CN107334832A - 用于治疗脾虚不摄所致鼻衄的中药复方制剂及制备方法 - Google Patents
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Abstract
一种用于治疗脾虚不摄所致鼻衄的中药复方制剂及制备方法。制剂由用量为重量比的下列药物原料制成：炙黄芪18‑48、党参6‑15、炒白术9‑24、茯苓9‑24、当归6‑15、炒酸枣仁9‑24、阿胶6‑15、仙鹤草18‑48、大枣9‑24、生甘草4‑10。本发明制剂是采用水煮提取的方法来提取原料药物中的有效成分，并保持其活性，这样不仅可使药物中有效成分的溶出度大大提高，而且有助于药物的吸收，从而能够提高其生物利用度。另外，本发明的药物为纯中药复方制剂，因而患者长期服用后不会产生毒副作用，所以安全性好。此外，本发明的制备方法工艺简单，操作方便。
Description
技术领域
本发明涉及一种中药制剂及其制备方法，特别是涉及一种以中药为原料制成的用于治疗脾虚不摄所致鼻衄的中药复方制剂及制备方法。
背景技术
鼻衄是指血从鼻孔中流出，是常见的一种病，可由多种疾患引起。鼻衄的记载最早见于《黄帝内经》，经历代医家研究，认为其发病与“热”、“寒”、肝肺病及劳伤有关。虽然目前临床上用于治疗鼻衄的药物品种较多，但由于导致鼻衄的因素有多种，而且鼻衄也分多种类型，因此这些药物缺乏针对性，疗程相对较长，且部分药物具有一定副作用或过敏反应，所以服用后对于治疗属于脾虚不摄所致的鼻衄这种疾病来说效果不理想。
发明内容
为了解决上述问题，本发明的目的在于提供一种用于治疗脾虚不摄所致鼻衄的中药复方制剂及其制备方法。
为了达到上述目的，本发明提供的用于治疗脾虚不摄所致鼻衄的中药复方制剂由用量为重量比的下列药物原料制成：
所述的用于治疗脾虚不摄所致鼻衄的中药复方制剂的制备方法是按照下列步骤顺序进行∶所述的制备方法是按照下列步骤顺序进行∶
(a)将上述药物原料中除阿胶之外的其它药物原料按照配比进行称量并混合，然后加水浸泡25分钟，之后煎煮30分钟，过滤去渣；
(b)将阿胶粉碎成小块或粉末，加入少许黄酒，隔水加热蒸至溶化；
(c)将步骤(a)所得清液与步骤(b)所得阿胶溶液混合均匀即可制成所述的用于治疗脾虚不摄所致鼻衄的中药复方制剂。
所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
本发明提供的用于治疗脾虚不摄所致鼻衄的中药复方制剂是采用水煮提取的方法来提取原料药物中的有效成分，并保持其活性，这样不仅可使药物中有效成分的溶出度大大提高，而且有助于药物的吸收，从而能够提高其生物利用度。另外，本发明的药物为纯中药复方制剂，因而患者长期服用后不会产生毒副作用，所以安全性好。此外，本发明的制备方法工艺简单，操作方便。
具体实施方式
鼻衄症状复杂，病程迁延，并发症较多。临床常见虚证、实证和虚实夹杂证等。此方立法于益气摄血。方中炙黄芪甘微温，健脾补中，升阳举陷，益卫固表，利尿，托毒生肌，为补中益气之要药，为君药。党参甘平，补脾肺气，补血，生津；茯苓甘淡平，利水渗湿，健脾化痰，宁心安神；炒酸枣仁甘酸平，养心益肝，安神，敛汗；仙鹤草苦涩平，收敛止血，补虚，以上诸药，补气血，利水健脾，养心安神，共为臣药。炒白术甘苦温，益气健脾，燥湿利尿，为补气健脾第一要药；当归甘辛温，补血，活血止痛；阿胶甘平，补血止血，滋阴润肺，为补血之要药；大枣甘温，补中益气，养血安神，以上诸药，健脾益气，滋阴补血，养血安神，为佐药。生甘草甘平，补脾益气，清热解毒止痛，调和诸药，以为使药。本方健脾养心，滋补肝肾，补气血，止血，故适用于治疗脾虚不摄所致的鼻衄。
下面结合实施例对本发明提供的用于治疗脾虚不摄所致鼻衄的中药复方制剂及其制备方法进行详细说明。
实施例1：
本实施例提供的用于治疗脾虚不摄所致鼻衄的中药复方制剂由用量为重量比的下列药物原料制成：
所述的用于治疗脾虚不摄所致鼻衄的中药复方制剂的制备方法是按照下列步骤顺序进行：
(a)将上述药物原料中除阿胶之外的其它药物原料按照配比进行称量并混合，然后加水浸泡25分钟，之后煎煮30分钟，过滤去渣；
(b)将阿胶粉碎成小块或粉末，加入少许黄酒，隔水加热蒸至溶化；
(c)将步骤(a)所得清液与步骤(b)所得阿胶溶液混合均匀即可制成所述的用于治疗脾虚不摄所致鼻衄的中药复方制剂。
另外，所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
实施例2：
本实施例提供的用于治疗脾虚不摄所致鼻衄的中药复方制剂由用量为重量比的下列药物原料制成：
制备方法同实施例1
实施例3：
本实施例提供的用于治疗脾虚不摄所致鼻衄的中药复方制剂由用量为重量比的下列药物原料制成：
制备方法同实施例1
本发明提供的用于治疗脾虚不摄所致鼻衄的中药复方制剂呈棕色至棕褐色；气淡，味微苦。为了验证该中药复方制剂的治疗效果，本发明人利用上述中药复方制剂对279例患有脾虚不摄型鼻衄的患者进行了系统临床观察，其中21-30岁患者55例，31-40岁110例，41-50岁114例,每次用药150ml，每日3次，120天为1个疗程。经1个疗程治疗后共治愈(出血症状基本消失)124例，占44.4％；有效(主要症状有改善)102例，占36.6％；无效(主要症状无改善)53例，占19.0％；总有效率为81.0％。经2个疗程治疗后共治愈188例，占67.4％；有效77例，占27.6％；无效14例，占5.0％；总有效率为95.0％。
同时，本发明人对治疗效果与年龄、治疗效果与疗程之间的关系进行了分析，分析结果分别见表1、表2。
表1：本发明提供的中药复方制剂治疗效果与年龄关系表
将上述表1中的数据用x2检验法进行计算，结果为0.050＞P＞0.025，由此可以证明服用本发明提供的中药复方制剂来治疗脾虚不摄型鼻衄，对各年龄组的治疗效果不随年龄而变化。
表2：本发明提供的中药复方制剂治疗效果与疗程关系表
将上述表2中的数据用x2检验法进行计算，结果为P＜0.005，由此可以证明服用本发明提供的中药复方制剂来治疗脾虚不摄型鼻衄，随着治疗的深入，治愈率、有效率均明显提高。
Claims (3)
1.一种用于治疗脾虚不摄所致鼻衄的中药复方制剂，其特征在于：所述的用于治疗脾虚不摄所致鼻衄的中药复方制剂由用量为重量比的下列药物原料制成：
2.一种如权利要求1所述的用于治疗脾虚不摄所致鼻衄的中药复方制剂的制备方法，其特征在于：所述的制备方法是按照下列步骤顺序进行∶
(a)将上述药物原料中除阿胶之外的其它药物原料按照配比进行称量并混合，然后加水浸泡25分钟，之后煎煮30分钟，过滤去渣；
(b)将阿胶粉碎成小块或粉末，加入少许黄酒，隔水加热蒸至溶化；
(c)将步骤(a)所得清液与步骤(b)所得阿胶溶液混合均匀即可制成所述的用于治疗脾虚不摄所致鼻衄的中药复方制剂。
3.根据权利要求2所述的制备方法，其特征在于：所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
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| CN111228444A (zh) * | 2020-03-31 | 2020-06-05 | 重庆三峡医药高等专科学校 | 一种治疗鼻出血的中药组合物及其提取物和应用 |
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| Title |
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| 焦中华等: "《实用中医血液病学》", 30 June 1989, 青岛出版社 * |
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| CN111228444A (zh) * | 2020-03-31 | 2020-06-05 | 重庆三峡医药高等专科学校 | 一种治疗鼻出血的中药组合物及其提取物和应用 |
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