CN107666861B - 在利用尺寸不同的药物洗脱微球珠粒进行经动脉化疗栓塞之后的药物浓度确定 - Google Patents

在利用尺寸不同的药物洗脱微球珠粒进行经动脉化疗栓塞之后的药物浓度确定 Download PDF

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CN107666861B
CN107666861B CN201580077916.XA CN201580077916A CN107666861B CN 107666861 B CN107666861 B CN 107666861B CN 201580077916 A CN201580077916 A CN 201580077916A CN 107666861 B CN107666861 B CN 107666861B
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contrast agent
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tumor
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CN107666861A (zh
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C·哈泽
D·谢弗
E·S·汉西斯
T·克林德
M·格拉斯
M·D·林
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Koninklijke Philips NV
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computed tomography [CT]
    • A61B6/032—Transmission computed tomography [CT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/42—Arrangements for detecting radiation specially adapted for radiation diagnosis
    • A61B6/4208—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
    • A61B6/4241—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector using energy resolving detectors, e.g. photon counting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/48—Diagnostic techniques
    • A61B6/481—Diagnostic techniques involving the use of contrast agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/48—Diagnostic techniques
    • A61B6/482—Diagnostic techniques involving multiple energy imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/504—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for diagnosis of blood vessels, e.g. by angiography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414—Particles, beads, capsules or spheres
    • A61K49/0419—Microparticles, microbeads, microcapsules, microspheres, i.e. having a size or diameter higher or equal to 1 micrometer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/40—Arrangements for generating radiation specially adapted for radiation diagnosis
    • A61B6/405—Source units specially adapted to modify characteristics of the beam during the data acquisition process
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00—ICT specially adapted for the handling or processing of medical images
    • G16H30/20—ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Theoretical Computer Science (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Dentistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Surgical Instruments (AREA)
CN201580077916.XA 2015-03-18 2015-12-04 在利用尺寸不同的药物洗脱微球珠粒进行经动脉化疗栓塞之后的药物浓度确定 Active CN107666861B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562134639P 2015-03-18 2015-03-18
US62/134,639 2015-03-18
EP15166519.7 2015-05-06
EP15166519 2015-05-06
PCT/EP2015/078737 WO2016146214A1 (en) 2015-03-18 2015-12-04 Drug concentration determination after transarterial chemoembolization with different sized drug-eluting microsphere beads

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CN107666861A CN107666861A (zh) 2018-02-06
CN107666861B true CN107666861B (zh) 2022-03-01

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US (1) US11172896B2 (https=)
EP (1) EP3270785B1 (https=)
JP (1) JP2018513715A (https=)
CN (1) CN107666861B (https=)
WO (1) WO2016146214A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3400877A1 (de) 2017-05-10 2018-11-14 Siemens Healthcare GmbH Verfahren zur bildgebung eines untersuchungsbereichs mit erstem kontrastmittel und zweitem kontrastmittel
DE102019218589A1 (de) * 2019-11-29 2021-06-02 Bayer Aktiengesellschaft Simultane Bilddarstellung von zwei unterschiedlichen funktionellen Bereichen
CN113546234B (zh) * 2020-04-24 2022-09-20 苏州医本生命科技有限公司 一种血管介入具有示踪功能的药物制剂及其输送系统
DE102021210860A1 (de) 2021-09-28 2023-03-30 Siemens Healthcare Gmbh Computerimplementiertes Verfahren zur Auswertung von Bilddaten eines Patienten, Eingriffsanordnung, Computerprogramm und elektronisch lesbarer Datenträger
US12484865B2 (en) * 2024-02-02 2025-12-02 Varian Medical Systems, Inc. Selective internal radiation therapy mapping via microbeads with different contrast materials

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101820861A (zh) * 2007-07-25 2010-09-01 西洛诺瓦生物科学公司 用于治疗和/或诊断应用的颜色编码和一定尺寸的可承载的聚合物颗粒及其制备和使用方法
CN102098963A (zh) * 2008-07-18 2011-06-15 皇家飞利浦电子股份有限公司 谱成像
CN104271044A (zh) * 2012-05-02 2015-01-07 皇家飞利浦有限公司 可成像药物洗脱珠的光谱ct可视化

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101090710B (zh) 2004-10-25 2012-03-14 宝利策尼克斯有限公司 治疗和/或诊断用途的含聚磷腈的可负载聚合颗粒和制备方法及其应用
US9114162B2 (en) * 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
US9107850B2 (en) * 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
RU2529804C2 (ru) * 2008-10-23 2014-09-27 Конинклейке Филипс Электроникс, Н.В. Молекулярная визуализация
US9149605B2 (en) * 2009-07-28 2015-10-06 Clement Kleinstreuer Methods and devices for targeted injection of microspheres
US9730759B2 (en) * 2011-04-28 2017-08-15 Koninklijke Philips N.V. Spectral imaging based decision support, treatment planning and/or intervention guidance
US10032268B2 (en) * 2012-08-06 2018-07-24 Koninklijke Philips N.V. Dynamic contrast-enhanced imaging based permeability metric

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101820861A (zh) * 2007-07-25 2010-09-01 西洛诺瓦生物科学公司 用于治疗和/或诊断应用的颜色编码和一定尺寸的可承载的聚合物颗粒及其制备和使用方法
CN102098963A (zh) * 2008-07-18 2011-06-15 皇家飞利浦电子股份有限公司 谱成像
CN104271044A (zh) * 2012-05-02 2015-01-07 皇家飞利浦有限公司 可成像药物洗脱珠的光谱ct可视化

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Publication number Publication date
CN107666861A (zh) 2018-02-06
US20180035960A1 (en) 2018-02-08
EP3270785B1 (en) 2020-07-08
EP3270785A1 (en) 2018-01-24
US11172896B2 (en) 2021-11-16
WO2016146214A1 (en) 2016-09-22
JP2018513715A (ja) 2018-05-31

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