CN107875173A - Cod-liver oil micro-capsule and preparation method thereof - Google Patents
Cod-liver oil micro-capsule and preparation method thereof Download PDFInfo
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- CN107875173A CN107875173A CN201711187914.3A CN201711187914A CN107875173A CN 107875173 A CN107875173 A CN 107875173A CN 201711187914 A CN201711187914 A CN 201711187914A CN 107875173 A CN107875173 A CN 107875173A
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- parts
- capsule
- cod
- micro
- liver oil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/60—Fish, e.g. seahorses; Fish eggs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Marine Sciences & Fisheries (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses cod-liver oil micro-capsule, and it is included by weight：10 20 parts of cod-liver oil, 6 12 parts of turpentine oil, 8 10 parts of microcrystalline celluloses, 48 parts of Arabic gums, 6 10 parts of Potassium aluminum sulfate dodecahydrates and 20 30 parts of deionized waters.The beneficial effects of the invention are as follows the microcrystalline cellulose of addition can promote the preforming of capsule material, obtained cod-liver oil micro-capsule shape is specific, and without repeatedly condensing repeatedly, turpentine oil and Potassium aluminum sulfate dodecahydrate can accelerate the cohesion and solidification of micro-capsule, shorten the reaction time, form stable micro-capsule.
Description
Technical field
The present invention relates to field of pharmaceutical preparations, more particularly to cod-liver oil micro-capsule and preparation method thereof.
Background technology
Microencapsulation（Abbreviation micro-capsule）System utilizes high polymer material（It is generally called capsule material）, by solid drugs or liquid medicine（It is logical
Claim capsule core material）It is rolled into a diameter of 0.01-200 μm of tiny capsules.After medicament microcapsule, there is slow releasing function, medicine can be improved
The stability of thing, the bad smell and taste of medicine are covered, reduce medicine to the excitant of intestines and stomach, reduce matching somebody with somebody for compound medicine
5 taboos, improve the mobility and compressibility of medicine, make liquid drug can solidification.The preparation method of micro-capsule is a lot, can conclude
For physical-chemical process, chemical method and physicomechanical processes three major types.Can according to the particle diameter of the property and micro-capsule of medicine and capsule material, release
The requirements such as performance are put to be selected.Wherein Simple coacervation and complex coacervation application is wider.Simple coacervation：By a kind of flocculating agent（By force
Hydrophilic electrolyte or non-electrolyte, such as sodium sulphate, sulfuric acid hinge, ethanol, propyl alcohol）Add in the solution of certain water-soluble capsule material
（Wherein emulsify or suspension core material）, because substantial amounts of moisture content is combined with flocculating agent, make capsule material in system solubility reduce and
Cohesion comes out, and eventually forms micro-capsule.Or medicine is dispersed in the organic solvent miscible with water containing cellulose derivative, after
Add the concentrated solution of inorganic salts, capsule material is condensed into cyst membrane and form micro-capsule.Complex coacervation：Using two kinds of polymer in different PH
When, the change of electric charge（Generate opposite electric charge）Cause phase separation-coacervation, referred to as complex coacervation.Such as use Arabic gum（It is negatively charged
Lotus）And gelatin（PH is negatively charged more than isoelectric point, positively charged below isoelectric point）Make capsule material, medicine elder generation and Arabic gum
Mix, be made suspension or emulsion, negative electrical charge colloid is continuous phase, medicine（Core）For dispersed phase, at a temperature of 40-60 DEG C
(now gelatin is negatively charged or substantially negatively charged) is mixed with equivalent gelatin solution, then adjusts below pH4.5 with diluted acid
Make gelatin is all positively charged to be condensed with negatively charged Arabic gum, be wrapped medicine.
The flocculating result of Simple coacervation is uncontrollable, it is necessary to by satisfied micro-capsule can just repeatedly be made repeatedly, less efficient,
Cost is higher；Requirement of the complex coacervation to operation is higher, solution is stirred when adjusting pH value, and reach specific pH
It is worth section, is stirred all the time during preparing micro-capsule, and foam can be produced so as to reduce yield by stirring.
The content of the invention
The technical problem to be solved in the present invention is that existing coacervation prepares many defects existing for cod-liver oil micro-capsule, is this
There is provided a kind of flocculating result it is expectable, operation require low cod-liver oil micro-capsule and preparation method thereof.
The technical scheme is that：Cod-liver oil micro-capsule, it is included by weight：10-20 parts cod-liver oil, 6-12 parts pine
Fuel-economizing, 8-10 parts microcrystalline cellulose, 4-8 parts Arabic gum, 6-10 parts Potassium aluminum sulfate dodecahydrate and 20-30 part deionized waters.
The preparation method of cod-liver oil micro-capsule, it comprises the following steps：8-10 part microcrystalline celluloses are placed in going for 20-30 parts
40-50 DEG C is heated to after being stirred in ionized water, original volume 1/4-1/6 softwood is made in concentration distillation, by 6-12 parts pine
Fuel-economizing adds in softwood to stir after being heated to 60-70 DEG C is incubated 20-30min at 20-30 DEG C；Add 10-20 part fish livers
It is put into reactor and stirs after oil, mixing speed 50-60r/min；60-70 is heated to after adding 4-8 part Arabic gums
DEG C insulation 10-20min；10-14 DEG C is cooled in 3-7min after addition 6-10 part Potassium aluminum sulfate dodecahydrates both to obtain.
The beneficial effects of the invention are as follows the microcrystalline cellulose of addition can promote the preforming of capsule material, obtained cod-liver oil micro-capsule
Shape is specific, and without repeatedly condensing repeatedly, turpentine oil and Potassium aluminum sulfate dodecahydrate can accelerate the cohesion and solidification of micro-capsule, shortens anti-
Between seasonable, stable micro-capsule is formed.
Embodiment
The cod-liver oil micro-capsule of the present invention, it is included by weight：10-20 parts cod-liver oil, 6-12 parts turpentine oil, 8-10 parts
Microcrystalline cellulose, 4-8 parts Arabic gum, 6-10 parts Potassium aluminum sulfate dodecahydrate and 20-30 part deionized waters.
The preparation method of cod-liver oil micro-capsule, it comprises the following steps：8-10 part microcrystalline celluloses are placed in going for 20-30 parts
40-50 DEG C is heated to after being stirred in ionized water, original volume 1/4-1/6 softwood is made in concentration distillation, by 6-12 parts pine
Fuel-economizing adds in softwood to stir after being heated to 60-70 DEG C is incubated 20-30min at 20-30 DEG C；Add 10-20 part fish livers
It is put into reactor and stirs after oil, mixing speed 50-60r/min；60-70 is heated to after adding 4-8 part Arabic gums
DEG C insulation 10-20min；10-14 DEG C is cooled in 3-7min after addition 6-10 part Potassium aluminum sulfate dodecahydrates both to obtain.
With reference to embodiment, the present invention will be further described.
Embodiment 1：Cod-liver oil micro-capsule, it is included by weight：10 parts of cod-liver oil, 6 parts of turpentine oil, 8 parts of microcrystalline celluloses
Element, 4 parts of Arabic gums, 6 parts of Potassium aluminum sulfate dodecahydrates and 20 parts of deionized waters.
The preparation method of cod-liver oil micro-capsule, it comprises the following steps：8 parts of microcrystalline celluloses are placed in 20 parts of deionized water
In stir after be heated to 40 DEG C, the softwood of original volume 1/4 is made in concentration distillation, after 6 parts of turpentine oil are heated into 60 DEG C
Add in softwood to stir and be incubated 20min at 20 DEG C；It is put into reactor and stirs after 10 parts of cod-liver oil of addition, stirs
Speed is 50r/min；60 DEG C of insulation 10min are heated to after adding 4 parts of Arabic gums；Add 6 parts of Potassium aluminum sulfate dodecahydrates after
10 DEG C are cooled in 3min both to obtain.
Embodiment 2：Cod-liver oil micro-capsule, it is included by weight：15 parts of cod-liver oil, 8 parts of turpentine oil, 9 parts of microcrystalline celluloses
Element, 6 parts of Arabic gums, 8 parts of Potassium aluminum sulfate dodecahydrates and 25 parts of deionized waters.
The preparation method of cod-liver oil micro-capsule, it comprises the following steps：9 parts of microcrystalline celluloses are placed in 25 parts of deionized water
In stir after be heated to 45 DEG C, the softwood of original volume 1/5 is made in concentration distillation, after 8 parts of turpentine oil are heated into 65 DEG C
Add in softwood to stir and be incubated 25min at 25 DEG C；It is put into reactor and stirs after 15 parts of cod-liver oil of addition, stirs
Speed is 55r/min；65 DEG C of insulation 15min are heated to after adding 6 parts of Arabic gums；Add 8 parts of Potassium aluminum sulfate dodecahydrates after
12 DEG C are cooled in 5min both to obtain.
Embodiment 3：Cod-liver oil micro-capsule, it is included by weight：20 parts of cod-liver oil, 12 parts of turpentine oil, 10 parts of crystallite fibres
Tie up element, 8 parts of Arabic gums, 10 parts of Potassium aluminum sulfate dodecahydrates and 30 parts of deionized waters.
The preparation method of cod-liver oil micro-capsule, it comprises the following steps：10 parts of microcrystalline celluloses are placed in 30 parts of deionization
50 DEG C are heated to after being stirred in water, the softwood of original volume 1/6 is made in concentration distillation, and 12 parts of turpentine oil are heated into 70 DEG C
Add in softwood to stir afterwards and be incubated 30min at 30 DEG C；It is put into reactor and stirs after 20 parts of cod-liver oil of addition, stirs
It is 60r/min to mix speed；70 DEG C of insulation 20min are heated to after adding 8 parts of Arabic gums；After adding 10 parts of Potassium aluminum sulfate dodecahydrates
14 DEG C are cooled in 7min both to obtain.
The present invention utilizes the high medicine saturation of microcrystalline cellulose, and cod-liver oil is accommodated in the inner, it is ensured that it condenses shaping
State it is controllable, terebinthine add helps speed up the speed of cohesion, it is hardened at a lower temperature, 12 water sulphur
The addition of sour aluminium potassium at low temperature can improve the stability of cohesion solidification, it is ensured that micro-capsule expected from formation.
Claims (2)
1. cod-liver oil micro-capsule, it is characterized in that it is included by weight：10-20 parts cod-liver oil, 6-12 parts turpentine oil, 8-10 parts are micro-
Crystalline cellulose, 4-8 parts Arabic gum, 6-10 parts Potassium aluminum sulfate dodecahydrate and 20-30 part deionized waters.
2. the preparation method of cod-liver oil micro-capsule as claimed in claim 1, it is characterized in that it comprises the following steps：8-10 parts is micro-
Crystalline cellulose is placed in the deionized water of 20-30 parts stir after be heated to 40-50 DEG C, original volume 1/ is made in concentration distillation
4-1/6 softwood, stirred after 6-12 part turpentine oil is heated into 60-70 DEG C in addition softwood and be incubated 20- at 20-30 DEG C
30min；It is put into reactor and stirs after addition 10-20 part cod-liver oil, mixing speed 50-60r/min；Add 4-8 parts
60-70 DEG C of insulation 10-20min is heated to after Arabic gum；Cooled down after adding 6-10 part Potassium aluminum sulfate dodecahydrates in 3-7min
Both obtained to 10-14 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711187914.3A CN107875173A (en) | 2017-11-24 | 2017-11-24 | Cod-liver oil micro-capsule and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711187914.3A CN107875173A (en) | 2017-11-24 | 2017-11-24 | Cod-liver oil micro-capsule and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107875173A true CN107875173A (en) | 2018-04-06 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711187914.3A Pending CN107875173A (en) | 2017-11-24 | 2017-11-24 | Cod-liver oil micro-capsule and preparation method thereof |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106265823A (en) * | 2016-08-09 | 2017-01-04 | 广州华农大实验兽药有限公司 | A kind of Herba Epimedii extract slow-releasing microcapsule and preparation method and application |
-
2017
- 2017-11-24 CN CN201711187914.3A patent/CN107875173A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106265823A (en) * | 2016-08-09 | 2017-01-04 | 广州华农大实验兽药有限公司 | A kind of Herba Epimedii extract slow-releasing microcapsule and preparation method and application |
Non-Patent Citations (3)
| Title |
|---|
| DAVIDOV-PARDO, G.等: "Utilization of Different Wall Materials to Microencapsulate Fish Oil Evaluation of its Behavior in Bread Products", 《AMERICAN JOURNAL OF FOOD TECHNOLOGY》 * |
| 刘超: "鳕鱼肝油的提取工艺优化及品质评价", 《中国优秀硕士学位论文全文数据库医药卫生科技辑》 * |
| 杨彩然等: "《兽医基础》", 30 September 2009, 河北科学技术出版社 * |
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Application publication date: 20180406 |