CN107709300A - 新型酰胺基杂芳基芳酰基酰肼乙炔 - Google Patents
新型酰胺基杂芳基芳酰基酰肼乙炔 Download PDFInfo
- Publication number
- CN107709300A CN107709300A CN201680028615.2A CN201680028615A CN107709300A CN 107709300 A CN107709300 A CN 107709300A CN 201680028615 A CN201680028615 A CN 201680028615A CN 107709300 A CN107709300 A CN 107709300A
- Authority
- CN
- China
- Prior art keywords
- methyl
- alkyl
- bases
- pyridine
- hydrazinocarbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 Cc(ccc(C(I)=*)c1)c1C#C Chemical compound Cc(ccc(C(I)=*)c1)c1C#C 0.000 description 3
- CAIDUXQQJKUUII-HWKANZROSA-N C/C=C(\C)/CC(NN)=O Chemical compound C/C=C(\C)/CC(NN)=O CAIDUXQQJKUUII-HWKANZROSA-N 0.000 description 1
- YJASEAPNCREBGV-UHFFFAOYSA-N CC(C(C1)=C)=CC=C1C(I)=[O]=C Chemical compound CC(C(C1)=C)=CC=C1C(I)=[O]=C YJASEAPNCREBGV-UHFFFAOYSA-N 0.000 description 1
- BLBHFUSLEFNOLO-UHFFFAOYSA-N NNC(C1=CC=[I]C=C1)=O Chemical compound NNC(C1=CC=[I]C=C1)=O BLBHFUSLEFNOLO-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B43/00—Formation or introduction of functional groups containing nitrogen
- C07B43/06—Formation or introduction of functional groups containing nitrogen of amide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1953MU2015 | 2015-05-18 | ||
| IN1953/MUM/2015 | 2015-05-18 | ||
| PCT/IN2016/050142 WO2016185490A1 (en) | 2015-05-18 | 2016-05-18 | Novel amidoheteroaryl aroyl hydrazide ethynes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107709300A true CN107709300A (zh) | 2018-02-16 |
Family
ID=57319598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680028615.2A Withdrawn CN107709300A (zh) | 2015-05-18 | 2016-05-18 | 新型酰胺基杂芳基芳酰基酰肼乙炔 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10150733B2 (https=) |
| EP (1) | EP3297991B1 (https=) |
| JP (1) | JP6689887B2 (https=) |
| KR (1) | KR20180011772A (https=) |
| CN (1) | CN107709300A (https=) |
| AU (1) | AU2016263311A1 (https=) |
| BR (1) | BR112017024633A2 (https=) |
| CA (1) | CA2985161A1 (https=) |
| EA (1) | EA032697B1 (https=) |
| ES (1) | ES2774501T3 (https=) |
| MX (1) | MX2017014752A (https=) |
| WO (1) | WO2016185490A1 (https=) |
| ZA (1) | ZA201707664B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201810294QA (en) | 2016-06-02 | 2018-12-28 | Sun Pharma Advanced Res Co Ltd | Treatment for parkinson's disease |
| EA037697B1 (ru) * | 2016-06-02 | 2021-05-12 | Сан Фарма Адвансед Ресёрч Компани Лимитед | Лечение болезни паркинсона |
| RU2768887C2 (ru) * | 2017-03-15 | 2022-03-25 | Сан Фарма Эдвансд Рисёч Компани Лимитед | Новая аморфная дисперсия (5-{ 5-[n'-(2-хлор-6-метилбензоил)гидразинокарбонил]-2-метил-фенилэтинил} -пиридин-2-ил)амида циклопропанкарбоновой кислоты |
| CN113292537B (zh) | 2018-06-15 | 2024-04-05 | 汉达癌症医药责任有限公司 | 激酶抑制剂的盐类及其组合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007249924B2 (en) * | 2006-05-08 | 2013-07-04 | Ariad Pharmaceuticals, Inc. | Acetylenic heteroaryl compounds |
| WO2012089106A1 (zh) * | 2010-12-27 | 2012-07-05 | Sun Shuping | 作为蛋白激酶抑制剂的芳炔类衍生物及其医疗用途 |
| CN103502217B (zh) * | 2011-01-21 | 2015-11-25 | 太阳医药高级研究有限公司 | 包含酪氨酸激酶抑制剂的二芳基乙炔酰肼 |
| US8859541B2 (en) * | 2012-02-27 | 2014-10-14 | Boehringer Ingelheim International Gmbh | 6-alkynylpyridines |
-
2016
- 2016-05-18 ES ES16796030T patent/ES2774501T3/es active Active
- 2016-05-18 MX MX2017014752A patent/MX2017014752A/es unknown
- 2016-05-18 AU AU2016263311A patent/AU2016263311A1/en not_active Abandoned
- 2016-05-18 US US15/574,967 patent/US10150733B2/en active Active
- 2016-05-18 EP EP16796030.1A patent/EP3297991B1/en active Active
- 2016-05-18 KR KR1020177033739A patent/KR20180011772A/ko not_active Withdrawn
- 2016-05-18 EA EA201792445A patent/EA032697B1/ru not_active IP Right Cessation
- 2016-05-18 BR BR112017024633A patent/BR112017024633A2/pt not_active Application Discontinuation
- 2016-05-18 CN CN201680028615.2A patent/CN107709300A/zh not_active Withdrawn
- 2016-05-18 WO PCT/IN2016/050142 patent/WO2016185490A1/en not_active Ceased
- 2016-05-18 CA CA2985161A patent/CA2985161A1/en not_active Abandoned
- 2016-05-18 JP JP2017560135A patent/JP6689887B2/ja not_active Expired - Fee Related
-
2017
- 2017-11-13 ZA ZA2017/07664A patent/ZA201707664B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA032697B1 (ru) | 2019-07-31 |
| BR112017024633A2 (pt) | 2018-07-31 |
| JP2018515550A (ja) | 2018-06-14 |
| CA2985161A1 (en) | 2016-11-24 |
| EA201792445A1 (ru) | 2018-04-30 |
| MX2017014752A (es) | 2018-03-23 |
| US20180127372A1 (en) | 2018-05-10 |
| EP3297991B1 (en) | 2020-01-29 |
| ES2774501T3 (es) | 2020-07-21 |
| EP3297991A4 (en) | 2018-11-21 |
| AU2016263311A1 (en) | 2017-11-30 |
| ZA201707664B (en) | 2019-08-28 |
| US10150733B2 (en) | 2018-12-11 |
| JP6689887B2 (ja) | 2020-04-28 |
| WO2016185490A1 (en) | 2016-11-24 |
| KR20180011772A (ko) | 2018-02-02 |
| EP3297991A1 (en) | 2018-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180216 |