CN107693630A - 治疗气血双亏所致血友病及血管性假血友病的制剂及方法 - Google Patents

治疗气血双亏所致血友病及血管性假血友病的制剂及方法 Download PDF

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CN107693630A
CN107693630A CN201710938749.4A CN201710938749A CN107693630A CN 107693630 A CN107693630 A CN 107693630A CN 201710938749 A CN201710938749 A CN 201710938749A CN 107693630 A CN107693630 A CN 107693630A
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马力
王维蔚
齐燕松
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Tianjin City Hongxing Good Economic Technology Development Co Ltd
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Abstract

一种治疗气血双亏所致血友病及血管性假血友病的制剂及方法。制剂由用量为重量比的下列药物原料制成：生黄芪18‑48、党参6‑15、生白术9‑24、茯苓9‑24、陈皮6‑15、当归6‑15、阿胶6‑15、枸杞子6‑15、补骨脂6‑15、石榴皮6‑15、大枣9‑24、炙甘草4‑10。本发明制剂是采用水煮提取的方法来提取原料药物中有效成分，并保持其活性，这样不仅可使药物中有效成分溶出度大大提高，且有助于药物的吸收，从而能够提高其生物利用度。另外，药物为纯中药复方制剂，因而患者长期服用后不会产生毒副作用，所以安全性好。此外，本发明的制备方法工艺简单，操作方便。

Description

治疗气血双亏所致血友病及血管性假血友病的制剂及方法
技术领域
本发明涉及一种中药制剂及其制备方法，特别是涉及一种以中药为原料制成的用于治疗气血双亏所致血友病及血管性假血友病的中药复方制剂及其制备方法。
背景技术
血友病为一种遗传性出血性疾病。其共同特征为活性凝血酶生成障碍，凝血时间长，患者有轻度创伤即可一起严重出血。血管性假血友病是一种以出血时间延长，血浆抗血友病球蛋白缺乏，及血小板粘附性降低为特征的出血性疾病。虽然目前临床上用于治疗血友病及血管性假血友病的药物品种很多，但由于导致血友病及血管性假血友病的因素有多种，而且血友病及血管性假血友病也分多种类型，因此这些药物缺乏针对性，疗程相对较长，且部分药物具有一定副作用或过敏反应，所以服用后对于治疗属于气血双亏所致的血友病及血管性假血友病这种疾病来说效果不理想。
发明内容
为了解决上述问题，本发明的目的在于提供一种用于治疗气血双亏所致血友病及血管性假血友病的中药复方制剂及其制备方法。
为了达到上述目的，本发明提供的治疗气血双亏所致血友病及血管性假血友病的制剂由用量为重量比的下列药物原料制成：
所述的治疗气血双亏所致血友病及血管性假血友病的制剂的制备方法是按照下列步骤顺序进行∶
(a)将上述药物原料中除阿胶之外的其它药物原料按照配比进行称量并混合，然后加水浸泡25分钟，之后煎煮30分钟，过滤去渣；
(b)将阿胶粉碎成小块或粉末，加入少许黄酒，隔水加热蒸至溶化；
(c)将步骤(a)所得清液与步骤(b)所得阿胶溶液混合均匀即可制成所述的用于治疗气血双亏所致血友病及血管性假血友病的中药复方制剂。
所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
本发明提供的用于治疗气血双亏所致血友病及血管性假血友病的中药复方制剂是采用水煮提取的方法来提取原料药物中的有效成分，并保持其活性，这样不仅可使药物中有效成分的溶出度大大提高，而且有助于药物的吸收，从而能够提高其生物利用度。另外，本发明的药物为纯中药复方制剂，因而患者长期服用后不会产生毒副作用，所以安全性好。此外，本发明的制备方法工艺简单，操作方便。
具体实施方式
血友病及血管性假血友病症状复杂，病程迁延，并发症较多。临床常见虚证、实证和虚实夹杂证等。此方立法于益气补血。方中生黄芪甘微温，健脾补中，升阳举陷，益卫固表，利尿，托毒生肌，为补中益气之要药，故为君药。党参甘平，补脾肺气，补血，生津；茯苓甘淡平，利水渗湿，健脾化痰，宁心安神；当归甘辛温，补血，活血止痛；枸杞子甘平，滋补肝肾，益精明目，为平补肾精肝血之精品；石榴皮酸涩温，涩肠止血，收敛止血，以上诸药，健脾益气，活血补血止血，共为臣药。生白术甘苦温，益气健脾，燥湿利尿，为补气健脾第一要药；陈皮辛苦温，理气健脾，燥湿化痰；阿胶甘平，补血止血，滋阴润肺，为补血之要药；补骨脂苦辛温，补肾壮阳，固精缩尿，温脾止泻，纳气平喘；大枣甘温，补中益气，养血安神，以上诸药，理气补气，补血止血，滋阴补阳，共为佐药。炙甘草甘平，补脾益气，清热解毒止痛，调和诸药，以为使药。本方益气健脾，补血止血，故适用于治疗气血双亏所致的血友病及血管性假血友病。
下面结合实施例对本发明提供的用于治疗气血双亏所致血友病及血管性假血友病的中药复方制剂及其制备方法进行详细说明。
实施例1：
本实施例用于治疗气血双亏所致血友病及血管性假血友病的中药复方制剂由用量为重量比的下列药物原料制成：
所述的用于治疗气血双亏所致血友病及血管性假血友病的中药复方制剂的制备方法是按照下列步骤顺序进行∶
(a)将上述药物原料中除阿胶之外的其它药物原料按照配比进行称量并混合，然后加水浸泡25分钟，之后煎煮30分钟，过滤去渣；
(b)将阿胶粉碎成小块或粉末，加入少许黄酒，隔水加热蒸至溶化；
(c)将步骤(a)所得清液与步骤(b)所得阿胶溶液混合均匀即可制成所述的用于治疗气血双亏所致血友病及血管性假血友病的中药复方制剂。
另外，所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
实施例2：
本实施例用于治疗气血双亏所致血友病及血管性假血友病的中药复方制剂由用量为重量比的下列药物原料制成：
制备方法同实施例1。
实施例3：
本实施例用于治疗气血双亏所致血友病及血管性假血友病的中药复方制剂由用量为重量比的下列药物原料制成：
制备方法同实施例1。
本发明提供的用于治疗气血双亏所致血友病及血管性假血友病的中药复方制剂呈棕色至棕褐色；气淡，味微苦。为了验证该中药复方制剂的治疗效果，本发明人利用上述中药复方制剂对332例患有气血双亏型血友病及血管性假血友病的患者进行了系统临床观察，其中21-30岁患者91例，31-40岁127例，41-50岁114例,每次用药150ml，每日3次，120天为1个疗程。经1个疗程治疗后共治愈(出血症状基本消失)156例，占47.0％；有效(主要症状有改善)145例，占43.7％；无效(主要症状无改善)31例，占9.3％；总有效率为90.7％。经2个疗程治疗后共治愈235例，占70.8％；有效82例，占24.7％；无效15例，占4.5％；总有效率为95.5％。
同时，本发明人对治疗效果与年龄、治疗效果与疗程之间的关系进行了分析，分析结果分别见表1、表2。
表1：本发明提供的中药复方制剂治疗效果与年龄关系表
将上述表1中的数据用x2检验法进行计算，结果为0.050＞P＞0.025，由此可以证明服用本发明提供的中药复方制剂来治疗气血双亏型血友病及血管性假血友病，对各年龄组的治疗效果不随年龄而变化。
表2：本发明提供的中药复方制剂治疗效果与疗程关系表
将上述表2中的数据用x2检验法进行计算，结果为P＜0.005，由此可以证明服用本发明提供的中药复方制剂来治疗气血双亏型血友病及血管性假血友病，随着治疗的深入，治愈率、有效率均明显提高。

Claims (3)

1.一种治疗气血双亏所致血友病及血管性假血友病的制剂，其特征在于：所述的治疗气血双亏所致血友病及血管性假血友病的制剂由用量为重量比的下列药物原料制成：
生黄芪18-48 党参6-15 生白术9-24 茯苓9-24 陈皮6-15
当归6-15 阿胶6-15 枸杞子6-15 补骨脂6-15 石榴皮6-15
大枣9-24 炙甘草4-10。
2.一种如权利要求1所述的治疗气血双亏所致血友病及血管性假血友病的制剂的制备方法，其特征在于：所述的制备方法是按照下列步骤顺序进行∶
(a)将上述药物原料中除阿胶之外的其它药物原料按照配比进行称量并混合，然后加水浸泡25分钟，之后煎煮30分钟，过滤去渣；
(b)将阿胶粉碎成小块或粉末，加入少许黄酒，隔水加热蒸至溶化；
(c)将步骤(a)所得清液与步骤(b)所得阿胶溶液混合均匀即可制成所述的用于治疗气血双亏所致血友病及血管性假血友病的中药复方制剂。
3.根据权利要求2所述的制备方法，其特征在于：所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
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