CN107648409A - 治疗气虚不摄所致血友病及血管性假血友病的制剂及方法 - Google Patents

治疗气虚不摄所致血友病及血管性假血友病的制剂及方法 Download PDF

Info

Publication number
CN107648409A
CN107648409A CN201710916829.XA CN201710916829A CN107648409A CN 107648409 A CN107648409 A CN 107648409A CN 201710916829 A CN201710916829 A CN 201710916829A CN 107648409 A CN107648409 A CN 107648409A
Authority
CN
China
Prior art keywords
preparation
angiohemophilia
hemophilia
deficiency
medicine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201710916829.XA
Other languages
English (en)
Inventor
马力
王维蔚
齐燕松
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tianjin City Hongxing Good Economic Technology Development Co Ltd
Original Assignee
Tianjin City Hongxing Good Economic Technology Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tianjin City Hongxing Good Economic Technology Development Co Ltd filed Critical Tianjin City Hongxing Good Economic Technology Development Co Ltd
Priority to CN201710916829.XA priority Critical patent/CN107648409A/zh
Publication of CN107648409A publication Critical patent/CN107648409A/zh
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)

Abstract

一种治疗气虚不摄所致血友病及血管性假血友病的制剂及方法。制剂由用量为重量比的下列药物原料制成：生黄芪18‑48、生白术9‑24、茯苓9‑24、陈皮6‑15、当归6‑15、牡丹皮6‑15、仙鹤草18‑48、棕榈炭6‑15、艾叶炭6‑15、阿胶6‑15、侧柏叶6‑15、炙甘草4‑10。本发明制剂是采用水煮提取的方法来提取原料药物中的有效成分，并保持其活性，这样不仅可使药物中有效成分的溶出度大大提高，而且有助于药物的吸收，从而能够提高其生物利用度。另外，本发明的药物为纯中药复方制剂，因而患者长期服用后不会产生毒副作用，所以安全性好。此外，本发明的制备方法工艺简单，操作方便。

Description

治疗气虚不摄所致血友病及血管性假血友病的制剂及方法
技术领域
本发明涉及一种中药制剂及其制备方法，特别是涉及一种以中药为原料制成的用于治疗气虚不摄所致血友病及血管性假血友病的中药复方制剂及制备方法。
背景技术
血友病为一种遗传性出血性疾病。其共同特征为活性凝血酶生成障碍，凝血时间长，患者有轻度创伤即可一起严重出血。血管性假血友病是一种以出血时间延长，血浆抗血友病球蛋白缺乏，及血小板粘附性降低为特征的出血性疾病。虽然目前临床上用于治疗血友病及血管性假血友病的药物品种很多，但由于导致血友病及血管性假血友病的因素有多种，而且血友病及血管性假血友病也分多种类型，因此这些药物缺乏针对性，疗程相对较长，且部分药物具有一定副作用或过敏反应，所以服用后对于治疗属于气虚不摄所致的血友病及血管性假血友病这种疾病来说效果不理想。
发明内容
为了解决上述问题，本发明的目的在于提供一种用于治疗气虚不摄所致血友病及血管性假血友病的中药复方制剂及制备方法。
为了达到上述目的，本发明提供的治疗气虚不摄所致血友病及血管性假血友病的制剂由用量为重量比的下列药物原料制成：
所述的治疗气虚不摄所致血友病及血管性假血友病的制剂的制备方法是按照下列步骤顺序进行∶
(a)将上述药物原料中除阿胶之外的其它药物原料按照配比进行称量并混合，然后加水浸泡25分钟，之后煎煮30分钟，过滤去渣；
(b)将阿胶粉碎成小块或粉末，加入少许黄酒，隔水加热蒸至溶化；
(c)将步骤(a)所得清液与步骤(b)所得阿胶溶液混合均匀即可制成所述的用于治疗气虚不摄所致血友病及血管性假血友病的中药复方制剂。
所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
本发明提供的用于治疗气虚不摄所致血友病及血管性假血友病的中药复方制剂是采用水煮提取的方法来提取原料药物中的有效成分，并保持其活性，这样不仅可使药物中有效成分的溶出度大大提高，而且有助于药物的吸收，从而能够提高其生物利用度。另外，本发明的药物为纯中药复方制剂，因而患者长期服用后不会产生毒副作用，所以安全性好。此外，本发明的制备方法工艺简单，操作方便。
具体实施方式
血友病及血管性假血友病症状复杂，病程迁延，并发症较多。临床常见虚证、实证和虚实夹杂证等。此方立法于益气摄血。方中生黄芪甘微温，健脾补中，升阳举陷，益卫固表，利尿，托毒生肌，为补中益气之要药，故为君药。生白术甘苦温，益气健脾，燥湿利尿，为补气健脾第一要药；陈皮辛苦温，理气健脾，燥湿化痰；牡丹皮苦甘微寒，清热凉血，活血祛瘀；棕榈炭苦涩平，收敛止血；阿胶甘平，补血止血，滋阴润肺，为补血之要药，以上诸药，补气补血，凉血止血，共为臣药。茯苓甘淡平，利水渗湿，健脾化痰，宁心安神；当归甘辛温，补血，活血止痛；仙鹤草苦涩平，收敛止血，补虚；艾叶炭辛苦温，温经止血，散寒调经；侧柏叶苦涩寒，凉血止血，化痰止咳，以上诸药，活血补血，温经止血，共为佐药。炙甘草甘平，补脾益气，清热解毒止痛，调和诸药，以为使药。本方健脾益气，养血摄血，故适用于治疗气虚不摄所致的血友病及血管性假血友病。
下面结合实施例对本发明提供的用于治疗气虚不摄所致血友病及血管性假血友病的中药复方制剂及其制备方法进行详细说明。
实施例1：
本实施例提供的用于治疗气虚不摄所致血友病及血管性假血友病的中药复方制剂由用量为重量比的下列药物原料制成：
所述的用于治疗气虚不摄所致血友病及血管性假血友病的中药复方制剂的制备方法是按照下列步骤顺序进行∶
(a)将上述药物原料中除阿胶之外的其它药物原料按照配比进行称量并混合，然后加水浸泡25分钟，之后煎煮30分钟，过滤去渣；
(b)将阿胶粉碎成小块或粉末，加入少许黄酒，隔水加热蒸至溶化；
(c)将步骤(a)所得清液与步骤(b)所得阿胶溶液混合均匀即可制成所述的用于治疗气虚不摄所致血友病及血管性假血友病的中药复方制剂。
另外，所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
实施例2：
本实施例提供的用于治疗气虚不摄所致血友病及血管性假血友病的中药复方制剂由用量为重量比的下列药物原料制成：
制备方法同实施例1。
实施例3：
本实施例提供的用于治疗气虚不摄所致血友病及血管性假血友病的中药复方制剂由用量为重量比的下列药物原料制成：
制备方法同实施例1。
本发明提供的用于治疗气虚不摄所致血友病及血管性假血友病的中药复方制剂呈棕色至棕褐色；气淡，味微苦。为了验证该中药复方制剂的治疗效果，本发明人利用上述中药复方制剂对281例患有气虚不摄型血友病及血管性假血友病的患者进行了系统临床观察，其中21-30岁患者73例，31-40岁102例，41-50岁106例,每次用药150ml，每日3次，120天为1个疗程。经1个疗程治疗后共治愈(出血症状基本消失)146例，占52.0％；有效(主要症状有改善)101例，占35.9％；无效(主要症状无改善)34例，占12.1％；总有效率为87.9％。经2个疗程治疗后共治愈209例，占74.4％；有效51例，占18.1％；无效21例，占7.5％；总有效率为92.5％。
同时，本发明人对治疗效果与年龄、治疗效果与疗程之间的关系进行了分析，分析结果分别见表1、表2。
表1：本发明提供的中药复方制剂治疗效果与年龄关系表
将上述表1中的数据用x2检验法进行计算，结果为0.050＞P＞0.025，由此可以证明服用本发明提供的中药复方制剂来治疗气虚不摄型血友病及血管性假血友病，对各年龄组的治疗效果不随年龄而变化。
表2：本发明提供的中药复方制剂治疗效果与疗程关系表
将上述表2中的数据用x2检验法进行计算，结果为P＜0.005，由此可以证明服用本发明提供的中药复方制剂来治疗气虚不摄型血友病及血管性假血友病，随着治疗的深入，治愈率、有效率均明显提高。

Claims (3)

1.一种治疗气虚不摄所致血友病及血管性假血友病的制剂，其特征在于：所述的治疗气虚不摄所致血友病及血管性假血友病的制剂由用量为重量比的下列药物原料制成：
2.一种如权利要求1所述的治疗气虚不摄所致血友病及血管性假血友病的制剂的制备方法，其特征在于：所述的制备方法是按照下列步骤顺序进行∶
(a)将上述药物原料中除阿胶之外的其它药物原料按照配比进行称量并混合，然后加水浸泡25分钟，之后煎煮30分钟，过滤去渣；
(b)将阿胶粉碎成小块或粉末，加入少许黄酒，隔水加热蒸至溶化；
(c)将步骤(a)所得清液与步骤(b)所得阿胶溶液混合均匀即可制成所述的用于治疗气虚不摄所致血友病及血管性假血友病的中药复方制剂。
3.根据权利要求2所述的制备方法，其特征在于：所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
CN201710916829.XA 2017-09-30 2017-09-30 治疗气虚不摄所致血友病及血管性假血友病的制剂及方法 Withdrawn CN107648409A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710916829.XA CN107648409A (zh) 2017-09-30 2017-09-30 治疗气虚不摄所致血友病及血管性假血友病的制剂及方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710916829.XA CN107648409A (zh) 2017-09-30 2017-09-30 治疗气虚不摄所致血友病及血管性假血友病的制剂及方法

Publications (1)

Publication Number Publication Date
CN107648409A true CN107648409A (zh) 2018-02-02

Family

ID=61116216

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201710916829.XA Withdrawn CN107648409A (zh) 2017-09-30 2017-09-30 治疗气虚不摄所致血友病及血管性假血友病的制剂及方法

Country Status (1)

Country Link
CN (1) CN107648409A (zh)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
王启政: "《实用中医血液病治疗学》", 31 March 1994, 中国中医药出版社 *

Similar Documents

Publication Publication Date Title
CN107519297A (zh) 治疗气不摄血所致血小板减少性紫癜的制剂及制备方法
CN107648409A (zh) 治疗气虚不摄所致血友病及血管性假血友病的制剂及方法
CN107551022A (zh) 治疗表卫不固所致非过敏性紫癜的复方制剂及制备方法
CN107334832A (zh) 用于治疗脾虚不摄所致鼻衄的中药复方制剂及制备方法
CN107519380A (zh) 治疗阴虚火旺所致非过敏性紫癜的复方制剂及制备方法
CN107693630A (zh) 治疗气血双亏所致血友病及血管性假血友病的制剂及方法
CN107582697A (zh) 治疗血热妄行所致血友病及血管性假血友病的制剂及方法
CN107184717A (zh) 用于治疗气虚血亏所致贫血病的中药复方制剂及制备方法
CN107551124A (zh) 治疗虚热出血所致血友病及血管性假血友病的制剂及方法
CN107638455A (zh) 治疗气虚不固所致非过敏性紫癜的复方制剂及制备方法
CN107669921A (zh) 治疗热郁血分所致血友病及血管性假血友病的制剂及方法
CN106822764A (zh) 用于治疗脾胃气虚所致白血病的中药复方制剂及制备方法
CN107519370A (zh) 治疗脾肾亏虚所致非过敏性紫癜的复方制剂及制备方法
CN107569555A (zh) 治疗瘀血出血所致血友病及血管性假血友病的制剂及方法
CN107149627A (zh) 用于治疗阴阳两虚所致贫血病的中药复方制剂及制备方法
CN107693657A (zh) 治疗瘀血阻络所致非过敏性紫癜的复方制剂及制备方法
CN107158194A (zh) 用于治疗肾阴亏虚所致鼻衄的中药复方制剂及制备方法
CN107582665A (zh) 治疗外伤淤血所致血友病及血管性假血友病的制剂及方法
CN107519379A (zh) 治疗阴虚内热所致血小板减少性紫癜的制剂及制备方法
CN107362259A (zh) 用于治疗气滞血瘀所致吐血的中药复方制剂及制备方法
CN107693595A (zh) 治疗气虚不摄所致过敏性紫癜的中药复方制剂及制备方法
CN107137575A (zh) 用于治疗阴虚火炎所致齿衄的中药复方制剂及制备方法
CN107029082A (zh) 用于治疗脾肾阳虚所致贫血病的中药复方制剂及制备方法
CN107260837A (zh) 用于治疗脾虚血虚所致便血的中药复方制剂及制备方法
CN107582894A (zh) 治疗热毒内蕴所致过敏性紫癜的中药复方制剂及制备方法

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WW01 Invention patent application withdrawn after publication

Application publication date: 20180202

WW01 Invention patent application withdrawn after publication