CN107635986A - 取代的喹喔啉衍生物 - Google Patents

取代的喹喔啉衍生物 Download PDF

Info

Publication number
CN107635986A
CN107635986A CN201680027578.3A CN201680027578A CN107635986A CN 107635986 A CN107635986 A CN 107635986A CN 201680027578 A CN201680027578 A CN 201680027578A CN 107635986 A CN107635986 A CN 107635986A
Authority
CN
China
Prior art keywords
methyl
quinoxalin
indol
amine
pyridin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680027578.3A
Other languages
English (en)
Chinese (zh)
Inventor
C-H·R·Y·法布里蒂乌斯
M·O·诺瓦克
K·A·维克里克
A·B·萨比尼尔兹
M·D·比恩
A·M·布达
P·S·古兹克
K·R·雅库别茨
M·马丘斯扎克
K·克维辛斯科
M·M·托姆奇克
M·M·加莱佐夫斯基
A·龚德拉
L·P·杜德克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Selvita Sp zoo
Original Assignee
Selvita Sp zoo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Selvita Sp zoo filed Critical Selvita Sp zoo
Publication of CN107635986A publication Critical patent/CN107635986A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/42—Benzopyrazines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201680027578.3A 2015-05-13 2016-05-12 取代的喹喔啉衍生物 Pending CN107635986A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP15001451.2 2015-05-13
EP15460017.5 2015-05-13
EP15001451 2015-05-13
EP15460017 2015-05-14
PCT/EP2016/000783 WO2016180536A1 (en) 2015-05-13 2016-05-12 Substituted quinoxaline derivatives

Publications (1)

Publication Number Publication Date
CN107635986A true CN107635986A (zh) 2018-01-26

Family

ID=56081443

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680027578.3A Pending CN107635986A (zh) 2015-05-13 2016-05-12 取代的喹喔啉衍生物

Country Status (9)

Country Link
US (1) US20180148429A1 (enExample)
EP (1) EP3294729A1 (enExample)
JP (1) JP2018515612A (enExample)
CN (1) CN107635986A (enExample)
AU (1) AU2016261031A1 (enExample)
CA (1) CA2979302A1 (enExample)
IL (1) IL254870A0 (enExample)
TW (1) TW201713641A (enExample)
WO (1) WO2016180536A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110698418A (zh) * 2019-09-11 2020-01-17 广西师范大学 一种3-芳胺基喹喔啉-2-甲酰胺类衍生物及其制备方法和应用
CN114901654A (zh) * 2019-08-06 2022-08-12 北卡罗来纳查佩尔山大学 Rna靶向配体、其组合物以及其制备和使用方法
CN115515959A (zh) * 2020-05-08 2022-12-23 默克专利股份公司 用作tead结合剂的三环杂环
CN116134016A (zh) * 2020-07-23 2023-05-16 默克专利股份公司 三环杂环

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2823180T3 (es) * 2016-07-14 2021-05-06 Bristol Myers Squibb Co Compuestos bicíclicos sustituidos con heteroarilo
EP3538518A1 (en) * 2016-11-08 2019-09-18 Merck Patent GmbH Substituted quinoxaline derivatives as inhibitors of pfkfb
GB201705263D0 (en) * 2017-03-31 2017-05-17 Probiodrug Ag Novel inhibitors
US20200275661A1 (en) * 2017-09-26 2020-09-03 Nippon Soda Co., Ltd. Quinoline compound, and agricultural and horticultural fungicide
EP3737680A1 (en) 2018-01-08 2020-11-18 F. Hoffmann-La Roche AG Octahydropyrido[1,2-alpha]pyrazines as magl inhibitors
DK3768684T3 (da) 2018-03-22 2023-04-24 Hoffmann La Roche Oxazin-monoacylglycerol-lipase (MAGL)-hæmmere
JP7478142B2 (ja) 2018-06-07 2024-05-02 ディスアーム セラピューティクス， インコーポレイテッド Ｓａｒｍ１阻害剤
MY210507A (en) 2018-08-13 2025-09-28 Hoffmann La Roche New heterocyclic compounds as monoacylglycerol lipase inhibitors
JP2022508751A (ja) * 2018-10-15 2022-01-19 ゲロ ディスカバリー リミテッド ライアビリティ カンパニー Ｐｆｋｆｂ３阻害剤とその使用
WO2020104494A1 (en) 2018-11-22 2020-05-28 F. Hoffmann-La Roche Ag New heterocyclic compounds
AU2019387370A1 (en) 2018-11-30 2021-06-10 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
CA3123215C (en) 2018-12-19 2024-04-02 Disarm Therapeutics, Inc. Inhibitors of sarm1 in combination with neuroprotective agents
CN114072405A (zh) 2019-07-03 2022-02-18 豪夫迈·罗氏有限公司 杂环单酰基甘油脂肪酶(magl)抑制剂
KR20220034104A (ko) 2019-07-09 2022-03-17 에프. 호프만-라 로슈 아게 신규 헤테로고리 화합물
PH12022550339A1 (en) 2019-09-12 2023-03-13 Hoffmann La Roche 4,4a,5,7,8,8a-hexapyrido[4,3-b][1,4]oxazin-3-one compounds as magl inhibitors
MX2022003023A (es) 2019-09-23 2022-04-07 Hoffmann La Roche Compuestos heterociclicos.
WO2022043284A1 (en) 2020-08-26 2022-03-03 F. Hoffmann-La Roche Ag Heterocyclic compounds useful as magl inhibitors
PE20231372A1 (es) 2020-09-03 2023-09-07 Hoffmann La Roche Compuestos heterociclicos
WO2022115521A1 (en) 2020-11-25 2022-06-02 Servier Pharmaceuticals, Llc (heteo)aryl substituted pyrrolo-, pyrazolo- and triazolopyridazine derivates as mat2a inhibitors
EP4337653A4 (en) * 2021-06-02 2025-07-23 Univ North Carolina Chapel Hill RNA TARGETING LIGANDS, COMPOSITIONS THEREOF, AND METHODS OF MAKING AND USING THE SAME
WO2023247670A1 (en) 2022-06-24 2023-12-28 F. Hoffmann-La Roche Ag New heterocyclic-carbonyl-cyclic compounds as magl inhibitors
WO2025084787A1 (ko) * 2023-10-17 2025-04-24 가천대학교 산학협력단 신규 퀴녹살린 화합물, 이의 제조방법 및 이의 용도

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5633218A (en) * 1995-05-24 1997-05-27 E. I. Du Pont De Nemours And Company Herbicidal benzodioxoles and benzodioxanes
WO2011103557A1 (en) * 2010-02-22 2011-08-25 Advanced Cancer Therapeutics, Llc Small molecule inhibitors of pfkfb3 and glycolytic flux and their methods of use as anti-cancer therapeutics
WO2012176856A2 (en) * 2011-06-24 2012-12-27 Ishihara Sangyo Kaisha, Ltd. Pesticide
US20140128392A1 (en) * 2009-03-19 2014-05-08 Bioenergenix Heterocyclic compounds for the inhibition of pask
CN104520274A (zh) * 2012-03-29 2015-04-15 先进癌症治疗有限责任公司 Pfkfb3抑制剂和用作抗癌治疗剂的方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5633218A (en) * 1995-05-24 1997-05-27 E. I. Du Pont De Nemours And Company Herbicidal benzodioxoles and benzodioxanes
US20140128392A1 (en) * 2009-03-19 2014-05-08 Bioenergenix Heterocyclic compounds for the inhibition of pask
WO2011103557A1 (en) * 2010-02-22 2011-08-25 Advanced Cancer Therapeutics, Llc Small molecule inhibitors of pfkfb3 and glycolytic flux and their methods of use as anti-cancer therapeutics
WO2012176856A2 (en) * 2011-06-24 2012-12-27 Ishihara Sangyo Kaisha, Ltd. Pesticide
CN104520274A (zh) * 2012-03-29 2015-04-15 先进癌症治疗有限责任公司 Pfkfb3抑制剂和用作抗癌治疗剂的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DARBY G. BROOKE, ET AL: "Targeting the Warburg Effect in cancer; relationships for 2-arylpyridazinones as inhibitors of the key glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3)", 《BIOORGANIC & MEDICINAL CHEMISTRY》 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114901654A (zh) * 2019-08-06 2022-08-12 北卡罗来纳查佩尔山大学 Rna靶向配体、其组合物以及其制备和使用方法
CN114901654B (zh) * 2019-08-06 2025-08-05 北卡罗来纳查佩尔山大学 Rna靶向配体、其组合物以及其制备和使用方法
CN110698418A (zh) * 2019-09-11 2020-01-17 广西师范大学 一种3-芳胺基喹喔啉-2-甲酰胺类衍生物及其制备方法和应用
CN110698418B (zh) * 2019-09-11 2022-07-01 广西师范大学 一种3-芳胺基喹喔啉-2-甲酰胺类衍生物及其制备方法和应用
CN115515959A (zh) * 2020-05-08 2022-12-23 默克专利股份公司 用作tead结合剂的三环杂环
CN116134016A (zh) * 2020-07-23 2023-05-16 默克专利股份公司 三环杂环
CN116134016B (zh) * 2020-07-23 2026-08-07 默克专利股份公司 三环杂环

Also Published As

Publication number Publication date
JP2018515612A (ja) 2018-06-14
CA2979302A1 (en) 2016-11-17
WO2016180536A1 (en) 2016-11-17
AU2016261031A1 (en) 2017-10-05
EP3294729A1 (en) 2018-03-21
US20180148429A1 (en) 2018-05-31
TW201713641A (zh) 2017-04-16
IL254870A0 (en) 2017-12-31

Similar Documents

Publication Publication Date Title
CN113166153B (zh) 作为a2a/a2b抑制剂的稠合吡嗪衍生物
US10851080B2 (en) Methods of treatment using pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds
TW201713641A (zh) 經取代之喹喏啉衍生物
TWI753892B (zh) 作為ｔａｍ抑制劑之吡咯并三嗪化合物
CN103874700B (zh) 吡唑并[3,4‑c]吡啶化合物和使用方法
TWI545122B (zh) 吡唑喹噁啉激酶抑制劑
CN118745177A (zh) 含氮杂环类衍生物调节剂、其制备方法和应用
IL297165A (en) Soysag tricyclic CRS inhibitors
CN112105609A (zh) 作为prmt5抑制剂的取代的咪唑烷-2-酮衍生物
CN105452257B (zh) 新型稠合嘧啶化合物或其盐
CN120712252A (zh) 包含sos1抑制剂和抗癌药物的用于治疗癌症的药物组合物
DK2834248T3 (en) UNKNOWN THIENOPYRIMIDINE DERIVATIVES, METHODS OF PRODUCING THEREOF, AND THERAPEUTIC APPLICATIONS THEREOF
CN110036004A (zh) 细胞周期蛋白依赖性激酶7(cdk7)的抑制剂
TW201811799A (zh) 吡唑并嘧啶化合物及其用途
US11040981B2 (en) Pyrrolotriazine compounds and methods of inhibiting TAM kinases
JP2021516674A (ja) ５−ヘテロアリール置換イミダゾール−３−カルボキサミドならびにその調製および使用の方法
WO2021233236A1 (zh) 取代的杂芳基化合物及其组合物和用途
EP4724443A1 (en) Pyrazolo-pyrimidinone compounds for use in methods of inhibiting wee1 a kinase
WO2025113625A1 (zh) 作为pkmyt1抑制剂的杂芳环和杂双环化合物及其应用
HK40100302A (en) Indazole compounds as kinase inhibitors
HK40070099B (en) Substituted fused heteroaromatic bicyclic compounds as kinase inhibitors and the use thereof
EA049140B1 (ru) Замещенные конденсированные гетероароматические бициклические соединения в качестве ингибиторов киназ и их применение
HK1193807B (en) Pyrazolo[3,4-c]pyridine compounds and methods of use
HK1193807A (en) Pyrazolo[3,4-c]pyridine compounds and methods of use

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20180126