CN107661357A - Leech medicinal liquor preparation method - Google Patents
Leech medicinal liquor preparation method Download PDFInfo
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- CN107661357A CN107661357A CN201711138401.3A CN201711138401A CN107661357A CN 107661357 A CN107661357 A CN 107661357A CN 201711138401 A CN201711138401 A CN 201711138401A CN 107661357 A CN107661357 A CN 107661357A
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- leech
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- liquor preparation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
- C12G3/00—Preparation of other alcoholic beverages
- C12G3/04—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Genetics & Genomics (AREA)
- Tropical Medicine & Parasitology (AREA)
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- Medicines Containing Plant Substances (AREA)
- Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
Abstract
The present invention relates to a kind of leech medicinal liquor preparation method, belongs to leech deep process technology field.It includes will the fresh leech that just capture not feeding 1 day~3 days；Leech by the processing of not feeding is put into salt solution, pulled out after its death, is dried；The leech being dried to obtain is put into mesh container, and by blowing away the impurity on leech table body；Then, leech is put into yellow rice wine, sealing immersion；Wherein, the previous moon soaked in sealing, it is ultrasonically treated daily.The present invention, which first passes through leech being put into certain density salt solution, to be soaked, and is changed the tension force of its superficial cell, is then placed into certain density yellow rice wine, using the specificity of its alcohol concentration, utilizes the dissolution of its hirudin；Finally it is finally reached the purpose of the dissolution rate for the hirudin for improving leech by being specifically ultrasonically treated again.
Description
Technical field
The present invention relates to leech deep process technology field, especially a kind of leech medicinal liquor preparation method.
Background technology
Leech, popular name leech.Hirudin is a kind of polypeptide in fresh leech glandula, is made up of several amino acids, asparagus fern
It is propylhomoserin 10, glutamic acid 13, cysteine 6, serine 4, glycine 9, threonine 4, alanine 1, valine 3, leucine 4, different
Leucine 2, proline 3, phenylalanine 2, cruel propylhomoserin 2, histidine 1 and lysine 4（Digitized representation molecular number）, because in its molecule
It is higher to have dihydric amino acid content, therefore its isoelectric point is ph3.8, it is more stable to reaction of degeneration (RD)；Sterling is grey or white
Color scale or powder, in acidity, it is dissolved in water, physiological saline and pyridine, several not dissolve in alcohol, acetone and benzene, heat or in diluted acid
In it is perishable.
Leech has very high value of being used as medicine in itself, is used as medicine by drying entirety, contains hirudin and abundant albumen
Matter, the effect of also invigorating blood circulation, dissipate the stasis of blood, stimulate the menstrual flow.It is frequently used in the symptoms such as amenorrhoea, blood stasis abdominal pain, traumatic injury.
With the deep development of leech medical value, its market demand potential is huge, and leech Prospects of Deep Processing is good.Mesh
Before, the deep processing of traditional leech is mainly dried based on entirety with being made, such as in the following manner：
1. net system：Cloth is uniformly removed with quick lime rapidly or is puddled, after vexed 20~30 minutes, leech struggles and dead, then with clear
Water is cleaned or well sifted lime, dries or is dried with heated kang or insulating box, you can is sold；Also the leech of capture can be put into light salt brine
In, pulled out after its death, be finished product after drying or drying, can sell or store；
2. talcum powder system：Talcum powder is put in people's pot, leech is added after making popular with high heat, does not stop to stir-fry, when leech scalded into it is micro-
Taken out during drum, weed out talcum powder, it is finished product to cool after drying；
3. honey system：Take honey to add leech after being diluted with boiling water, mix thoroughly it is braised through after place pot in, with slow fire fry to do not stick for degree,
Taking-up cools.Every 10 grams of leech, with 120 grams of honey；
4. swill system：Leech was soaked for 1 night with water in which rice has been washed, then puts and is fried in pot to coke yellow, take out, dry；
5. oil system：Take clean leech to place in pot, fried to coke yellow and taken out with lard, be finished product after drying；
6. roasting：Fetch water the fiery roasting method of leech, roast to faint yellow, with clear-cut to spend, face used time levigation；
7. the metric system：In leech and the meter Yi Qi hot pots of falling people of fetching water, heated with slow fire, fry to rice be in yellow when taking-up dry in the air cool, weed out rice.
0.5 kilogram-meter of every 1 kilogram of leech；
It is 8. ironed：Clean fine sand is taken, is placed in pot, leech section is put into after heating, does not then stop stir-fry and mixes, fry to expansion and taken when heaving
Go out, weed out sand, cool drying, as finished product；
9. vinegar system：Take clean fine sand, place in pot, leech is put into after making popular, stir-fry is mixed to leech takes out when bubbling, and weeds out after sand again
Add the wax that people is appropriate, inhale thoroughly, dry or dry；Also boiled after leech being added to vinegar with pot, 0.35 kilogram of vinegar of every kilogram of leech, treat vinegar
Take out, dry after blotting；
10. wine system：Leech is cleaned into decontamination with clear water, bubble is pulled out, dried for about 1 hour, is then mixed uniformly with yellow rice wine leaching, is put people
In pot, simmer in water to wine and exhaust, taking-up is dried in the air cool, segment, is dried, 20 kilograms of yellow rice wine of every kilogram of leech.
In addition to above-mentioned processing mode, the deep processed products such as medicinal liquor can also be made in leech.However, due to by technical merit
Etc. the influence of factor, hirudin its Average dissolution contained in leech is not high, cause leech addition in leech medicinal liquor compared with
Greatly, it is higher to prepare cost for leech medicinal liquor.
The content of the invention
The present invention a kind of leech medicinal liquor preparation method of offer, it can solve in existing leech medicinal liquor preparation process due to
Its Average dissolution of the hirudin contained in leech is not high, causes the leech addition in leech medicinal liquor larger, leech medicinal liquor system
The problem of standby cost is higher.
In order to solve the above-mentioned technical problem, the technical solution adopted in the present invention is：
It comprises the following steps：
A. by the fresh leech just captured not feeding 1 day~3 days；
B. it will be put into by the step A leech that feeding is not handled in salt solution, pull out, dry after its death；
C. leech step B being dried to obtain is put into mesh container, and by blowing away the impurity on leech table body；
D. the leech for handling to obtain by step C is put into yellow rice wine, sealing immersion；Wherein, in the previous of sealing immersion
Month, it is ultrasonically treated daily.
In above-mentioned technical proposal, more specifically technical scheme can also be：Step B, the concentration of the salt solution is 0.3wt%
~0.5 wt%.
Further, in D steps, the alcoholic strength of the yellow rice wine is 50 degree~60 degree.
Further, in D steps, the specific method of the supersound process is：Ultrasonic power be ultrasonic power be 40W~
50W, supersonic frequency are 20KHz~30KHz, 25 DEG C~45 DEG C of ultrasonic temperature, ultrasonic time 20min~40min.
By adopting the above-described technical solution, the present invention has following remarkable result compared with prior art：
The present invention, which first passes through leech being put into certain density salt solution, to be soaked, and is changed the tension force of its superficial cell, is then put again
Enter in certain density yellow rice wine, using the specificity of its alcohol concentration, utilize the dissolution of its hirudin；Finally again by specific
It is ultrasonically treated, is finally reached the purpose of the dissolution rate for the hirudin for improving leech.
Embodiment
Below in conjunction with specific embodiment, the invention will be further described, and protection scope of the present invention is not only limited to
In following examples.
Embodiment 1 --- leech medicinal liquor preparation method
It comprises the following steps：
A. by the fresh leech just captured not feeding 1 day；
B. it will be put into by the step A leech that feeding is not handled in the salt solution that concentration is 0.3wt%, pull out, do after its death
It is dry；
C. leech step B being dried to obtain is put into mesh container, and by blowing away the impurity on leech table body；
D. the leech for handling to obtain by step C is put into the yellow rice wine that alcoholic strength is 50 degree, sealing immersion；Wherein, sealing
The previous moon of immersion, it is daily 40W in ultrasonic power to it, supersonic frequency 20KHz, 25 DEG C of ultrasonic temperature, ultrasonic time
It is ultrasonically treated under 20min.
In the present embodiment, the dissolution rate of the hirudin contained in leech reaches 96%.
Embodiment 2 --- leech medicinal liquor preparation method
It comprises the following steps：
A. by the fresh leech just captured not feeding 3 days；
B. it will be put into by the step A leech that feeding is not handled in the salt solution that concentration is 0.5 wt%, pull out, do after its death
It is dry；
C. leech step B being dried to obtain is put into mesh container, and by blowing away the impurity on leech table body；
D. the leech for handling to obtain by step C is put into the yellow rice wine that alcoholic strength is 60 degree, sealing immersion；Wherein, sealing
The previous moon of immersion, it is daily 50W in ultrasonic power to it, supersonic frequency 30KHz, 45 DEG C of ultrasonic temperature, ultrasonic time
It is ultrasonically treated under 40min.
In the present embodiment, the dissolution rate of the hirudin contained in leech reaches 95%.
Embodiment 3 --- leech medicinal liquor preparation method
A. by the fresh leech just captured not feeding 2 days；
B. it will be put into by the step A leech that feeding is not handled in the salt solution that concentration is 0.4wt%, pull out, do after its death
It is dry；
C. leech step B being dried to obtain is put into mesh container, and by blowing away the impurity on leech table body；
D. the leech for handling to obtain by step C is put into the yellow rice wine that alcoholic strength is 55 degree, sealing immersion；Wherein, sealing
The previous moon of immersion, it is daily 46W in ultrasonic power to it, supersonic frequency 26KHz, 30 DEG C of ultrasonic temperature, ultrasonic time
It is ultrasonically treated under 30min.
In the present embodiment, the dissolution rate of the hirudin contained in leech reaches 95.5%.
Comparative example 1 --- leech medicinal liquor preparation method
It comprises the following steps：
A. by the fresh leech just captured not feeding 1 day；
B. it will be put into by the step A leech that feeding is not handled in boiling water, pull out, dry after its death；
C. leech step B being dried to obtain is put into mesh container, and by blowing away the impurity on leech table body；
D. the leech for handling to obtain by step C is put into the yellow rice wine that alcoholic strength is 50 degree, sealing immersion；Wherein, sealing
The previous moon of immersion, it is daily 40W in ultrasonic power to it, supersonic frequency 20KHz, 25 DEG C of ultrasonic temperature, ultrasonic time
It is ultrasonically treated under 20min.
In this comparative example, the dissolution rate of the hirudin contained in leech is only 80%.
Comparative example 2 --- leech medicinal liquor preparation method
It comprises the following steps：
A. by the fresh leech just captured not feeding 3 days；
B. it will be put into by the step A leech that feeding is not handled in the salt solution that concentration is 0.5 wt%, pull out, do after its death
It is dry；
C. leech step B being dried to obtain is put into mesh container, and by blowing away the impurity on leech table body；
D. the leech for handling to obtain by step C is put into the yellow rice wine that alcoholic strength is 10 degree, sealing immersion；Wherein, sealing
The previous moon of immersion, it is daily 50W in ultrasonic power to it, supersonic frequency 30KHz, 45 DEG C of ultrasonic temperature, ultrasonic time
It is ultrasonically treated under 40min.
In this comparative example, the dissolution rate of the hirudin contained in leech is only 81%.
Comparative example 3 --- leech medicinal liquor preparation method
A. by the fresh leech just captured not feeding 2 days；
B. it will be put into by the step A leech that feeding is not handled in the salt solution that concentration is 0.4wt%, pull out, do after its death
It is dry；
C. leech step B being dried to obtain is put into mesh container, and by blowing away the impurity on leech table body；
D. the leech for handling to obtain by step C is put into the yellow rice wine that alcoholic strength is 55 degree, sealing immersion.
In this comparative example, the dissolution rate of the hirudin contained in leech is only 78%.
Claims (4)
1. a kind of leech medicinal liquor preparation method, it is characterised in that comprise the following steps：
A. by the fresh leech just captured not feeding 1 day~3 days；
B. it will be put into by the step A leech that feeding is not handled in salt solution, pull out, dry after its death；
C. leech step B being dried to obtain is put into mesh container, and by blowing away the impurity on leech table body；
D. the leech for handling to obtain by step C is put into yellow rice wine, sealing immersion；Wherein, in the previous of sealing immersion
Month, it is ultrasonically treated daily.
2. leech medicinal liquor preparation method according to claim 1, it is characterised in that：Step B, the concentration of the salt solution are
The wt% of 0.3wt%~0.5.
3. leech medicinal liquor preparation method according to claim 1 or 2, it is characterised in that：In D steps, the wine of the yellow rice wine
Precision is 50 degree~60 degree.
4. leech medicinal liquor preparation method according to claim 3, it is characterised in that：In D steps, the tool of the supersound process
Body method is：Ultrasonic power is that ultrasonic power is 40W~50W, and supersonic frequency is 20KHz~30KHz, ultrasonic temperature 25 DEG C~45
DEG C, ultrasonic time 20min~40min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711138401.3A CN107661357A (en) | 2017-11-16 | 2017-11-16 | Leech medicinal liquor preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711138401.3A CN107661357A (en) | 2017-11-16 | 2017-11-16 | Leech medicinal liquor preparation method |
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| Publication Number | Publication Date |
|---|---|
| CN107661357A true CN107661357A (en) | 2018-02-06 |
Family
ID=61145075
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711138401.3A Withdrawn CN107661357A (en) | 2017-11-16 | 2017-11-16 | Leech medicinal liquor preparation method |
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| CN (1) | CN107661357A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110585424A (en) * | 2019-09-18 | 2019-12-20 | 周维海 | Preparation method of leech polypeptide medicinal liquor for preventing and treating cardiovascular and cerebrovascular diseases |
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| CN1423929A (en) * | 2003-01-15 | 2003-06-18 | 周维海 | Culture of hiruto and extraction of hirutin |
| CN101759803A (en) * | 2009-11-27 | 2010-06-30 | 广东海洋大学 | Hirudin saline-polyethylene glycol double aqueous phase extraction method |
| CN101974085A (en) * | 2010-11-01 | 2011-02-16 | 南宁市金贝生物技术有限责任公司 | Method for extracting high-anticoagulation-activity hirudin from natural leeches |
| CN102286098A (en) * | 2011-08-18 | 2011-12-21 | 周维官 | Production method of natural hirudin |
| CN106188277A (en) * | 2016-09-30 | 2016-12-07 | 重庆志微生物技术有限公司 | A kind of blood-eating hirudo adult feeds and the sustainable extracting method of hirudin and special equipment |
| CN107325177A (en) * | 2017-09-01 | 2017-11-07 | 荆州市民康生物科技有限公司 | A kind of method for improving Bufrudin extract yield |
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2017
- 2017-11-16 CN CN201711138401.3A patent/CN107661357A/en not_active Withdrawn
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1423929A (en) * | 2003-01-15 | 2003-06-18 | 周维海 | Culture of hiruto and extraction of hirutin |
| CN101759803A (en) * | 2009-11-27 | 2010-06-30 | 广东海洋大学 | Hirudin saline-polyethylene glycol double aqueous phase extraction method |
| CN101974085A (en) * | 2010-11-01 | 2011-02-16 | 南宁市金贝生物技术有限责任公司 | Method for extracting high-anticoagulation-activity hirudin from natural leeches |
| CN102286098A (en) * | 2011-08-18 | 2011-12-21 | 周维官 | Production method of natural hirudin |
| CN106188277A (en) * | 2016-09-30 | 2016-12-07 | 重庆志微生物技术有限公司 | A kind of blood-eating hirudo adult feeds and the sustainable extracting method of hirudin and special equipment |
| CN107325177A (en) * | 2017-09-01 | 2017-11-07 | 荆州市民康生物科技有限公司 | A kind of method for improving Bufrudin extract yield |
Non-Patent Citations (2)
| Title |
|---|
| 张岚: "水蛭的提取工艺研究", 《黑龙江医药》 * |
| 马琳: "动物药水蛭酒炙炮制工艺研究", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110585424A (en) * | 2019-09-18 | 2019-12-20 | 周维海 | Preparation method of leech polypeptide medicinal liquor for preventing and treating cardiovascular and cerebrovascular diseases |
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Application publication date: 20180206 |
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