CN107708687A - 四氢‑N,N‑二甲基‑2,2‑二苯基‑3‑呋喃甲胺的对映体（ANAVEX2‑73）及其在治疗阿尔海默氏病和其他由σ1受体调节的疾病中的用途 - Google Patents

四氢‑N,N‑二甲基‑2,2‑二苯基‑3‑呋喃甲胺的对映体（ANAVEX2‑73）及其在治疗阿尔海默氏病和其他由σ1受体调节的疾病中的用途 Download PDF

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CN107708687A
CN107708687A CN201680033151.4A CN201680033151A CN107708687A CN 107708687 A CN107708687 A CN 107708687A CN 201680033151 A CN201680033151 A CN 201680033151A CN 107708687 A CN107708687 A CN 107708687A
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receptor
sigma
enantiomer
anevex2
agonist
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G·內利阿
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Anavex Life Sciences Corp
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Anavex Life Sciences Corp
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57834974&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN107708687(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Anavex Life Sciences Corp filed Critical Anavex Life Sciences Corp
Priority to CN202310897135.1A priority Critical patent/CN116687906A/zh
Publication of CN107708687A publication Critical patent/CN107708687A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells

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  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Molecular Biology (AREA)
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  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
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  • Biotechnology (AREA)
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  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
CN201680033151.4A 2015-07-22 2016-07-19 四氢‑N,N‑二甲基‑2,2‑二苯基‑3‑呋喃甲胺的对映体（ANAVEX2‑73）及其在治疗阿尔海默氏病和其他由σ1受体调节的疾病中的用途 Pending CN107708687A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202310897135.1A CN116687906A (zh) 2015-07-22 2016-07-19 ANAVEX2-73的对映体及其在治疗阿尔海默氏病和其他由σ1受体调节的疾病中的用途

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562195417P 2015-07-22 2015-07-22
US62/195,417 2015-07-22
PCT/IB2016/001158 WO2017013496A1 (en) 2015-07-22 2016-07-19 Enantiomers of tetrahydro-n,n-dimethyl-2,2-diphenyl-3-furanmethanamine (anavex2-73) and use thereof in the treatment of alzheimer's disease and other disorders modulated by the sigma 1 receptor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202310897135.1A Division CN116687906A (zh) 2015-07-22 2016-07-19 ANAVEX2-73的对映体及其在治疗阿尔海默氏病和其他由σ1受体调节的疾病中的用途

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CN107708687A true CN107708687A (zh) 2018-02-16

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CN201680033151.4A Pending CN107708687A (zh) 2015-07-22 2016-07-19 四氢‑N,N‑二甲基‑2,2‑二苯基‑3‑呋喃甲胺的对映体（ANAVEX2‑73）及其在治疗阿尔海默氏病和其他由σ1受体调节的疾病中的用途
CN202310897135.1A Pending CN116687906A (zh) 2015-07-22 2016-07-19 ANAVEX2-73的对映体及其在治疗阿尔海默氏病和其他由σ1受体调节的疾病中的用途

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Country Status (7)

Country Link
US (3) US11617734B2 (enrdf_load_stackoverflow)
EP (2) EP3324956B1 (enrdf_load_stackoverflow)
JP (4) JP7429942B2 (enrdf_load_stackoverflow)
CN (2) CN107708687A (enrdf_load_stackoverflow)
CA (1) CA2986345A1 (enrdf_load_stackoverflow)
HK (1) HK1247847A1 (enrdf_load_stackoverflow)
WO (1) WO2017013496A1 (enrdf_load_stackoverflow)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112105349A (zh) * 2018-04-12 2020-12-18 阿纳韦克斯生命科学公司 A2-73结晶多晶型物质组合物及其使用方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1247926A1 (zh) 2015-07-22 2018-10-05 阿纳韦克斯生命科学公司 四氢-n，n-二甲基-2，2-二苯基-3-呋喃甲胺盐酸盐的晶型，制备这样晶型的方法，及其药物组合物
CN111712241B (zh) * 2017-11-28 2024-02-13 阿纳韦克斯生命科学公司 σ-1受体激动剂收缩期血压疗法
WO2019222754A1 (en) 2018-05-18 2019-11-21 Anavex Life Sciences Corp. Optimized sigma-1 agonist method of responder selection and treatment
US20230058102A1 (en) 2020-02-04 2023-02-23 Teva Pharmaceuticals International Gmbh Solid state forms of blarcamesine salts

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013008044A1 (en) * 2011-07-08 2013-01-17 Anavex Life Sciences Corp. Synthesis of (+) and (-) 1 -(5,5-diphenyltetrahydrofuran-3- yl)-n,n-dimethylmethanamine, (+) and (-) 1-(2,2-diphenyltetrahydrofuran-3-yl)-n,n- dimethylmethanamine and (+) and (-) 1-(2,2- dffhenyltetrahydrofuran-3-yl)-n-metihylmethanamine
WO2014155138A1 (en) * 2013-03-28 2014-10-02 Alexandre Vamvakides Optimization and therapeutic valorization of the symptomatic treatment of alzheimer's disease with rivastigmine, galantamine or donepezil, by selected aminotetrahydrofurans acting as mixed sigma-1 / muscarinic ligands

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2636625B1 (fr) 1988-09-01 1990-11-09 Jouveinal Sa Benzylamines disubstituees, leur procede de preparation, leur utilisation comme medicament et leurs intermediaires de synthese
GR1002616B (el) 1996-02-21 1997-02-20 Συνθεση και μεθοδος συνθεσης μοριου: τετραυδρο-ν,ν-διμεθυλο-2,2-διφαινυλο-3-φουρανομεθαναμινης (αε 37), αντισπασμωδικης, αντικαταθλιπτικης και νοοτροπικης δρασης.
US20110206780A1 (en) 2010-01-06 2011-08-25 Auspex Pharmaceuticals, Inc. Morphinan modulators of nmda receptors, sigma1 receptors, sigma2 receptors, and/or a3b4 nicotinic receptors
CA2846611A1 (en) 2011-08-25 2013-02-28 Cognition Therapeutics, Inc. Compositions and methods for treating neurodegenerative disease
FR2983732B1 (fr) 2011-12-09 2013-11-22 Servier Lab Nouvelle association entre le 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}pharmaceutiques qui la contiennent

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013008044A1 (en) * 2011-07-08 2013-01-17 Anavex Life Sciences Corp. Synthesis of (+) and (-) 1 -(5,5-diphenyltetrahydrofuran-3- yl)-n,n-dimethylmethanamine, (+) and (-) 1-(2,2-diphenyltetrahydrofuran-3-yl)-n,n- dimethylmethanamine and (+) and (-) 1-(2,2- dffhenyltetrahydrofuran-3-yl)-n-metihylmethanamine
WO2014155138A1 (en) * 2013-03-28 2014-10-02 Alexandre Vamvakides Optimization and therapeutic valorization of the symptomatic treatment of alzheimer's disease with rivastigmine, galantamine or donepezil, by selected aminotetrahydrofurans acting as mixed sigma-1 / muscarinic ligands

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112105349A (zh) * 2018-04-12 2020-12-18 阿纳韦克斯生命科学公司 A2-73结晶多晶型物质组合物及其使用方法
US12180174B2 (en) 2018-04-12 2024-12-31 Anavex Life Sciences Corp. A2-73 crystalline polymorph compositions of matter and methods of use thereof

Also Published As

Publication number Publication date
US11617734B2 (en) 2023-04-04
WO2017013496A1 (en) 2017-01-26
US20250120938A1 (en) 2025-04-17
EP4484953A2 (en) 2025-01-01
EP3324956A1 (en) 2018-05-30
JP7627963B2 (ja) 2025-02-07
JP2023073373A (ja) 2023-05-25
EP4484953A3 (en) 2025-03-12
CN116687906A (zh) 2023-09-05
JP7429942B2 (ja) 2024-02-09
JP2021152077A (ja) 2021-09-30
JP2018524306A (ja) 2018-08-30
HK1247847A1 (zh) 2018-10-05
JP2025061540A (ja) 2025-04-10
US20230044710A1 (en) 2023-02-09
US20180169059A1 (en) 2018-06-21
CA2986345A1 (en) 2017-01-26
US12208079B2 (en) 2025-01-28
EP3324956B1 (en) 2024-11-20
EP3324956A4 (en) 2019-02-20

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