CN107596269A - A kind of Chinese medicine composition for treating cervical spondylopathy and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating cervical spondylopathy and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine composition for treating cervical spondylopathy and preparation method thereof, belong to technical field of traditional Chinese medicines.A kind of Chinese medicine composition for treating cervical spondylopathy, is made up of following raw materials：42 60 parts of Borago officinalis Borage, 23 30 parts of Dicentra spectabilis, 18 25 parts of China rose, 18 25 parts of balsamine, 23 40 parts of bauhinia, 42 60 parts of uncaria tomentosa.A kind of Chinese medicine composition for treating cervical spondylopathy of the present invention, extraction process is used to part material, fully improve the rate of transform of active ingredient, eliminate invalid components and impurity, add activity, so as to which pharmacological action is obviously improved, and the partial raw material dregs of a decoction extract again, the sufficient utilization played to medicinal material, it can be mitigated for symptom in terms of cervical spondylopathy, especially nerve root cervical vertebra sickness, sympathetic type of cervical spon dylosis etc. have the effect of good, sufficiently lower the incidence of disease, and have no side effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for treating cervical spondylopathy and preparation method thereof, belong to technical field of traditional Chinese medicines.
Background technology
With the innovation of the change of people's habits and customs, especially science and technology, increasing people are allowed to indulge in hand
In the sci-tech products such as mechanical, electrical brain, this reduces motion, so as to generate the problem that growing thickly for disease, especially cervical spondylopathy.Neck
Vertebra disease refers to that degeneration of cervical intervertebral disc, cervical vertebra plumpness hyperplasia and neck injury etc. cause cervical vertebrae hyperosteogeny, or interverbebral disc
Abjection, ligament thicken, stimulate or oppress cervical spinal, cervical neural, blood vessel and produce the clinical syndrome of a series of symptoms.Mainly
Show as neck and shoulder ache, dizziness headache, upper limb numbness, muscular atrophy, severe patient's double lower limb spasm, difficulty in walking, or even four limbs fiber crops
Numbness, stool and urine obstacle, paralyses.
The primary treatment regimen for cervical spondylopathy is that operation or basic pharmaceutical are treated at present, danger of the operative treatment for body
Evil property is self-evident, and dangerous very big, it is easy to sequelae is produced, and drug therapy is also with analgesia in terms of Western medicine
Medicine based on anti-inflammatory, most of medicines that also simply analgesia is invigorated blood circulation in terms of Chinese medicine, it is all temporary transient alleviation cervical spondylopathy
The slight illness brought, and good improvement can not be obtained, and there is certain side effect.
The content of the invention
It is an object of the invention to solve weak point existing for above-mentioned prior art, there is provided a kind of not only to delay rapidly
Solve symptom, and effect persistently, the Chinese medicine composition for the treatment of cervical spondylopathy that has no side effect and preparation method thereof.
The present invention is achieved by the following technical solutions：
A kind of Chinese medicine composition for treating cervical spondylopathy, it is characterized in that is made up of following raw materials：Ripple
The more leaf 42-60 parts of that, Dicentra spectabilis 23-30 parts, China rose 18-25 parts, balsamine 18-25 parts, bauhinia 23-40 parts, suede
Uncaria hirsuta 42-60 parts, cherokee rose root 16-32 parts, safflower 15-30 parts, dalbergia wood 12-25 parts, agalloch eaglewood 13-20 parts, frankincense 12-35 parts,
Wide muscle rattan 16-20 parts, root of bidentate achyranthes 18-25 parts, bush 13-23 parts, pyrrosia lingua 8-14 parts, garden burnet 10-17 parts, turpentine 15-30 parts, rhizoma Gastrodiae
8-19 parts, cassia twig 5-9 parts, withy 4-8 parts, Kadsura Root-bark 2-4 parts, Ramulus Taxilli 3-8 parts, Ligusticum wallichii 2-5 parts, root tuber of aromatic turmeric 4-8 parts, red sage root 5-
9 parts, fructus choerospondiatis 6-12 parts, dipsacus root 8-11 parts, wild aconite root 10-20 parts, aconiti preparata,radix 10-20 parts, stir-baked MYRRHA 11-22 parts；
Preferably, Borago officinalis Borage, Dicentra spectabilis, Flos Rosae Laevigatae, China rose, balsamine, bauhinia are the original after natural air drying
Expect component；
A kind of Chinese medicine composition for treating cervical spondylopathy, is made up of the raw material of following optimal proportion by weight：Boldo tree
55 parts of leaf, 28 parts of Dicentra spectabilis, 21 parts of China rose, 21 parts of balsamine, 36 parts of bauhinia, 52 parts of uncaria tomentosa, 20 parts of cherokee rose root,
22 parts of safflower, 19 parts of dalbergia wood, 17 parts of agalloch eaglewood, 23 parts of frankincense, 18 parts of wide muscle rattan, 21 parts of the root of bidentate achyranthes, 17 parts of bush, 11 parts of pyrrosia lingua,
14 parts of elm, 22 parts of turpentine, 10 parts of rhizoma Gastrodiae, 7 parts of cassia twig, 6 parts of withy, 3 parts of Kadsura Root-bark, 5 parts of Ramulus Taxilli, 3 parts of Ligusticum wallichii, 6 parts of root tuber of aromatic turmeric,
7 parts of the red sage root, 8 parts of fructus choerospondiatis, 9 parts of dipsacus root, 15 parts of wild aconite root, 15 parts of aconiti preparata,radix, 16 parts of stir-baked MYRRHA；
A kind of preparation method for the Chinese medicine composition for treating cervical spondylopathy, it, which is characterized in that, comprises the following steps：
（1）Prepare extract：
Boldo tree leaf extract：Raw material is weighed, with distilled water refluxing extraction 2-3 times, 7-15 times of distilled water is added every time and boils
1-3 hours, filtering, merging filtrate, concentration；
Dicentra spectabilis extract：Raw material is weighed, with distilled water refluxing extraction 2-3 times, 7-15 times of distilled water is added every time and boils 1-3
Hour, filtering, merging filtrate, concentration；
Fols Rosae extract：Raw material is weighed, with distilled water refluxing extraction 2-3 times, adding 7-15 times of distilled water every time, to boil 1-3 small
When, filtering, merging filtrate, concentration；
Extracts from Flowers of Impatiens balsamina L：Raw material is weighed, is extracted 2-3 times with 50-90% alcohol refluxs, 5-14 times of ethanol is added every time and decocts 1-3
Hour, filtering, merging filtrate, concentration；
Cercis flower extract：Raw material is weighed, with distilled water refluxing extraction 2-3 times, adding 7-15 times of distilled water every time, to boil 1-3 small
When, filtering, merging filtrate, concentration；
Uncaria tomentosa extract：Raw material is weighed, with distilled water refluxing extraction 2-3 times, 7-15 times of distilled water is added every time and boils 1-3
Hour, filtering, merging filtrate, concentration；
Cherokee rose root extract：Raw material is weighed, is boiled 2-3 times with decocting, 5-15 times of water is added every time, decocts 1-3 hours, filtering,
Merging filtrate, concentration；
Safflower extract：Raw material is weighed, with distilled water refluxing extraction 2-3 times, adding 7-15 times of distilled water every time, to boil 1-3 small
When, filtering, merging filtrate, concentration；
Lignum Dalbergiae Odoriferae extract：Raw material is weighed, is extracted 2-3 times with 50-90% alcohol refluxs, it is small to add 5-14 times of ethanol decoction 1-3 every time
When, filtering, merging filtrate, concentration；
Lignum Aquilariae Resinatum extract：Raw material is weighed, is extracted 2-3 times with 50-90% alcohol refluxs, it is small to add 5-14 times of ethanol decoction 1-3 every time
When, filtering, merging filtrate, concentration；
Olibanum extract：Raw material is weighed, is extracted 2-3 times with 50-90% alcohol refluxs, it is small to add 5-14 times of ethanol decoction 1-3 every time
When, filtering, merging filtrate, concentration；
Herba Lycopodii extract：Raw material is weighed, is boiled 2-3 times with decocting, 5-15 times of water is added every time, decocts 1-3 hours, filtering,
Merging filtrate, concentration；
Achyranthes bidentata extract：Raw material is weighed, is boiled 2-3 times with decocting, 5-15 times of water is added every time, decocts 1-3 hours, filtering, close
And filtrate, concentration；
Logwood extract：Raw material is weighed, is boiled 2-3 times with decocting, 5-15 times of water is added every time, decocts 1-3 hours, filtering, close
And filtrate, concentration；
Folium Pyrrosiae extract：Raw material is weighed, is extracted 2-3 times with 50-90% alcohol refluxs, it is small to add 5-14 times of ethanol decoction 1-3 every time
When, filtering, merging filtrate, concentration；
Radix Sangusorbae extract：Raw material is weighed, is boiled 2-3 times with decocting, 5-15 times of water is added every time, decocts 1-3 hours, filtering, close
And filtrate, concentration；
Lignum Pini Nodi extrat：Raw material is weighed, is boiled 2-3 times with decocting, 5-15 times of water is added every time, decocts 1-3 hours, filtering, close
And filtrate, concentration；
Rhizoma Gastrodiae extract：Raw material is weighed, is extracted 2-3 times with 50-90% alcohol refluxs, it is small to add 5-14 times of ethanol decoction 1-3 every time
When, filtering, merging filtrate, concentration；
（2）Cassia twig, withy, Kadsura Root-bark, Ramulus Taxilli, Ligusticum wallichii are added water to cook 2-3 times, each 1-3 hours, collecting decoction, filtered,
The dregs of a decoction are separately deposited standby；Filtrate concentrates, and adding 50-90% ethanol makes in solution containing amount of alcohol to be 50-95%, and standing makes precipitation, takes
Supernatant reclaims ethanol, is concentrated into paste；
（3）By cassia twig, withy, Kadsura Root-bark, Ramulus Taxilli, Ligusticum wallichii in step（2）The dregs of a decoction after decoction add 5-14 times and measure 50-
90% ethanol is extracted 2-3 times, each 1-3 hours, filtering, merging filtrate, and recovery ethanol is measured to without alcohol taste with 5-10 times
80-90 DEG C of hot water fully dissolves, and filters while hot, and filtrate is concentrated into paste；
（4）Root tuber of aromatic turmeric, the red sage root, fructus choerospondiatis, dipsacus root are added to 3-10 times of 50-90 ethanol, soaked 2-3 times at 40-50 DEG C, each 8-
20 hours, filtering, merging filtrate, recovery ethanol were condensed into thick paste to without alcohol taste；
（5）By wild aconite root, aconiti preparata,radix, stir-baked MYRRHA mixed grinding into fine powder, 80-120 mesh sieve is crossed；
（6）By step（1）All extracts prepared and step（2）、（3）、（4）Gained thick paste mixes, and adds step
（5）Fine powder, mix, dry, sieving, medicament is made.
Preferably, capsule is such as made, loads medicament, granulation, you can.Formulation is made and is not limited to capsule, can also be tablet,
The conventional pharmaceutical dosage form such as granule powder, oral liquid.
The effect of each traditional Chinese medicinal components：
Borago officinalis Borage：Rich in benzylisoquinoline alkaloid, the total amount of alkaloid is in 0.4%-0.5%, at least 17 kinds of differences
Alkaloid, wherein boldine is most important alkaloid, accounts for the 0.12%-0.14% of blade, accounts for the 12%-19% of total alkaloid,
Boldine has the effects such as anti-oxidant, antitumor, protection cell, anti-inflammatory, resisting atherosis, also containing tannin, volatile oil, Huang
Ketone compounds, these are all the key substances of boldo tree leaf extract antioxidation, can effectively play strengthening the bones and muscles,
It is antiviral to wait effect, beneficial to the recovery of cervical spondylopathy；
Dicentra spectabilis：With analgesia, spasmolysis, diuresis, menstruation regulating, dissipate blood and blood, except wind, disappear sore and other effects；
China rose：Volatile oil containing armaticity, predominantly terpene alcohol compound, separately containing nerol, Geraniol, no citronellol, food
The compositions such as sub- acid, there is stronger antifungic action, and primary efficacy is promoting blood circulation for regulating menstruation, soothing liver-qi stagnation；
Balsamine：With wind-dispelling, removing toxic substances, promoting blood circulation, detumescence, analgesic and other effects, but also there is certain inhibitory action to bacterium；
Bauhinia：With clearing heat and cooling blood, wind-dispelling removing toxic substances, invigorate blood circulation, swelling and pain relieving and other effects；
Uncaria tomentosa：Mainly contain alkaloids, quinoline sour glycoside, Polyphenols, quinoline sour fat etc., its extract has a variety of work
Property, such as anti-inflammatory, anti-oxidant, antitumor, immunological regulation, central nervous system regulation, anti-mutation, antibacterial；
Cherokee rose root：With restrain astringent or styptic treatment for spontaneous sweating, arresting bleeding and treating cutaneous pyogenic infection, dispel interior promoting blood circulation, analgesic, desinsection and other effects；
Safflower：Containing carthamin, carthamin yellow, there is broken stasis of blood, invigorate blood circulation, stimulate the menstrual flow and other effects；
Dalbergia wood：Containing volatile oil, mainly with the hemostasis of the row stasis of blood, swelling and pain relieving and other effects；
Agalloch eaglewood：Containing volatile oil and resin, sending down abnormally ascending, cold dispelling, it may be analgesia that it, which is acted on, calm；
Frankincense：Containing boswellic acid, mastic hydrocarbon, frankincense hypo acid, masticinic acid etc., another containing oil is played, promoting blood circulation and stopping pain relaxing muscles and tendons, it is acted on
May be analgesia and anti-inflammatory；
Wide muscle rattan：Relaxing tendons and activating collaterals, wind-expelling pain-stopping；
The root of bidentate achyranthes：Blood stasis removing analgesic, invigorate blood circulation, tonify the liver and kidney；
Bush：Haematoxylin containing pigment composition, volatile oil etc., there is hemostasis promoting circulation of blood dissolving stasis, remove obstruction in channels to relieve pain and other effects, also have certain
Suppression nervous centralis effect, play a part of analgesia analgesic；
Pyrrosia lingua：Containing saponin, Anthraquinones, flavonoids bracken triterpene, different mangiferin etc., there is diuresis, clearing away heat to stop bleeding, antibacterial, anti-current
Influenza Virus and other effects,
Garden burnet：Containing tannin（For catechu class）, sanguisorbin and retinoid material, there is clearing heat and cooling blood, stop blooding, have detumescence to stop
Bitterly, Thyme Extract；
Turpentine：Resinous, volatile oil, have and dispel pathogenic wind and remove dampness, promoting blood circulation and stopping pain and other effects；
Rhizoma Gastrodiae：Containing vanillyl alcohol, vanillic aldehyde, glucoside, mucilaginous substance and micro amount of oxygen give birth to plain A classes material, have wind-dispelling antispastic contraction, and it is acted on
Calmness, ease pain, be anticonvulsion；
Cassia twig：Containing volatile oil, wherein mainly containing cinnaldehydrum, cassia bark acetic acid esters etc. and without linalool, primary efficacy be supporing yang inducing diaphoresis,
Warming meridian, Wen Huashui are wet, also have the function that analgesia, antibacterial；
Withy：Containing salicin, there is the effect of expelling wind and removing dampness, removing toxicity for detumescence；
Kadsura Root-bark：Its is mild-natured, bitter, and enter liver, spleen two pass through, and has the effect of invigorate blood circulation, subdhing swelling and detoxicating, main for cervical spondylopathy
Play a part of anti-inflammatory and antalgic, resisting pathogenic microbes；
Ramulus Taxilli：Folic acid containing olive and chromocor compound, mistletoe glucoside, there is filling liver kidney, curing rheumatism, strengthening the bones and muscles, blood-nourishing peace
Tire and other effects, also there is the effect such as decompression, antiviral；
Ligusticum wallichii：Containing phenolic substances such as alkaloid, forulic acids, also have, chuanxingol, Diligustilide, ligustrazine, trimethylamine hydrochloride,
Choline hydrochloride etc., there is promoting blood circulation and stopping pain and other effects；
Root tuber of aromatic turmeric：Containing volatile oil, there is qi-regulating, dissipate the stasis of blood, analgesic and other effects；
The red sage root：The second of the first, tanshinone containing tanshinone, tanshinone third, Cryptotanshinone, and contain vitamin E, there is promoting blood circulation and removing obstruction in channels, cool blood
Subside a swelling, relieving restlessness clears away heart-fire and other effects；
Fructus choerospondiatis：With the promoting flow of qi and blood circulation, nourishing heart, the effect of calming the nerves；
Dipsacus root：There is the effect of antivitamin E shortages, there is enhancing promoting blood circulation arteries and veins, degrading the channel and other effects；
Wild aconite root：For the Preparation process product of radix aconiti agrestis, there is dispelling wind and eliminating dampness, antalgic；
Aconiti preparata,radix：For the Preparation process product of monkshood, there is dispelling wind and eliminating dampness, antalgic；
Stir-baked MYRRHA：A kind of concocting method of myrrh, there is the effect of dissipating blood stasis eliminatings, detumescence ding-tong.
A kind of Chinese medicine composition for treating cervical spondylopathy of the present invention, uses extraction process to part material, fully improves
The rate of transform of active ingredient, eliminates invalid components and impurity, adds activity, so as to which pharmacological action is obviously improved, and portion
The raw material dregs of a decoction divided extract again, the sufficient utilization played to medicinal material, can be mitigated for symptom in terms of cervical spondylopathy, especially
It is that nerve root cervical vertebra sickness, sympathetic type of cervical spon dylosis etc. have the effect of good, sufficiently lower the incidence of disease, and make without pair
With.
Embodiment
Embodiment of the invention given below, for being described in further detail to the composition of the present invention.
Embodiment 1
A kind of Chinese medicine composition for treating cervical spondylopathy of the present embodiment, is made up of following raw materials：Bordeaux
42 parts of leaf, 23 parts of Dicentra spectabilis, 18 parts of China rose, 18 parts of balsamine, 23 parts of bauhinia, 42 parts of uncaria tomentosa, cherokee rose root 16
Part, 15 parts of safflower, 12 parts of dalbergia wood, 13 parts of agalloch eaglewood, 12 parts of frankincense, 16 parts of wide muscle rattan, 18 parts of the root of bidentate achyranthes, 13 parts of bush, 8 parts of pyrrosia lingua,
10 parts of garden burnet, 15 parts of turpentine, 8 parts of rhizoma Gastrodiae, 5 parts of cassia twig, 4 parts of withy, 2 parts of Kadsura Root-bark, 3 parts of Ramulus Taxilli, 2 parts of Ligusticum wallichii, root tuber of aromatic turmeric 4
Part, 5 parts of the red sage root, 6 parts of fructus choerospondiatis, 8 parts of dipsacus root, 10 parts of wild aconite root, 10 parts of aconiti preparata,radix, 11 parts of stir-baked MYRRHA；
Preferably, Borago officinalis Borage, Dicentra spectabilis, Flos Rosae Laevigatae, China rose, balsamine, bauhinia are the original after natural air drying
Expect component.
Embodiment 2
A kind of Chinese medicine composition for treating cervical spondylopathy of the present embodiment, is made up of following raw materials：Bordeaux
60 parts of leaf, 30 parts of Dicentra spectabilis, 25 parts of China rose, 25 parts of balsamine, 40 parts of bauhinia, 60 parts of uncaria tomentosa, cherokee rose root 32
Part, 30 parts of safflower, 25 parts of dalbergia wood, 20 parts of agalloch eaglewood, 35 parts of frankincense, 20 parts of wide muscle rattan, 25 parts of the root of bidentate achyranthes, 23 parts of bush, 14 parts of pyrrosia lingua,
17 parts of garden burnet, 30 parts of turpentine, 19 parts of rhizoma Gastrodiae, 9 parts of cassia twig, 8 parts of withy, 4 parts of Kadsura Root-bark, 8 parts of Ramulus Taxilli, 5 parts of Ligusticum wallichii, root tuber of aromatic turmeric 8
Part, 9 parts of the red sage root, 12 parts of fructus choerospondiatis, 11 parts of dipsacus root, 20 parts of wild aconite root, 20 parts of aconiti preparata,radix, 22 parts of stir-baked MYRRHA.
Embodiment 3
A kind of Chinese medicine composition for treating cervical spondylopathy of the present embodiment, is made up of the raw material of following optimal proportion by weight：Ripple
You are more 55 parts of leaves, 28 parts of Dicentra spectabilis, 21 parts of China rose, 21 parts of balsamine, 36 parts of bauhinia, 52 parts of uncaria tomentosa, Jin Ying
20 parts of root, 22 parts of safflower, 19 parts of dalbergia wood, 17 parts of agalloch eaglewood, 23 parts of frankincense, 18 parts of wide muscle rattan, 21 parts of the root of bidentate achyranthes, 17 parts of bush, pyrrosia lingua
11 parts, 14 parts of garden burnet, 22 parts of turpentine, 10 parts of rhizoma Gastrodiae, 7 parts of cassia twig, 6 parts of withy, 3 parts of Kadsura Root-bark, 5 parts of Ramulus Taxilli, 3 parts of Ligusticum wallichii,
6 parts of root tuber of aromatic turmeric, 7 parts of the red sage root, 8 parts of fructus choerospondiatis, 9 parts of dipsacus root, 15 parts of wild aconite root, 15 parts of aconiti preparata,radix, 16 parts of stir-baked MYRRHA.
A kind of preparation method of Chinese medicine composition for treating cervical spondylopathy of above example, comprises the following steps：
（1）Prepare extract：
Boldo tree leaf extract：Raw material is weighed, with distilled water refluxing extraction 3 times, adding 10 times of distilled water every time, to boil 2 small
When, filtering, merging filtrate, concentration；
Dicentra spectabilis extract：Raw material is weighed, with distilled water refluxing extraction 3 times, 10 times of distilled water is added every time and boils 2 hours,
Filtering, merging filtrate, concentration；
Fols Rosae extract：Raw material is weighed, with distilled water refluxing extraction 3 times, 10 times of distilled water is added every time and boils 2 hours, mistake
Filter, merging filtrate, concentration；
Extracts from Flowers of Impatiens balsamina L：Raw material is weighed, is extracted 3 times with 50-90% alcohol refluxs, 8 times of ethanol is added every time and decocts 2 hours, mistake
Filter, merging filtrate, concentration；
Cercis flower extract：Raw material is weighed, with distilled water refluxing extraction 3 times, 10 times of distilled water is added every time and boils 2 hours, mistake
Filter, merging filtrate, concentration；
Uncaria tomentosa extract：Raw material is weighed, with distilled water refluxing extraction 3 times, 10 times of distilled water is added every time and boils 2 hours,
Filtering, merging filtrate, concentration；
Cherokee rose root extract：Raw material is weighed, is boiled 3 times with decocting, 10 times of water is added every time, decocts 2 hours, filtering, merge filter
Liquid, concentration；
Safflower extract：Raw material is weighed, with distilled water refluxing extraction 3 times, 10 times of distilled water is added every time and boils 2 hours, filtering,
Merging filtrate, concentration；
Lignum Dalbergiae Odoriferae extract：Raw material is weighed, is extracted 2 times with 75% alcohol reflux, 8 times of ethanol is added every time and decocts 2 hours, filtering, close
And filtrate, concentration；
Lignum Aquilariae Resinatum extract：Raw material is weighed, is extracted 2 times with 75% alcohol reflux, 8 times of ethanol is added every time and decocts 2 hours, filtering, close
And filtrate, concentration；
Olibanum extract：Raw material is weighed, is extracted 2 times with 75% alcohol reflux, 8 times of ethanol is added every time and decocts 2 hours, filtering, close
And filtrate, concentration；
Herba Lycopodii extract：Raw material is weighed, is boiled 3 times with decocting, 12 times of water is added every time, decocts 2 hours, filtering, merge filter
Liquid, concentration；
Achyranthes bidentata extract：Weigh raw material, boiled 3 times with decocting, add 12 times of water every time, decoct 2 hours, filtering, merging filtrate,
Concentration；
Logwood extract：Weigh raw material, boiled 3 times with decocting, add 12 times of water every time, decoct 2 hours, filtering, merging filtrate,
Concentration；
Folium Pyrrosiae extract：Raw material is weighed, is extracted 1 time with 75% alcohol reflux, 10 times of ethanol is added every time and decocts 2 hours, filtering,
Merging filtrate, concentration；
Radix Sangusorbae extract：Weigh raw material, boiled 3 times with decocting, add 12 times of water every time, decoct 2 hours, filtering, merging filtrate,
Concentration；
Lignum Pini Nodi extrat：Weigh raw material, boiled 3 times with decocting, add 12 times of water every time, decoct 2 hours, filtering, merging filtrate,
Concentration；
Rhizoma Gastrodiae extract：Raw material is weighed, is extracted 2 times with 75% alcohol reflux, 10 times of ethanol is added every time and decocts 2 hours, filtering,
Merging filtrate, concentration；
（2）Cassia twig, withy, Kadsura Root-bark, Ramulus Taxilli, Ligusticum wallichii are added water to cook 2 times, 2 hours every time, collecting decoction, filtered, the dregs of a decoction
Separately deposit standby；Filtrate concentrates, and adding 75% ethanol makes in solution containing amount of alcohol be 50-95%, and standing makes precipitation, takes supernatant time
Ethanol is received, is concentrated into paste；
（3）By cassia twig, withy, Kadsura Root-bark, Ramulus Taxilli, Ligusticum wallichii in step（2）The dregs of a decoction after decoction add 10 times of 75% ethanol of amount
Extraction 2 times, 2 hours every time, it is fully molten to measure 85 DEG C of hot water to without alcohol taste with 5-10 times for filtering, merging filtrate, recovery ethanol
Solution, is filtered, filtrate is concentrated into paste while hot；
（4）Root tuber of aromatic turmeric, the red sage root, fructus choerospondiatis, dipsacus root are added into 8 times of 75% ethanol, soaks 3 times at 4 DEG C, 12 hours every time, filter,
Merging filtrate, recovery ethanol are condensed into thick paste to without alcohol taste；
（5）By wild aconite root, aconiti preparata,radix, stir-baked MYRRHA mixed grinding into fine powder, 100 mesh sieve are crossed；
（6）By step（1）All extracts prepared and step（2）、（3）、（4）Gained thick paste mixes, and adds step
（5）Fine powder, mix, dry, sieving, medicament is made.
Preferably, capsule is such as made, loads medicament, granulation, you can.Formulation is made and is not limited to capsule, can also be tablet,
The conventional pharmaceutical dosage form such as granule powder, oral liquid.
A kind of Chinese medicine composition for treating cervical spondylopathy of above example, extraction process is used to part material, fully carried
The rate of transform of active ingredient has been risen, has eliminated invalid components and impurity, has added activity, so as to which pharmacological action is obviously improved, and
And the partial raw material dregs of a decoction extract again, the sufficient utilization played to medicinal material, can be mitigated for symptom in terms of cervical spondylopathy,
Especially nerve root cervical vertebra sickness, sympathetic type of cervical spon dylosis etc. have the effect of good, sufficiently lower the incidence of disease, Er Qiewu
Side effect.
Clinical observation：
Before inventor treats to 100 patients with cervical spondylopathy, and continuous medication contrast experiment after one month, respectively
In pain degree（Neck and head）, dizziness degree, numb limb degree, rotation neck experiment do scoring and compare：
Pain degree（Neck and head）Rank is divided into O degree：Not bitterly；I degree：Mild pain, it is intermittent pain；II degree：Moderate pain,
For Continuous Pain, influence to rest, anodyne need to be used；III degree：Severe pain, is Continuous Pain, and not medication is unable to pain of alleviation； Ⅳ
Degree：Serious pain is lasting severe pain with the change such as blood pressure, pulse.
Dizziness degree is divided into 0 degree：No, duration 0 second；I degree：Slightly, the duration 5-10 seconds；II degree：Slightly, hold
Continuous second time 10-30；III degree：Moderate, second duration 30-60；IV degree：Severe, more than 1 minute；
Numb limb degree rank is divided into O degree：No；I degree：It is slight numb, activity and resistance are not influenceed；II degree：Gently
Degree is numb, can be movable, can be to antigravity but without resistive drag force；III degree：Moderate is numb, can be movable, but without to antigravity and resistance；
IV degree：Severe is numb, can palpation or visual examination find contraction of muscle but without joint motions；
Revolve neck experiment：It is divided into 0 degree：It is negative to revolve neck experiment；I degree：It is positive to revolve neck experiment；II degree：Revolve neck experiment strong positive；
Result of the test shows that 92 patients each degree before and after medication substantially weakens, and each degree changes without big before and after 8 medications, with
Under provide the contrast of each degree of 6 typical cases：
Claims (4)
1. a kind of Chinese medicine composition for treating cervical spondylopathy, it is characterised in that be made up of following raw materials：Bohr
More leaf 42-60 parts, Dicentra spectabilis 23-30 parts, China rose 18-25 parts, balsamine 18-25 parts, bauhinia 23-40 parts, fine hair
Yncaria stem with hooks 42-60 parts, cherokee rose root 16-32 parts, safflower 15-30 parts, dalbergia wood 12-25 parts, agalloch eaglewood 13-20 parts, frankincense 12-35 parts, width
Muscle rattan 16-20 parts, root of bidentate achyranthes 18-25 parts, bush 13-23 parts, pyrrosia lingua 8-14 parts, garden burnet 10-17 parts, turpentine 15-30 parts, rhizoma Gastrodiae 8-
19 parts, cassia twig 5-9 parts, withy 4-8 parts, Kadsura Root-bark 2-4 parts, Ramulus Taxilli 3-8 parts, Ligusticum wallichii 2-5 parts, root tuber of aromatic turmeric 4-8 parts, red sage root 5-9
Part, fructus choerospondiatis 6-12 parts, dipsacus root 8-11 parts, wild aconite root 10-20 parts, aconiti preparata,radix 10-20 parts, stir-baked MYRRHA 11-22 parts.
2. a kind of Chinese medicine composition for treating cervical spondylopathy according to claim 1, it is characterised in that Borago officinalis Borage, pocket are male
Pellet, Flos Rosae Laevigatae, China rose, balsamine, bauhinia are the raw material component after natural air drying.
3. a kind of Chinese medicine composition for treating cervical spondylopathy according to claim 1, it is characterised in that matched somebody with somebody by weight by following
The raw material of ratio is made：55 parts of Borago officinalis Borage, 28 parts of Dicentra spectabilis, 21 parts of China rose, 21 parts of balsamine, 36 parts of bauhinia, suede
52 parts of uncaria hirsuta, 20 parts of cherokee rose root, 22 parts of safflower, 19 parts of dalbergia wood, 17 parts of agalloch eaglewood, 23 parts of frankincense, 18 parts of wide muscle rattan, the root of bidentate achyranthes 21
Part, 17 parts of bush, 11 parts of pyrrosia lingua, 14 parts of garden burnet, 22 parts of turpentine, 10 parts of rhizoma Gastrodiae, 7 parts of cassia twig, 6 parts of withy, 3 parts of Kadsura Root-bark, mulberry
Parasitic 5 parts, 3 parts of Ligusticum wallichii, 6 parts of root tuber of aromatic turmeric, 7 parts of the red sage root, 8 parts of fructus choerospondiatis, 9 parts of dipsacus root, 15 parts of wild aconite root, 15 parts of aconiti preparata,radix, stir-baked MYRRHA
16 part 10.
4. a kind of preparation method for the Chinese medicine composition for treating cervical spondylopathy described in claim 1-3, it is characterised in that including following
Step：
（1）Prepare extract：
Boldo tree leaf extract：Raw material is weighed, with distilled water refluxing extraction 2-3 times, 7-15 times of distilled water is added every time and boils
1-3 hours, filtering, merging filtrate, concentration；
Dicentra spectabilis extract：Raw material is weighed, with distilled water refluxing extraction 2-3 times, 7-15 times of distilled water is added every time and boils 1-3
Hour, filtering, merging filtrate, concentration；
Fols Rosae extract：Raw material is weighed, with distilled water refluxing extraction 2-3 times, adding 7-15 times of distilled water every time, to boil 1-3 small
When, filtering, merging filtrate, concentration；
Extracts from Flowers of Impatiens balsamina L：Raw material is weighed, is extracted 2-3 times with 50-90% alcohol refluxs, 5-14 times of ethanol is added every time and decocts 1-3
Hour, filtering, merging filtrate, concentration；
Cercis flower extract：Raw material is weighed, with distilled water refluxing extraction 2-3 times, adding 7-15 times of distilled water every time, to boil 1-3 small
When, filtering, merging filtrate, concentration；
Uncaria tomentosa extract：Raw material is weighed, with distilled water refluxing extraction 2-3 times, 7-15 times of distilled water is added every time and boils 1-3
Hour, filtering, merging filtrate, concentration；
Cherokee rose root extract：Raw material is weighed, is boiled 2-3 times with decocting, 5-15 times of water is added every time, decocts 1-3 hours, filtering,
Merging filtrate, concentration；
Safflower extract：Raw material is weighed, with distilled water refluxing extraction 2-3 times, adding 7-15 times of distilled water every time, to boil 1-3 small
When, filtering, merging filtrate, concentration；
Lignum Dalbergiae Odoriferae extract：Raw material is weighed, is extracted 2-3 times with 50-90% alcohol refluxs, it is small to add 5-14 times of ethanol decoction 1-3 every time
When, filtering, merging filtrate, concentration；
Lignum Aquilariae Resinatum extract：Raw material is weighed, is extracted 2-3 times with 50-90% alcohol refluxs, it is small to add 5-14 times of ethanol decoction 1-3 every time
When, filtering, merging filtrate, concentration；
Olibanum extract：Raw material is weighed, is extracted 2-3 times with 50-90% alcohol refluxs, it is small to add 5-14 times of ethanol decoction 1-3 every time
When, filtering, merging filtrate, concentration；
Herba Lycopodii extract：Raw material is weighed, is boiled 2-3 times with decocting, 5-15 times of water is added every time, decocts 1-3 hours, filtering,
Merging filtrate, concentration；
Achyranthes bidentata extract：Raw material is weighed, is boiled 2-3 times with decocting, 5-15 times of water is added every time, decocts 1-3 hours, filtering, close
And filtrate, concentration；
Logwood extract：Raw material is weighed, is boiled 2-3 times with decocting, 5-15 times of water is added every time, decocts 1-3 hours, filtering, close
And filtrate, concentration；
Folium Pyrrosiae extract：Raw material is weighed, is extracted 2-3 times with 50-90% alcohol refluxs, it is small to add 5-14 times of ethanol decoction 1-3 every time
When, filtering, merging filtrate, concentration；
Radix Sangusorbae extract：Raw material is weighed, is boiled 2-3 times with decocting, 5-15 times of water is added every time, decocts 1-3 hours, filtering, close
And filtrate, concentration；
Lignum Pini Nodi extrat：Raw material is weighed, is boiled 2-3 times with decocting, 5-15 times of water is added every time, decocts 1-3 hours, filtering, close
And filtrate, concentration；
Rhizoma Gastrodiae extract：Raw material is weighed, is extracted 2-3 times with 50-90% alcohol refluxs, it is small to add 5-14 times of ethanol decoction 1-3 every time
When, filtering, merging filtrate, concentration；
（2）Cassia twig, withy, Kadsura Root-bark, Ramulus Taxilli, Ligusticum wallichii are added water to cook 2-3 times, each 1-3 hours, collecting decoction, filtered,
The dregs of a decoction are separately deposited standby；Filtrate concentrates, and adding 50-90% ethanol makes in solution containing amount of alcohol to be 50-95%, and standing makes precipitation, takes
Supernatant reclaims ethanol, is concentrated into paste；
（3）By cassia twig, withy, Kadsura Root-bark, Ramulus Taxilli, Ligusticum wallichii in step（2）The dregs of a decoction after decoction add 5-14 times and measure 50-
90% ethanol is extracted 2-3 times, each 1-3 hours, filtering, merging filtrate, and recovery ethanol is measured to without alcohol taste with 5-10 times
80-90 DEG C of hot water fully dissolves, and filters while hot, and filtrate is concentrated into paste；
（4）Root tuber of aromatic turmeric, the red sage root, fructus choerospondiatis, dipsacus root are added to 3-10 times of 50-90 ethanol, soaked 2-3 times at 40-50 DEG C, each 8-
20 hours, filtering, merging filtrate, recovery ethanol were condensed into thick paste to without alcohol taste；
（5）By wild aconite root, aconiti preparata,radix, stir-baked MYRRHA mixed grinding into fine powder, 80-120 mesh sieve is crossed；
（6）By step（1）All extracts prepared and step（2）、（3）、（4）Gained thick paste mixes, and adds step
（5）Fine powder, mix, dry, sieving, medicament is made.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008112561A1 (en) * | 2007-03-09 | 2008-09-18 | Pfantastic Medical Research Institute, Llc | Combination therapy for alleviating pain-related conditions |
| CN102475852A (en) * | 2010-11-25 | 2012-05-30 | 陈冠卿 | Traditional Chinese preparation for treating cervical spondylosis |
| CN105582478A (en) * | 2016-02-28 | 2016-05-18 | 彭小虎 | Traditional Chinese medicine composition for expelling wind, dispelling cold and eliminating dampness |
-
2017
- 2017-09-30 CN CN201710924180.6A patent/CN107596269A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008112561A1 (en) * | 2007-03-09 | 2008-09-18 | Pfantastic Medical Research Institute, Llc | Combination therapy for alleviating pain-related conditions |
| CN102475852A (en) * | 2010-11-25 | 2012-05-30 | 陈冠卿 | Traditional Chinese preparation for treating cervical spondylosis |
| CN105582478A (en) * | 2016-02-28 | 2016-05-18 | 彭小虎 | Traditional Chinese medicine composition for expelling wind, dispelling cold and eliminating dampness |
Non-Patent Citations (1)
| Title |
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| 许利嘉等: "具开发前景的南美洲常用草药简介", 《现代药物与临床》 * |
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