CN107669921A - 治疗热郁血分所致血友病及血管性假血友病的制剂及方法 - Google Patents
治疗热郁血分所致血友病及血管性假血友病的制剂及方法 Download PDFInfo
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Abstract
一种治疗热郁血分所致血友病及血管性假血友病的制剂及方法。制剂由用量为重量比的下列药物原料制成:炒栀子6‑15、牡丹皮6‑15、生大黄6‑15、白茅根18‑48、萹蓄6‑15、大蓟6‑15、小蓟6‑15、茜草9‑24、仙鹤草18‑48、侧柏叶6‑15、荆芥炭6‑15、生甘草4‑10。本发明制剂是采用水煮提取方法来提取原料药物中的有效成分,并保持其活性,这样不仅可使药物中有效成分的溶出度提高,而且有助于药物的吸收,从而能提高其生物利用度。另外,药物为纯中药复方制剂,因而患者长期服用后不会产生毒副作用,所以安全性好。此外,本发明的制备方法工艺简单,操作方便。
Description
技术领域
本发明涉及一种中药制剂及其制备方法,特别是涉及一种以中药为原料制成的用于治疗热郁血分所致血友病及血管性假血友病的中药复方制剂及其制备方法。
背景技术
血友病为一种遗传性出血性疾病。其共同特征为活性凝血酶生成障碍,凝血时间长,患者有轻度创伤即可一起严重出血。血管性假血友病是一种以出血时间延长,血浆抗血友病球蛋白缺乏,及血小板粘附性降低为特征的出血性疾病。虽然目前临床上用于治疗血友病及血管性假血友病的药物品种很多,但由于导致血友病及血管性假血友病的因素有多种,而且血友病及血管性假血友病也分多种类型,因此这些药物缺乏针对性,疗程相对较长,且部分药物具有一定副作用或过敏反应,所以服用后对于治疗属于热郁血分所致的血友病及血管性假血友病这种疾病来说效果不理想。
发明内容
为了解决上述问题,本发明的目的在于提供一种用于治疗热郁血分所致血友病及血管性假血友病的中药复方制剂及其制备方法。
为了达到上述目的,本发明提供的治疗热郁血分所致血友病及血管性假血友病的制剂由用量为重量比的下列药物原料制成:
炒栀子6-15 牡丹皮6-15 生大黄6-15 白茅根18-48 萹蓄6-15
大蓟6-15 小蓟6-15 茜草9-24 仙鹤草18-48 侧柏叶6-15
荆芥炭6-15 生甘草4-10
所述的治疗热郁血分所致血友病及血管性假血友病的制剂的制备方法是按照下列步骤顺序进行:
(a)将上述药物原料中除生大黄之外的其它药物原料按照配比进行称量并混合,然后加水浸泡25分钟,之后开始煎煮;
(b)待步骤(a)中群药煎煮至25分钟时,加入生大黄,继续煎煮5-10分钟,过滤去渣即可制成所述的用于治疗热郁血分所致血友病及血管性假血友病的中药复方制剂。
所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
本发明提供的用于治疗热郁血分所致血友病及血管性假血友病的中药复方制剂是采用水煮提取的方法来提取原料药物中的有效成分,并保持其活性,这样不仅可使药物中有效成分的溶出度大大提高,而且有助于药物的吸收,从而能够提高其生物利用度。另外,本发明的药物为纯中药复方制剂,因而患者长期服用后不会产生毒副作用,所以安全性好。此外,本发明的制备方法工艺简单,操作方便。
具体实施方式
血友病及血管性假血友病症状复杂,病程迁延,并发症较多。临床常见虚证、实证和虚实夹杂证等。此方立法于清热止血。方中炒栀子苦寒,泻火除烦,清热利湿,凉血解毒,故为君药。牡丹皮苦甘微寒,清热凉血,活血祛瘀;白茅根甘寒,凉血止血,清热利尿,清肺胃热;大蓟甘苦凉,凉血止血,散瘀解毒消痈;茜草苦寒,凉血化瘀止血,通经;侧柏叶苦涩寒,凉血止血,化痰止咳,以上诸药,清热凉血,化瘀止血,共为臣药。生大黄苦寒,泻下攻积,清热泻火,凉血解毒,逐瘀通经;萹蓄苦微寒,利尿通淋,杀虫止痒;小蓟甘苦凉,凉血止血,散瘀解毒消痈;仙鹤草苦涩平,收敛止血,补虚;荆芥炭辛微温,祛风解表,透疹消疮,止血,以上诸药,泻下,利尿,清热凉血,解毒消肿,共为佐药。生甘草甘平,补脾益气,清热解毒止痛,调和诸药,以为使药。本方清热散郁,凉血止血,故适用于治疗热郁血分所致的血友病及血管性假血友病。
下面结合实施例对本发明提供的用于治疗热郁血分所致血友病及血管性假血友病的中药复方制剂及其制备方法进行详细说明。
实施例1:
本实施例用于治疗热郁血分所致血友病及血管性假血友病的中药复方制剂由用量为重量比的下列药物原料制成:
炒栀子6 牡丹皮6 生大黄6 白茅根18 萹蓄6
大蓟6 小蓟6 茜草9 仙鹤草18 侧柏叶6
荆芥炭6 生甘草4
所述的用于治疗热郁血分所致血友病及血管性假血友病的中药复方制剂的制备方法是按照下列步骤顺序进行:
(a)将上述药物原料中除生大黄之外的其它药物原料按照配比进行称量并混合,然后加水浸泡25分钟,之后开始煎煮;
(b)待步骤(a)中群药煎煮至25分钟时,加入生大黄,继续煎煮5-10分钟,过滤去渣即可制成所述的用于治疗热郁血分所致血友病及血管性假血友病的中药复方制剂。
另外,所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
实施例2:
本实施例用于治疗热郁血分所致血友病及血管性假血友病的中药复方制剂由用量为重量比的下列药物原料制成:
炒栀子15 牡丹皮15 生大黄15 白茅根48 萹蓄15
大蓟15 小蓟15 茜草24 仙鹤草48 侧柏叶15
荆芥炭15 生甘草10
制备方法同实施例1。
实施例3:
本实施例用于治疗热郁血分所致血友病及血管性假血友病的中药复方制剂由用量为重量比的下列药物原料制成:
炒栀子8 牡丹皮8 生大黄8 白茅根25 萹蓄8
大蓟8 小蓟8 茜草12 仙鹤草25 侧柏叶8
荆芥炭8 生甘草5
制备方法同实施例1。
本发明提供的用于治疗热郁血分所致血友病及血管性假血友病的中药复方制剂呈棕色至棕褐色;气淡,味微苦。为了验证该中药复方制剂的治疗效果,本发明人利用上述中药复方制剂对285例患有热郁血分型血友病及血管性假血友病的患者进行了系统临床观察,其中21-30岁患者68例,31-40岁105例,41-50岁112例,每次用药150ml,每日3次,120天为1个疗程。经1个疗程治疗后共治愈(出血症状基本消失)135例,占47.4%;有效(主要症状有改善)124例,占43.5%;无效(主要症状无改善)26例,占9.1%;总有效率为90.9%。经2个疗程治疗后共治愈209例,占73.3%;有效68例,占23.9%;无效8例,占2.8%;总有效率为97.2%。
同时,本发明人对治疗效果与年龄、治疗效果与疗程之间的关系进行了分析,分析结果分别见表1、表2。
表1:本发明提供的中药复方制剂治疗效果与年龄关系表
将上述表1中的数据用x2检验法进行计算,结果为0.050>P>0.025,由此可以证明服用本发明提供的中药复方制剂来治疗热郁血分型血友病及血管性假血友病,对各年龄组的治疗效果不随年龄而变化。
表2:本发明提供的中药复方制剂治疗效果与疗程关系表
将上述表2中的数据用x2检验法进行计算,结果为P<0.005,由此可以证明服用本发明提供的中药复方制剂来治疗热郁血分型血友病及血管性假血友病,随着治疗的深入,治愈率、有效率均明显提高。
Claims (3)
1.一种治疗热郁血分所致血友病及血管性假血友病的制剂,其特征在于:所述的治疗热郁血分所致血友病及血管性假血友病的制剂由用量为重量比的下列药物原料制成:
2.一种如权利要求1所述的治疗热郁血分所致血友病及血管性假血友病的制剂的制备方法,其特征在于:所述的制备方法是按照下列步骤顺序进行:
(a)将上述药物原料中除生大黄之外的其它药物原料按照配比进行称量并混合,然后加水浸泡25分钟,之后开始煎煮;
(b)待步骤(a)中群药煎煮至25分钟时,加入生大黄,继续煎煮5-10分钟,过滤去渣即可制成所述的用于治疗热郁血分所致血友病及血管性假血友病的中药复方制剂。
3.根据权利要求2所述的制备方法,其特征在于:所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
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王启政: "《实用中医血液病治疗学》", 31 March 1994, 中国中医药出版社 * |
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