CN107753463A - Sulfadimidine micro-capsule and preparation method thereof - Google Patents
Sulfadimidine micro-capsule and preparation method thereof Download PDFInfo
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- CN107753463A CN107753463A CN201711180778.5A CN201711180778A CN107753463A CN 107753463 A CN107753463 A CN 107753463A CN 201711180778 A CN201711180778 A CN 201711180778A CN 107753463 A CN107753463 A CN 107753463A
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Abstract
The invention discloses sulfadimidine micro-capsule, and it is included by weight：10 20 parts of sulfadimidines, 6 12 parts of rosin, 8 10 parts of crystalline lactose powder, 48 parts of glucofructans, 6 10 parts of distannous citrates and 20 30 parts of deionized waters.The beneficial effects of the invention are as follows the crystalline lactose powder of addition can promote the preforming of capsule material, obtained sulfadimidine micro-capsule shape is specific, and without repeatedly condensing repeatedly, rosin and distannous citrate can accelerate the cohesion and solidification of micro-capsule, shorten the reaction time, form stable micro-capsule.
Description
Technical field
The present invention relates to field of pharmaceutical preparations, more particularly to sulfadimidine micro-capsule and preparation method thereof.
Background technology
Microencapsulation（Abbreviation micro-capsule）System utilizes high polymer material（It is generally called capsule material）, by solid drugs or liquid medicine（It is logical
Claim capsule core material）It is rolled into a diameter of 0.01-200 μm of tiny capsules.After medicament microcapsule, there is slow releasing function, medicine can be improved
The stability of thing, the bad smell and taste of medicine are covered, reduce medicine to the excitant of intestines and stomach, reduce matching somebody with somebody for compound medicine
5 taboos, improve the mobility and compressibility of medicine, make liquid drug can solidification.The preparation method of micro-capsule is a lot, can conclude
For physical-chemical process, chemical method and physicomechanical processes three major types.Can according to the particle diameter of the property and micro-capsule of medicine and capsule material, release
The requirements such as performance are put to be selected.Wherein Simple coacervation and complex coacervation application is wider.Simple coacervation：By a kind of flocculating agent（By force
Hydrophilic electrolyte or non-electrolyte, such as sodium sulphate, sulfuric acid hinge, ethanol, propyl alcohol）Add in the solution of certain water-soluble capsule material
（Wherein emulsify or suspension core material）, because substantial amounts of moisture content is combined with flocculating agent, make capsule material in system solubility reduce and
Cohesion comes out, and eventually forms micro-capsule.Or medicine is dispersed in the organic solvent miscible with water containing cellulose derivative, after
Add the concentrated solution of inorganic salts, capsule material is condensed into cyst membrane and form micro-capsule.Complex coacervation：Using two kinds of polymer in different PH
When, the change of electric charge（Generate opposite electric charge）Cause phase separation-coacervation, referred to as complex coacervation.Such as use Arabic gum（It is negatively charged
Lotus）And gelatin（PH is negatively charged more than isoelectric point, positively charged below isoelectric point）Make capsule material, medicine elder generation and glucofructan
Mix, be made suspension or emulsion, negative electrical charge colloid is continuous phase, medicine（Core）For dispersed phase, at a temperature of 40-60 DEG C
(now gelatin is negatively charged or substantially negatively charged) is mixed with equivalent gelatin solution, then adjusts below pH4.5 with diluted acid
Make gelatin is all positively charged to be condensed with negatively charged glucofructan, be wrapped medicine.
The flocculating result of Simple coacervation is uncontrollable, it is necessary to by satisfied micro-capsule can just repeatedly be made repeatedly, less efficient,
Cost is higher；Requirement of the complex coacervation to operation is higher, solution is stirred when adjusting pH value, and reach specific pH
It is worth section, is stirred all the time during preparing micro-capsule, and foam can be produced so as to reduce yield by stirring.
The content of the invention
The technical problem to be solved in the present invention is that existing coacervation prepares many existing for sulfadimidine micro-capsule lack
Fall into, provided for this kind of flocculating result it is expectable, operate require low sulfadimidine micro-capsule and preparation method thereof.
The technical scheme is that：Sulfadimidine micro-capsule, it is included by weight：10-20 part sulfanilamide (SN) diformazans
Pyrimidine, 6-12 parts rosin, 8-10 part crystalline lactoses powder, 4-8 parts glucofructan, 6-10 parts distannous citrate and 20-30 parts
Deionized water.
The preparation method of sulfadimidine micro-capsule, it comprises the following steps：8-10 part crystalline lactose powder is placed in 20-30
40-50 DEG C is heated to after being stirred in the deionized water of part, original volume 1/4-1/6 softwood is made in concentration distillation, by 6-
12 parts of rosin, which are ground into fine powder, to be crossed to add in softwood to stir after 100 mesh sieves and is incubated 20-30min at 20-30 DEG C；Add 10-
It is put into reactor and stirs after 20 parts of sulfadimidines, mixing speed 50-60r/min；Add 4-8 part glucofructans
After be heated to 60-70 DEG C insulation 10-20min；10-14 DEG C is cooled in 3-7min after adding 6-10 part distannous citrates
Both.
The preforming of capsule material can be promoted the beneficial effects of the invention are as follows the crystalline lactose powder of addition, obtained sulfanilamide (SN) diformazan is phonetic
Pyridine micro-capsule shape is specific, and without repeatedly condensing repeatedly, rosin and distannous citrate can accelerate the cohesion and solidification of micro-capsule, contracting
Short reaction time, form stable micro-capsule.
Embodiment
The sulfadimidine micro-capsule of the present invention, it is included by weight：10-20 parts sulfadimidine, 6-12 parts
Rosin, 8-10 part crystalline lactoses powder, 4-8 parts glucofructan, 6-10 parts distannous citrate and 20-30 part deionized waters.
The preparation method of sulfadimidine micro-capsule, it comprises the following steps：8-10 part crystalline lactose powder is placed in 20-30
40-50 DEG C is heated to after being stirred in the deionized water of part, original volume 1/4-1/6 softwood is made in concentration distillation, by 6-
12 parts of rosin, which are ground into fine powder, to be crossed to add in softwood to stir after 100 mesh sieves and is incubated 20-30min at 20-30 DEG C；Add 10-
It is put into reactor and stirs after 20 parts of sulfadimidines, mixing speed 50-60r/min；Add 4-8 part glucofructans
After be heated to 60-70 DEG C insulation 10-20min；10-14 DEG C is cooled in 3-7min after adding 6-10 part distannous citrates
Both.
With reference to embodiment, the present invention will be further described.
Embodiment 1：Sulfadimidine micro-capsule, it is included by weight：10 parts of sulfadimidines, 6 parts of rosin, 8
Part crystalline lactose powder, 4 parts of glucofructans, 6 parts of distannous citrates and 20 parts of deionized waters.
The preparation method of sulfadimidine micro-capsule, it comprises the following steps：8 parts of crystalline lactose powder are placed in 20-30 parts
Deionized water in stir after be heated to 40 DEG C, the softwood of original volume 1/4 is made in concentration distillation, and 6 parts of rosin are ground into
Fine powder is crossed to add in softwood to stir after 100 mesh sieves is incubated 20min at 20 DEG C；It is put into after adding 10 parts of sulfadimidines
Stirred in reactor, mixing speed 50r/min；60 DEG C of insulation 10min are heated to after adding 4 parts of glucofructans；Add 6
10 DEG C are cooled in 3min after part distannous citrate both to obtain.
Embodiment 2：Sulfadimidine micro-capsule, it is included by weight：15 parts of sulfadimidines, 8 parts of rosin, 9
Part crystalline lactose powder, 6 parts of glucofructans, 8 parts of distannous citrates and 25 parts of deionized waters.
The preparation method of sulfadimidine micro-capsule, it comprises the following steps：9 parts of crystalline lactose powder are placed in 25 parts
45 DEG C are heated to after being stirred in ionized water, the softwood of original volume 1/5 is made in concentration distillation, and 8 parts of rosin are ground into fine powder
Cross to add in softwood to stir after 100 mesh sieves and be incubated 25min at 25 DEG C；Reaction is put into after adding 15 parts of sulfadimidines
Stirred in kettle, mixing speed 55r/min；65 DEG C of insulation 15min are heated to after adding 6 parts of glucofructans；Add 8 parts of lemons
12 DEG C are cooled to after lemon acid is Distannous in 5min both to obtain.
Embodiment 3：Sulfadimidine micro-capsule, it is included by weight：20 parts of sulfadimidines, 12 parts of rosin,
10 parts of crystalline lactose powder, 8 parts of glucofructans, 10 parts of distannous citrates and 30 parts of deionized waters.
The preparation method of sulfadimidine micro-capsule, it comprises the following steps：10 parts of crystalline lactose powder are placed in 30 parts
50 DEG C are heated to after being stirred in deionized water, the softwood of original volume 1/6 is made in concentration distillation, and 12 parts of rosin are ground into carefully
Powder is crossed to add in softwood to stir after 100 mesh sieves is incubated 30min at 30 DEG C；It is put into instead after adding 20 parts of sulfadimidines
Answer in kettle and stir, mixing speed 60r/min；70 DEG C of insulation 20min are heated to after adding 8 parts of glucofructans；Add 10
14 DEG C are cooled in 7min after part distannous citrate both to obtain.
The present invention utilizes the high medicine saturation of crystalline lactose powder, and sulfadimidine is accommodated in the inner, it is ensured that it is solidifying
It is polymerized to that the state of type is controllable, the addition of rosin helps speed up the speed of cohesion, it is hardened at a lower temperature, lemon
Sour Distannous addition at low temperature can improve the stability of cohesion solidification, it is ensured that micro-capsule expected from formation.
Claims (2)
1. sulfadimidine micro-capsule, it is characterized in that it is included by weight：10-20 parts sulfadimidine, 6-12 parts pine
Perfume, 8-10 part crystalline lactoses powder, 4-8 parts glucofructan, 6-10 parts distannous citrate and 20-30 part deionized waters.
2. the preparation method of sulfadimidine micro-capsule as claimed in claim 1, it is characterized in that it comprises the following steps：By 8-
10 parts of crystalline lactose powder are placed in the deionized water of 20-30 parts stir after be heated to 40-50 DEG C, concentration distillation is made original
Volume 1/4-1/6 softwood, is ground into fine powder by 6-12 part rosin and crosses to add in softwood after 100 mesh sieves and stir at 20-30 DEG C
Lower insulation 20-30min；It is put into reactor and stirs after addition 10-20 part sulfadimidines, mixing speed 50-
60r/min；60-70 DEG C of insulation 10-20min is heated to after adding 4-8 part glucofructans；Add 6-10 part distannous citrates
10-14 DEG C is cooled in 3-7min afterwards both to obtain.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711180778.5A CN107753463A (en) | 2017-11-23 | 2017-11-23 | Sulfadimidine micro-capsule and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201711180778.5A CN107753463A (en) | 2017-11-23 | 2017-11-23 | Sulfadimidine micro-capsule and preparation method thereof |
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| CN107753463A true CN107753463A (en) | 2018-03-06 |
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| CN201711180778.5A Withdrawn CN107753463A (en) | 2017-11-23 | 2017-11-23 | Sulfadimidine micro-capsule and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109776430A (en) * | 2019-02-01 | 2019-05-21 | 福建农林大学 | Sulfamethazine eutectic crystal and preparation method thereof |
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| CN1586709A (en) * | 2004-07-09 | 2005-03-02 | 清华大学 | Process for preparing polyhydroxy acid ester micro capsule |
| CN101658510A (en) * | 2008-08-25 | 2010-03-03 | 沈阳皓天万嘉医药科技有限公司 | Coenzyme Q10 self-emulsifying microcapsules and preparation method thereof |
| CN102671591A (en) * | 2012-05-26 | 2012-09-19 | 云南恩典科技产业发展有限公司 | Water-encapsulated microcapsule wall material and water-encapsulated microcapsule prepared through same |
| CN105287438A (en) * | 2015-11-20 | 2016-02-03 | 昆明积大制药股份有限公司 | Sucralfate self-emulsifying microcapsule and preparation method thereof |
| CN107281158A (en) * | 2016-04-12 | 2017-10-24 | 王玉万 | Capsule core material and its micro-capsule containing tylosin are prepared with tylosin anti-stripping agent |
-
2017
- 2017-11-23 CN CN201711180778.5A patent/CN107753463A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1586709A (en) * | 2004-07-09 | 2005-03-02 | 清华大学 | Process for preparing polyhydroxy acid ester micro capsule |
| CN101658510A (en) * | 2008-08-25 | 2010-03-03 | 沈阳皓天万嘉医药科技有限公司 | Coenzyme Q10 self-emulsifying microcapsules and preparation method thereof |
| CN102671591A (en) * | 2012-05-26 | 2012-09-19 | 云南恩典科技产业发展有限公司 | Water-encapsulated microcapsule wall material and water-encapsulated microcapsule prepared through same |
| CN105287438A (en) * | 2015-11-20 | 2016-02-03 | 昆明积大制药股份有限公司 | Sucralfate self-emulsifying microcapsule and preparation method thereof |
| CN107281158A (en) * | 2016-04-12 | 2017-10-24 | 王玉万 | Capsule core material and its micro-capsule containing tylosin are prepared with tylosin anti-stripping agent |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109776430A (en) * | 2019-02-01 | 2019-05-21 | 福建农林大学 | Sulfamethazine eutectic crystal and preparation method thereof |
| CN109776430B (en) * | 2019-02-01 | 2022-05-13 | 福建农林大学 | Sulfadimidine eutectic crystal and preparation method thereof |
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Application publication date: 20180306 |
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