特征在于：所述预消化型全营养液的pH 为6.5-7.5。
3.根据权利要求1或2所述的预消化型全营养液，其特征在于：所述复配维生素为维生素A6000-8500IU/g,维生素D700-1100IU/g，维生素E12-20mg/g，维生素K0.3- 0.5mg/g，维生素B18-12mg/g，维生素B27-10mg/g，维生素B66-9mg/g，维生素 B1213.5-19.5mcg/g，维生素C100-200mg/g,泛酸8-12mg/g，生物素0.15-0.3mg/g， 叶酸0.25-0.5mg/g，烟酸20-30mg/g。
4.根据权利要求3所述的预消化型全营养液，其特征在于：所述复配矿物质为铁20-35mg/g，锌20-30mg/g，钙200-400mg/g，镁100-300mg/g，铜1.5-2.0mg/g，硒0.1-0.2mg/ g。
5.根据权利要求4所述的预消化型全营养液，其特征在于：所述水解蛋白质来源于水解乳清蛋白、水解酪蛋白或水解大豆蛋白中的一种或几种。
6.根据权利要求4所述的预消化型全营养液，其特征在于：所述植物油脂肪中的中链甘油三酯含量≥30%总脂肪，亚油酸供能占总能量的2-4%，所述植物油来源于玉米油、大豆油、椰子油、棕榈油、菜籽油、紫苏油、中链甘油三酯中的一种或几种。
7.根据权利要求4所述的预消化型全营养液，其特征在于：所述乳化剂来源于亲水亲油平衡值HLB＜10的单硬脂酸甘油酯、聚甘油脂肪酸酯和磷脂中的一种或几种。
8.根据权利要求4所述的预消化型全营养液，其特征在于：所述稳定剂来源于阿拉伯胶、微晶纤维素、黄原胶的一种或几种。
9.一种预消化型全营养液的制备方法，其特征在于包括如下步骤：
（1）配制料液：先将水溶性物料加60-80℃纯水搅拌溶解形成均匀分散的水相，再将脂溶性物料加60-80℃纯水搅拌，经高速剪切乳化，条件为5000-20000r/min,5-15min，溶解形成均匀分散的油相，最后将水相及油相混合剪切，条件为5000-20000r/min,5-15min，并搅拌除去泡沫，调整混合液pH=6.5-7之间；
（2）将配制好的混合液经高压均质，条件为30-100MPa,5-15min后冷却至30℃暂存于储料罐中；
（3）将均质冷却后的混合液在自动灌装线灌装于输液用玻璃瓶中；
（4）将灌装后的产品置于旋转式蒸汽灭菌釜中灭菌，灭菌温度为121-137℃，灭菌时间为3-20min。
10.根据权利要求9所述的预消化型全营养液的制备方法，其特征在于：所述水溶性物料为水解蛋白质、麦芽糊精、复配维生素、复配矿物质和稳定剂，所述脂溶性物料为植物油和乳化剂。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711075108.7A CN107744140A (zh) | 2017-11-06 | 2017-11-06 | 一种预消化型全营养液及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711075108.7A CN107744140A (zh) | 2017-11-06 | 2017-11-06 | 一种预消化型全营养液及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107744140A true CN107744140A (zh) | 2018-03-02 |
Family
ID=61253586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711075108.7A Pending CN107744140A (zh) | 2017-11-06 | 2017-11-06 | 一种预消化型全营养液及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107744140A (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109329949A (zh) * | 2018-12-07 | 2019-02-15 | 广东君悦营养医学有限公司 | 包含hmb钙和乳清蛋白的全营养混悬液及制备方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4340592A (en) * | 1980-03-14 | 1982-07-20 | Adibi Siamak A | Nutrient compositions and method of administering the same |
| CN105455133A (zh) * | 2015-12-08 | 2016-04-06 | 西安力邦临床营养股份有限公司 | 一种预消化型全营养液及其制备方法 |
| KR20170059326A (ko) * | 2015-11-20 | 2017-05-30 | 전북대학교산학협력단 | 청국장 첨가 발효 두유 및 이의 제조방법 |
-
2017
- 2017-11-06 CN CN201711075108.7A patent/CN107744140A/zh active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4340592A (en) * | 1980-03-14 | 1982-07-20 | Adibi Siamak A | Nutrient compositions and method of administering the same |
| KR20170059326A (ko) * | 2015-11-20 | 2017-05-30 | 전북대학교산학협력단 | 청국장 첨가 발효 두유 및 이의 제조방법 |
| CN105455133A (zh) * | 2015-12-08 | 2016-04-06 | 西安力邦临床营养股份有限公司 | 一种预消化型全营养液及其制备方法 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109329949A (zh) * | 2018-12-07 | 2019-02-15 | 广东君悦营养医学有限公司 | 包含hmb钙和乳清蛋白的全营养混悬液及制备方法 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105455133A (zh) | 一种预消化型全营养液及其制备方法 | |
| CN106473153A (zh) | 全营养配方食品及其制备方法 | |
| JP5779348B2 (ja) | 酸性液状栄養組成物 | |
| CN102550677B (zh) | 一种对中老年人具有保健功能的液态乳制品及其生产方法 | |
| CN105982331A (zh) | 一种创伤修复通用型水产胶原蛋白肽食品 | |
| CN109198641A (zh) | 一种低碳水化合物含量的食品配方及由其制备的防弹咖啡 | |
| CN106890312A (zh) | 一种适用于肝癌患者的肠内营养剂及其制备方法 | |
| CN108175024A (zh) | 一种向日葵花粉固体饮料及制备方法 | |
| US9492502B2 (en) | Method for producing a protein comprising composition with reduced digestive coagulation | |
| CN106819121A (zh) | 一种乳糜回流障碍婴幼儿奶粉 | |
| CN107744140A (zh) | 一种预消化型全营养液及其制备方法 | |
| JP5789981B2 (ja) | 液状栄養組成物 | |
| JPH0570606B2 (zh) | ||
| JPH0423968A (ja) | 食品用組成物 | |
| JP2750467B2 (ja) | ペプチド混合物及び経腸栄養組成物 | |
| CN115644429A (zh) | 一种乳清蛋白-豆类蛋白共稳定的全营养特殊医学用途配方食品乳剂及其制备方法 | |
| CN1685885A (zh) | 一种桑楂琥铬糖参王降糖助睡益肠夜酸豆奶制备方法 | |
| JP2001316278A (ja) | 液状経腸栄養組成物 | |
| CN101804196A (zh) | 一种大豆基整蛋白型肠内营养粉剂及其制备方法 | |
| CN106805252A (zh) | 一种鱼短肽及其在营养强化剂中的应用 | |
| CN106377756A (zh) | 一种重症脑梗死患者的肠内营养乳剂 | |
| RU2262240C1 (ru) | Продукт энтерального питания "унипит" | |
| CN1709406A (zh) | 一种微米珍珠王助睡益肠补钙夜乳制备方法 | |
| RU2290824C2 (ru) | Молочный продукт энтерального питания "нутриэн стандарт" | |
| CN109588728A (zh) | 一种口服全营养组合物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180302 |
|
| WD01 | Invention patent application deemed withdrawn after publication |