CN107648199A - Atoleine micro-capsule and preparation method thereof - Google Patents
Atoleine micro-capsule and preparation method thereof Download PDFInfo
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- CN107648199A CN107648199A CN201711187692.5A CN201711187692A CN107648199A CN 107648199 A CN107648199 A CN 107648199A CN 201711187692 A CN201711187692 A CN 201711187692A CN 107648199 A CN107648199 A CN 107648199A
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- atoleine
- rosin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/501—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Botany (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses atoleine micro-capsule, and it is included by weight：10 20 parts of atoleines, 6 12 parts of rosin, 8 10 parts of amylum pregelatinisatums, 48 parts of Arabic gums, 6 10 parts of Solid aluminum sulfates and 20 30 parts of deionized waters.The beneficial effects of the invention are as follows the amylum pregelatinisatum of addition can promote the preforming of capsule material, obtained atoleine micro-capsule shape is specific, and without repeatedly condensing repeatedly, rosin and Solid aluminum sulfate can accelerate the cohesion and solidification of micro-capsule, shorten the reaction time, form stable micro-capsule.
Description
Technical field
The present invention relates to field of pharmaceutical preparations, more particularly to atoleine micro-capsule and preparation method thereof.
Background technology
Microencapsulation（Abbreviation micro-capsule）System utilizes high polymer material（It is generally called capsule material）, by solid drugs or liquid medicine（It is logical
Claim capsule core material）It is rolled into a diameter of 0.01-200 μm of tiny capsules.After medicament microcapsule, there is slow releasing function, medicine can be improved
The stability of thing, the bad smell and taste of medicine are covered, reduce medicine to the excitant of intestines and stomach, reduce matching somebody with somebody for compound medicine
5 taboos, improve the mobility and compressibility of medicine, make liquid drug can solidification.The preparation method of micro-capsule is a lot, can conclude
For physical-chemical process, chemical method and physicomechanical processes three major types.Can according to the particle diameter of the property and micro-capsule of medicine and capsule material, release
The requirements such as performance are put to be selected.Wherein Simple coacervation and complex coacervation application is wider.Simple coacervation：By a kind of flocculating agent（By force
Hydrophilic electrolyte or non-electrolyte, such as sodium sulphate, sulfuric acid hinge, ethanol, propyl alcohol）Add in the solution of certain water-soluble capsule material
（Wherein emulsify or suspension core material）, because substantial amounts of moisture content is combined with flocculating agent, make capsule material in system solubility reduce and
Cohesion comes out, and eventually forms micro-capsule.Or medicine is dispersed in the organic solvent miscible with water containing cellulose derivative, after
Add the concentrated solution of inorganic salts, capsule material is condensed into cyst membrane and form micro-capsule.Complex coacervation：Using two kinds of polymer in different PH
When, the change of electric charge（Generate opposite electric charge）Cause phase separation-coacervation, referred to as complex coacervation.Such as use Arabic gum（It is negatively charged
Lotus）And gelatin（PH is negatively charged more than isoelectric point, positively charged below isoelectric point）Make capsule material, medicine elder generation and Arabic gum
Mix, be made suspension or emulsion, negative electrical charge colloid is continuous phase, medicine（Core）For dispersed phase, at a temperature of 40-60 DEG C
(now gelatin is negatively charged or substantially negatively charged) is mixed with equivalent gelatin solution, then adjusts below pH4.5 with diluted acid
Make gelatin is all positively charged to be condensed with negatively charged Arabic gum, be wrapped medicine.
The flocculating result of Simple coacervation is uncontrollable, it is necessary to by satisfied micro-capsule can just repeatedly be made repeatedly, less efficient,
Cost is higher；Requirement of the complex coacervation to operation is higher, solution is stirred when adjusting pH value, and reach specific pH
It is worth section, is stirred all the time during preparing micro-capsule, and foam can be produced so as to reduce yield by stirring.
The content of the invention
The technical problem to be solved in the present invention is that existing coacervation prepares many defects existing for atoleine micro-capsule, is
A kind of this flocculating result of offer is expectable, operation requires low atoleine micro-capsule and preparation method thereof.
The technical scheme is that：Atoleine micro-capsule, it is included by weight：10-20 parts atoleine, 6-12
Part rosin, 8-10 parts amylum pregelatinisatum, 4-8 parts Arabic gum, 6-10 parts Solid aluminum sulfate and 20-30 part deionized waters.
The preparation method of atoleine micro-capsule, it comprises the following steps：8-10 part amylum pregelatinisatums are placed in 20-30 parts
40-50 DEG C is heated to after being stirred in deionized water, original volume 1/4-1/6 softwood is made in concentration distillation, by 6-12 parts
Rosin, which is ground into fine powder, to be crossed to add in softwood to stir after 100 mesh sieves and is incubated 20-30min at 20-30 DEG C；Add 10-20 parts
It is put into reactor and stirs after atoleine, mixing speed 50-60r/min；It is heated to after adding 4-8 part Arabic gums
60-70 DEG C of insulation 10-20min；10-14 DEG C is cooled in 3-7min after addition 6-10 part Solid aluminum sulfates both to obtain.
The preforming of capsule material can be promoted the beneficial effects of the invention are as follows the amylum pregelatinisatum of addition, obtained atoleine is micro-
Scrotiform shape is specific, and without repeatedly condensing repeatedly, rosin and Solid aluminum sulfate can accelerate the cohesion and solidification of micro-capsule, when shortening reaction
Between, form stable micro-capsule.
Embodiment
The atoleine micro-capsule of the present invention, it is included by weight：10-20 parts atoleine, 6-12 parts rosin, 8-10
Part amylum pregelatinisatum, 4-8 parts Arabic gum, 6-10 parts Solid aluminum sulfate and 20-30 part deionized waters.
The preparation method of atoleine micro-capsule, it comprises the following steps：8-10 part amylum pregelatinisatums are placed in 20-30 parts
40-50 DEG C is heated to after being stirred in deionized water, original volume 1/4-1/6 softwood is made in concentration distillation, by 6-12 parts
Rosin, which is ground into fine powder, to be crossed to add in softwood to stir after 100 mesh sieves and is incubated 20-30min at 20-30 DEG C；Add 10-20 parts
It is put into reactor and stirs after atoleine, mixing speed 50-60r/min；It is heated to after adding 4-8 part Arabic gums
60-70 DEG C of insulation 10-20min；10-14 DEG C is cooled in 3-7min after addition 6-10 part Solid aluminum sulfates both to obtain.
With reference to embodiment, the present invention will be further described.
Embodiment 1：Atoleine micro-capsule, it is included by weight：10 parts of atoleines, 6 parts of rosin, 8 parts of compressibility
Starch, 4 parts of Arabic gums, 6 parts of Solid aluminum sulfates and 20 parts of deionized waters.
The preparation method of atoleine micro-capsule, it comprises the following steps：8 parts of amylum pregelatinisatums are placed in going for 20-30 parts
40 DEG C are heated to after being stirred in ionized water, the softwood of original volume 1/4 is made in concentration distillation, and 6 parts of rosin are ground into fine powder
Cross to add in softwood to stir after 100 mesh sieves and be incubated 20min at 20 DEG C；It is put into after adding 10 parts of atoleines in reactor
Stir, mixing speed 50r/min；60 DEG C of insulation 10min are heated to after adding 4 parts of Arabic gums；Add 6 parts of solid sulfurs
10 DEG C are cooled to after sour aluminium in 3min both to obtain.
Embodiment 2：Atoleine micro-capsule, it is included by weight：15 parts of atoleines, 8 parts of rosin, 9 parts of compressibility
Starch, 6 parts of Arabic gums, 8 parts of Solid aluminum sulfates and 25 parts of deionized waters.
The preparation method of atoleine micro-capsule, it comprises the following steps：9 parts of amylum pregelatinisatums are placed in 25 parts of deionization
45 DEG C are heated to after being stirred in water, the softwood of original volume 1/5 is made in concentration distillation, and 8 parts of rosin are ground into fine powder and cross 100
Add in softwood to stir after mesh sieve and be incubated 25min at 25 DEG C；Stirring in reactor is put into after adding 15 parts of atoleines
Uniformly, mixing speed 55r/min；65 DEG C of insulation 15min are heated to after adding 6 parts of Arabic gums；Add 8 parts of Solid aluminum sulfates
12 DEG C are cooled in 5min afterwards both to obtain.
Embodiment 3：Atoleine micro-capsule, it is included by weight：20 parts of atoleines, 12 parts of rosin, 10 parts can press
Property starch, 8 parts of Arabic gums, 10 parts of Solid aluminum sulfates and 30 parts of deionized waters.
The preparation method of atoleine micro-capsule, it comprises the following steps：By 10 parts of amylum pregelatinisatums be placed in 30 parts go from
50 DEG C are heated to after being stirred in sub- water, the softwood of original volume 1/6 is made in concentration distillation, and 12 parts of rosin are ground into fine powder mistake
Add in softwood to stir after 100 mesh sieves and be incubated 30min at 30 DEG C；It is put into reactor and stirs after 20 parts of atoleines of addition
Mix uniformly, mixing speed 60r/min；70 DEG C of insulation 20min are heated to after adding 8 parts of Arabic gums；Add 10 parts of solid sulfurs
14 DEG C are cooled to after sour aluminium in 7min both to obtain.
The present invention utilizes the high medicine saturation of amylum pregelatinisatum, atoleine is accommodated in the inner, it is ensured that it is condensed into
The state of type is controllable, and the addition of rosin helps speed up the speed of cohesion, it is hardened at a lower temperature, solid sulphuric acid
The addition of aluminium at low temperature can improve the stability of cohesion solidification, it is ensured that micro-capsule expected from formation.
Claims (2)
1. atoleine micro-capsule, it is characterized in that it is included by weight：10-20 parts atoleine, 6-12 parts rosin, 8-10 parts
Amylum pregelatinisatum, 4-8 parts Arabic gum, 6-10 parts Solid aluminum sulfate and 20-30 part deionized waters.
2. the preparation method of atoleine micro-capsule as claimed in claim 1, it is characterized in that it comprises the following steps：By 8-10 parts
Amylum pregelatinisatum is placed in the deionized water of 20-30 parts stir after be heated to 40-50 DEG C, original volume is made in concentration distillation
1/4-1/6 softwood, 6-12 part rosin is ground into fine powder crosses to add in softwood to stir after 100 mesh sieves and protected at 20-30 DEG C
Warm 20-30min；It is put into reactor and stirs after addition 10-20 part atoleines, mixing speed 50-60r/min；Add
60-70 DEG C of insulation 10-20min is heated to after entering 4-8 part Arabic gums；It is cold in 3-7min after addition 6-10 part Solid aluminum sulfates
But both obtained to 10-14 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711187692.5A CN107648199A (en) | 2017-11-24 | 2017-11-24 | Atoleine micro-capsule and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711187692.5A CN107648199A (en) | 2017-11-24 | 2017-11-24 | Atoleine micro-capsule and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
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| CN107648199A true CN107648199A (en) | 2018-02-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201711187692.5A Withdrawn CN107648199A (en) | 2017-11-24 | 2017-11-24 | Atoleine micro-capsule and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1775868A (en) * | 2005-11-24 | 2006-05-24 | 山东省科学院生物研究所 | Water dispersion capsorubin mcrocapsule and its preparing method |
| CN102671591A (en) * | 2012-05-26 | 2012-09-19 | 云南恩典科技产业发展有限公司 | Water-encapsulated microcapsule wall material and water-encapsulated microcapsule prepared through same |
| CN104722252A (en) * | 2015-02-06 | 2015-06-24 | 宁波高新区零零七工业设计有限公司 | Preparation process for microcapsule |
| CN105477093A (en) * | 2015-12-15 | 2016-04-13 | 广西大海阳光药业有限公司 | Preparation method of micro-capsules for treating rheumatism |
-
2017
- 2017-11-24 CN CN201711187692.5A patent/CN107648199A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1775868A (en) * | 2005-11-24 | 2006-05-24 | 山东省科学院生物研究所 | Water dispersion capsorubin mcrocapsule and its preparing method |
| CN102671591A (en) * | 2012-05-26 | 2012-09-19 | 云南恩典科技产业发展有限公司 | Water-encapsulated microcapsule wall material and water-encapsulated microcapsule prepared through same |
| CN104722252A (en) * | 2015-02-06 | 2015-06-24 | 宁波高新区零零七工业设计有限公司 | Preparation process for microcapsule |
| CN105477093A (en) * | 2015-12-15 | 2016-04-13 | 广西大海阳光药业有限公司 | Preparation method of micro-capsules for treating rheumatism |
Non-Patent Citations (2)
| Title |
|---|
| 张秋香等: ""石蜡微胶囊相变材料的制备及其在建筑节能领域中的应用"", 《材料导报Ａ：综述篇》 * |
| 马保国等: ""石蜡相变微胶囊的制备及在建材中的应用"", 《建材世界》 * |
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Application publication date: 20180202 |
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