CN107649214A - A kind of micro flow control chip device for taking new fluid type of drive - Google Patents
A kind of micro flow control chip device for taking new fluid type of drive Download PDFInfo
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- CN107649214A CN107649214A CN201610627475.2A CN201610627475A CN107649214A CN 107649214 A CN107649214 A CN 107649214A CN 201610627475 A CN201610627475 A CN 201610627475A CN 107649214 A CN107649214 A CN 107649214A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
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- General Health & Medical Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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Abstract
The present invention relates to a kind of micro flow control chip device for taking new fluid type of drive, belong to analysis testing field.The substrate of micro-fluidic chip, some problems of physical presence are made using dimethyl silicone polymer i.e. PDMS that is cheap and easily processing；Its surface of the PDMS material is strongly hydrophobic, and targetedly surface is modified or surface modification, its effect are difficult to persistently, and this case aims to solve the problem that the serial relevant issues.This case main points are, the selected PDMS with ecosystem surface of substrate, and by the elastic clip that miniature ultrasonic transducer units are attached on its clamping limb with elastic force snap-in location in its neighbor positions of the sample liquid stream terminal of the micro-fluidic chip, interfacial tension is reduced with ultrasonic wave, strong absorbability using PDMS to ultrasonic wave simultaneously, reach ultrasonic intensity rapid decrement in short distance, and interfacial tension difference thus is formed at the both ends of the chip, thereby drive sample liquid stream to be flowed along originally hydrophobic capillary channel to the terminal direction.
Description
Technical field
The present invention relates to a kind of micro flow control chip device for taking new fluid type of drive, belong to analysis testing field.
Background technology
For the microflow control technique overall general picture of itself, famous micro-fluidic expert Mr. Lin Ping Cheng may refer to not
The monograph " diagram Microfluid based Lab on a chip " gone out before long, the monograph is published via Science Press, and the monograph is for miniflow
Past of control technology, now, and, vision of the future etc. etc., suffer from detail, be deep into long opinion of detail
State.
The field that micro-fluidic chip is often applied to include to containing large biological molecule sample solution carry out it is various analysis,
Detection.
The basic framework of micro-fluidic chip, including be etched with the substrate of small fluid course and fit together therewith
Cover plate, the small fluid course on the substrate, before upper cover plate is assembled, it is apparent on see to be exactly some micro-channels, to wait until
After covering cover plate thereon, just really closure forms the small fluid course, the conduit inner surface of the micro-channel together with
The part cover plate that surround the micro-channel forms described small fluid course together；So, it is clear that after assembling completes
The small fluid course, the major part of its inner surface area is the inner surface area of that micro-channel, in other words, should
The state or property of micro-channel inner surface substantially determine the integrality or property of the small fluid course；Therefore say, this
The inner surface state or inner surface property of micro-channel of the individual structure on substrate are key factors；In principle, it is any can
The material of its solid forms is kept or kept substantially, can be used to make substrate and cover plate, such as, it can act as substrate and lid
The material of piece can be monocrystalline silicon piece, quartz plate, sheet glass, high polymer for example dimethyl silicone polymer, polymethyl methacrylate,
Makrolon etc.；Certainly, the selection of substrate and the selection of cover plate be able to can also be differed with identical；From material consumption, make
From the point of view of difficulty and application popularization prospect etc. etc., not small difference, the especially choosing of that substrate between these materials be present
Material, have a great influence.
In various substrate making materials, dimethyl silicone polymer, i.e. PDMS, comparatively very easily shaping, at this
It is extremely simple that micro-channel is made on the substrate of sample, and the lower cost for material, base is made with the polydimethyl siloxane material
Piece, micro-channel, and the cover plate phase made with the cheap material such as glass or polypropylene or other plastic sheets are being suppressed or etched thereon
Coordinate, be a kind of more satisfactory selection seemingly；Certainly, patch material can also select to use cheap dimethyl silicone polymer
Material：So, this substrate selection is the scheme of polydimethyl siloxane material, and material is extremely cheap, and making is extremely simple, seems
It should be extremely easy to popularize, promote.
But thing is really not so simple.
First, this polydimethyl siloxane material, that is, the material that alphabetical PDMS is referred to of abridging, itself are a kind of strong
Strong hydrophobic material, micro-channel is built on this material, if without being operated for the modified of the micro-channel surface, that
, after overall assembling is completed, that is, after covering cover plate, because the micro-channel its inner surface in structure occupies most liquid
The inner surface of circulation road, then, its strong hydrophobic property of the PDMS micro-channels inner surface, is deciding factor, it can cause
Similar to the aqueous solution the fine liquid stream of polar liquid by becoming very difficult, its flow resistance is big, or even in general is micro-
Pump is all difficult to promote, certainly, if cover plate also selects to use the PDMS material, then, problem is substantially identical, similar；
Therefore, among prior art, modification is modified particular for the micro-channel inner surface on the PDMS material, is necessary behaviour
Make；So, this is pretty troublesome for the modified operation of PDMS micro-channel inner surfacesThat falls nor this problem, is formed tight
Weight technology puzzlement, be another problem：PDMS polymer molecules inside its body phase of this PDMS material substrate have automatic
The characteristic diffuse to the surface, migrated, the spy that this substrate body phase inside PDMS polymer molecules are diffused to the surface, migrated automatically
Property, the state after modification by its inner surface of that micro-channel of surface modifying and decorating will be caused can not to maintain long enough
Time, the holding time for micro-channel its inner surface state after that is surface-modified be substantially only sufficient to complete laboratory internal
The time of test experiments needs；In other words, by surface modification or the PDMS micro-channel inner surfaces of surface modification, it is modified
The surface state that is formed can not be lasting afterwards or after saying modification, but soon automatically tends to or say and become surface modification again
Surface state before, the strong hydrophobic surface state of that script is returned in the shorter time, then, just think, this
The micro-fluidic chip of sample can largely make, mass storage, be widely popularized, and answer is it is obvious that is, impossible.This
Micro-channel on PDMS material, if not doing surface modification, similar to the aqueous solution the fine liquid stream of polar solvent can not pump it is logical
Cross, chip also cannot just use；And if having done surface modification, its state after modifying can not be persistently kept again, or together
Sample can not popularization and application.
So, how to accomplish that substrate can either be made using cheap PDMS material, and the microflute can be released
Road inner surface decorating state can not persistently, chip can not largely make, largely lay in and then be widely popularized and such a make ability
The puzzlement that the numerous professionals in domain are entangled with for a long time, the highly difficult problem that exactly one its obvious technology barrier can not despise.
Be present many year in the highly difficult problem, so far, not yet properly settled.
Second, the PDMS material of non-surface modification, it is stated that, its surface is strongly hydrophobic above, this strong hydrophobic
Material surface and also have another problem, that is, this strong hydrophobic PDMS surfaces can adsorb large biological molecule, and
And these adsorbed large biological molecules can also further depression further on PDMS surfaces, gradually fall into it is gradually deep, until
It is heavy to be trapped within the body phase of PDMS substrates, in fact, this process, partly it is also due to PDMS material body phase interior polymer
Molecule, which has, to be diffused to the surface, caused by travel motion；Such case, it can also be explained from another angle, i.e. continue not
Disconnectedly from inside PDMS body phases to those polymer molecules of its diffusion into the surface, migration, its result moved, be little by little by that
It has been involved in a bit by the large biological molecule of adsorption within the body phase of PDMS substrates, briefly, these adsorbed biologies
Macromolecular is exactly to be swallowed up by PDMS substrate body phases；So, this PDMS substrates body phase swallows up the phenomenon of large biological molecule, its institute
Caused by influence, necessarily cause the severe deviations of all kinds of test data of experiment for being related to large biological molecule.
As described above, the problem of PDMS substrates, is, its not only adsorption large biological molecule, and swallow up biological big point
Son, so, as the large biological molecule of experiment test object, its disappearance will not stop because surface saturation is adsorbed, and
It is, it is constantly adsorbed, also constantly swallowed up.
On PDMS substrates, its body phase is constantly swallowed up and tests showing for associated biomolecule macromolecular in related experiment test process
As, it is to say that another kind, which is explained, substantial amounts of Minute pores in PDMS body phases be present, associated biomolecule macromolecular by after adsorption,
Depression enters these Minute pores, and then is swallowed up；However, inventor thinks, those can allow the sky of miniature scale
Qi leel squeezes into the Minute pores therebetween, not equal to saying that they also can directly allow the large biological molecule of relative large scale to enter
Enter, both difference on yardstick are huge, must not make sweeping generalizations.Explanation is bypassed, in any case, as dependence test analysis object
Large biological molecule is adsorbed by PDMS substrate micro-channels inner surface, and then is constantly swallowed up by PDMS substrate body phases, and this is person in charge of reception at ceremonies
Phenomenon existing for sight.
, can be from containment PDMS surfaces pair in order to prevent swallow up effect of this PDMS substrate bodies relative to large biological molecule
The absorption of large biological molecule addresses, and method is chemically modified modification aiming at the PDMS material surface, for
For PDMS is the situation of substrate material, modification exactly is chemically modified to the surface of described micro-channel part, by changing
The micro-channel inner surface of modification is learned, its absorption to large biological molecule can be contained, and then avoid large biological molecule
Swallowed up by PDMS substrate body phases；But or that old problem, that is, the chemical modification on PDMS material surface is modified
Surface state afterwards can not persistently be kept, the polymer molecule inside the PDMS substrate body phases its diffuse to the surface, move automatically
The process of shifting, it soon can become that micro-channel inner surface state being modified by surface chemical modification again script strong and dredge
Water and the state of strong adsorption large biological molecule, in other words, no matter how professionals in the field turn from side to side, the PDMS bases
Its micro-channel inner surface of piece is always rapidly to strong hydrophobic surface state evolution.
So, how can either obtain that PDMS material price is extremely cheap, substrate makes extremely easy benefit, and can is enough
Reach and contain the absorption process of the PDMS substrate micro-channel inner surfaces to large biological molecule for a long time, and then prevent PDMS substrate body phases
The effect of swallowing up to large biological molecule so that related chip manufactured goods be able to maintain that one it is prolonged enough, reasonably guarantee the quality
Phase, it is exactly a very intractable problem.The problem equally makes this area numerous as another problem addressed above
Professional is entangled with, perplexed for a long time, and the problem is equally the highly difficult problem that its obvious technology barrier can not despise.
Also be present many year in the problem, so far, also not yet properly settled.
The content of the invention
The technical problem to be solved by the invention is to provide a package solution, while solve to address above
Two problems.
The present invention solves the technical problem by following scheme, and the device that the program provides is a kind of to take new fluid
The micro flow control chip device of type of drive, the structure of the device include micro-fluidic chip, and the structure of the micro-fluidic chip includes phase
Mutually the substrate and cover plate of fitting installing together, its test liquid of the micro-fluidic chip flow into the end at sample end and the sample fluid flow
End is located remotely from each other, and the distance between the sample introduction end and the terminal are between 3 centimetres and 10 centimetres, its sample of the micro-fluidic chip
Liquid stream sample introduction end offers sample introduction end liquid pool, and the terminal of the sample fluid flow offers terminal liquid pool, the pipeline in chip its
Both ends connect with sample introduction end liquid pool and the terminal liquid pool respectively, and emphasis is that its material of the substrate is polydimethylsiloxanes
Alkane material, its surface of the substrate are the surfaces of primary form, the surface of the primary form its be intended to refer to not by any
The surface of the primary form of surface chemical modification or the material of any surface chemical modification, the structure of the device also include elastic force
Folder, two opposite clamping limb snap-in locations of the elastic clip are in the position of the neighbouring terminal of the micro-fluidic chip, at least
Fixation is attached described in one of which on clamping limb and is equiped with miniature ultrasonic transducer units, and, higher-order of oscillation electric signal passes
Transmission cable, one end and the miniature ultrasonic transducer units of the higher-order of oscillation electric signal transmission cable link together；The elastic clip
Provide a function of facilitating the device to disassemble；Its major function of the miniature ultrasonic transducer units is actual in micro-fluidic chip
When sample introduction is tested, the ultrasonic wave launched using it reduce the inwall of sample solution and its inner passage of micro-fluidic chip it
Between interfacial tension, can be compatible, also, utilize the sample introduction end and the terminal and the miniature ultrasonic transducer units
Difference in the distance between installation position difference and its ultrasonic intensity experienced, sample introduction end described in induced synthesis its
Difference between interfacial tension and the terminal its interfacial tension, the interfacial tension difference meeting between the micro-fluidic chip both ends
Pressure gap is formed between the both ends of the micro-fluidic chip, the pressure gap can drive sample solution to the terminal stream
It is dynamic；The ultrasonic wave that its function of the miniature ultrasonic transducer units also includes being launched with it checks big point of biology contained in sample
Its absorption on the micro-fluidic chip its inner passage inner surface of son, and then check the substrate of the dimethyl silicone polymer material
Swallow up effect of its body phase to the large biological molecule；It is soft and have the substrate of the dimethyl silicone polymer material of elasticity its function
Including with its property to the strong absorption of ultrasonic wave, being absorbed strongly to ultrasonic wave, and thereby at the micro-fluidic chip end
The rapid decrement that ultrasonic intensity is realized within the limited short distance between the sample introduction end is held, is filled with the terminal liquid pool
Some high hydroscopic resin particles, its opening end of the terminal liquid pool are covered by breathable microporous film.
The word of elastic clip one art-recognized meanings of itself are known.
Only for professional of the word of ultrasonic transducer one art-recognized meanings of itself for ultrasonic technology field,
It is known.
Various sizes, variously-shaped ultrasonic transducer are commercially available；Its size of commercially available miniature ultrasonic transducer units
It may diminish to the magnitude only calculated with millimeter.
Only with regard to miniature ultrasonic transducer units its technique for fixing on general industry application solid body surface its
It is known general technology for the professional in ultrasonic technology field for body.This case is not to this expansion superfluous words.
Only with regard to naked PDMS substrates itself micro-channel molding or lithographic technique for, be open-and-shut known skill
Art；Similarly, the technology of hole-opening is even more known simple technique on naked PDMS substrates.This case is not also superfluous to this expansion
Speech.
The industrial products market of involved its all size of higher-order of oscillation electric signal transmission cable is on sale.
The structure of the device can also include higher-order of oscillation electric signal generator；The higher-order of oscillation electric signal transmission cable
Its other end can be connected with the higher-order of oscillation electric signal generator.
The involved higher-order of oscillation electric signal generator technology of itself, come for the professional in ultrasonic technology field
Say, be simple and known；The higher-order of oscillation electric signal generator can customize to ultrasonic instrument specialized factory.
The preferred scope of its specified ultrasonic wave transmission power of the miniature ultrasonic transducer units is between 2 milliwatts and 9000 milliwatts
Between；The preferred scope of the frequency of its ultrasonic wave operationally launched of the miniature ultrasonic transducer units be between 100KHz with
Between 12MHz.
Only for the word of high hydroscopic resin one art-recognized meanings of itself, come for the professional of chemical field
Say, be known.
The high hydroscopic resin is commercially available.
Only for the word of breathable microporous film one art-recognized meanings of itself, for the professional of technical field of membrane,
It is known.
The breathable microporous film is commercially available.
This case device can further include some annexes certainly, and the annex can for example coordinate with micro-fluidic chip
The electrically or optically detection device used.The equipment that the electricity, optics etc. are used cooperatively with micro-fluidic chip, may refer to
The monograph.
The cover plate in chip structure, its material can allow to be any electrical insulating property material, such as：Polypropylene,
Glass, polymethyl methacrylate, dimethyl silicone polymer, etc., in order to make smaller size of micro-fluidic chip, for example do
Into the micro-fluidic chip of only 2.0 centimetres to 3.0 centimetres of super-small of length, and realized in the extremely short distance to ultrasonic wave
Extremely fast decay, can preferably dimethyl silicone polymer be used as cover plate.Certainly, selected on large-sized micro-fluidic chip
Using dimethyl silicone polymer it is used as the cover plate, and this case technical scheme is allowed.
Described its thickness of cover plate and substrate can allow be any setting the thickness for being easy to assembling, the thickness of recommendation or say
Preferable thickness is between 1.0 millimeters and 5.0 millimeters.Less thickness is advantageous to save material.
It is an advantage of the invention that in elastic force described in the terminal of the micro-fluidic chip its close position snap-in location
Folder, with the clamping limb of the elastic clip institute attaching install miniature ultrasonic transducer units, using the miniature ultrasonic transducer units its
The low-power launched, the ultrasonic wave of high-frequency band so that without strong hydrophobic micro-fluidic core of surface chemical modification
Compatibility between its tube wall of piece internal pipeline and the test object aqueous solution is significantly increased, and this is sample liquid stream by providing
One realistic possibility；Meanwhile using its strong absorbability to ultrasonic wave of dimethyl silicone polymer substrate, shorter
In distance, it is, in from the terminal to the very short distance of only several centimeters yardsticks the sample introduction end, reach ultrasound
The rapid decrement of intensity of wave, the difference of the interfacial tension is thereby caused at the both ends of the micro-fluidic chip, and then, utilize
Pressure gap between its both ends for being formed of the difference of interfacial tension between the both ends, driving sample liquid stream is micro-fluidic
Flowed originally in strong hydrophobic capillary channel to the terminal direction in chip.By this case liquid stream drive scheme, completely
Any surface chemical modification or surface chemistry need not be carried out to the substrate and its internal pipeline of the dimethyl silicone polymer material
It is modified, altogether dispense with the laborious procedures of the surface chemical modification or surface chemical modification；And traditional sense is altogether dispensed with
On Micropump etc equipment；On the other hand, the ultrasonic wave of the low-power, high-frequency band, additionally it is possible to contain the biology in sample
Absorption of the macromolecular on literalness naked its inner surface of pipeline of dimethyl silicone polymer substrate, and then contain the poly- diformazan
Swallow up effect of its body phase of radical siloxane substrate to the large biological molecule；Due to described suction-operated and described swallow up
Effect is effectively contained that therefore, dependence test result will be better able to objectively reflect actual conditions.
Due to the surface chemical modification for the dimethyl silicone polymer substrate its relevant surfaces or surface need not be carried out
Chemical modification operates, and therefore, this surface chemical modification layer or surface chemical modification layer not need to exist, then, should
Its body phase interior polymer molecule of dimethyl silicone polymer substrate constantly diffuses to the surface automatically, migrate caused by it to described
The damaging influence of surface chemical modification layer or surface chemical modification layer is also just not present.
It is related that the technical scheme of this case has dissolved its application to dimethyl silicone polymer substrate addressed above totally
A series of technical barriers.Based on this case scheme, the very cheap polydimethyl siloxane material of this kind is just possible to micro- at this
It is prepared by fluidic chip, production, using etc. field play bigger effect.
The miniature ultrasonic transducer units have been installed in fixation on the elastic clip its clamping limb in this case structure, and the structure carries
A function of facilitating the device to disassemble is supplied, in this way, the elastic clip just can together with miniature ultrasonic transducer units appended thereon
It is enough to be easily mutually disengaged with the micro-fluidic chip, then, the component that the part can freely depart from just can circulate benignly it is heavy
It is multiple to use many times；The architectural feature is advantageous to save the use cost of the device.
Brief description of the drawings
Fig. 1 is its rough outside side view of this case device.
In figure, 1 is elastic clip, and 2,7 be two clamping limbs of elastic clip respectively, and 3 be the terminal of the micro-fluidic chip,
4 be the sample introduction end of the micro-fluidic chip, and 5 be the substrate of dimethyl silicone polymer material, and 6 be cover plate, and 8 be miniature ultrasonic
Transducer, 9 be higher-order of oscillation electric signal transmission cable, and 10 be tension spring；The spring clamp structure in legend is only signal
Legend structure, actual spring clamp structure are not limited to the legend spring clamp structure；Arrow in legend indicates the micro-fluidic core
Piece its in actual motion, by pressure at two ends difference drive, the flow direction of its sample liquid stream.
Embodiment
In this case that Fig. 1 is shown embodiment, the structure of the device includes micro-fluidic chip, the micro-fluidic chip
Structure includes being bonded to each other the substrate 5 and cover plate 6 of installing together, and its test liquid of the micro-fluidic chip flows into sample end 4 and the examination
The terminal 3 of sample fluid flow is located remotely from each other, the distance between the sample introduction end 4 and the terminal 3 between 3 centimetres and 10 centimetres,
Its test liquid of the micro-fluidic chip flows into sample end and offers sample introduction end liquid pool, and the terminal of the sample fluid flow offers terminal liquid
Pond, its both ends of pipeline in chip connect with sample introduction end liquid pool and the terminal liquid pool respectively, and emphasis is, the substrate 5 its
Material is dimethyl silicone polymer material, and its surface of substrate 5 is the surface of primary form, its meaning of the surface of the primary form
Refer to not by any surface chemical modification or the surface of the primary form of the material of any surface chemical modification, the dress
The structure put also includes elastic clip 1, and two opposite clamping limbs 2,7 snap-in locations of the elastic clip 1 are in the micro-fluidic chip
Fixation, which is attached, adjacent to the position of the terminal 3, on a clamping limb at least in is equiped with miniature ultrasonic transducing
Device, in this example, the miniature ultrasonic transducer units 8 are fixed on clamping limb 7 by attaching, and, higher-order of oscillation electric signal transmission electricity
Cable 9, one end of the higher-order of oscillation electric signal transmission cable 9 link together with the miniature ultrasonic transducer units 8；Can also be two
It is all fixed respectively on individual clamping limb 2,7 to install miniature ultrasonic transducer units, but in general, only installed on a clamping limb
Miniature ultrasonic transducer units are just enough to deal with provides a function of facilitating the device to disassemble using needs, the elastic clip 1；Should
Its major function of miniature ultrasonic transducer units 8 is the ultrasonic wave launched using it in the test of micro-fluidic chip actual sample introduction
, can be compatible to reduce the interfacial tension between sample solution and the inwall of its inner passage of micro-fluidic chip, also,
Using the sample introduction end 4 and the distance between the terminal 3 and the installation position of miniature ultrasonic transducer units 8 difference and its
The difference on ultrasonic intensity experienced, its interfacial tension of sample introduction end 4 described in induced synthesis and described its interface of terminal 3
Difference between power, the interfacial tension difference between the micro-fluidic chip both ends 3,4 can be at the both ends of the micro-fluidic chip
3rd, pressure gap is formed between 4, the pressure gap can drive sample solution to be flowed to the direction of terminal 3；The miniature ultrasonic
The ultrasonic wave that its function of transducer 8 also includes being launched with it checks large biological molecule contained in sample, and it is micro-fluidic at this
Absorption on its inner passage inner surface of chip, and then check the substrate 5 of the dimethyl silicone polymer material its body phase to the life
The effect of swallowing up of thing macromolecular；Softness simultaneously has its function of the substrate 5 of the dimethyl silicone polymer material of elasticity including right with its
The property that ultrasonic wave absorbs strongly, ultrasonic wave is absorbed strongly, and thereby in the micro-fluidic chip, the terminal 3 arrives the sample introduction
The rapid decrement of ultrasonic intensity is realized within limited short distance between end 4, is inhaled in the terminal liquid pool filled with some height
Water-resin particle, its opening end of the terminal liquid pool are covered by breathable microporous film.
Arrow in legend indicate the micro-fluidic chip its in actual motion, by pressure at two ends difference drive, its try
The flow direction of sample liquid stream.
Fig. 1 is depicted without the associate members such as the higher-order of oscillation electric signal generator.
Involved elastic clip 1 is commercially available.It is available for the commercially available alternative spring clamp structure and make that this case structure uses
Type and size etc., quality is various, and specific elastic clip pattern can be selected as needed.
Involved miniature ultrasonic transducer units 8 are commercially available；It can also be customized to ultrasonic transducer producer.
Involved higher-order of oscillation electric signal transmission cable 9 is commercially available；Can also be special to ultrasonic transducer producer or cable
Industry producer customizes.
Involved higher-order of oscillation electric signal generator market has the product close to needs commercially available；It can also determine to relevant manufacturers
System.
Its inner passage of the micro-fluidic chip involved by this case is the pipeline of hydrophobic capillary form.
Claims (5)
1. a kind of micro flow control chip device for taking new fluid type of drive, the structure of the device includes micro-fluidic chip, should
The structure of micro-fluidic chip includes being bonded to each other the substrate and cover plate of installing together, and its test liquid of the micro-fluidic chip flows into sample
The terminal with the sample fluid flow is held to be located remotely from each other, the distance between the sample introduction end and the terminal are between 3 centimetres and 10 centimetres
Between, its test liquid of the micro-fluidic chip flows into sample end and offers sample introduction end liquid pool, and the terminal of the sample fluid flow offers
Terminal liquid pool, its both ends of pipeline in chip connect with sample introduction end liquid pool and the terminal liquid pool respectively, it is characterised in that
Its material of the substrate is dimethyl silicone polymer material, and its surface of the substrate is the surface of primary form, the table of the primary form
Face its be intended to refer to the not no primary form of the material by any surface chemical modification or any surface chemical modification
Surface, the structure of the device also include elastic clip, and two opposite clamping limb snap-in locations of the elastic clip are in the micro-fluidic core
The position of the neighbouring terminal of piece, attach on a clamping limb at least in and fixed be equiped with miniature ultrasonic and change
Energy device, and, higher-order of oscillation electric signal transmission cable, one end and the miniature ultrasonic of the higher-order of oscillation electric signal transmission cable
Transducer links together；The elastic clip provides a function of facilitating the device to disassemble；The miniature ultrasonic transducer units its
Major function is that the ultrasonic wave launched using it is micro- with this to reduce sample solution in the actual sample introduction test of micro-fluidic chip
Interfacial tension between the inwall of its inner passage of fluidic chip, can be compatible, also, utilizes the sample introduction end and institute
State on the distance between terminal and the miniature ultrasonic transducer units installation position difference and its ultrasonic intensity experienced
Difference, the difference between its interfacial tension of sample introduction end described in induced synthesis and the terminal its interfacial tension, the micro-fluidic core
Interfacial tension difference between the piece both ends can form pressure gap between the both ends of the micro-fluidic chip, the pressure gap
Sample solution can be driven to the end flow；Its function of the miniature ultrasonic transducer units also includes the ultrasonic wave launched with it
Check in sample contained large biological molecule its absorption on the micro-fluidic chip its inner passage inner surface, and then check
Swallow up effect of its body phase of the substrate of the dimethyl silicone polymer material to the large biological molecule；It is soft and have elasticity this poly- two
Its function of the substrate of methylsiloxane material is included with its property to the strong absorption of ultrasonic wave, and ultrasonic wave is inhaled strongly
Receive, and thereby realize ultrasonic intensity within micro-fluidic chip terminal to the limited short distance between the sample introduction end
Rapid decrement, some high hydroscopic resin particles are filled with the terminal liquid pool, its opening end of the terminal liquid pool is by breathable microporous film
Covered.
A kind of 2. micro flow control chip device for taking new fluid type of drive according to claim 1, it is characterised in that
Its material of the cover plate is dimethyl silicone polymer material.
A kind of 3. micro flow control chip device for taking new fluid type of drive according to claim 1, it is characterised in that
Described its thickness of cover plate and substrate is between 1.0 millimeters and 5.0 millimeters.
A kind of 4. micro flow control chip device for taking new fluid type of drive according to claim 1, it is characterised in that
The structure of the device also includes higher-order of oscillation electric signal generator, and its other end of the higher-order of oscillation electric signal transmission cable is with being somebody's turn to do
Higher-order of oscillation electric signal generator connects.
A kind of 5. micro flow control chip device for taking new fluid type of drive according to claim 1, it is characterised in that
Between 2 milliwatts and 9000 milliwatts, the miniature ultrasonic changes its specified ultrasonic wave transmission power of the miniature ultrasonic transducer units
The frequency of its ultrasonic wave operationally launched of energy device is between 100KHz and 12MHz.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610627475.2A CN107649214A (en) | 2016-07-26 | 2016-07-26 | A kind of micro flow control chip device for taking new fluid type of drive |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610627475.2A CN107649214A (en) | 2016-07-26 | 2016-07-26 | A kind of micro flow control chip device for taking new fluid type of drive |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107649214A true CN107649214A (en) | 2018-02-02 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610627475.2A Pending CN107649214A (en) | 2016-07-26 | 2016-07-26 | A kind of micro flow control chip device for taking new fluid type of drive |
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|---|---|
| CN (1) | CN107649214A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101817495A (en) * | 2010-03-25 | 2010-09-01 | 湖南大学 | Micro fluid control chip and preparation method and application thereof |
| CN102645429A (en) * | 2012-04-23 | 2012-08-22 | 宁波大学 | Self-cleaning and vibration wave energy digestion link containing electrogenerated chemiluminescence analyzing and detecting device |
-
2016
- 2016-07-26 CN CN201610627475.2A patent/CN107649214A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101817495A (en) * | 2010-03-25 | 2010-09-01 | 湖南大学 | Micro fluid control chip and preparation method and application thereof |
| CN102645429A (en) * | 2012-04-23 | 2012-08-22 | 宁波大学 | Self-cleaning and vibration wave energy digestion link containing electrogenerated chemiluminescence analyzing and detecting device |
Non-Patent Citations (1)
| Title |
|---|
| JAMES FRIEND ET AL.: "Microscale acoustofluidics: microfluidics driven via acoustics and ultrasonics", 《REVIEWS OF MODERN PHYSICS》 * |
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Application publication date: 20180202 |