CN107614695B - 用胰高血糖素受体拮抗性抗体治疗肥胖症和非酒精性脂肪肝病或非酒精性脂肪性肝炎的方法 - Google Patents

用胰高血糖素受体拮抗性抗体治疗肥胖症和非酒精性脂肪肝病或非酒精性脂肪性肝炎的方法 Download PDF

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CN107614695B
CN107614695B CN201680030380.0A CN201680030380A CN107614695B CN 107614695 B CN107614695 B CN 107614695B CN 201680030380 A CN201680030380 A CN 201680030380A CN 107614695 B CN107614695 B CN 107614695B
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antigen binding
binding protein
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CN107614695A (zh
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严海
吉姆·施
吴政
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Remd Biotherapeutics Inc
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
    • C07K2319/92—Fusion polypeptide containing a motif for post-translational modification containing an intein ("protein splicing")domain

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  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201680030380.0A 2015-04-02 2016-03-31 用胰高血糖素受体拮抗性抗体治疗肥胖症和非酒精性脂肪肝病或非酒精性脂肪性肝炎的方法 Active CN107614695B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562142257P 2015-04-02 2015-04-02
US62/142,257 2015-04-02
PCT/US2016/025336 WO2016161154A1 (en) 2015-04-02 2016-03-31 Methods for treating obesity and nonalcoholic fatty liver disease or nonalcoholic steatohepatitis using glucagon receptor antagonistic antibodies

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CN107614695A CN107614695A (zh) 2018-01-19
CN107614695B true CN107614695B (zh) 2022-01-25

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EP (1) EP3277830A4 (enExample)
JP (1) JP6861641B2 (enExample)
KR (1) KR20170138456A (enExample)
CN (1) CN107614695B (enExample)
AU (1) AU2016242935B2 (enExample)
CA (1) CA2980765A1 (enExample)
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EP3565559A4 (en) * 2017-01-09 2020-07-08 Temple University - Of The Commonwealth System of Higher Education PHARMACEUTICAL METHODS AND COMPOSITIONS FOR THE TREATMENT OF NON-ALCOHOLIC STEATOHEPATITIS
SG11201906682YA (en) 2017-01-27 2019-08-27 Ngm Biopharmaceuticals Inc Glucagon receptor binding proteins and methods of use thereof
KR102686854B1 (ko) * 2017-08-09 2024-07-18 사노피 지방간 질환 및 지방간염의 치료에서의 glp-1/글루카곤 수용체 작용제
JP2021514662A (ja) * 2018-03-08 2021-06-17 フェインズ セラピューティクス，インコーポレーテッド 抗ｔｉｐ−１抗体及びその使用
CN110357959B (zh) * 2018-04-10 2023-02-28 鸿运华宁（杭州）生物医药有限公司 Gcgr抗体及其与glp-1的融合蛋白质，以及其药物组合物和应用
EP3829636A1 (en) 2018-07-27 2021-06-09 NGM Biopharmaceuticals, Inc. Use of glucagon receptor antagonists with immunotherapeutic agent
CN111068042B (zh) * 2018-10-18 2023-10-13 中山大学 一种多肽化合物在制备治疗非酒精性肝病、特发性肺间质纤维化和动脉硬化药物中的应用
WO2020097054A1 (en) * 2018-11-06 2020-05-14 Georgetown University Treating non-alcoholic steatohepatitis with cck inhibitors
CN115947849A (zh) 2018-12-21 2023-04-11 江苏恒瑞医药股份有限公司 双特异性蛋白
WO2025178928A1 (en) * 2024-02-23 2025-08-28 Remd Biotherapeutics, Inc. Combination therapy for the treatment of obesity

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CL2007002668A1 (es) * 2006-09-20 2008-05-09 Amgen Inc Proteina de union a antigeno que se une al receptor de glucagon humano; acido nucleico que la codifica; metodo de produccion; composicion farmaceutica que la comprende; y su uso para tratar o prevenir la diabetes tipo 2.
US8501686B2 (en) 2008-06-05 2013-08-06 University Of Michigan Method of treating fatty liver diseases and conditions in non-lipodystrophic subjects
PA8830501A1 (es) * 2008-06-17 2010-07-27 Univ Indiana Res & Tech Corp Co-agonistas del receptor de glucagon/glp-1
CN108410868A (zh) * 2011-09-20 2018-08-17 Ionis制药公司 Gcgr表达的反义调节
WO2014181229A2 (en) * 2013-05-07 2014-11-13 Rinat Neuroscience Corp. Anti-glucagon receptor antibodies and methods of use thereof
US10626179B2 (en) * 2014-06-08 2020-04-21 Remd Biotherapeutics, Inc. Methods for treating type 1 diabetes using glucagon receptor antagonistic antibodies

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GLP-1 receptor agonists: effects on the progression of non-alcoholic fatty liver disease;Jia Liu等;《DIABETES/METABOLISM RESEARCH AND REVIEWS》;20140914;第31卷(第4期);第329页右栏第1-2段 *

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Publication number Publication date
CN107614695A (zh) 2018-01-19
JP6861641B2 (ja) 2021-04-21
WO2016161154A1 (en) 2016-10-06
AU2016242935B2 (en) 2020-10-01
US20180079820A1 (en) 2018-03-22
MX392496B (es) 2025-03-24
US10752693B2 (en) 2020-08-25
EP3277830A1 (en) 2018-02-07
US20200339697A1 (en) 2020-10-29
AU2016242935A1 (en) 2017-11-09
EP3277830A4 (en) 2018-11-21
JP2018512417A (ja) 2018-05-17
KR20170138456A (ko) 2017-12-15
CA2980765A1 (en) 2016-10-06
MX2017012694A (es) 2018-03-07

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