CN107714839B - Traditional Chinese medicine composition for treating chronic rhinitis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating chronic rhinitis and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/264—Aristolochia (Dutchman's pipe)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a traditional Chinese medicine composition for treating chronic rhinitis, which is prepared from the following raw materials in parts by weight: 8-12 parts of peach kernel, 3-6 parts of biond magnolia flower, 6-10 parts of astragalus root, 10-15 parts of wooly datchmanspipe herb, 2-5 parts of red paeony root, 3-6 parts of divaricate saposhnikovia root, 13-18 parts of nacre, 6-10 parts of largehead atractylodes rhizome and 2-5 parts of negundo chastetree leaf. The invention also discloses a preparation method of the traditional Chinese medicine composition for treating chronic rhinitis. The traditional Chinese medicine composition prepared by the invention has a reasonable formula, can effectively treat chronic rhinitis, is a natural pure traditional Chinese medicine preparation, has obviously reduced adverse reaction and side effect, particularly has no destructive effect on intestinal mucosa, is more easily accepted by wide consumers, and has wide market prospect.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating chronic rhinitis and a preparation method thereof.
Background
Chronic rhinitis is a chronic inflammation of the nasal mucosa and submucosa. The main characteristics are that the inflammation lasts for more than three months or attacks repeatedly, the inflammation is not cured, the inflammation can not be recovered in the intermission period, and the inflammation has no definite pathogenic microorganism and is accompanied by the obstruction of nasal obstruction with different degrees, secretion increase, swelling or thickening of nasal mucosa and the like. According to the pathological and functional disorder degree of chronic rhinitis, the chronic rhinitis can be divided into chronic simple rhinitis and chronic hypertrophic rhinitis, wherein the chronic rhinitis is chronic inflammation of nasal mucosa characterized by swelling and increased secretion of nasal mucosa, and the chronic rhinitis is chronic inflammation of nasal cavity characterized by limitation of mucosa, submucosa and even sclerotin or diffuse hypertrophic hypertrophy. The chronic simple rhinitis and the chronic hypertrophic rhinitis have basically the same etiology, and the latter is mostly developed and transformed from the former, lacks an absolute limit between the two in histology and often has a transitional type.
At present, many western medicines for treating chronic rhinitis exist, but most of the medicines have poor treatment effect and have the defects of high treatment cost, large side effect and the like, and even influence on the health of patients in severe cases. The clinical rhinitis treatment mainly comprises intranasal decongestants (oxymetazoline nasal spray, ephedrine nasal drops) and glucocorticoids, has curative effects, but cannot radically cure rhinitis, is easy to generate dependence, has obvious side effects, and has poor effect on hyperplasia and hypertrophy caused by long-term rhinitis. In the prior art, a plurality of traditional Chinese medicines for treating chronic rhinitis exist, but the traditional Chinese medicines have the defect of poor curative effect.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating chronic rhinitis and a preparation method thereof, and aims to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme:
a traditional Chinese medicine composition for treating chronic rhinitis is prepared from the following raw materials in parts by weight: 8-12 parts of peach kernel, 3-6 parts of biond magnolia flower, 6-10 parts of astragalus root, 10-15 parts of wooly datchmanspipe herb, 2-5 parts of red paeony root, 3-6 parts of divaricate saposhnikovia root, 13-18 parts of nacre, 6-10 parts of largehead atractylodes rhizome and 2-5 parts of negundo chastetree leaf.
As a further scheme of the invention: the feed is prepared from the following raw materials in parts by weight: 9-11 parts of peach kernel, 4-5 parts of biond magnolia flower, 7-9 parts of astragalus root, 11-14 parts of wooly datchmanspipe herb, 3-4 parts of red paeony root, 4-5 parts of divaricate saposhnikovia root, 14-17 parts of nacre mother, 7-9 parts of largehead atractylodes rhizome and 3-4 parts of negundo chastetree leaf.
As a still further scheme of the invention: the feed is prepared from the following raw materials in parts by weight: 10 parts of peach kernel, 5 parts of biond magnolia flower, 8 parts of astragalus root, 13 parts of wooly datchmanspipe herb, 3 parts of red paeony root, 5 parts of divaricate saposhnikovia root, 15 parts of nacre mother of pearl, 8 parts of largehead atractylodes rhizome and 3 parts of negundo chastetree leaf.
The preparation method of the traditional Chinese medicine composition for treating chronic rhinitis comprises the following steps:
1) weighing peach kernels, cleaning, drying and grinding into peach kernel paste for later use;
2) weighing nacre, cleaning, drying, grinding, mixing the obtained nacre powder with the peach kernel paste, and uniformly stirring and mixing to obtain a first mixture;
3) weighing flos Magnoliae, radix astragali, herba Aristolochiae Mollissimae and radix Paeoniae Rubra, cleaning, oven drying, pulverizing, mixing, placing into a percolator, percolating with 15-20 times of ethanol water solution to obtain percolate and percolate residue;
4) adding the percolation residue into an ethanol water solution with the weight of 8-10 times, soaking for 2-3h, heating and refluxing for extraction for 1-2h, and filtering to obtain a first reflux extracting solution and a first reflux extracting residue;
5) adding the first reflux extraction residue into ethanol water solution with the weight of 6-8 times, soaking for 1h, heating and reflux extracting for 0.5-1h, and filtering to obtain a second reflux extraction solution and a second reflux extraction residue;
6) weighing radix Saposhnikoviae, Atractylodis rhizoma and folium Viticis negundo, cleaning, oven drying, pulverizing, mixing, adding 5-6 times of ethanol water solution, soaking for 10-15 hr, ultrasonic extracting for 40-50min, and filtering to obtain ultrasonic extractive solution and ultrasonic extraction residue;
7) adding the ultrasonic extraction residue into an ethanol aqueous solution with the weight of 8-10 times that of the ultrasonic extraction residue, soaking for 1-2h, heating and refluxing for extraction for 1-2h, and filtering to obtain a third reflux extracting solution and a third reflux extraction residue;
8) mixing the percolate, the first reflux extractive solution, the second reflux extractive solution, the ultrasonic extractive solution and the third reflux extractive solution, evaporating and concentrating to obtain soft extract;
9) adding the thick paste into the first mixture, and stirring and mixing uniformly to obtain a second mixture;
10) quickly freezing the second mixture into powder, and making into tablet or capsule.
As a still further scheme of the invention: the volume concentration of ethanol in the ethanol water solution is 60%.
As a still further scheme of the invention: in the step 6), the ultrasonic extraction frequency is 60-80 kHz.
As a still further scheme of the invention: in the step 8), the evaporation and concentration are negative pressure evaporation.
As a still further scheme of the invention: in the step 8), the relative density of the thick paste is 1.18-1.22.
The application of the traditional Chinese medicine composition in preparing the medicine for treating chronic rhinitis.
Compared with the prior art, the invention has the beneficial effects that:
the traditional Chinese medicine composition prepared by the invention has a reasonable formula, can effectively treat chronic rhinitis, is a natural pure traditional Chinese medicine preparation, has obviously reduced adverse reaction and side effect, particularly has no destructive effect on intestinal mucosa, is more easily accepted by wide consumers, and has wide market prospect.
Detailed Description
The technical solution of the present invention will be described in further detail with reference to specific embodiments.
Example 1
A traditional Chinese medicine composition for treating chronic rhinitis is prepared from the following raw materials in parts by weight: 8 parts of peach kernel, 3 parts of biond magnolia flower, 6 parts of astragalus root, 10 parts of wooly datchmanspipe herb, 2 parts of red paeony root, 3 parts of divaricate saposhnikovia root, 13 parts of nacre, 6 parts of largehead atractylodes rhizome and 2 parts of negundo chastetree leaf.
In this embodiment, the preparation method of the traditional Chinese medicine composition for treating chronic rhinitis comprises the following steps:
1) weighing peach kernels, cleaning, drying and grinding into peach kernel paste for later use;
2) weighing nacre, cleaning, drying, grinding, mixing the obtained nacre powder with the peach kernel paste, and uniformly stirring and mixing to obtain a first mixture;
3) weighing flos Magnoliae, radix astragali, herba Aristolochiae Mollissimae and radix Paeoniae Rubra, cleaning, oven drying, pulverizing, mixing, placing into a percolator, percolating with 15 times of ethanol water solution to obtain percolate and percolate residue;
4) adding the percolation residue into an ethanol water solution with the weight 8 times that of the percolation residue, soaking for 2 hours, heating, refluxing and extracting for 1 hour, and filtering to obtain a first reflux extracting solution and a first reflux extracting residue;
5) adding the first reflux extraction residue into ethanol water solution with the weight 6 times that of the first reflux extraction residue, soaking for 1h, heating and refluxing for extraction for 0.5h, and filtering to obtain a second reflux extraction solution and a second reflux extraction residue;
6) weighing radix Saposhnikoviae, Atractylodis rhizoma and folium Viticis negundo, cleaning, oven drying, pulverizing, mixing, adding 5 times of ethanol water solution, soaking for 10h, ultrasonic extracting for 40min, and filtering to obtain ultrasonic extractive solution and ultrasonic extraction residue, wherein the ultrasonic extraction frequency is 60 kHz;
7) adding the ultrasonic extraction residue into an ethanol water solution with the weight of 8 times, soaking for 1 hour, heating and refluxing for extraction for 1 hour, and filtering to obtain a third reflux extracting solution and a third reflux extraction residue;
8) mixing the percolate, the first reflux extracting solution, the second reflux extracting solution, the ultrasonic extracting solution and the third reflux extracting solution, and evaporating and concentrating to obtain thick paste, wherein the evaporation and concentration adopts negative pressure evaporation, and the relative density of the thick paste is 1.18;
9) adding the thick paste into the first mixture, and stirring and mixing uniformly to obtain a second mixture;
10) quickly freezing the second mixture into powder, and making into tablet.
The volume concentration of ethanol in the ethanol water solution is 60 percent.
Example 2
A traditional Chinese medicine composition for treating chronic rhinitis is prepared from the following raw materials in parts by weight: 9 parts of peach kernel, 4 parts of biond magnolia flower, 9 parts of astragalus root, 14 parts of hairy birthwort, 3 parts of red paeony root, 4 parts of divaricate saposhnikovia root, 14 parts of nacre, 9 parts of largehead atractylodes rhizome and 4 parts of negundo chastetree leaf.
In this embodiment, the preparation method of the traditional Chinese medicine composition for treating chronic rhinitis comprises the following steps:
1) weighing peach kernels, cleaning, drying and grinding into peach kernel paste for later use;
2) weighing nacre, cleaning, drying, grinding, mixing the obtained nacre powder with the peach kernel paste, and uniformly stirring and mixing to obtain a first mixture;
3) weighing flos Magnoliae, radix astragali, herba Aristolochiae Mollissimae and radix Paeoniae Rubra, cleaning, oven drying, pulverizing, mixing, placing into a percolator, percolating with 16 times of ethanol water solution to obtain percolate and percolate residue;
4) adding the percolation residue into an ethanol water solution with the weight of 8 times, soaking for 2.5h, heating, refluxing and extracting for 1h, and filtering to obtain a first reflux extracting solution and a first reflux extracting residue;
5) adding the first reflux extraction residue into ethanol water solution with the weight 6 times that of the first reflux extraction residue, soaking for 1h, heating and refluxing for extraction for 0.5h, and filtering to obtain a second reflux extraction solution and a second reflux extraction residue;
6) weighing radix Saposhnikoviae, Atractylodis rhizoma and folium Viticis negundo, cleaning, oven drying, pulverizing, mixing, adding 5 times of ethanol water solution, soaking for 11h, ultrasonic extracting for 42min, and filtering to obtain ultrasonic extractive solution and ultrasonic extraction residue, wherein the ultrasonic extraction frequency is 60 kHz;
7) adding the ultrasonic extraction residue into an ethanol water solution with the weight of 8 times, soaking for 1.5h, heating and refluxing for extraction for 1.5h, and filtering to obtain a third reflux extracting solution and a third reflux extraction residue;
8) mixing the percolate, the first reflux extracting solution, the second reflux extracting solution, the ultrasonic extracting solution and the third reflux extracting solution, and evaporating and concentrating to obtain thick paste, wherein the evaporation and concentration adopts negative pressure evaporation, and the relative density of the thick paste is 1.20;
9) adding the thick paste into the first mixture, and stirring and mixing uniformly to obtain a second mixture;
10) quickly freezing the second mixture into powder, and making into capsule.
The volume concentration of ethanol in the ethanol water solution is 60 percent.
Example 3
A traditional Chinese medicine composition for treating chronic rhinitis is prepared from the following raw materials in parts by weight: 10 parts of peach kernel, 5 parts of biond magnolia flower, 8 parts of astragalus root, 13 parts of wooly datchmanspipe herb, 3 parts of red paeony root, 5 parts of divaricate saposhnikovia root, 15 parts of nacre mother of pearl, 8 parts of largehead atractylodes rhizome and 3 parts of negundo chastetree leaf.
In this embodiment, the preparation method of the traditional Chinese medicine composition for treating chronic rhinitis comprises the following steps:
1) weighing peach kernels, cleaning, drying and grinding into peach kernel paste for later use;
2) weighing nacre, cleaning, drying, grinding, mixing the obtained nacre powder with the peach kernel paste, and uniformly stirring and mixing to obtain a first mixture;
3) weighing flos Magnoliae, radix astragali, herba Aristolochiae Mollissimae and radix Paeoniae Rubra, cleaning, oven drying, pulverizing, mixing, placing into a percolator, percolating with 18 times of ethanol water solution to obtain percolate and percolate residue;
4) adding the percolation residue into 9 times of ethanol water solution, soaking for 2.5h, heating and refluxing for extraction for 1.5h, and filtering to obtain a first reflux extracting solution and a first reflux extracting residue;
5) adding the first reflux extraction residue into an ethanol water solution with the weight 7 times that of the first reflux extraction residue, soaking for 1 hour, heating and refluxing for extraction for 1 hour, and filtering to obtain a second reflux extraction solution and a second reflux extraction residue;
6) weighing radix Saposhnikoviae, Atractylodis rhizoma and folium Viticis negundo, cleaning, oven drying, pulverizing, mixing, adding 6 times of ethanol water solution, soaking for 13h, ultrasonic extracting for 45min, and filtering to obtain ultrasonic extractive solution and ultrasonic extraction residue, wherein the ultrasonic extraction frequency is 70 kHz;
7) adding the ultrasonic extraction residue into 9 times of ethanol water solution, soaking for 1.5h, heating and refluxing for extraction for 1.5h, and filtering to obtain a third reflux extracting solution and a third reflux extraction residue;
8) mixing the percolate, the first reflux extracting solution, the second reflux extracting solution, the ultrasonic extracting solution and the third reflux extracting solution, and evaporating and concentrating to obtain thick paste, wherein the evaporation and concentration adopts negative pressure evaporation, and the relative density of the thick paste is 1.20;
9) adding the thick paste into the first mixture, and stirring and mixing uniformly to obtain a second mixture;
10) quickly freezing the second mixture into powder, and making into capsule.
The volume concentration of ethanol in the ethanol water solution is 60 percent.
Example 4
A traditional Chinese medicine composition for treating chronic rhinitis is prepared from the following raw materials in parts by weight: 11 parts of peach kernel, 5 parts of biond magnolia flower, 7 parts of astragalus root, 11 parts of wooly datchmanspipe herb, 4 parts of red paeony root, 5 parts of divaricate saposhnikovia root, 17 parts of nacre mother of pearl, 7 parts of largehead atractylodes rhizome and 3 parts of negundo chastetree leaf.
In this embodiment, the preparation method of the traditional Chinese medicine composition for treating chronic rhinitis comprises the following steps:
1) weighing peach kernels, cleaning, drying and grinding into peach kernel paste for later use;
2) weighing nacre, cleaning, drying, grinding, mixing the obtained nacre powder with the peach kernel paste, and uniformly stirring and mixing to obtain a first mixture;
3) weighing flos Magnoliae, radix astragali, herba Aristolochiae Mollissimae and radix Paeoniae Rubra, cleaning, oven drying, pulverizing, mixing, placing into a percolator, percolating with 18 times of ethanol water solution to obtain percolate and percolate residue;
4) adding the percolation residue into 10 times of ethanol water solution, soaking for 2.5h, heating, refluxing, extracting for 2h, and filtering to obtain a first reflux extracting solution and a first reflux extracting residue;
5) adding the first reflux extraction residue into an ethanol water solution with the weight 7 times that of the first reflux extraction residue, soaking for 1 hour, heating and refluxing for extraction for 1 hour, and filtering to obtain a second reflux extraction solution and a second reflux extraction residue;
6) weighing radix Saposhnikoviae, Atractylodis rhizoma and folium Viticis negundo, cleaning, oven drying, pulverizing, mixing, adding 5 times of ethanol water solution, soaking for 14h, ultrasonic extracting for 47min, and filtering to obtain ultrasonic extractive solution and ultrasonic extraction residue, wherein the ultrasonic extraction frequency is 80 kHz;
7) adding the ultrasonic extraction residue into 10 times of ethanol water solution, soaking for 1.5h, heating and refluxing for extraction for 2h, and filtering to obtain a third reflux extracting solution and a third reflux extraction residue;
8) mixing the percolate, the first reflux extracting solution, the second reflux extracting solution, the ultrasonic extracting solution and the third reflux extracting solution, and evaporating and concentrating to obtain thick paste, wherein the evaporation and concentration adopts negative pressure evaporation, and the relative density of the thick paste is 1.22;
9) adding the thick paste into the first mixture, and stirring and mixing uniformly to obtain a second mixture;
10) quickly freezing the second mixture into powder, and making into tablet.
The volume concentration of ethanol in the ethanol water solution is 60 percent.
Example 5
A traditional Chinese medicine composition for treating chronic rhinitis is prepared from the following raw materials in parts by weight: 12 parts of peach kernel, 6 parts of biond magnolia flower, 10 parts of astragalus root, 15 parts of wooly datchmanspipe herb, 5 parts of red paeony root, 6 parts of divaricate saposhnikovia root, 18 parts of nacre, 10 parts of largehead atractylodes rhizome and 5 parts of negundo chastetree leaf.
In this embodiment, the preparation method of the traditional Chinese medicine composition for treating chronic rhinitis comprises the following steps:
1) weighing peach kernels, cleaning, drying and grinding into peach kernel paste for later use;
2) weighing nacre, cleaning, drying, grinding, mixing the obtained nacre powder with the peach kernel paste, and uniformly stirring and mixing to obtain a first mixture;
3) weighing flos Magnoliae, radix astragali, herba Aristolochiae Mollissimae and radix Paeoniae Rubra, cleaning, oven drying, pulverizing, mixing, placing into a percolator, percolating with 20 times of ethanol water solution to obtain percolate and percolate residue;
4) adding the percolation residue into 10 times of ethanol water solution, soaking for 3h, heating and refluxing for extraction for 2h, and filtering to obtain a first reflux extracting solution and a first reflux extracting residue;
5) adding the first reflux extraction residue into an ethanol water solution with the weight 8 times that of the first reflux extraction residue, soaking for 1 hour, heating and refluxing for extraction for 1 hour, and filtering to obtain a second reflux extraction solution and a second reflux extraction residue;
6) weighing radix Saposhnikoviae, Atractylodis rhizoma and folium Viticis negundo, cleaning, oven drying, pulverizing, mixing, adding 6 times of ethanol water solution, soaking for 15h, ultrasonic extracting for 50min, and filtering to obtain ultrasonic extractive solution and ultrasonic extraction residue, wherein the ultrasonic extraction frequency is 80 kHz;
7) adding the ultrasonic extraction residue into 10 times of ethanol water solution, soaking for 2h, heating and refluxing for extraction for 2h, and filtering to obtain a third reflux extracting solution and a third reflux extraction residue;
8) mixing the percolate, the first reflux extracting solution, the second reflux extracting solution, the ultrasonic extracting solution and the third reflux extracting solution, and evaporating and concentrating to obtain thick paste, wherein the evaporation and concentration adopts negative pressure evaporation, and the relative density of the thick paste is 1.22;
9) adding the thick paste into the first mixture, and stirring and mixing uniformly to obtain a second mixture;
10) quickly freezing the second mixture into powder, and making into tablet.
The volume concentration of ethanol in the ethanol water solution is 60 percent.
Example 6
Compared with the example 3, the formulation does not contain the Aristolochia mollissima and the folium Viticis negundo, and the rest is the same as the example 3.
Example 7
The formulation does not contain Vitex negundo L.leaf and Atractylodes macrocephala koidz, as compared with example 3, and the rest is the same as example 3.
Example 8
Compared with the example 3, the formulation does not contain the Aristolochia mollissima and the biond magnolia flower, and the rest is the same as the example 3.
Example 9
The traditional Chinese medicine composition has the effect on mouse ear swelling caused by dimethylbenzene
Taking 140 healthy ICR mice, each half of the mice is divided into 7 groups and 20 mice per group, namely a model group, a low-dose group, a medium-dose group and a high-dose group of the traditional Chinese medicine composition (the traditional Chinese medicine composition prepared in the embodiment 3), a control group (the traditional Chinese medicine composition prepared in the embodiment 6), a control two groups (the traditional Chinese medicine composition prepared in the embodiment 7) and a control three groups (the traditional Chinese medicine composition prepared in the embodiment 8). Each mouse is administrated 1 time per day for 20 days continuously, 60min after the last administration, the right ear of the mouse is evenly coated with 0.03mL of dimethylbenzene/mouse to cause swelling, after 2h, the ears are cut off, the ears are punched, the ears are weighed, and the ear swelling value (mg) is calculated. Ear swelling value (mg) is right ear weight-left ear weight. The test results are shown in table 1.
Table 1 mouse ear swelling test results (
±S，n=20）
The results show that the low, medium and high dose groups of the traditional Chinese medicine composition can obviously reduce the ear swelling value of mice caused by dimethylbenzene compared with the model group, and the traditional Chinese medicine composition has the effect of obviously inhibiting the ear swelling of the mice induced by the dimethylbenzene. In addition, the control group, the control two groups and the control three groups can also reduce the ear swelling value, but the effect is far lower than that of each dosage group of the traditional Chinese medicine composition. The invention has reasonable formula compatibility and obvious anti-inflammatory effect.
Example 10
Clinical trial
150 patients with chronic rhinitis were randomly selected for clinical observation and treatment, wherein 81 males and 69 females were aged 23-60 years. Among them, 96 cases of simple rhinitis and 54 cases of hypertrophic rhinitis.
The treatment method comprises the following steps: taking the capsules prepared in the example 3, wherein each capsule contains 0.5g of crude drug, taking orally, taking twice a day, 8-10 capsules each time, taking one month as a treatment course, and evaluating the effect after two treatment courses.
Criteria for therapeutic effect
And (3) curing: the symptoms are totally disappeared; the main physical and chemical detection indexes are normal.
The effect is shown: total symptom elimination or chief symptom elimination; the physical and chemical detection indexes are basically normal.
The method has the following advantages: the primary symptoms substantially disappeared; the main physical and chemical detection indexes are improved.
And (4) invalidation: the main physical and chemical detection indexes are unchanged from those before treatment.
Clinical results
83 cases are cured, 45 cases are obviously effective, 20 cases are effective, 2 cases are ineffective, and the total effective rate is 98.7%.
The traditional Chinese medicine composition prepared by the invention has a reasonable formula, can effectively treat chronic rhinitis, is a natural pure traditional Chinese medicine preparation, has obviously reduced adverse reaction and side effect, particularly has no destructive effect on intestinal mucosa, is more easily accepted by wide consumers, and has wide market prospect.
While the preferred embodiments of the present invention have been described in detail, the present invention is not limited to the above embodiments, and various changes can be made without departing from the spirit of the present invention within the knowledge of those skilled in the art.
Claims (9)
1. The traditional Chinese medicine composition for treating chronic rhinitis is characterized by being prepared from the following raw materials in parts by weight: 8-12 parts of peach kernel, 3-6 parts of biond magnolia flower, 6-10 parts of astragalus root, 10-15 parts of wooly datchmanspipe herb, 2-5 parts of red paeony root, 3-6 parts of divaricate saposhnikovia root, 13-18 parts of nacre, 6-10 parts of largehead atractylodes rhizome and 2-5 parts of negundo chastetree leaf.
2. The traditional Chinese medicine composition for treating chronic rhinitis according to claim 1, which is prepared from the following raw materials in parts by weight: 9-11 parts of peach kernel, 4-5 parts of biond magnolia flower, 7-9 parts of astragalus root, 11-14 parts of wooly datchmanspipe herb, 3-4 parts of red paeony root, 4-5 parts of divaricate saposhnikovia root, 14-17 parts of nacre mother, 7-9 parts of largehead atractylodes rhizome and 3-4 parts of negundo chastetree leaf.
3. The traditional Chinese medicine composition for treating chronic rhinitis according to claim 2, which is prepared from the following raw materials in parts by weight: 10 parts of peach kernel, 5 parts of biond magnolia flower, 8 parts of astragalus root, 13 parts of wooly datchmanspipe herb, 3 parts of red paeony root, 5 parts of divaricate saposhnikovia root, 15 parts of nacre mother of pearl, 8 parts of largehead atractylodes rhizome and 3 parts of negundo chastetree leaf.
4. A method for preparing a Chinese medicinal composition for treating chronic rhinitis according to any one of claims 1 to 3, which comprises the following steps:
1) weighing peach kernels, cleaning, drying and grinding into peach kernel paste for later use;
2) weighing nacre, cleaning, drying, grinding, mixing the obtained nacre powder with the peach kernel paste, and uniformly stirring and mixing to obtain a first mixture;
3) weighing flos Magnoliae, radix astragali, herba Aristolochiae Mollissimae and radix Paeoniae Rubra, cleaning, oven drying, pulverizing, mixing, placing into a percolator, percolating with 15-20 times of ethanol water solution to obtain percolate and percolate residue;
4) adding the percolation residue into an ethanol water solution with the weight of 8-10 times, soaking for 2-3h, heating and refluxing for extraction for 1-2h, and filtering to obtain a first reflux extracting solution and a first reflux extracting residue;
5) adding the first reflux extraction residue into ethanol water solution with the weight of 6-8 times, soaking for 1h, heating and reflux extracting for 0.5-1h, and filtering to obtain a second reflux extraction solution and a second reflux extraction residue;
6) weighing radix Saposhnikoviae, Atractylodis rhizoma and folium Viticis negundo, cleaning, oven drying, pulverizing, mixing, adding 5-6 times of ethanol water solution, soaking for 10-15 hr, ultrasonic extracting for 40-50min, and filtering to obtain ultrasonic extractive solution and ultrasonic extraction residue;
7) adding the ultrasonic extraction residue into an ethanol aqueous solution with the weight of 8-10 times that of the ultrasonic extraction residue, soaking for 1-2h, heating and refluxing for extraction for 1-2h, and filtering to obtain a third reflux extracting solution and a third reflux extraction residue;
8) mixing the percolate, the first reflux extractive solution, the second reflux extractive solution, the ultrasonic extractive solution and the third reflux extractive solution, evaporating and concentrating to obtain soft extract;
9) adding the thick paste into the first mixture, and stirring and mixing uniformly to obtain a second mixture;
10) quickly freezing the second mixture into powder, and making into tablet or capsule.
5. The preparation method of the traditional Chinese medicine composition for treating chronic rhinitis according to claim 4, wherein the volume concentration of ethanol in the ethanol aqueous solution is 60%.
6. The preparation method of the traditional Chinese medicine composition for treating chronic rhinitis according to claim 4, wherein in the step 6), the ultrasonic extraction frequency is 60-80 kHz.
7. The method for preparing a Chinese medicinal composition for treating chronic rhinitis according to claim 4, wherein in step 8), the evaporation concentration is negative pressure evaporation.
8. The preparation method of the traditional Chinese medicine composition for treating chronic rhinitis according to claim 4, wherein in the step 8), the relative density of the thick paste is 1.18-1.22.
9. Use of the Chinese medicinal composition as claimed in any one of claims 1-3 in the preparation of a medicament for treating chronic rhinitis.
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Citations (3)
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| CN101091745A (en) * | 2007-07-16 | 2007-12-26 | 罗连珍 | Decoction medicine for treating chronic one-way rhinitis, and preparation method |
| CN103948675A (en) * | 2014-05-29 | 2014-07-30 | 张玉芳 | Traditional Chinese medicine for treating chronic rhinitis |
| CN106511650A (en) * | 2016-12-19 | 2017-03-22 | 陈文星 | Traditional Chinese medicine composition for treating chronic rhinitis and preparation method thereof |
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| CN101091745A (en) * | 2007-07-16 | 2007-12-26 | 罗连珍 | Decoction medicine for treating chronic one-way rhinitis, and preparation method |
| CN103948675A (en) * | 2014-05-29 | 2014-07-30 | 张玉芳 | Traditional Chinese medicine for treating chronic rhinitis |
| CN106511650A (en) * | 2016-12-19 | 2017-03-22 | 陈文星 | Traditional Chinese medicine composition for treating chronic rhinitis and preparation method thereof |
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