CN107693565B

CN107693565B - Method for improving concentration efficiency and spray drying yield of myrrh extract

Info

Publication number: CN107693565B
Application number: CN201710871687.XA
Authority: CN
Inventors: 韩鹏; 叶兴法; 包世寅
Original assignee: ZHEJIANG JINGYUETANG PHARMACEUTICAL CO Ltd
Current assignee: ZHEJIANG JINGYUETANG PHARMACEUTICAL CO Ltd
Priority date: 2017-09-25
Filing date: 2017-09-25
Publication date: 2020-10-30
Anticipated expiration: 2037-09-25
Also published as: CN107693565A

Abstract

The invention relates to a method for improving the concentration efficiency and spray drying yield of a myrrh extract, belonging to the technical field of processing of traditional Chinese medicine formula granules of myrrh. Compared with the prior art, under the same concentration condition and the same spray drying condition, the invention can use few auxiliary materials by adding the auxiliary material anti-caking agent into the myrrh extracting solution, thereby improving the concentration efficiency, increasing the yield of concentrated solid matters and improving the spray drying yield.

Description

Method for improving concentration efficiency and spray drying yield of myrrh extract

Technical Field

The invention relates to a method for improving the concentration efficiency and spray drying yield of a myrrh extract, belonging to the technical field of processing of traditional Chinese medicine formula granules of myrrh.

Background

Myrrha is dried resin of Commiphora myrrha Engl. or Commiphora molmol Engl. of Canarium family. Pungent, bitter and mild in nature. It enters heart, liver and spleen meridians. Has effects in removing blood stasis, relieving pain, eliminating swelling, and promoting granulation. The main components are resin, gum and volatile oil, and experiments show that the myrrh water decoction has the function of reducing blood fat. The traditional Chinese medicine formula particle is prepared by carrying out water extraction, concentration, drying and granulation on single traditional Chinese medicine decoction pieces, and is taken by patients after being prepared according to a traditional Chinese medicine clinical formula. The traditional Chinese medicine formula particle is a supplement for traditional Chinese medicine decoction pieces. The production process of the traditional Chinese medicine formula particle myrrh adopts a water decoction process, and the myrrh contains gum and resin, the water extract of the myrrh is directly concentrated without adding auxiliary materials, so that the liquid medicine is adhered to a honeycomb heating pipe, the wall of a concentrator and other production pipelines in the concentrator in the concentration process due to high viscosity of the liquid medicine, the concentration efficiency is reduced, partial materials are lost, and the spray yield is reduced due to serious wall adhesion phenomenon in the spray drying process.

Disclosure of Invention

In order to overcome the defects of the prior art, the invention provides a method for improving the concentration efficiency and spray drying yield of a myrrh extract, which has the advantages of less using amount of auxiliary materials, effectively preventing the myrrh extract from adhering to production pipelines and walls in the concentration process, reducing material loss and overcoming the wall adhesion phenomenon in the spray drying process.

In order to achieve the purpose, the technical scheme adopted by the invention is as follows:

a method for improving the concentration efficiency and spray drying yield of the extract of myrrh comprises concentrating and spray drying, and adding anti-caking agent into the extract of myrrh. Namely, the invention prepares the myrrh extract containing the anti-caking agent into the traditional Chinese medicine formula granules by concentrating, spray drying and dry granulating, thereby realizing the purpose of improving the concentration efficiency and the spray drying yield of the myrrh extract.

As a further configuration of the above solution, the anti-caking agent is silicate or stearate.

The silicate is talcum powder or magnesium trisilicate; the stearate is calcium stearate or magnesium stearate.

The use amount of the anti-caking agent is 0.1-1.0% of the dry extract content (namely, the anti-caking agent which is equivalent to 0.1-1.0% of the dry extract content by weight percent is added).

The air inlet temperature of the spray drying process is controlled to be 130-160 ℃, and the air outlet temperature is controlled to be 50-80 ℃.

The invention utilizes the inert powder particles of silicate and stearate anti-caking agents to be dispersed in the myrrh extracting solution, so that the viscous substances are not easy to gather, thereby reducing the viscosity of the traditional Chinese medicine extracting solution, increasing the fluidity of the liquid medicine, and the liquid medicine is not easy to adhere to a honeycomb heating pipe in the circulating concentration process in a concentrator, thereby shortening the concentration time and improving the concentration efficiency. Reduce material loss, prevent the wall adhesion phenomenon in the spray drying process and improve the spray drying yield. Can reduce the production cost of artificial water and electricity. The anti-caking agent selected by the invention is not easy to dissolve in water and can influence the dissolubility of the product, but the dosage of the anti-caking agent is very small and only accounts for 0.1-1.0% of the solid content, so that the prepared myrrh formula particles can still meet the dissolubility requirements related to Chinese pharmacopoeia.

Compared with the prior art, the method of the invention has the following advantages:

1. the myrrh extract adopts the auxiliary material (anti-caking agent) adding technology in the extract under the same concentration condition, compared with maltodextrin, the viscosity of the traditional Chinese medicine extract can be reduced, the liquidity of the liquid medicine can be increased, the concentration time of the liquid medicine can be reduced, the concentration efficiency can be improved, the time can be shortened by 20 percent, and the material loss is less by using less auxiliary materials. The yield of the concentrated solid is improved by 5 percent.

2. The myrrh extract adopts the auxiliary material (anti-caking agent) adding technology in the extract, and the obtained concentrated solution can use less auxiliary materials and can obtain better spray drying yield under the same spray condition compared with the maltodextrin. The yield is improved by 10 percent.

3. The myrrh extract is prepared by adding the auxiliary material (anti-caking agent) into the extract, and compared with maltodextrin, the myrrh extract is prepared by concentrating, spray drying and granulating, wherein the proportion of the active ingredients of myrrh in the prepared granules is increased by 20 percent.

Detailed Description

The present invention will be further illustrated by the following specific examples, but the present invention is not limited to the following examples.

Example 1

Putting myrrh decoction pieces into a multifunctional extraction tank, adding water, decocting twice, mixing decoctions, taking 500 kg of myrrh extract, adding 27.5g of magnesium stearate (accounting for 0.5 percent of solid content) with the solid content (namely the dry extract content) of 1.1 percent, uniformly mixing, concentrating, spray-drying, controlling the air inlet temperature at 150 ℃ and the air outlet temperature at 60-70 ℃, collecting extract powder, and granulating by a dry method to obtain the myrrh oral liquid.

Example 2

Taking 500 kg of myrrh extract, wherein the solid content (namely the dry extract content) is 1.1%, adding 27.5g of talcum powder (accounting for 0.5% of the solid content), uniformly mixing, concentrating, then carrying out spray drying, controlling the air inlet temperature to be 160 ℃ and the air outlet temperature to be 70-80 ℃, collecting extract powder, and carrying out dry granulation to obtain the myrrh compound powder.

Example 3

Taking 500 kg of myrrh extract, adding 27.5g of magnesium trisilicate (accounting for 0.5 percent of solid content) into the myrrh extract with the solid content (namely the dry extract content) of 1.1 percent, uniformly mixing, concentrating, then carrying out spray drying, controlling the air inlet temperature to be 150 ℃ and the air outlet temperature to be 60-70 ℃, collecting extract powder, and carrying out dry granulation to obtain the myrrh extract.

Example 4

Taking 500 kg of myrrh extract, adding 27.5g of calcium stearate (accounting for 0.5 percent of solid content) into the myrrh extract with the solid content (namely the dry extract content) of 1.1 percent, uniformly mixing, concentrating, then carrying out spray drying, controlling the air inlet temperature to be 150 ℃ and the air outlet temperature to be 60-70 ℃, collecting extract powder, and carrying out dry granulation to obtain the myrrh compound powder.

Example 5

Taking 500 kg of myrrh extract, wherein the solid content (namely the dry extract content) is 1.1%, adding 5.5g of magnesium trisilicate (accounting for 0.1% of the solid content), uniformly mixing, concentrating, then carrying out spray drying, controlling the air inlet temperature to be 160 ℃ and the air outlet temperature to be 70-80 ℃, collecting extract powder, and carrying out dry granulation to obtain the myrrh compound powder.

Example 6

Taking 500 kg of myrrh extract, adding 55.0g of magnesium trisilicate (accounting for 1.0 percent of solid content) into the myrrh extract with the solid content (namely the dry extract content), uniformly mixing, concentrating, then carrying out spray drying, controlling the air inlet temperature to be 130 ℃ and the air outlet temperature to be 50-60 ℃, collecting extract powder, and carrying out dry granulation to obtain the myrrh compound powder.

Comparative test

Taking 500 kg of myrrh extract, adding 1100g of maltodextrin (accounting for 20 percent of solid content) into the myrrh extract with the solid content (namely the dry extract content) of 1.1 percent, concentrating, spray drying, collecting extract powder, and performing dry granulation to obtain the myrrh compound powder.

The test results are given in the following table:

it can be seen from the above examples and comparative examples that under the same concentration conditions and the same spray drying conditions, the present invention can use less excipients, improve the concentration efficiency, increase the yield of concentrated solids, and improve the yield of spray drying by adding the excipient anti-caking agent to the myrrh extract.

The above-mentioned embodiments are only used for explaining the inventive concept of the present invention, and do not limit the protection of the claims of the present invention, and any insubstantial modifications of the present invention using this concept shall fall within the protection scope of the present invention.

Claims

1. A method for improving the concentration efficiency and spray drying yield of a myrrh extracting solution comprises a concentration process and a spray drying process, and is characterized in that: adding an anti-caking agent into the myrrh extract;

the anti-caking agent is silicate or stearate;

the silicate is talcum powder or magnesium trisilicate; the stearate is calcium stearate or magnesium stearate;

the usage amount of the anti-caking agent is 0.1-1.0% of the content of the dry extract.

2. The method for improving the concentration efficiency and the spray drying yield of the myrrh extracting solution as claimed in claim 1, wherein: the air inlet temperature of the spray drying process is controlled to be 130-160 ℃, and the air outlet temperature is controlled to be 50-80 ℃.