CN107597221A - Drop formation device and drop formation system - Google Patents
Drop formation device and drop formation system Download PDFInfo
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- CN107597221A CN107597221A CN201710929020.0A CN201710929020A CN107597221A CN 107597221 A CN107597221 A CN 107597221A CN 201710929020 A CN201710929020 A CN 201710929020A CN 107597221 A CN107597221 A CN 107597221A
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Abstract
The invention discloses a kind of drop formation device, belong to the technical scheme in droplet generation field, including injection mechanism, dispersed phase liquid storage tank, continuous phase liquid storage tank and microchannel, the output end of the injection mechanism and the conducting of the dispersed phase liquid storage tank, one end of the microchannel turns on the dispersed phase liquid storage tank, the other end of the microchannel turns on the continuous phase liquid storage tank, and the width of the microchannel and the depth of the microchannel are different.The size of the microchannel is less than the size with the continuous phase liquid storage tank being connected, when dispersed phase enters mobile phase liquid storage tank from microchannel outlet so that fluid increases in microchannel with Laplce's pressure difference in microchannel exit, so as to form drop.By drop made of this device, only influenceed by the size of microchannel, the flow velocity of dispersed phase and continuous phase is to the size and stability influence very little of drop, so that the generation of drop is more stable, easy and quick reliable.
Description
Technical field
The present invention relates to the technical scheme in droplet generation field, more particularly to a kind of drop formation device and drop formation system
System.
Background technology
The method for preparing drop at present mainly has microfluidic control for method, spray-on process and capillary drop control method etc..
Wherein, microfluidic methods prepare drop using some specialized fluids flow mechanisms in MCA, its caused drop chi
The very little uniformity is high, and controllability is strong, has significant superiority compared with other method；Wherein, using microfluidic control for drop
Method mainly includes T-shaped passage method and fluid focus method, specific as follows：
1st, T-shaped passage method is the geometrical feature using two microchannel cross, and the forward position for making to treat dispersion fluid is in the friendship
At fork turn when, continuous phase shearing force promotion under caused by momentum change and generate drop；
2nd, flow focusing method is continuous phase fluid is come " extruding " dispersion fluid forward position from infall both sides, and utilizes liquid
" neck-shaped " structure of passage at the downstream of body forward position, shrink the dispersing liquid forward position and deform and unstability, so as to form drop.
Obviously, it is to be required for the flow velocity by adjusting mobile phase and dispersed phase the shortcomings that both approaches, liquid is formed with this
Drop, and the change of mobile phase and dispersed phase flow velocity can influence the size and stability of drop, it is therefore desirable to pass through two-way pressure
Control could realize the pressure balance of continuous phase and dispersed phase, can be only achieved the purpose of generation drop, and whole control process is complicated
Difficulty, substantially increase the manufacturing cost of drop.
The content of the invention
It is an object of the invention to provide a kind of drop formation device and drop formation system, to solve prior art to liquid
The problem of drop generation control is difficult.
A kind of drop formation device, including injection mechanism, dispersed phase liquid storage tank, continuous phase liquid storage tank and microchannel, it is described
The output end of injection mechanism turns on the inside of the dispersed phase liquid storage tank, one end of the microchannel and the dispersed phase liquid storage
The inside conducting in pond, the other end of the microchannel turn on the inside of the continuous phase liquid storage tank, the width of the microchannel
Different with the depth of the microchannel, the size of the microchannel is less than the chi with the continuous phase liquid storage tank being connected
It is very little.
Relevant drop formation device, ratio >=2 of the microchannel width and the microchannel depth, or the microchannel
Ratio≤0.5 of width and the microchannel depth.
Relevant drop formation device, the width of the microchannel is 5-200um, the microchannel height 5-200um.
Relevant drop formation device, the drop formation device also include transfering channel and drop collecting pit, the transfer
One end of passage turns on the inside of the continuous phase liquid storage tank, the other end of the transfering channel and the drop collecting pit
Inside conducting.
Relevant drop formation device, one end of the microchannel turn on the lower inside of the dispersed phase liquid storage tank, institute
The other end for stating microchannel turns on the lower inside of the continuous phase liquid storage tank；One end of the transfering channel with it is described continuous
The inner upper conducting of phase liquid storage tank, the other end of the transfering channel turn on the inner upper of the drop collecting pit.
Relevant drop formation device, the drop formation device also include gangway for transhipment and transfer pond, the gangway for transhipment
One end turned on the inside of the dispersed phase liquid storage tank, the conducting of the inside in transfer pond described in the other end of the gangway for transhipment；
The continuous phase liquid storage tank and the microchannel inside the transfer pond, the microchannel be it is a plurality of, it is a plurality of described micro-
Passage around the continuous phase liquid storage tank in circumferentially, the inside of one end of every microchannel with the transfer pond
Conducting, the inside of the other end of every microchannel with the continuous phase liquid storage tank turn on.
Relevant drop formation device, the dispersed phase liquid storage tank are provided with sealed interface, the sealed interface and the injection
The output end connection conducting of mechanism.
A kind of drop formation system, including at least two above-mentioned drop formation devices.
Relevant drop formation system, each drop formation device couples the injection mechanism described in one jointly, described
The output end connection of injection mechanism has injection assignment channel, and the output end of the injection assignment channel and the injection mechanism is led
Logical, the injection assignment channel is provided with multiple ports, and each port of the injection assignment channel is corresponding and one described scattered
The inside conducting of phase liquid storage tank.
Relevant drop formation system, the drop formation system also include total liquid storage tank, and total liquid storage tank connection has
Continuous phase assignment channel, the continuous phase assignment channel turn on the inside of total liquid storage tank, the continuous phase assignment channel
Provided with multiple ports, each port of the continuous phase assignment channel corresponds to the inside with a continuous phase liquid storage tank respectively
Conducting.
Beneficial effects of the present invention are as follows：
Because one end of the microchannel turns on the inside of the dispersed phase liquid storage tank, the other end of the microchannel with
The inside conducting of the continuous phase liquid storage tank, the width of the microchannel and the depth of the microchannel are different, micro- logical
The place that road outlet is connected with continuous phase liquid storage tank, because microchannel depth-to-width ratio is inconsistent, in exit, size becomes big suddenly
When, cause drop different in the laplace pressure of all directions, generate drop so as to which step emulsification occur, pass through this
The drop that mode generates, only influenceed by the size of microchannel, the influence of the flow velocity of dispersed phase and continuous phase to the size of drop compared with
It is small, so that the generation of drop more stability and quick reliable.
Brief description of the drawings
In order to illustrate more clearly of technical scheme, the required accompanying drawing used in embodiment will be made below
Simply introduce, it should be apparent that, drawings in the following description are only some embodiments of the present invention, general for this area
For logical technical staff, on the premise of not paying creative work, other accompanying drawings can also be obtained according to these accompanying drawings.
Fig. 1 is the structural representation one that drop formation device preferred embodiment of the present invention provides；
Fig. 2 is the structural representation two that drop process units preferred embodiment of the present invention provides；
Fig. 3 is the structural representation three that drop formation device preferred embodiment of the present invention provides；
Fig. 4 is the structural representation four that drop process units preferred embodiment of the present invention provides；
Fig. 5 is the structural representation one that drop formation system preferred embodiment of the present invention provides；
Fig. 6 is the partial structural diagram one that drop formation system preferred embodiment of the present invention provides；
Fig. 7 is the structural representation two that drop formation system preferred embodiment of the present invention provides；
Fig. 8 is the partial structural diagram two that drop formation system preferred embodiment of the present invention provides..
Reference is as follows：
1st, injection mechanism；2nd, dispersed phase liquid storage tank；3rd, continuous phase liquid storage tank；4th, microchannel；5th, transfering channel；6th, drop is received
Ji Chi；7th, gangway for transhipment；8th, transfer pond；9th, sealed interface；10th, assignment channel is injected；11st, total liquid storage tank；12nd, continuous phase partitioning
Passage.
Embodiment
Below in conjunction with the accompanying drawing in embodiment of the present invention, the technical scheme in embodiment of the present invention is carried out clear
Chu, it is fully described by.
It was found from Fig. 1 to 8, the drop formation device described in embodiment of the present invention, including the storage of injection mechanism 1, dispersed phase
Liquid pool 2, continuous phase liquid storage tank 3 and microchannel 4, the output end of the injection mechanism 1 and the inside of the dispersed phase liquid storage tank 2 are led
Logical, one end of the microchannel 4 turns on the inside of the dispersed phase liquid storage tank 2, the other end and the company of the microchannel 4
The inside conducting of continuous phase liquid storage tank 3, the width of the microchannel 4 and the depth of the microchannel 4 are different, the microchannel
4 size is less than the size with the continuous phase liquid storage tank 3 being connected.
Because one end of the microchannel 4 turns on the inside of the dispersed phase liquid storage tank 2, the microchannel 4 it is another
End turns on the inside of the continuous phase liquid storage tank 3, and the width of the microchannel 4 and the depth of the microchannel 4 are different,
The place being connected with continuous phase liquid storage tank 3 is exported in microchannel 4, the port of microchannel 4 is smaller, the inside of continuous phase liquid storage tank 3
Space is larger, so microchannel 4 will cause the outlet of microchannel 4 to become big suddenly with continuous phase liquid storage tank 3, due to microchannel 4
Depth-to-width ratio is inconsistent, when size becomes big suddenly in exit, causes drop different in the laplace pressure of all directions,
Drop is generated so as to which step emulsification occur, the drop generated by this mode is only influenceed by the size of microchannel 4, is disperseed
Mutually and continuous phase influence of the flow velocity to the size of drop it is smaller so that the generation of drop more stability and fast may be used
Lean on.
The present invention relates to the high flux droplet generation technique based on micro-fluidic chip.Microlayer model due to small volume, can avoid
The cross pollution of sample room, stable reaction conditions, while drop can flexibly be manipulated, realize droplets mixing, separation etc.
Advantage is thus a kind of very good microreactor.Microreactor has been used for studying numerous reaction under the conditions of minute yardstick
And its process, and expand out important application in chemistry and the field such as life science, as chemical synthesis, micro-extraction, crystallization of protein,
Enzymatic synthesis and its every field such as cell culture and analysis, drop PCR.
In fig 1 and 2, the distance in microchannel two sidelines about 4 is the height of microchannel 4, and microchannel 4 is perpendicular to paper
Direction is the direction of its thickness, so the breadth depth ratio about microchannel 4, the drop formation device described in embodiment of the present invention can
Improved as follows, the width of microchannel 4 and ratio >=2 of the depth of microchannel 4, or the width of the microchannel 4 and institute
Ratio≤0.5 of the depth of microchannel 4 is stated, on this basis, the width of the microchannel 4 can also be set as 5-200um, it is described
The height of microchannel 4 is 5-200um.
Now the breadth depth ratio of microchannel 4 is not consistent, so when exit size becomes big suddenly, causes drop to exist
The laplace pressure of all directions is different, and drop is generated so as to which step emulsification occur, the drop generated by this mode,
And when the breadth depth ratio of microchannel 4 is >=2 or≤0.5, it is generated, and the size of drop is more particularly suitable, stability is higher, and
Width in microchannel 4 is 5-200um, and when the height of microchannel 4 is 5-200um, the size and stability of drop will be more preferable.
As shown in Fig. 2 there is the collection of drop, the drop formation device described in embodiment of the present invention can be changed as follows
Enter, the drop formation device also includes transfering channel 5 and drop collecting pit 6, one end of the transfering channel 5 with it is described continuous
The inside conducting of phase liquid storage tank 3, the other end of the transfering channel 5 turn on the inside of the drop collecting pit 6.
In actual design process, because dispersed phase liquid storage tank 2, microchannel 4 and continuous phase liquid storage tank 3 want mutual conduction to match somebody with somebody
Close, therefore shape, the size of continuous phase liquid storage tank 3 can be construed as limiting, i.e., continuous phase liquid storage tank 3 there may not be sufficient space
Accommodate drop；And after setting up drop collecting pit 6, drop will transferred passage 5 be moved to drop collecting pit 6 and be collected, by
Do not limited in the shape size of drop collecting pit 6 by dispersed phase liquid storage tank 2, microchannel 4 and continuous phase liquid storage tank 3, so as to solve
The problem of drop collecting amount of having determined easily is limited.
As shown in Fig. 2 the conduction mode about dispersed phase liquid storage tank 2, continuous phase liquid storage tank 3 and drop collecting pit 6, this hair
Drop formation device described in bright embodiment can be improved as follows, one end of the microchannel 4 and the dispersed phase liquid storage
The lower inside conducting in pond 2, the other end of the microchannel 4 turn on the lower inside of the continuous phase liquid storage tank 3；Described turn
The one end in Mobile Communication road 5 turns on the inner upper of the continuous phase liquid storage tank 3, the other end and the liquid of the transfering channel 5
Drip the inner upper conducting of collecting pit 6.
First, when injection mechanism 1 is injected, the solution in dispersed phase liquid storage tank 2 moves down compression, due to microchannel
4 one end turns on the lower inside of dispersed phase liquid storage tank 2, so as to which the solution being more convenient in dispersed phase liquid storage tank 2 is transferred to company
Continuous phase liquid storage tank 3.
Secondly as the density of drop is less than the density of solution in continuous phase liquid storage tank 3, so drop will be in continuous phase
Floated in liquid storage tank 3, and one end of transfering channel 5 turns on the inner upper of continuous phase liquid storage tank 3, so as to the company of being more convenient for
Droplet transfer in continuous phase liquid storage tank 3 is to drop collecting pit 6.
Furthermore because the density of drop is less than the density of solution in drop collecting pit 6, so drop will be collected in drop
Floated in pond 6, and the other end of transfering channel 5 turns on the inner upper of drop collecting pit 6, it will so that droplet transfer
To drop collecting pit 6, the floating-upward process for removing drop on the liquid level in drop collecting pit 6 from is placed directly within, drop of being more convenient for
Obtain and utilize.
Further, in order that droplet transfer it is more smooth to the process of drop collecting pit 6, can control continuous phase receive
Collect the liquid level in pond higher than the liquid level in drop collecting pit 6, and cause transfer to turn on inclined arrangement, be i.e. transfer is logical
The port of the top of road 5 turns on the inner upper of continuous phase collecting pit, the port that transfering channel 5 issues and drop collecting pit 6
Inner upper turns on, so that drop can be moved to drop collecting pit 6 naturally under the driving of gravity, convenience simple in construction,
More save the cost for setting associated mechanisms to control drop to be moved to drop collecting pit 6.
It is also pointed out that, when the density of drop is less than the density of continuous phase solution, drop can be floated, so should in addition
It can be easy to droplet transfer to drop collecting pit 6 with above-mentioned embodiment；But the density of drop can also be higher than continuously mix
The density of liquid, now drop will sink down into the bottom of continuous phase liquid storage tank 3, so can be as shown in figure 3, one end by microchannel 4
Turned on the lower inside of dispersed phase liquid storage tank 2, the other end of microchannel 4 turns on the inner upper of continuous phase liquid storage tank 3, i.e.,
So that the liquid level in continuous phase liquid storage tank 3 should be less than the liquid level in dispersed phase liquid storage tank 2, in order to which drop is in continuous phase liquid storage tank
After generating in 3, the bottom of continuous phase liquid storage tank 3 can be sunk down into, certainly, also can as shown in figure 4, by one end of transfering channel 5 with
The lower inside conducting of continuous phase liquid storage tank 3, the other end of transfering channel 5 turn on the inner upper of drop collecting pit 6, even if
Liquid level in continuous phase liquid storage tank 3 should be higher than that liquid level in drop collecting pit 6, be easy to drop to be transferred quickly to drop collecting pit
6。
As shown in fig. 6, the conduction mode about dispersed phase liquid storage tank 2, continuous phase liquid storage tank 3 and microchannel 4, the present invention is real
Applying the drop formation device described in mode can be improved as follows, and the drop formation device also includes gangway for transhipment 7 and transfer
Pond 8, one end of the gangway for transhipment 7 turn on the inside of the dispersed phase liquid storage tank 2, the other end institute of the gangway for transhipment 7
State the inside conducting in transfer pond 8；The continuous phase liquid storage tank 3 and the microchannel 4 are described inside the transfer pond 8
Microchannel 4 is a plurality of, and a plurality of microchannel 4 is in circumferentially every microchannel around the continuous phase liquid storage tank 3
Inside of 4 one end with the transfer pond 8 turns on, the other end of every microchannel 4 with the continuous phase liquid storage tank 3
Inside conducting.
In the generating process of drop, the solution in dispersed phase liquid storage tank 2 will be first transferred in transfer pond 8, to be injected
After mechanism 1 starts injection, the solution in transfer pond 8 will be entered in continuous phase liquid storage tank 3 by a plurality of microchannel 4 simultaneously, i.e.,
A plurality of microchannel 4 can generate drop simultaneously, substantially increase the formation efficiency of drop.
As illustrated in fig. 1 and 2, the encapsulation process about drop formation device, the drop formation described in embodiment of the present invention
Device can be improved as follows, and the dispersed phase liquid storage tank 2 is provided with sealed interface 9, the sealed interface 9 and the injection mechanism
1 output end connection conducting.
Sealing structure can realize the sealed attachment between injection mechanism 1 and dispersed phase liquid storage tank 2, so in injection mechanism
During 1 is injected, either solution or air pressure will not leak, so as to ensure that injection mechanism 1 can smoothly will be molten
Liquid is sent into microchannel 4, and the generation of drop is carried out with this.
In summary, after above-mentioned improvement is combined, a kind of embodiment of drop formation device can be drawn, including
Have injection mechanism 1, sealed interface 9, dispersed phase liquid storage tank 2, gangway for transhipment 7, transfer pond 8, continuous phase liquid storage tank 3, microchannel 4,
Transfering channel 5 and drop collecting pit 6, wherein：
Injection mechanism 1, the output end of injection mechanism 1 couple conducting with sealed interface 9；
Sealed interface 9, sealed interface 9 are located at the top of dispersed phase liquid storage tank 2, and sealed interface 9 is to dispersed phase liquid storage tank 2
Sealing closing is realized, and the output end of injection mechanism 1 is turned on the inside of dispersed phase liquid storage tank 2；
Dispersed phase liquid storage tank 2, the inside of dispersed phase liquid storage tank 2 is an accommodating chamber, for accommodating dispersed phase solution；
Gangway for transhipment 7, gangway for transhipment 7 have two ports, a port and the dispersed phase liquid storage tank 2 of gangway for transhipment 7
Inner lower turns on, and another port of gangway for transhipment 7 turns on the bottom in transfer pond 8；
Continuous phase liquid storage tank 3, continuous phase liquid storage tank 3 are located at the middle part in transfer pond 8, and the inside of continuous phase liquid storage tank 3 is one
Accommodating chamber, for accommodating continuous phase solution；
Microchannel 4, microchannel 4 are a plurality of, and a plurality of microchannel 4 is in transfer pond 8, and a plurality of microchannel 4 is around continuous
For phase liquid storage tank 3 in circumferentially, every microchannel 4 is equipped with two ports, a port of every microchannel 4 with transfer pond
8 inside turn on, and the lower inside of another port of every microchannel 4 with continuous phase liquid storage tank 3 turns on；
Transfering channel 5, transfering channel 5 have two ports, and two ports of transfering channel 5 are placed in different height positions
Put, i.e. the state of 5 inclined arrangement of transfering channel, transfering channel 5 is placed on the port of top and the inside of continuous phase liquid storage tank 3
Side's conducting, another port placed below of transfering channel 5 turns on the inner upper of drop collecting pit 6；
Drop collecting pit 6, the inside of drop collecting pit 6 has an accommodating chamber, for accommodating the drop of generation.
Its course of work approximately as：
1st, dispersed phase solution is loaded in injection mechanism 1, the dispersed phase solution can be deionized water, and with 4ul/min
Speed injected；
2nd, dispersed phase solution is in the presence of injection mechanism 1, successively by dispersed phase liquid storage tank 2, gangway for transhipment 7, transfer
Pond 8 and microchannel 4, subsequently into in continuous phase liquid storage tank 3；
3rd, there is continuous phase solution in continuous phase liquid storage tank 3, the continuous phase solution can be fluorinated oil, and in fluorinated oil
The surfactant of 2% mass fraction is added, so when dispersed phase solution enters to the moment of continuous phase liquid storage tank 3, Bian Kesheng
Into drop；
4th, the drop of generation floats up to the top of continuous phase solution, and then transferred passage 5 is transferred to drop collecting pit 6
It is interior, so as to complete whole drop formation, collection process.
It is also pointed out that injection mechanism 1 can also be provided purely for infusion pressure, deionized water is for example loaded into dispersed phase in advance
In liquid storage tank 2, now injection mechanism 1 need to inject pressure, and the deionized water in dispersed phase liquid storage tank 2 will be pressed into microchannel 4
It is interior, so as to realize follow-up drop formation process.
It may be noted that injection mechanism 1 is either transfused dispersed phase solution or pressure, it is due to the microchannel 4
Size is less than the size with the continuous phase liquid storage tank 3 being connected, so when dispersed phase enters mobile phase from microchannel outlet,
The size of microchannel and the size difference of continuous phase liquid storage tank are big, so that fluid goes out in microchannel 4 with microchannel 4
Laplce's pressure difference increase at mouthful, so as to cause liquid to be cut off, forms drop.
It was found from Fig. 5 to 8, the drop formation system described in embodiment of the present invention, including at least two above-mentioned drops
Generating means.
I.e. liquid generating system can be equipped with multiple drop formation devices, in application process, multiple drop formations simultaneously
Device can generate same kind of drop simultaneously, each drop formation device can also be responsible for generating different drops, not only
The effect of drop formation is improved, more make it that generation is achieved while different drops.
Wherein, the quantity of drop formation device is preferably 8-96, within this range, can ensure drop formation unit
Flux, this design structure and size can enter with existing 8 union or 96 orifice plates it is accommodating dock, to ensure micro-fluidic core
Piece and the high flux requirement of the matching and drop formation system of existing consumptive material.
And as it can be seen in figures 5 and 6, the drop of generation can be transferred to drop collecting pit 6 and be collected, can also be such as Fig. 7 and 8
Shown, the drop of generation is directly stored in continuous phase liquid storage tank 3.
As it can be seen in figures 5 and 6, the injection system about drop formation system, the drop formation described in embodiment of the present invention
System can be improved as follows, and each drop formation device couples the injection mechanism 1 described in one, the injector jointly
The output end connection of structure 1 has injection assignment channel 10, and the output end of the injection assignment channel 10 and the injection mechanism 1 is led
Logical, the injection assignment channel 10 is provided with multiple ports, and each port of the injection assignment channel 10 is corresponding and described in one
The inside conducting of dispersed phase liquid storage tank 2.
An injection mechanism 1 is now only needed to be injected, injected material can be transferred to each point through injecting assignment channel 10
In dephasing liquid storage tank 2, avoid repeating to set multiple injection mechanisms 1 and increase cost, also simplify the structure of drop formation system,
Substantially increase the structural compactness of drop formation system.
As it can be seen in figures 5 and 6, the solution distribution about continuous phase liquid storage tank 3, the drop formation described in embodiment of the present invention
System can be improved as follows, and the drop formation system also includes total liquid storage tank 11, and total connection of liquid storage tank 11 has company
Continuous phase partitioning passage 12, the continuous phase assignment channel 12 turn on the inside of total liquid storage tank 11, the continuous phase partitioning
Passage 12 is provided with multiple ports, and each port of the continuous phase assignment channel 12 corresponds to and a continuous phase liquid storage respectively
The inside conducting in pond 3.
When in use, continuous phase solution can be positioned in total liquid storage tank 11, continuous phase solution can pass through continuous phase point
It is transferred to passage 12 in each continuous phase liquid storage tank 3, increases cost so as to avoid setting multiple solution adding sets, it is also simple
Change the structure of drop formation system, substantially increase the structural compactness of drop formation system.
In summary, after above-mentioned improvement is combined, a kind of embodiment of drop formation system can be drawn, including
Have：
Drop formation device, eight drop formation devices are arranged side by side；
Injection mechanism 1, injection mechanism 1 are one, and the connection of injection mechanism 1 has injection assignment channel 10, injects assignment channel
10 collect port and eight distribution ports provided with one, inject the output end for collecting port and injection mechanism 1 of assignment channel 10
Conducting, inject dispersed phase liquid storage tank 2 of the eight distribution ports of assignment channel 10 respectively with eight drop formation devices and turn on；
Total liquid storage tank 11, total liquid storage tank 11 are one, and total connection of liquid storage tank 11 has continuous phase assignment channel 12, continuous phase point
Collect port and eight distribution ports provided with one with passage 12, continuous phase assignment channel 12 collects port and total liquid storage tank 11
Inside conducting, eight of the continuous phase assignment channel 12 distribution ports continuous phase liquid storage tank with eight drop formation devices respectively
3 conductings.
Its course of work approximately as：
1st, there is continuous phase solution in total liquid storage tank 11, the continuous phase solution can be fluorinated oil, and in fluorinated oil
The surfactant of 2% mass fraction is added, then continuous phase solution will be transferred to eight liquid by continuous phase assignment channel 12
In the continuous phase liquid storage tank 3 for dripping generating means；
2nd, dispersed phase solution is loaded in injection mechanism 1, the dispersed phase solution can be deionized water, and with 4ul/min
Speed injected, now dispersed phase solution will be transferred to the scattered of eight drop formation devices by injecting assignment channel 10
In phase liquid storage tank 2；
3rd, eight drop formation devices independently carry out drop formation and collection, complete whole drop formation with this, collect
Journey.
Described above is the preferred embodiment of the present invention, it is noted that for those skilled in the art
For, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications are also considered as
Protection scope of the present invention.
Claims (10)
1. a kind of drop formation device, it is characterised in that including injection mechanism, dispersed phase liquid storage tank, continuous phase liquid storage tank and micro-
Passage, the output end of the injection mechanism turn on the inside of the dispersed phase liquid storage tank, one end of the microchannel with it is described
The inside conducting of dispersed phase liquid storage tank, the other end of the microchannel turns on the inside of the continuous phase liquid storage tank, described micro-
The width of passage and the depth of the microchannel are different, and the size of the microchannel is less than and the continuous phase being connected
The size of liquid storage tank.
2. drop formation device according to claim 1, it is characterised in that the microchannel width is deep with the microchannel
Ratio >=2 of degree, or ratio≤0.5 of the microchannel width and the microchannel depth.
3. drop formation device according to claim 2, it is characterised in that the width of the microchannel is 5-200um, institute
State the height 5-200um of microchannel.
4. drop formation device according to claim 1, it is characterised in that it is logical that the drop formation device also includes transfer
Road and drop collecting pit, one end of the transfering channel turn on the inside of the continuous phase liquid storage tank, the transfering channel
The other end turns on the inside of the drop collecting pit.
5. drop formation device according to claim 4, it is characterised in that
One end of the microchannel turns on the lower inside of the dispersed phase liquid storage tank, the other end of the microchannel with it is described
The lower inside conducting of continuous phase liquid storage tank；
One end of the transfering channel turns on the inner upper of the continuous phase liquid storage tank, the other end of the transfering channel with
The inner upper conducting of the drop collecting pit.
6. drop formation device according to claim 1, it is characterised in that
The drop formation device also includes gangway for transhipment and transfer pond, one end of the gangway for transhipment and the dispersed phase liquid storage
The inside conducting in pond, the inside conducting in transfer pond described in the other end of the gangway for transhipment；
Inside the transfer pond, the microchannel is a plurality of, a plurality of institute for the continuous phase liquid storage tank and the microchannel
Microchannel is stated around the continuous phase liquid storage tank in circumferentially, one end of every microchannel with the transfer pond
Inside conducting, the inside of the other end of every microchannel with the continuous phase liquid storage tank turn on.
7. drop formation device according to claim 1, it is characterised in that the dispersed phase liquid storage tank connects provided with sealing
Mouthful, the sealed interface couples conducting with the output end of the injection mechanism.
8. a kind of drop formation system, it is characterised in that including the drop life described at least two any one of claim 1 to 7
Into device.
9. drop formation system according to claim 8, it is characterised in that each drop formation device couples jointly
Injection mechanism described in one, the output end connection of the injection mechanism have an injection assignment channel, the injection assignment channel with
The output end conducting of the injection mechanism, the injection assignment channel is provided with multiple ports, described to inject each of assignment channel
Port is corresponding to be turned on the inside of a dispersed phase liquid storage tank.
10. drop formation system according to claim 8, it is characterised in that the drop formation system also includes always
Liquid storage tank, total liquid storage tank, which couples, continuous phase assignment channel, and the continuous phase assignment channel is interior with total liquid storage tank
Portion turns on, and the continuous phase assignment channel is provided with multiple ports, each port of the continuous phase assignment channel correspond to respectively and
The inside conducting of one continuous phase liquid storage tank.
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| CN201710929020.0A CN107597221A (en) | 2017-09-30 | 2017-09-30 | Drop formation device and drop formation system |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110075934A (en) * | 2019-03-25 | 2019-08-02 | 绍兴钠钇光电有限公司 | A kind of method that 3D printing micro-fluidic device and its big flux prepare monodisperse emulsion |
| CN110743635A (en) * | 2019-10-27 | 2020-02-04 | 苏州济研生物医药科技有限公司 | Liquid drop generating device based on negative pressure and without fluid shearing force |
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