CN107638515A - It is a kind of to be used to prevent and treat medicine of chicken breathing problem and preparation method thereof - Google Patents
It is a kind of to be used to prevent and treat medicine of chicken breathing problem and preparation method thereof Download PDFInfo
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- CN107638515A CN107638515A CN201711042252.0A CN201711042252A CN107638515A CN 107638515 A CN107638515 A CN 107638515A CN 201711042252 A CN201711042252 A CN 201711042252A CN 107638515 A CN107638515 A CN 107638515A
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Abstract
The present invention relates to the medicine of poultry disease, more particularly to a kind of medicine for being used to prevent and treat chicken breathing problem, including following raw material：Asian puccoon, mistletoe, the stem of noble dendrobium, mushroom, mulberries；Pass through certain composition of raw materials, preparation method, medicament all has good therapeutic effect to virus type and bacteria type breathing problem, 92.5% is up to the cure rate of bacteria type breathing problem after being administered 3 days, and has good control action to the state of an illness, dead example is less；80.0% is up to the cure rate of virus type breathing problem, and has good control action to the state of an illness.
Description
Technical field
The present invention relates to the medicine of poultry disease, more particularly to a kind of medicine for being used to prevent and treat chicken breathing problem
And preparation method thereof.
Background technology
With expanding economy, living standard increase, Countryside Egg, chicken meat, which commercially compare, to get consumer reception.But
It is, because understanding of the raiser for disease knowledge and prophylaxis is relatively fewer, to cause chicken cultivation disease occur more
Hair, epidemic situation are popular to aggravate equivalent risk.Breathing problem in chicken cultivation is relatively common.Because the disease belongs to heavy disease, easily
Hair, multiple, recurrent exerbation, it frequently can lead to chicken decreased growth, meat egg product carries disease etc..In chicken breeding process, respiratory tract
Disease can synoptically be divided into two big types, i.e. bacteria type, virus type.It is right due to lacking effective medicine at present
Mainly aimed at prevention in the breathing problem of chicken, preventing and treating combines.
The content of the invention
The present invention is in order to solve the above technical problems, provide a kind of for preventing and treating chicken breathing problem medicine and its preparation
Method, realized particular by following technical scheme.
One kind is used to prevent and treat chicken breathing problem medicine, including following mass parts raw material：Asian puccoon 10-100 parts, Mongolian oak are posted
Raw 5-70 parts, stem of noble dendrobium 10-60 parts, mushroom 15-55 parts, mulberries 4-40 parts.
Further, it is described to be used to prevent and treat chicken breathing problem medicine, including following mass parts raw material：Asian puccoon 40-
43.5 parts, mistletoe 34-38 parts, stem of noble dendrobium 20-27 parts, mushroom 17-24 parts, mulberries 10-15 parts.
Further, it is described to be used to prevent and treat chicken breathing problem medicine, including following preparation method：
1) stem of noble dendrobium, mushroom mixing, are crushed, and add water that the compound that water content is 30-40% is made, and ferment 3- at 30-40 DEG C
5 days, fermentation material is obtained, the ethanol of 4-5 times of fermentation material quality is added, 30-40min, mistake is extracted under 30-35 KHz supersonic frequency
Filter, filtrate decompression backflow recovery ethanol, obtains material 1；
2) Asian puccoon, mistletoe mixing, are crushed, hot-pressing processing, are added 0.8-1 times of solution 1,50-55 DEG C of vibration 1.5-2h, are obtained
Material 2,17.2-19 times of solution 2 is added, Microwave Extraction, filtering, filtrate decompression backflow, obtains material 3；
3) material 1 and the mixing of material 3, add liquid nitrogen flash freezer 20-30min, add 4-5 times of acetic acid solution, 40-45 DEG C of closing is stirred
Mix 1-2h, add sodium hydroxide regulation pH, filter, extract solution 1；Described acetic acid solution is that volume fraction is 20-
23.5%；
3) mulberries crush, and add 5-7 times of solution 3, stand at low temperature 2-3h, 40-45 DEG C of heating 40-50min, filtering, obtain
Extract solution 2；
4) extract solution 1 and extract solution 2 mix, and add the hydrogenperoxide steam generator of 5-6% mixed liquor quality, 30-35 DEG C of stirring
1.4-2h, filtering, takes precipitation, obtains material 4；
5) add 20-25 times and expect that the cornstarch of 4 mass, 5-7% expect the sodium carboxymethylcellulose of 4 mass, water, mix,
Granulation, dry, both.
Further, described hot-pressing processing, it is to handle 5-7min at 3.3-3.6MPa, 200-250 DEG C.
Further, described solution 1, for 2.3-4% pectase, 3-5% cellulase, 10-12.55 white orchid
Ground mixed liquor, wherein described percentage is mass percent.
Further, described solution 2, ethanol, methanol, acetic acid, water are according to volume ratio 34-35:5.6-7:3.5-5:43-
44 mix.
Further, described Microwave Extraction, it is that 9-14 min are extracted under 800-1000MHz frequency.
Further, described addition sodium hydroxide regulation pH, it is that 7.5-7.8. is arrived into pH regulations
Further, described solution 3 is blue or green lemon, beer according to mass ratio 3-5:12-13 is mixed, on ice ultrasonication 30-
35min, the urea of 6-7% green grass or young crops lemon quality is added, stir 30-40min, 10000-12000rpm centrifugation 30-35min, both.
Further, described stand at low temperature, it is that 45-50min is placed in 3-7 DEG C of environment, 370-400nm's is ultraviolet
Light irradiation 20-30min.
Beneficial effect：Medicament prepared by the present invention, low toxicity, safety.By to virus infection type and bacteria type respiratory tract disease
The clinical trial of the chicken of disease understands that, by different composition of raw materials, preparation method, medicament has different treatments to experimental subjects
Effect, experimental result find, by the special preparation method of the present invention, all have very to virus type and bacteria type breathing problem
Good therapeutic effect, 92.5% is up to the cure rate of bacteria type breathing problem after being administered 3 days, and has good control to the state of an illness
Make and use, dead example is less；80.0% is up to the cure rate of virus type breathing problem, and has control well to make to the state of an illness
With.
In summary, the medicament for preparing of the present invention is for treatment chicken infection breathing problem, either virus type or thin
Bacterial type all has good therapeutic effect, has good inhibiting effect to pathogenic bacteria and virus.In addition, also there is enhancing chicken to exempt from
Epidemic disease power, resistivity of the chicken to disease is enhanced, effectively prevent the damage brought in chicken breeding process due to infection breathing problem
Become estranged food-safety problem.
Embodiment
The embodiment of the present invention is described in further detail below, but the invention is not limited in these realities
Mode is applied, any improvement or replacement on the present embodiment essence spirit, it is claimed to still fall within the claims in the present invention
Scope.
Embodiment 1-7 formula composition is as shown in table 1, and preparation method is all identical.
The embodiment 1-7 of table 1 formula compositions (g)
| Asian puccoon | Mistletoe | The stem of noble dendrobium | Mushroom | Mulberries | |
| Embodiment 1 | 40 | 34 | 20 | 17 | 10 |
| Embodiment 2 | 42 | 36 | 24 | 20 | 13 |
| Embodiment 3 | 43.5 | 38 | 27 | 24 | 15 |
| Embodiment 4 | - | 38 | 27 | 24 | 15 |
| Embodiment 5 | 43.5 | - | 27 | 24 | 15 |
| Embodiment 6 | 43.5 | 38 | - | 24 | 15 |
| Embodiment 7 | 43.5 | 38 | - | - | 15 |
Preparation method：
It is described to be used to prevent and treat chicken breathing problem medicine, including following preparation method：
1) stem of noble dendrobium, mushroom mixing, are crushed, and are added water that the compound that water content is 30% is made, are fermented 3 days, must send out at 30 DEG C
Ferment material, the ethanol of 4 times of fermentation material quality is added, 30min is extracted under 30KHz supersonic frequency, is filtered, filtrate decompression backflow recovery
Ethanol, obtain material 1；
2) Asian puccoon, mistletoe mixing, are crushed, hot-pressing processing, are added 0.8 times of solution, 1,50 DEG C of vibration 1.5h, are obtained material 2, add
Enter 17.2 times of solution 2, Microwave Extraction, filtering, filtrate decompression backflow, obtain material 3；
3) material 1 and the mixing of material 3, add liquid nitrogen flash freezer 20min, add 4 times of acetic acid solution, 40 DEG C of closing stirring 1h, add
Enter sodium hydroxide regulation pH, filter, extract solution 1；Described acetic acid solution is that volume fraction is 20%；
3) mulberries crush, and add 5 times of solution 3, stand at low temperature 2h, 40 DEG C of heating 40min, filtering, obtain extract solution 2；
4) extract solution 1 and extract solution 2 are mixed, and add the hydrogenperoxide steam generator of 5% mixed liquor quality, and 30 DEG C are stirred 1.4h,
Filtering, takes precipitation, obtains material 4；
5) cornstarch, the sodium carboxymethylcellulose of the mass of 5% material 4 of 20 times of 4 mass of material are added, water, is mixed, granulation,
Dry, both.
Described hot-pressing processing, it is in 3.3MPa, 5min is handled at 200 DEG C.
Described solution 1, for 2.3% pectase, 3% cellulase, 10 brandy mixed liquor, wherein described
Percentage is mass percent.
Described solution 2, ethanol, methanol, acetic acid, water are according to volume ratio 34:5.6:3.5:43 mix.
Described Microwave Extraction, it is to extract 9min under 800MHz frequency.
Described addition sodium hydroxide regulation pH, is that pH regulations are arrived into 7.5.
Described solution 3 is blue or green lemon, beer according to mass ratio 3:12 mixing, ultrasonication 30min, it is blue or green to add 6% on ice
The urea of lemon quality, 30min being stirred, 10000rpm centrifuges 30 min, both.
Described stand at low temperature, it is that 45min is placed in 3 DEG C of environment, 370nm ultraviolet light 20min.
Embodiment 8
Embodiment 8 is identical with the formula composition of embodiment 3, and preparation method is different, and embodiment 8 is to mix raw material, adds 7
The clear water of times mixture quality, decocts 3-4h, filtering, has taken filtrate both, or filtrate is dried, and has taken medicinal extract both.
Embodiment 9
Embodiment 9 is identical with the formula composition of embodiment 3, and preparation method is different, and embodiment 9 is to mix raw material, crushes,
Both.
Experimental example
1st, acute toxicity is analyzed
Method according to embodiment 1-9 prepares medicine, mouse is fed according to 5000g/kg dosage, after observation mouse is edible
72h situations of change.
As a result：Found by acute toxicity, the medicament for preparing of the present invention, mouse eat in 72h without occur it is dead and
Any adverse reaction, by the way that mouse is dissected, its stomach, enteron aisle, kidney are observed, equally also without any damage of discovery
Wound.Thus illustrate, medicament prepared by the present invention, 5000g/kg is more than to the median lethal dose of mouse.
2nd, clinical trial results
The chicken of 2000 confirmation bacterial infection type breathing problems is randomly selected, is divided into 10 groups, and 2000
Only confirm the chicken of virus infection type breathing problem, be equally divided into 10 groups, spaced out between each experimental group, not mutually
Spread disease, feed the embodiment 1-9 medicaments prepared to 1-9 groups respectively, experimental group 10 feeds plain boiled water as blank control group.
Administrated method：Mixed feeding, will each embodiment prepare medicament mixed with the feed of 30 times of medicament stock quality, often
Day 3 times, medicine feed counts the recovery situation of every group of experimental subjects respectively after 3 days.
Chicken therapeutic effect of the medicine of table 2 to bacterial infection type breathing problem
Chicken therapeutic effect of the medicine of table 3 to virus infection type breathing problem
By the clinical trial to virus infection type and the chicken of bacteria type breathing problem, matched somebody with somebody by different raw materials
Side, preparation method, medicament have different therapeutic effects to experimental subjects, and experimental result is found by the special preparation of the present invention
Method, all there is good therapeutic effect to virus type and bacteria type breathing problem, to bacteria type respiratory tract disease after being administered 3 days
The cure rate of disease is up to 92.5%, and has good control action to the state of an illness, and dead example is less；To virus type breathing problem
Cure rate is up to 80.0%, and has good control action to the state of an illness.
In summary, the medicament for preparing of the present invention is for treatment chicken infection breathing problem, either virus type or thin
Bacterial type all has good therapeutic effect, has good inhibiting effect to pathogenic bacteria and virus.In addition, also there is enhancing chicken to exempt from
Epidemic disease power, resistivity of the chicken to disease is enhanced, effectively prevent the damage brought in chicken breeding process due to infection breathing problem
Become estranged food-safety problem.
Claims (10)
1. one kind is used to prevent and treat chicken breathing problem medicine, it is characterised in that including following mass parts raw material：Asian puccoon 10-100
Part, mistletoe 5-70 parts, stem of noble dendrobium 10-60 parts, mushroom 15-55 parts, mulberries 4-40 parts.
2. the medicine as claimed in claim 1 for being used to prevent and treat chicken breathing problem, it is characterised in that described is used to prevent and treat
Chicken breathing problem medicine, including following mass parts raw material：Asian puccoon 40-43.5 parts, mistletoe 34-38 parts, stem of noble dendrobium 20-27
Part, mushroom 17-24 parts, mulberries 10-15 parts.
3. the medicine as claimed in claim 1 for being used to prevent and treat chicken breathing problem, it is characterised in that described is used to prevent and treat
Chicken breathing problem medicine, including following preparation method：
1) stem of noble dendrobium, mushroom mixing, are crushed, and are added water that the compound that water content is 30-40% is made, are fermented 3-5 days at 30-40 DEG C,
Fermentation material is obtained, the ethanol of 4-5 times of fermentation material quality is added, 30-40min is extracted under 30-35KHz supersonic frequency, filter, filtrate
Reduced-pressure backflow reclaims ethanol, obtains material 1；
2) Asian puccoon, mistletoe mixing, are crushed, hot-pressing processing, are added 0.8-1 times of solution 1,50-55 DEG C of vibration 1.5-2h, are obtained material 2,
17.2-19 times of solution 2 is added, Microwave Extraction, filtering, filtrate decompression backflow, obtains material 3；
3) material 1 and the mixing of material 3, add liquid nitrogen flash freezer 20-30min, add 4-5 times of acetic acid solution, 40-45 DEG C of closing stirring 1-
2h, add sodium hydroxide regulation pH, filter, extract solution 1；Described acetic acid solution is that volume fraction is 20-23.5%；
3) mulberries crush, and add 5-7 times of solution 3, stand at low temperature 2-3h, 40-45 DEG C of heating 40-50min, filtering, must extract
Liquid 2；
4) extract solution 1 and extract solution 2 mix, and add the hydrogenperoxide steam generator of 5-6% mixed liquor quality, 30-35 DEG C of stirring 1.4-
2h, filtering, takes precipitation, obtains material 4；
5) add 20-25 times and expect that the cornstarch of 4 mass, 5-7% expect the sodium carboxymethylcellulose of 4 mass, water, mix, granulation,
Dry, both.
4. the medicine as claimed in claim 3 for being used to prevent and treat chicken breathing problem, it is characterised in that at described hot pressing
Reason, is to handle 5-7min at 3.3-3.6MPa, 200-250 DEG C.
5. the medicine as claimed in claim 3 for being used to prevent and treat chicken breathing problem, it is characterised in that described solution 1, be
2.3-4% pectase, 3-5% cellulase, 10-12.55 brandy mixed liquor, wherein described percentage is quality
Percentage.
6. the medicine as claimed in claim 3 for being used to prevent and treat chicken breathing problem, it is characterised in that described solution 2, second
Alcohol, methanol, acetic acid, water are according to volume ratio 34-35:5.6-7:3.5-5:43-44 is mixed.
7. the medicine as claimed in claim 3 for being used to prevent and treat chicken breathing problem, it is characterised in that described microwave carries
Take, be to extract 9-14min under 800-1000MHz frequency.
8. the medicine as claimed in claim 3 for being used to prevent and treat chicken breathing problem, it is characterised in that described addition hydrogen-oxygen
Change sodium regulation pH, be that 7.5-7.8 is arrived into pH regulations.
9. the medicine as claimed in claim 3 for being used to prevent and treat chicken breathing problem, it is characterised in that described solution 3, be
Blue or green lemon, beer are according to mass ratio 3-5:12-13 is mixed, on ice ultrasonication 30-35min, adds the urine of 6-7% green grass or young crops lemon quality
Element, 30-40min, 10000-12000rpm centrifugation 30-35min are stirred, both.
10. the medicine as claimed in claim 3 for being used to prevent and treat chicken breathing problem, it is characterised in that described low temperature is quiet
Put, be that 45-50min is placed in 3-7 DEG C of environment, 370-400nm ultraviolet light 20-30min.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711042252.0A CN107638515A (en) | 2017-10-30 | 2017-10-30 | It is a kind of to be used to prevent and treat medicine of chicken breathing problem and preparation method thereof |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101693220B1 (en) * | 2015-05-06 | 2017-01-05 | (주)비타바이오 | Composition comprising Althaea rosea root extract having activity of immune enhancement or for treating or preventing virus disease |
-
2017
- 2017-10-30 CN CN201711042252.0A patent/CN107638515A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101693220B1 (en) * | 2015-05-06 | 2017-01-05 | (주)비타바이오 | Composition comprising Althaea rosea root extract having activity of immune enhancement or for treating or preventing virus disease |
Non-Patent Citations (3)
| Title |
|---|
| 卫广森: "《百项养鸡新技术》", 31 October 1999, 辽宁科学技术出版社 * |
| 李敬云: "鸡传染性喉气管炎的中药治疗", 《中兽医学杂志》 * |
| 田新民等: "中草药在鸡养殖业中的应用", 《当代畜牧》 * |
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