CN107715057A - 一种治疗肝炎晚期病证的内服药物及其制备方法 - Google Patents
一种治疗肝炎晚期病证的内服药物及其制备方法 Download PDFInfo
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- CN107715057A CN107715057A CN201711030819.2A CN201711030819A CN107715057A CN 107715057 A CN107715057 A CN 107715057A CN 201711030819 A CN201711030819 A CN 201711030819A CN 107715057 A CN107715057 A CN 107715057A
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Abstract
本发明属于中药制剂领域,目的是根据中医治疗肝炎晚期病证的认识机理而提供一种治疗肝炎晚期病证的内服药物,所述药物的各个组分及其质量份比如下:郁金30~120g、陈皮30~160g、绿矾2~8g、枳实(炒)30~120g、青木香30~120g、大青叶100~160g、香附50~120g、川楝子50~100g、针砂90~160g、乌药80~160g、黄连30~60g、野菊花100~160g、蒲公英90~160g、茵陈60~160g、柴胡30~120g、鱼腥草150~350g、牛黄2~4g、紫草30~100g、黄芩30~100g、葛根90~160g、生石膏150~650g、知母60~150g、土茯苓150~650g、车前子90~160g、连翘60~160g、双花100~250g、天花粉100~160g,本发明提供的药物是一个很好的中药组方。
Description
技术领域
本发明属于中药制剂领域,具体涉及一种治疗肝炎晚期病证的内服药物,特别是供肝炎晚期病证患者使用的内服药物及其制备方法的领域。
背景技术
据有关数据显示:我国是世界上肝炎严重流行区之一,各型肝炎患者呈现上升趋势,如再不采取及时有效的治疗措施,肝脏不断受到损伤,到了肝炎晚期病情发展快,消化道症状严重,多伴重度黄疸、食欲减退、出血倾向等,常引发肝腹水、肝肾综合症、肝硬化、肝癌或肝功能衰竭等疾病,死亡率约70%以上,严重影响生活和生命,正成为人类健康的一大杀手。
就目前而言:现市面上尚缺乏有效的治疗方法,现代医学针对临床某一症状的治疗,往往达不到预期效果,找不到一个合适的治疗方法来克服上述缺陷。
那么,就如何找到一种可有效治疗肝炎晚期病证的中药组合物,是本领域技术人员亟待要解决的问题。
发明内容
随着我国中医中药学的不断发展,在治疗肝炎晚期病证上,人们逐渐意识到了中医治疗肝炎晚期病证的优点,且在治疗过程中疗效好、见效快、毒副作用小等优势,针对现有西医治疗肝炎晚期病证的现状,本发明的目的是在于提供一种治疗肝炎晚期病证的内服药物,以解决肝炎晚期病证患者早日恢复健康的问题。该药物是以常见的中药为原料,通过选择合理的药物及质量份比,可有效治疗上述肝炎晚期病证。
为达到上述发明的目的,本发明所采用的技术方案为:提供一种治疗肝炎晚期病证的内服药物及其制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
郁金30~120g、陈皮30~160g、绿矾2~8g、枳实(炒)30~120g、青木香30~120g、大青叶100~160g、香附50~120g、川楝子50~100g、针砂90~160g、乌药80~160g、黄连30~60g、野菊花100~160g、蒲公英90~160g、茵陈60~160g、柴胡30~120g、 鱼腥草150~350g、牛黄2~4g、紫草30~100g、黄芩30~100g、葛根90~160g、生石膏150~650g、知母60~150g、土茯苓150~650g、车前子90~160g、连翘60~160g、双花100~250g、天花粉100~160g、苦参30~120g、芥菜子100~160g、大黄50~250g、郁李仁30~100g、泽泻60~100g、金钱草160~600g、虎杖100~160g、薤白50~120g、麦芽100~160g、延胡索80~160g、桃仁80~160g、红花50~120g、益母草90~360g、牛膝150~300g、丹参50~160g、竹叶60~150g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
一种治疗肝炎晚期病证的内服药物及其制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
郁金38~105g、陈皮38~140g、绿矾3~7g、枳实(炒)38~105g、青木香38~105g、大青叶115~140g、香附58~105g、川楝子60~90g、针砂100~140g、乌药90~140g、黄连38~52g、野菊花115~140g、蒲公英100~140g、茵陈70~140g、柴胡38~105g、 鱼腥草180~310g、牛黄2.5~3.5g、紫草38~90g、黄芩38~90g、葛根100~140g、生石膏180~560g、 知母70~130g、土茯苓180~560g、车前子100~140g、连翘70~140g、双花115~220g、天花粉115~140g、苦参38~105g、芥菜子115~140g、大黄60~220g、郁李仁38~90g、泽泻70~90g、金钱草180~520g、虎杖115~140g、薤白58~105g、麦芽115~140g、延胡索90~140g、桃仁90~140g、红花58~105g、益母草100~320g、牛膝180~260g、丹参58~140g、竹叶70~130g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
一种治疗肝炎晚期病证的内服药物及其制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
郁金95g、陈皮120g、绿矾5g、枳实(炒)95g、青木香95g、大青叶120g、香附95g、川楝子80g、针砂120g、乌药120g、黄连45g、野菊花120g、蒲公英120g、茵陈120g、柴胡95g、 鱼腥草280g、牛黄3g、紫草80g、黄芩80g、葛根120g、生石膏480g、 知母115g、土茯苓480g、车前子120g、连翘120g、双花200g、天花粉120g、苦参95g、芥菜子120g、大黄200g、郁李仁80g、泽泻80g、金钱草450g、虎杖120g、薤白95g、麦芽120g、延胡索120g、桃仁120g、红花95g、益母草280g、牛膝230g、丹参120g、竹叶115g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
一种治疗肝炎晚期病证的内服药物及其制备方法,其特征在于,所述方法包括如下步骤制备而成:
A.除绿矾、牛黄(研细末)外,将上述其它原料中药拣去杂质和粉尘后,按照质量份比共粉碎成(30~50目)颗粒状包煎;
B.①将包好的原料中药放入冷开水中浸泡60min,然后再将浸泡好的药物放入砂锅内,加入原料中药重量7~9倍的冷开水进行第一次武火煎煮,待煎煮到18min时,转文火熬制125min,滤取药液;②药渣中再次加入原料中药重量6~7 倍的冷开水进行第二次武火煎煮,待煎煮到15min时,转文火熬制115min,滤取药液;③将两次药液混合浓缩成相对密度为1.08 的清膏,然后真空干燥、研细末和消毒后备用;
C.①按照传统制备中药胶囊剂的方法,将上述两种研磨好的细末过1500目筛后,加入适量的微粉硅胶、微晶纤维素和淀粉混合均匀,然后制备成胶囊剂(其胶囊锁合后总长度为23.3mm,药粉容量0.4~0.5g/粒),②继而抛光、消毒,分装密封即可。
一种治疗肝炎晚期病证的内服药物及其制备方法,其特征在于,所述服用方法为:将制备好的胶囊剂药物以每日三次服用,早中晚各服一次,给药量3g(6粒)/次,温开水送服,30天为一个疗程,服药9~11个疗程后,皮肤淤斑及肝区疼痛全部消失,肝大小基本恢复正常,嘱再续服一个疗程,病获痊愈。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料,充分发挥各组分的药理功效:
郁金,性味:味辛、苦、性寒,具有活血止能、行气解郁、清心凉血、疏肝利胆之功效,用于治疗胸腹胁肋诸痛、妇女痛经、经闭、癥瘕结块、热病神昏、癫狂、惊痫、吐血、衄备、血淋、砂淋、黄疸等症;
陈皮,性味:味辛、苦、性温,具有理气和中、燥湿化痰、利水通便之功效,用于治疗脾胃不和、脘腹胀痛、不思饮食、呕吐哕逆、痰湿阻肺、咳嗽痰多、胸膈满闷、头目眩晕、水肿、小便不利、大便秘结、乳痈疥癣、中鱼蟹毒、酒毒等症
绿矾,性味:味酸、涩、性寒,具有补血消积、解毒敛疮、燥湿杀虫之功效,用于治疗血虚萎黄、疳积、腹胀痞满、肠风便血、疮疡溃烂、喉痹口疮、烂弦风眼、疥癣瘙痒;
枳实(炒),性味:苦、辛、寒,具有破气消积、化痰除痞之功效,用于治疗积滞内停、痞满胀痛、大便秘结、泻痢后重、结胸、胃下垂、子宫脱垂、脱肛等症;
青木香,性味:辛、苦、寒,具有平肝止痛、解毒消肿之功效,用于治疗眩晕头痛、胸腹胀痛、痈肿疔疮、蛇虫咬伤;
大青叶,性味:苦、寒,具有清热解毒、凉血消斑之功效,用于治疗热病高热烦渴、神昏、斑疹、吐血、衄血、黄疸、泻痢、丹毒、喉痹、口疮、痄腮等症;
香附,性味:味辛、微寒,无毒,具有理气解郁、调经止痛、安胎之功效,用于治疗胁肋胀痛、乳房胀育、疝气疼痛、月经不调、脘腹痞满疼痛、嗳气吞酸、呕恶、经行腹痛、崩漏带下、胎动不安;
川楝子,性味:苦、寒,具有疏肝泄热、行气止痛、杀虫之功效,用于治疗肝郁化火、胸胁、脘腹胀痛、疝气疼痛、虫积腹痛;
针砂,性味:味辛、酸、咸、性微寒,具有镇心平肝、健脾消积、补血、利湿、消肿之功效,用于治疗惊悸癫狂、血虚黄肿、泄泻下痢、尿少水肿、风湿痹痛、项下气瘿;
乌药,性味:辛、温,具有顺气、开郁、散寒、止痛之功效,用于治疗气逆胸腹胀痛、宿食不消、反胃吐食、寒疝、脚气、小便频数;
黄连,性味:性寒、味苦,具有泻火,燥湿,解毒,杀虫之功效,用于治疗时行热毒、伤寒、热盛心烦、痞满呕逆、菌痢、热泻腹痛、肺结按、吐、衄、下血、消渴、疳积、蛔虫病、百日咳、咽喉肿痛、火眼、口疮、痈疽疮毒、湿疹、汤火烫伤;
野菊花,味苦、辛、性平,具有清热解毒、疏风平肝之功效,用于治疗疔疮、痈疽、丹毒、湿疹、皮炎、风热感冒、咽喉肿痛、高血压病等症;
蒲公英,性味:苦、甘, 具有清热解毒、消肿散结、利尿通淋之功效,用于治疗疔疮肿毒、乳痈、瘰疠、目赤、咽痛、肺痈、肠痈、湿热黄疸、热淋涩痛;
茵陈,性味:味苦、辛、性微寒, 具有清利湿热、利胆退黄之功效,用于治疗黄疸尿少、湿温暑湿、湿疮瘙痒;
柴胡,性味:味苦、辛、性微寒,具有解表退热、疏肝解郁、升举阳气之功效,用于治疗外感发热、寒热往来、疟疾、肝郁胁痛乳胀、头痛头眩、月经不调、气虚下陷之脱肛、子宫脱垂、胃下垂等症;
鱼腥草,性味:味辛、性微寒,具有清热解毒、利尿消肿之功效,用于治疗肺炎、肺脓疡、热痢、疟疾、水肿、淋病、白带、痈肿、痔疮、脱肛、湿疹、秃疮、疥癣等症;
牛黄,性味:甘、凉,具有清心、豁痰、开窍、凉肝、息风、解毒之功效,用于治疗热病神昏、中风痰迷、惊痫抽搐、癫痫发狂、咽喉肿痛、口舌生疮、痈肿疔疮;
紫草,性味:苦、寒,具有凉血、活血、透疹、解毒之功效,用于治疗斑疹、麻疹、吐血、衄血、尿血、紫癜、黄疸、痈疽、烫伤等症;
黄芩,性味:苦、寒,具有清热燥湿、泻火解毒、止血、安胎之功效,用于治疗湿温、暑温胸闷呕恶、湿热痞满、泻痢、黄疸、肺热咳嗽、高热烦渴、血热吐衄、痈肿疮毒、胎动不安;
葛根,性味:味甘、辛、性凉,具有解肌退热、透疹、生津止渴、升阳止泻之功效,用于治疗表证发热、项背强痛、麻疹不透、热病口渴、阴虚消渴、热泻热痢、脾虚泄泻;
生石膏,性味:味甘、辛,大寒,具有清热泻火、除烦止渴的功效,煅用:具有敛疮生肌、收湿、止血之功效,常用于外感热病、高热烦渴、肺热喘咳、胃火亢盛、头痛、牙痛等症;
知母,性味:味苦、性寒,具有清热泻火、滋阴润燥、止渴除烦之功效,用于治疗温热病、高热烦渴、咳嗽气喘、燥咳、便秘、骨蒸潮热、虚烦不眠、消渴淋浊;
土茯苓,性味:甘、淡、平,具有除湿、解毒、通利关节之功效,用于治疗湿热淋浊、带下、痈肿、瘰疬、疥癣、梅毒及汞中毒所致的肢体拘挛、筋骨疼痛;
车前子,性味:甘、微寒,具有清热利尿、渗湿通淋、明目、祛痰之功效,用于治疗水肿胀满、热淋涩痛、暑湿泄泻、目赤肿痛、痰热咳嗽;
连翘,性味:苦、微寒,具有清热解毒、消肿散结之功效,用于治疗痈疽、瘰疠、乳痈、丹毒、风热感冒、温病初起、温热入营、高热烦渴、神昏发斑、热淋尿闭;
双花,性味:性甘、寒,具有清热解毒、消炎退肿之功效,用于治疗外感风热或温病发热、中暑、热毒血痢、痈肿疔疮、喉痹、多种感染性疾病;
天花粉,性味:甘、微苦、微寒,具有清热泻火、生津止渴、消肿排脓之功效,用于治疗热病烦渴、肺热燥咳、内热消渴、疮疡肿毒等症;
苦参,性味:味苦、性寒,具有清热燥湿、祛风杀虫之功效,用于治疗湿热泻痢、肠风便血、黄疸、小便不利、水肿、带下、阴痒、疥癣、麻风、皮肤瘙痒、湿毒疮疡;
芥菜子,性味:辛、温,具有宣肺豁痰、温中利气之功效,用于治疗寒饮内盛、咳嗽痰滞、胸膈满闷;
大黄,性味:苦、寒,具有泻实热、破积滞、行瘀血之功效,用于治疗实热便秘、食积停滞、腹痛、急性阑尾炎、急性传染性肝炎、血瘀经闭、牙痛、衄血、急性结膜炎,外用治烧烫伤、化脓性皮肤病、痈肿疮疡等症;
郁李仁,性味:性平、味辛、苦、甘,具有缓泻、利尿之功效,属泻下药分类的润下药,用于大便秘结、水肿、尿少等症;
泽泻,性味:甘、寒,具有利小便、清湿热之功效,用于治疗小便不利、水肿胀满、泄泻尿少、痰饮眩晕、热淋涩痛,高血脂等症;
金钱草,性味:味甘、咸、性微寒,具有利湿退黄、利尿通淋、解毒消肿之功效,用于治疗湿热黄疸、胆胀胁痛、石淋、热淋、小便涩痛、痈肿疔疮、蛇虫咬伤;
虎杖,苦、酸、性微寒,具有活血散瘀、祛风通络、清热利湿、解毒之功效,用于治疗妇女经闭、痛经、产后恶露不下、癥瘕积聚、跌扑损伤、风湿痹痛、湿热黄疸、淋浊带下、疮疡肿毒、毒蛇咬伤、水火烫伤;
薤白,性味:辛、苦、温,具有通阳散结、行气导滞之功效,用于治疗胸痹心痛、脘腹痞满胀痛、泻痢后重;
麦芽,性味:甘、平,具有行气消食、健脾开胃、回乳消胀之功效,用于治疗食积不消、脘腹胀痛、脾虚食少、乳汁郁积、乳房胀痛、妇女断乳、肝郁胁痛、肝胃气痛;
延胡索,性味:辛、苦、温,无毒,具有活血、散瘀、理气、止痛之功效,用于治疗心腹腰膝诸痛、月经不调、症瘕、崩中、产后血晕、恶露不尽、跌打损伤;
桃仁,性味:苦甘、平,无毒,具有破血行瘀、润燥滑肠之功效,用于治疗经闭、癥瘕、热病蓄血、风痹、疟疾、跌打损伤、瘀血肿痛、血燥便秘;
红花,性味:味辛、性温,具有活血能经、祛瘀止痛之功效,用于治疗经闭、痛经、产后瘀阻腹痛、胞痹心痛症瘕积聚、跌打损伤、关节疼痛、中风偏竣、斑疹等症;
益母草,性味:苦、辛、微寒,具有活血调经、利尿消肿、清热解毒之功效,用于治疗月经不调、痛经经闭、恶露不尽、水肿尿少、疮疡肿毒;
牛膝,性味:苦、酸、性平,具有补肝肾、强筋骨、活血通经、引敌国(火)下行、利尿通淋之功效,用于治疗腰膝酸痛、下肢痿软、血滞经闭、痛经、产后血瘀腹痛、征瘕、胞衣不下、热淋、血淋、跌打损伤、痈肿恶疮、咽喉肿痛;
丹参,性味:味苦、性微寒,具有活血祛瘀、调经止痛、养血安神、凉血消痈之功效,用于治疗妇女月经不调、痛经、经闭、产后瘀滞腹痛、心腹疼痛、癥瘕积聚、热痹肿痛、跌打损伤、热入营血、烦躁不安、心烦失眠、痈疮肿毒;
竹叶,性味:味甘、淡、性寒,具有清热除烦、生津、利尿之功效 ,用于治疗热病烦渴、小儿惊痫、咳逆吐衄、小便短赤、口糜舌疮。
本发明药物是基于中医治疗肝炎晚期病证的原则,从依据肝炎晚期病证的病理机制及药理作用认为:就肝炎晚期病证,本发明所提供的药物中的各原料中药药效共奏,对上述疾病有很好的效果。
具体实施方式
本发明就是针对上述肝炎晚期病证的治疗而提出的一种中药配方,采用该配方制备的药物药效好,见效快,是一个很好的中药组方,特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述:
实施例1:
一种治疗肝炎晚期病证的内服药物,其特征在于,所述药物的各个组分及质量份比如下所示:
郁金95g、陈皮120g、绿矾5g、枳实(炒)95g、青木香95g、大青叶120g、香附95g、川楝子80g、针砂120g、乌药120g、黄连45g、野菊花120g、蒲公英120g、茵陈120g、柴胡95g、 鱼腥草280g、牛黄3g、紫草80g、黄芩80g、葛根120g、生石膏480g、 知母115g、土茯苓480g、车前子120g、连翘120g、双花200g、天花粉120g、苦参95g、芥菜子120g、大黄200g、郁李仁80g、泽泻80g、金钱草450g、虎杖120g、薤白95g、麦芽120g、延胡索120g、桃仁120g、红花95g、益母草280g、牛膝230g、丹参120g、竹叶115g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
实施例2:
一种治疗肝炎晚期病证的内服药物,其特征在于,所述药物的各个组分及质量份比如下所示:
郁金105g、陈皮140g、绿矾7g、枳实(炒)105g、青木香105g、大青叶140g、香附105g、川楝子90g、针砂140g、乌药140g、黄连52g、野菊花140g、蒲公英140g、茵陈140g、柴胡105g、 鱼腥草310g、牛黄3.5g、紫草90g、黄芩90g、葛根140g、生石膏560g、 知母130g、土茯苓560g、车前子140g、连翘140g、双花220g、天花粉140g、苦参105g、芥菜子140g、大黄220g、郁李仁90g、泽泻90g、金钱草520g、虎杖140g、薤白105g、麦芽140g、延胡索140g、桃仁140g、红花105g、益母草320g、牛膝260g、丹参140g、竹叶130g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
实施例3:
一种治疗肝炎晚期病证的内服药物,其特征在于,所述药物的各个组分及质量份比如下所示:
郁金120g、陈皮160g、绿矾8g、枳实(炒)120g、青木香120g、大青叶160g、香附120g、川楝子100g、针砂160g、乌药160g、黄连60g、野菊花160g、蒲公英160g、茵陈160g、柴胡120g、 鱼腥草350g、牛黄4g、紫草100g、黄芩100g、葛根160g、生石膏650g、 知母150g、土茯苓650g、车前子160g、连翘160g、双花250g、天花粉160g、苦参120g、芥菜子160g、大黄250g、郁李仁100g、泽泻100g、金钱草600g、虎杖160g、薤白120g、麦芽160g、延胡索160g、桃仁160g、红花120g、益母草360g、牛膝300g、丹参160g、竹叶150g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
典型病例
经临床诊断治疗肝炎晚期病证患者共1217例,年龄为47岁以上的615例,只有602例为47岁以下。1217例患者中痊愈的702例,有效的357例,无效的158例。总有效率达87%。
Claims (3)
1.一种治疗肝炎晚期病证的内服药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
郁金30~120g、陈皮30~160g、绿矾2~8g、枳实(炒)30~120g、青木香30~120g、大青叶100~160g、香附50~120g、川楝子50~100g、针砂90~160g、乌药80~160g、黄连30~60g、野菊花100~160g、蒲公英90~160g、茵陈60~160g、柴胡30~120g、 鱼腥草150~350g、牛黄2~4g、紫草30~100g、黄芩30~100g、葛根90~160g、生石膏150~650g、知母60~150g、土茯苓150~650g、车前子90~160g、连翘60~160g、双花100~250g、天花粉100~160g、苦参30~120g、芥菜子100~160g、大黄50~250g、郁李仁30~100g、泽泻60~100g、金钱草160~600g、虎杖100~160g、薤白50~120g、麦芽100~160g、延胡索80~160g、桃仁80~160g、红花50~120g、益母草90~360g、牛膝150~300g、丹参50~160g、竹叶60~150g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
2.根据权利要求1所述的治疗肝炎晚期病证的内服药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
郁金38~105g、陈皮38~140g、绿矾3~7g、枳实(炒)38~105g、青木香38~105g、大青叶115~140g、香附58~105g、川楝子60~90g、针砂100~140g、乌药90~140g、黄连38~52g、野菊花115~140g、蒲公英100~140g、茵陈70~140g、柴胡38~105g、 鱼腥草180~310g、牛黄2.5~3.5g、紫草38~90g、黄芩38~90g、葛根100~140g、生石膏180~560g、 知母70~130g、土茯苓180~560g、车前子100~140g、连翘70~140g、双花115~220g、天花粉115~140g、苦参38~105g、芥菜子115~140g、大黄60~220g、郁李仁38~90g、泽泻70~90g、金钱草180~520g、虎杖115~140g、薤白58~105g、麦芽115~140g、延胡索90~140g、桃仁90~140g、红花58~105g、益母草100~320g、牛膝180~260g、丹参58~140g、竹叶70~130g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
3.根据权利要求1至2所述的治疗肝炎晚期病证的内服药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
郁金95g、陈皮120g、绿矾5g、枳实(炒)95g、青木香95g、大青叶120g、香附95g、川楝子80g、针砂120g、乌药120g、黄连45g、野菊花120g、蒲公英120g、茵陈120g、柴胡95g、 鱼腥草280g、牛黄3g、紫草80g、黄芩80g、葛根120g、生石膏480g、 知母115g、土茯苓480g、车前子120g、连翘120g、双花200g、天花粉120g、苦参95g、芥菜子120g、大黄200g、郁李仁80g、泽泻80g、金钱草450g、虎杖120g、薤白95g、麦芽120g、延胡索120g、桃仁120g、红花95g、益母草280g、牛膝230g、丹参120g、竹叶115g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
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