CN107649207A - Micro flow control chip device using dimethyl silicone polymer as substrate material - Google Patents
Micro flow control chip device using dimethyl silicone polymer as substrate material Download PDFInfo
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- CN107649207A CN107649207A CN201610627452.1A CN201610627452A CN107649207A CN 107649207 A CN107649207 A CN 107649207A CN 201610627452 A CN201610627452 A CN 201610627452A CN 107649207 A CN107649207 A CN 107649207A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
- B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
- B01L2300/166—Suprahydrophobic; Ultraphobic; Lotus-effect
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- Health & Medical Sciences (AREA)
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Abstract
The present invention relates to a kind of micro flow control chip device using dimethyl silicone polymer as substrate material, belong to analysis testing field.The substrate of micro-fluidic chip is made using dimethyl silicone polymer i.e. PDMS that is cheap and easily processing, some problems be present；Its surface of the PDMS material is strongly hydrophobic, and targetedly surface is modified or surface modification, its effect are difficult to persistently, and this case aims to solve the problem that the serial relevant issues.This case main points are, the selected PDMS with ecosystem surface of substrate, and fastening is positioned at the sample liquid stream terminal of the micro-fluidic chip its neighbor positions manually by the hinge-type fixture for being attached to miniature ultrasonic transducer units, interfacial tension is reduced with ultrasonic wave, strong absorbability using PDMS to ultrasonic wave simultaneously, reach ultrasonic intensity rapid decrement in short distance, and interfacial tension difference thus is formed at the both ends of the chip, thereby drive sample liquid stream to be flowed along originally hydrophobic capillary channel to the terminal direction.
Description
Technical field
The present invention relates to a kind of micro flow control chip device using dimethyl silicone polymer as substrate material, belongs to analysis and surveys
Examination field.
Background technology
For the microflow control technique overall general picture of itself, famous micro-fluidic expert Mr. Lin Ping Cheng may refer to not
The monograph " diagram Microfluid based Lab on a chip " gone out before long, the monograph is published via Science Press, and the monograph is for miniflow
Past of control technology, now, and, vision of the future etc. etc., suffer from detail, be deep into long opinion of detail
State.
The field that micro-fluidic chip is often applied to include to containing large biological molecule sample solution carry out it is various analysis,
Detection.
The basic framework of micro-fluidic chip, including be etched with the substrate of small fluid course and fit together therewith
Cover plate, the small fluid course on the substrate, before upper cover plate is assembled, it is apparent on see to be exactly some micro-channels, to wait until
After covering cover plate thereon, just really closure forms the small fluid course, the conduit inner surface of the micro-channel together with
The part cover plate that surround the micro-channel forms described small fluid course together；So, it is clear that after assembling completes
The small fluid course, the major part of its inner surface area is the inner surface area of that micro-channel, in other words, should
The state or property of micro-channel inner surface substantially determine the integrality or property of the small fluid course；Therefore say, this
The inner surface state or inner surface property of micro-channel of the individual structure on substrate are key factors；In principle, it is any can
The material of its solid forms is kept or kept substantially, can be used to make substrate and cover plate, such as, it can act as substrate and lid
The material of piece can be monocrystalline silicon piece, quartz plate, sheet glass, high polymer for example dimethyl silicone polymer, polymethyl methacrylate,
Makrolon etc.；Certainly, the selection of substrate and the selection of cover plate be able to can also be differed with identical；From material consumption, make
From the point of view of difficulty and application popularization prospect etc. etc., not small difference, the especially choosing of that substrate between these materials be present
Material, have a great influence.
In various substrate making materials, dimethyl silicone polymer, i.e. PDMS, comparatively very easily shaping, at this
It is extremely simple that micro-channel is made on the substrate of sample, and the lower cost for material, base is made with the polydimethyl siloxane material
Piece, micro-channel, and the cover plate phase made with the cheap material such as glass or polypropylene or other plastic sheets are being suppressed or etched thereon
Coordinate, be a kind of more satisfactory selection seemingly；Certainly, patch material can also select to use cheap dimethyl silicone polymer
Material：So, this substrate selection is the scheme of polydimethyl siloxane material, and material is extremely cheap, and making is extremely simple, seems
It should be extremely easy to popularize, promote.
But thing is really not so simple.
First, this polydimethyl siloxane material, that is, the material that alphabetical PDMS is referred to of abridging, itself are a kind of strong
Strong hydrophobic material, micro-channel is built on this material, if without being operated for the modified of the micro-channel surface, that
, after overall assembling is completed, that is, after covering cover plate, because the micro-channel its inner surface in structure occupies most liquid
The inner surface of circulation road, then, its strong hydrophobic property of the PDMS micro-channels inner surface, is deciding factor, it can cause
Similar to the aqueous solution the fine liquid stream of polar liquid by becoming very difficult, its flow resistance is big, or even in general is micro-
Pump is all difficult to promote, certainly, if cover plate also selects to use the PDMS material, then, problem is substantially identical, similar；
Therefore, among prior art, modification is modified particular for the micro-channel inner surface on the PDMS material, is necessary behaviour
Make；So, this is pretty troublesome for the modified operation of PDMS micro-channel inner surfacesThat falls nor this problem, is formed tight
Weight technology puzzlement, be another problem：PDMS polymer molecules inside its body phase of this PDMS material substrate have automatic
The characteristic diffuse to the surface, migrated, the spy that this substrate body phase inside PDMS polymer molecules are diffused to the surface, migrated automatically
Property, the state after modification by its inner surface of that micro-channel of surface modifying and decorating will be caused can not to maintain long enough
Time, the holding time for micro-channel its inner surface state after that is surface-modified be substantially only sufficient to complete laboratory internal
The time of test experiments needs；In other words, by surface modification or the PDMS micro-channel inner surfaces of surface modification, it is modified
The surface state that is formed can not be lasting afterwards or after saying modification, but soon automatically tends to or say and become surface modification again
Surface state before, the strong hydrophobic surface state of that script is returned in the shorter time, then, just think, this
The micro-fluidic chip of sample can largely make, mass storage, be widely popularized, and answer is it is obvious that is, impossible.This
Micro-channel on PDMS material, if not doing surface modification, similar to the aqueous solution the fine liquid stream of polar solvent can not pump it is logical
Cross, chip also cannot just use；And if having done surface modification, its state after modifying can not be persistently kept again, or together
Sample can not popularization and application.
So, how to accomplish that substrate can either be made using cheap PDMS material, and the microflute can be released
Road inner surface decorating state can not persistently, chip can not largely make, largely lay in and then be widely popularized and such a make ability
The puzzlement that the numerous professionals in domain are entangled with for a long time, the highly difficult problem that exactly one its obvious technology barrier can not despise.
Be present many year in the highly difficult problem, so far, not yet properly settled.
Second, the PDMS material of non-surface modification, it is stated that, its surface is strongly hydrophobic above, this strong hydrophobic
Material surface and also have another problem, that is, this strong hydrophobic PDMS surfaces can adsorb large biological molecule, and
And these adsorbed large biological molecules can also further depression further on PDMS surfaces, gradually fall into it is gradually deep, until
It is heavy to be trapped within the body phase of PDMS substrates, in fact, this process, partly it is also due to PDMS material body phase interior polymer
Molecule, which has, to be diffused to the surface, caused by travel motion；Such case, it can also be explained from another angle, i.e. continue not
Disconnectedly from inside PDMS body phases to those polymer molecules of its diffusion into the surface, migration, its result moved, be little by little by that
It has been involved in a bit by the large biological molecule of adsorption within the body phase of PDMS substrates, briefly, these adsorbed biologies
Macromolecular is exactly to be swallowed up by PDMS substrate body phases；So, this PDMS substrates body phase swallows up the phenomenon of large biological molecule, its institute
Caused by influence, necessarily cause the severe deviations of all kinds of test data of experiment for being related to large biological molecule.
As described above, the problem of PDMS substrates, is, its not only adsorption large biological molecule, and swallow up biological big point
Son, so, as the large biological molecule of experiment test object, its disappearance will not stop because surface saturation is adsorbed, and
It is, it is constantly adsorbed, also constantly swallowed up.
On PDMS substrates, its body phase is constantly swallowed up and tests showing for associated biomolecule macromolecular in related experiment test process
As, it is to say that another kind, which is explained, substantial amounts of Minute pores in PDMS body phases be present, associated biomolecule macromolecular by after adsorption,
Depression enters these Minute pores, and then is swallowed up；However, inventor thinks, those can allow the sky of miniature scale
Qi leel squeezes into the Minute pores therebetween, not equal to saying that they also can directly allow the large biological molecule of relative large scale to enter
Enter, both difference on yardstick are huge, must not make sweeping generalizations.Explanation is bypassed, in any case, as dependence test analysis object
Large biological molecule is adsorbed by PDMS substrate micro-channels inner surface, and then is constantly swallowed up by PDMS substrate body phases, and this is person in charge of reception at ceremonies
Phenomenon existing for sight.
, can be from containment PDMS surfaces pair in order to prevent swallow up effect of this PDMS substrate bodies relative to large biological molecule
The absorption of large biological molecule addresses, and method is chemically modified modification aiming at the PDMS material surface, for
For PDMS is the situation of substrate material, modification exactly is chemically modified to the surface of described micro-channel part, by changing
The micro-channel inner surface of modification is learned, its absorption to large biological molecule can be contained, and then avoid large biological molecule
Swallowed up by PDMS substrate body phases；But or that old problem, that is, the chemical modification on PDMS material surface is modified
Surface state afterwards can not persistently be kept, the polymer molecule inside the PDMS substrate body phases its diffuse to the surface, move automatically
The process of shifting, it soon can become that micro-channel inner surface state being modified by surface chemical modification again script strong and dredge
Water and the state of strong adsorption large biological molecule, in other words, no matter how professionals in the field turn from side to side, the PDMS bases
Its micro-channel inner surface of piece is always rapidly to strong hydrophobic surface state evolution.
So, how can either obtain that PDMS material price is extremely cheap, substrate makes extremely easy benefit, and can is enough
Reach and contain the absorption process of the PDMS substrate micro-channel inner surfaces to large biological molecule for a long time, and then prevent PDMS substrate body phases
The effect of swallowing up to large biological molecule so that related chip manufactured goods be able to maintain that one it is prolonged enough, reasonably guarantee the quality
Phase, it is exactly a very intractable problem.The problem equally makes this area numerous as another problem addressed above
Professional is entangled with, perplexed for a long time, and the problem is equally the highly difficult problem that its obvious technology barrier can not despise.
Also be present many year in the problem, so far, also not yet properly settled.
The content of the invention
The technical problem to be solved by the invention is to provide a package solution, while solve to address above
Two problems.
The present invention solves the technical problem by following scheme, and the device that the program provides is one kind with poly dimethyl silicon
Micro flow control chip device of the oxygen alkane as substrate material, the structure of the device include micro-fluidic chip, the knot of the micro-fluidic chip
Structure includes being bonded to each other the substrate and cover plate of installing together, and its test liquid of the micro-fluidic chip flows into sample end and the sample liquid stream
The terminal of flowing is located remotely from each other, and the distance between the sample introduction end and the terminal are between 3 centimetres and 10 centimetres, the micro-fluidic core
Its test liquid of piece flows into sample end and offers sample introduction end liquid pool, and the terminal of the sample fluid flow offers terminal liquid pool, in chip
Its both ends of pipeline connected respectively with sample introduction end liquid pool and the terminal liquid pool, emphasis is that its material of the substrate is poly- two
Methylsiloxane material, its surface of the substrate are the surfaces of primary form, the surface of the primary form its be intended to refer to and do not have
By any surface chemical modification or the surface of the primary form of the material of any surface chemical modification, the structure of the device is also
Including hinge-type fixture, hinge-type fixture its appearance profile likeness in form hinge, the hinge-type fixture is by being mutually hinged
Two hinges and matched through a fastening screw of two hinges and one with the fastening screw and with the fastening spiral shell
What silk braid was connected together is used for the nut of fastening and hand break loose composition manually, and two hinges of the hinge-type fixture are respectively with its end
The tip is mutually drawn close and clamps the micro-fluidic chip, and the tip is positioned at the structure bit of the neighbouring terminal of the micro-fluidic chip
Put, fixation is attached in a hinge at least in and is equiped with miniature ultrasonic transducer units, and, higher-order of oscillation electricity
Signal transmission cable, one end and the miniature ultrasonic transducer units of the higher-order of oscillation electric signal transmission cable link together；Should
Hinge-type fixture provides a function of facilitating the device to disassemble；Its major function of the miniature ultrasonic transducer units is in miniflow
When the actual sample introduction of control chip is tested, it is internal logical to reduce sample solution and the micro-fluidic chip for the ultrasonic wave launched using it
Interfacial tension between the inwall in road, can be compatible, also, miniature super with this using the sample introduction end and the terminal
Difference in the distance between acoustic wave transducer installation position difference and its ultrasonic intensity experienced, induced synthesis institute
State the difference between its interfacial tension of sample introduction end and the terminal its interfacial tension, the interface between the micro-fluidic chip both ends
Tension difference can form pressure gap between the both ends of the micro-fluidic chip, and the pressure gap can drive sample solution to institute
State end flow；The ultrasonic wave that the miniature ultrasonic transducer units its functions also includes being launched with it is checked contained in sample
Its absorption on the micro-fluidic chip its inner passage inner surface of large biological molecule, and then check the dimethyl silicone polymer material
Swallow up effect of its body phase of the substrate of matter to the large biological molecule；The base of the dimethyl silicone polymer material that is soft and having elasticity
Its function of piece includes, with its property to the strong absorption of ultrasonic wave, absorbing ultrasonic wave strongly, and thereby micro-fluidic at this
The chip terminal is to the rapid decrement that ultrasonic intensity is realized within the limited short distance between the sample introduction end, the terminal liquid pool
Interior to be filled with some high hydroscopic resin particles, its opening end of the terminal liquid pool is covered by breathable microporous film.
Described miniature ultrasonic transducer units can certainly be all installed in two hinges；But only install one
Individual miniature ultrasonic transducer units are dealt with enough to be used.
The word of hinge one art-recognized meanings of itself are known.
Only for professional of the word of ultrasonic transducer one art-recognized meanings of itself for ultrasonic technology field,
It is known.
Various sizes, variously-shaped ultrasonic transducer are commercially available；Its size of commercially available miniature ultrasonic transducer units
It may diminish to the magnitude only calculated with millimeter.
Only with regard to miniature ultrasonic transducer units its technique for fixing on general industry application solid body surface its
It is known general technology for the professional in ultrasonic technology field for body.This case is not to this expansion superfluous words.
Only with regard to naked PDMS substrates itself micro-channel molding or lithographic technique for, be open-and-shut known skill
Art；Similarly, the technology of hole-opening is even more known simple technique on naked PDMS substrates.This case is not also superfluous to this expansion
Speech.
The industrial products market of involved its all size of higher-order of oscillation electric signal transmission cable is on sale.
The structure of the device can also include higher-order of oscillation electric signal generator；The higher-order of oscillation electric signal transmission cable
Its other end can be connected with the higher-order of oscillation electric signal generator.
The involved higher-order of oscillation electric signal generator technology of itself, come for the professional in ultrasonic technology field
Say, be simple and known；The higher-order of oscillation electric signal generator can customize to ultrasonic instrument specialized factory.
The preferred scope of its specified ultrasonic wave transmission power of the miniature ultrasonic transducer units is between 2 milliwatts and 9000 milliwatts
Between；The preferred scope of the frequency of its ultrasonic wave operationally launched of the miniature ultrasonic transducer units be between 100KHz with
Between 12MHz.
Only for the word of high hydroscopic resin one art-recognized meanings of itself, come for the professional of chemical field
Say, be known.
The high hydroscopic resin is commercially available.
Only for the word of breathable microporous film one art-recognized meanings of itself, for the professional of technical field of membrane,
It is known.
The breathable microporous film is commercially available.
This case device can further include some annexes certainly, and the annex can for example coordinate with micro-fluidic chip
The electrically or optically detection device used.The equipment that the electricity, optics etc. are used cooperatively with micro-fluidic chip, may refer to
The monograph.
The cover plate in chip structure, its material can allow to be any electrical insulating property material, such as：Polypropylene,
Glass, polymethyl methacrylate, dimethyl silicone polymer, etc., in order to make smaller size of micro-fluidic chip, for example do
Into the micro-fluidic chip of only 2.0 centimetres to 3.0 centimetres of super-small of length, and realized in the extremely short distance to ultrasonic wave
Extremely fast decay, can preferably dimethyl silicone polymer be used as cover plate.Certainly, selected on large-sized micro-fluidic chip
Using dimethyl silicone polymer it is used as the cover plate, and this case technical scheme is allowed.
Described its thickness of cover plate and substrate can allow be any setting the thickness for being easy to assembling, the thickness of recommendation or say
Preferable thickness is between 1.0 millimeters and 5.0 millimeters.Less thickness is advantageous to save material.
It is an advantage of the invention that its close position positions the hinge-type folder in the terminal of the micro-fluidic chip
Tool, the miniature ultrasonic transducer units installed with institute's attaching in the hinge-type fixture its hinge, the low-power launched using it, height
The ultrasonic wave of frequent section so that without in strong hydrophobic micro-fluidic chip of surface chemical modification or surface chemical modification
Compatibility between its tube wall of portion's pipeline and the test object aqueous solution is significantly increased, and this is sample liquid stream by providing one
Realistic possibility；Meanwhile using its strong absorbability to ultrasonic wave of dimethyl silicone polymer substrate, in shorter distance
It is interior, it is, in from the terminal to the very short distance of only several centimeters yardsticks the sample introduction end, it is strong to reach ultrasonic wave
The rapid decrement of degree, the difference of the interfacial tension is thereby caused at the both ends of the micro-fluidic chip, and then, using this two
Pressure gap between its both ends for being formed of the difference of interfacial tension between end, driving sample liquid stream is in such a original
Flowed in this strong hydrophobic capillary channel to the terminal direction.By this case liquid stream drive scheme, entirely without must be to this
The substrate and its internal pipeline of dimethyl silicone polymer material carry out any surface chemical modification or chemical modification, altogether dispense with
The laborious procedures of the surface chemical modification or chemical modification；And setting for traditional Micropump etc is altogether dispensed with
It is standby；On the other hand, the ultrasonic wave of the low-power, high-frequency band, additionally it is possible to contain the large biological molecule in sample at this without modification
Naked its inner surface of pipeline of dimethyl silicone polymer substrate on absorption, and then contain its body of the dimethyl silicone polymer substrate
The effect of swallowing up of relatively described large biological molecule；Because described suction-operated and the described effect of swallowing up effectively are held back
System, therefore, dependence test result will be better able to objectively reflect actual conditions.
Due to the surface chemical modification for the dimethyl silicone polymer substrate its relevant surfaces or surface need not be carried out
Chemical modification operates, and therefore, this surface chemical modification layer or surface chemical modification layer not need to exist, then, should
Its body phase interior polymer molecule of dimethyl silicone polymer substrate constantly diffuses to the surface automatically, migrate caused by it to described
The damaging influence of surface chemical modification layer or surface chemical modification layer is also just not present.
It is related that the technical scheme of this case has dissolved its application to dimethyl silicone polymer substrate addressed above totally
A series of technical barriers.Based on this case scheme, the very cheap polydimethyl siloxane material of this kind is just possible to micro- at this
It is prepared by fluidic chip, production, using etc. field play bigger effect.
The miniature ultrasonic transducer units have been installed in fixation in the hinge-type fixture its hinge in this case structure, the structure
A function of facilitating the device to disassemble is provided, in this way, the hinge-type fixture is together with miniature ultrasonic appended in its hinge
Transducer just easily can be mutually disengaged with the micro-fluidic chip, then, the component that the part can freely depart from just can be good
Property is re-used cyclically many times；The architectural feature is advantageous to save the use cost of the device.
Brief description of the drawings
Fig. 1 is its rough outside side view of this case micro flow control chip device.
In figure, 1 is hinge-type fixture, and 2 sign linkwork positions, 3 be fastening screw, and 4 be higher-order of oscillation telecommunication
Number transmission cable, 5 be miniature ultrasonic transducer units, and 6,11 be two different hinges of locations of structures respectively, and 7 be cover plate, and 8 be base
Piece, 9 be sample introduction end, and 10 be terminal, and 12 be nut；The hinge-type clamp structure in legend is only the legend structure of signal, real
Border its structure of the hinge-type fixture is not limited to the legend hinge-type clamp structure；Arrow in legend indicates the micro-fluidic core
Piece its in actual motion, by pressure at two ends difference drive, the flow direction of its sample liquid stream.
Embodiment
In this case that Fig. 1 is shown embodiment, the structure of the device includes micro-fluidic chip, the micro-fluidic chip
Structure includes being bonded to each other the substrate 8 and cover plate 7 of installing together, and its test liquid of the micro-fluidic chip flows into sample end 9 and the examination
The terminal 10 of sample fluid flow is located remotely from each other, the distance between the sample introduction end 9 and the terminal 10 between 3 centimetres with 10 centimetres it
Between, its test liquid of the micro-fluidic chip flows into sample end and offers sample introduction end liquid pool, and the terminal of the sample fluid flow offers end
Liquid pool is held, its both ends of pipeline in chip connect with sample introduction end liquid pool and the terminal liquid pool respectively, and emphasis is the substrate
8 its material are dimethyl silicone polymer materials, and its surface of substrate 8 is the surface of primary form, the surface of the primary form its
The surface of the primary form for the material for not passing through any surface chemical modification or any surface chemical modification is intended to refer to,
The structure of the device also includes hinge-type fixture 1, the hinge-type fixture 1 its appearance profile likeness in form hinge, the hinge-type fixture 1 by
Two hinges 6,11 for being mutually hinged and through a fastening screw 3 of two hinges 6,11 and one with should
The nut 12 of fastening and hand break loose manually that is used for that fastening screw 3 is matched and connected together with the fastening screw 3 is formed, should
Nut 12 employs in this example is easier manually operated butterfly nut, and butterfly nut is commercially available, the hinge-type fixture 1
Two hinges 6,11 respectively mutually drawn close with its tip and clamp the micro-fluidic chip, the tip is positioned at the micro-fluidic chip
The neighbouring terminal 10 locations of structures on, in a hinge at least in attach fixation is equiped with miniature ultrasonic
Wave transducer, in this example, the miniature ultrasonic transducer units 5 are to attach to be fixed in hinge 6, and, higher-order of oscillation electric signal passes
Transmission cable 4, one end of the higher-order of oscillation electric signal transmission cable 4 link together with the miniature ultrasonic transducer units 5；The hinge
Formula fixture 1 provides a function of facilitating the device to disassemble；Its major function of the miniature ultrasonic transducer units 5 is micro-fluidic
During the test of chip actual sample introduction, the ultrasonic wave launched using it reduces sample solution and its inner passage of the micro-fluidic chip
Inwall between interfacial tension, can be compatible, also, using the sample introduction end 9 and the terminal 10 it is miniature with this
Difference in the distance between the installation position of ultrasonic transducer 5 difference and its ultrasonic intensity experienced, induce shape
Difference between described its interfacial tension of sample introduction end 9 and the terminal 10 its interfacial tension, the micro-fluidic chip both ends 9,
Interfacial tension difference between 10 can form pressure gap between the both ends 9,10 of the micro-fluidic chip, the pressure gap meeting
Driving sample solution flows to the direction of terminal 10；Its function of the miniature ultrasonic transducer units 5 also includes what is launched with it
Ultrasonic wave checks in sample contained large biological molecule its absorption on the micro-fluidic chip its inner passage inner surface, enters
And check swallow up effect of its body phase of the substrate 8 of the dimethyl silicone polymer material to the large biological molecule；Softness simultaneously has elasticity
The substrate 8 of the dimethyl silicone polymer material its function include with its property to the strong absorption of ultrasonic wave, ultrasonic wave is entered
Row is strong to be absorbed, and is thereby realized within micro-fluidic chip terminal 10 to the limited short distance between the sample introduction end 9
The rapid decrement of ultrasonic intensity, some high hydroscopic resin particles are filled with the terminal liquid pool, its opening end of the terminal liquid pool
Covered by breathable microporous film.
Arrow in legend indicate the micro-fluidic chip its in actual motion, by pressure at two ends difference drive, its try
The flow direction of sample liquid stream.
Fig. 1 is depicted without the associate members such as the higher-order of oscillation electric signal generator.
Described its main body of hinge-type fixture can simply be changed a social system using commercially available hinge；Can also be to hardware processing factory
Customization.
Involved miniature ultrasonic transducer units 5 are commercially available；It can also be customized to ultrasonic transducer producer.
Involved higher-order of oscillation electric signal transmission cable 4 is commercially available；Can also be special to ultrasonic transducer producer or cable
Industry producer customizes.
Involved higher-order of oscillation electric signal generator market has the product close to needs commercially available；It can also determine to relevant manufacturers
System.
Its inner passage of the micro-fluidic chip involved by this case is the pipeline of hydrophobic capillary form.
Claims (5)
1. using dimethyl silicone polymer as the micro flow control chip device of substrate material, the structure of the device includes micro-fluidic core
Piece, the structure of the micro-fluidic chip include being bonded to each other the substrate and cover plate of installing together, its test liquid of the micro-fluidic chip
Flow into sample end and the terminal of the sample fluid flow be located remotely from each other, the distance between the sample introduction end and the terminal between 3 centimetres with
Between 10 centimetres, its test liquid of the micro-fluidic chip flows into sample end and offers sample introduction end liquid pool, the terminal of the sample fluid flow
Offer terminal liquid pool, its both ends of pipeline in chip connect with sample introduction end liquid pool and the terminal liquid pool respectively, and it is special
Sign is, its material of the substrate is dimethyl silicone polymer material, and its surface of the substrate is the surface of primary form, the primary shape
The surface of state its be intended to refer to the primary of the not no material by any surface chemical modification or any surface chemical modification
The surface of form, the structure of the device also include hinge-type fixture, hinge-type fixture its appearance profile likeness in form hinge, the hinge
Formula fixture by two hinges being mutually hinged and through a fastening screw of two hinges and one with should
The nut of fastening and hand break loose manually that is used for that fastening screw is matched and connected together with the fastening screw is formed, the hinge
Two hinges of formula fixture are respectively mutually drawn close with its tip and clamp the micro-fluidic chip, and the tip is positioned at the micro-fluidic core
Fixation, which is attached, in the locations of structures of the neighbouring terminal of piece, in a hinge at least in is equiped with miniature ultrasonic
Wave transducer, and, higher-order of oscillation electric signal transmission cable, one end of the higher-order of oscillation electric signal transmission cable is miniature super with this
Acoustic wave transducer links together；The hinge-type fixture provides a function of facilitating the device to disassemble；The miniature ultrasonic
Its major function of transducer is that the ultrasonic wave launched using it is molten to reduce sample in the actual sample introduction test of micro-fluidic chip
Interfacial tension between liquid and the inwall of its inner passage of micro-fluidic chip, can be compatible, also, utilizes the sample introduction
End and the distance between the terminal and the miniature ultrasonic transducer units installation position difference and its ultrasound experienced
Difference between difference in intensity of wave, its interfacial tension of sample introduction end described in induced synthesis and the terminal its interfacial tension, should
Interfacial tension difference between the micro-fluidic chip both ends can form pressure gap between the both ends of the micro-fluidic chip, should
Pressure gap can drive sample solution to the end flow；Its function of the miniature ultrasonic transducer units also includes being launched with it
Ultrasonic wave check in sample contained large biological molecule its absorption on the micro-fluidic chip its inner passage inner surface,
And then check swallow up effect of its body phase of the substrate of the dimethyl silicone polymer material to the large biological molecule；Softness simultaneously has elasticity
The substrate of the dimethyl silicone polymer material its function include, with its property to the strong absorption of ultrasonic wave, carrying out ultrasonic wave
It is strong to absorb, and thereby realize ultrasonic wave within micro-fluidic chip terminal to the limited short distance between the sample introduction end
The rapid decrement of intensity, some high hydroscopic resin particles are filled with the terminal liquid pool, its opening end of the terminal liquid pool is breathed freely
Microporous barrier is covered.
2. the micro flow control chip device according to claim 1 using dimethyl silicone polymer as substrate material, its feature
It is, its material of the cover plate is dimethyl silicone polymer material.
3. the micro flow control chip device according to claim 1 using dimethyl silicone polymer as substrate material, its feature
It is, described its thickness of cover plate and substrate is between 1.0 millimeters and 5.0 millimeters.
4. the micro flow control chip device according to claim 1 using dimethyl silicone polymer as substrate material, its feature
It is, the structure of the device also includes higher-order of oscillation electric signal generator, and its is another for the higher-order of oscillation electric signal transmission cable
End is connected with the higher-order of oscillation electric signal generator.
5. the micro flow control chip device according to claim 1 using dimethyl silicone polymer as substrate material, its feature
It is, its specified ultrasonic wave transmission power of the miniature ultrasonic transducer units is between 2 milliwatts and 9000 milliwatts, the miniature ultrasonic
The frequency of its ultrasonic wave operationally launched of wave transducer is between 100KHz and 12MHz.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610627452.1A CN107649207A (en) | 2016-07-26 | 2016-07-26 | Micro flow control chip device using dimethyl silicone polymer as substrate material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201610627452.1A CN107649207A (en) | 2016-07-26 | 2016-07-26 | Micro flow control chip device using dimethyl silicone polymer as substrate material |
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| CN107649207A true CN107649207A (en) | 2018-02-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610627452.1A Pending CN107649207A (en) | 2016-07-26 | 2016-07-26 | Micro flow control chip device using dimethyl silicone polymer as substrate material |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101817495A (en) * | 2010-03-25 | 2010-09-01 | 湖南大学 | Micro fluid control chip and preparation method and application thereof |
| CN102645429A (en) * | 2012-04-23 | 2012-08-22 | 宁波大学 | Self-cleaning and vibration wave energy digestion link containing electrogenerated chemiluminescence analyzing and detecting device |
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2016
- 2016-07-26 CN CN201610627452.1A patent/CN107649207A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101817495A (en) * | 2010-03-25 | 2010-09-01 | 湖南大学 | Micro fluid control chip and preparation method and application thereof |
| CN102645429A (en) * | 2012-04-23 | 2012-08-22 | 宁波大学 | Self-cleaning and vibration wave energy digestion link containing electrogenerated chemiluminescence analyzing and detecting device |
Non-Patent Citations (1)
| Title |
|---|
| JAMES FRIEND ETAL.: "Microscale acoustofluidics:microfluidics driven via acoustics and ultrasonics", 《REVIEWS OF MODERN PHYSICS》 * |
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