CN107593727A - A kind of Pesticidal combination - Google Patents

Abstract

A kind of insecticides of the present invention, active component are made up of (A) Ivermectin HCL and (B) four chlorantraniliprole, the active component（A）With（B）It is by weight ratio 1 to be by weight ratio:1‑1:100.Individually active, the of the invention Pesticidal combination compared to each compound, described active component（A）With（B）By weight ratio in foregoing ratio range, Pesticidal combination of the invention shows obvious synergistic activity.Described Pesticidal combination is used for the purposes for preventing or controlling harmful organism, especially controls the purposes of the insects such as Panonychus citri, Tetranychus cinnabarinus, Tetranychus urticae, pear sucker, aphid, diamondback moth, rice leaf roller, striped rice borer.The present invention also provide it is a kind of prevent or the method for control pest infestation, be included in target useful plant or its environment, object noxious livings or its environment, target useful plant propagating materials on any active component for wishing sequentially or simultaneously to apply described in the Pesticidal combination of the present invention（A）With（B）.

Description

A kind of Pesticidal combination

Technical field

The present invention relates to a kind of Pesticidal combination, and active component is by (A) Ivermectin HCL and (B) four chlorantraniliprole group Into.It is used for the purposes for preventing or controlling harmful organism the invention further relates to described Pesticidal combination.

Background technology

In agricultural production, chemical agent is to prevent and treat the maximally efficient means of plant pest, still, with agricultural pests The influence of the extension of chemical prevention medication history, the agricultural chemicals not factor such as scientifical use, in recent years, agricultural pests resistance is increasingly tight Weight, the pest species for producing resistance are persistently increasing, and resistance level is higher, and resistance development speed is relatively fast.Agricultural pests Resistance problem turns into a global problem.

Ivermectin HCL (Ivermectin) is the antibiotic insecticide developed by Merck companies.Ivermectin HCL by with Chloride channel combines, and prevents the normal operation of chlorion from playing a role.The effect target body of Ivermectin HCL is insect peripheral nerve R- aminobutyric acids in system（GABA）Acceptor.It can promote r- aminobutyric acids to be discharged from nerve endings, strengthen r- aminobutyric acids And the combination of acceptor on cell membrane, so that into the chlorion increase of cell, cell membrane hyperpolarization, cause nerve signal transmission It is suppressed, cause paralysis, death.Ivermectin HCL is mainly used in preventing and treating animal parasite at present, agriculturally using less.Therefore, Ivermectin HCL will have broad prospects as pesticide developing.

The activity of the individual compounds is good；However, in low rate of application or they are not when being used for single insect It is that can meet the high request that insecticide, acaricide or nematicide must are fulfilled for.

Field of pest control occur a typical demand be need reduce prevent and treat active component close rate and Unfavorable environment or toxicological effects are reduced or avoided, while still allows for the control of insect of effect.Also need to combine and knock down activity With the pest control agent for extending the preventing and treating time, i.e. snap action and long-acting.

It is to repeat using another difficulty of insecticide and uniquely uses single Pesticidal compound in many cases Cause to produce the active component quick selection that is natural or adapting to drug-fast insect.It is therefore desirable to have help prevent or Overcome drug-fast pest control agent.

Therefore Agricultural pest control field continues the needs for providing pesticide combination be present, and pesticide combination tends to provide improvement Characteristic, such as biological characteristics, synergism characteristic.

The content of the invention

The invention aims to solve above-mentioned technical problem, there is provided a kind of Pesticidal combination, said composition pass through by Active component (A) Ivermectin HCL and (B) four chlorantraniliprole are combined so that obtained composition has in prevention effect to be increased Beneficial effect, and insecticidal spectrum has been expanded, the snap action and long-acting of control of insect are improved, has delayed drug-fast production It is raw.

It is at least one in described problem it is an object of the present invention to provide solving, such as improve biological characteristics, carry For synergism characteristic, close rate is reduced, expand activity profile or combine and knock down activity and extend the preventing and treating time or resistance to the action of a drug management is killed Worm composition, delaying drug resistance.

The technical solution adopted for the present invention to solve the technical problems is：

A kind of Pesticidal combination, active component are made up of (A) Ivermectin HCL and (B) four chlorantraniliprole, the active component（A）With （B）It is 1 by weight ratio:1-1:100, preferably 1:1-1:50, further preferably 1:1-1:40, more preferably 1:1-1:35, more preferably 1: 1-1:30, more preferably 1:1-1:25, more preferably 1:1-1:20, more preferably 1:1-1:15, more preferably 1:1-1:10.

Four chlorantraniliproles（SYP-9080）, chemical name：The bromo- N- of 3- (2,4- bis- chloro- 6- (methyl-carbamoyl) phenyl)- 1- (3,5- dichloro-2-pyridyls base) -1H- pyrazoles -5- formamides.Four chlorantraniliproles are the ryania of Shenyang Chemical Engineering Inst's synthesis The high insecticidal active compound of acceptor inhibitor class, four chlorantraniliproles developed with E.I.Du Pont Company have similar structures.Such chemical combination Thing controls calcium ion release channel, influences contraction of muscle, benumb insect muscle contractility by acting on ryanodine receptor, So as to show insecticidal activity.Ryanodine receptor insecticides have the mechanism of action of uniqueness during desinsection, so as to show Go out wide spectrum, it is efficient, less toxic, safe the features such as.Four chlorantraniliproles to rice leaf roller, striped rice borer, corn borer, armyworm, diamondback moth, The lepidoptera pests such as beet armyworm have higher insecticidal activity.

Active component (A) Ivermectin HCL and (B) four chlorantraniliprole in the present invention for example can also be 1 by weight ratio: 100, 1:90,1:80, 1:70, 1:60, 1:50, 1:45, 1:40, 1:35, 1:30, 1:25,1:24, 1:23, 1: 22, 1:21, 1:20,1:19, 1:18, 1:17,1:16, 1:15, 1:14, 1:13,1:12, 1:11, 1:10,1:9, 1:8, 1:7,1:6,1:5,1:4, 1:3, 1:2, 1:1。

A kind of Pesticidal combination, active component are made up of (A) Ivermectin HCL and (B) four chlorantraniliprole, the active component (A) and（B）Weight account for the 0.5%-90% of the composition by weight altogether.

A kind of Pesticidal combination, active component are made up of (A) Ivermectin HCL and (B) four chlorantraniliprole, the active component (A) and（B）Weight account for the 1%-80% of the composition by weight altogether.

A kind of Pesticidal combination, active component are made up of (A) Ivermectin HCL and (B) four chlorantraniliprole, the active component (A) and（B）Weight account for the 1%-70% of the composition by weight altogether.

A kind of Pesticidal combination, active component are made up of (A) Ivermectin HCL and (B) four chlorantraniliprole, the active component (A) and（B）Weight account for the 1%-60% of the composition by weight altogether.

A kind of Pesticidal combination, active component are made up of (A) Ivermectin HCL and (B) four chlorantraniliprole, the active component (A) and（B）Weight account for the 1%-50% of the composition by weight altogether.

A kind of Pesticidal combination, active component are made up of (A) Ivermectin HCL and (B) four chlorantraniliprole, the active component (A) and（B）Weight account for the 1%-40% of the composition by weight altogether.

A kind of Pesticidal combination, active component are made up of (A) Ivermectin HCL and (B) four chlorantraniliprole, the active component (A) and（B）Weight account for the 1%-30% of the composition by weight altogether.

A kind of Pesticidal combination, active component are made up of (A) Ivermectin HCL and (B) four chlorantraniliprole, the active component (A) and（B）Weight account for the 1%-20% of the composition by weight altogether.

A kind of Pesticidal combination, active component are made up of (A) Ivermectin HCL and (B) four chlorantraniliprole, the active component (A) and（B）Weight account for the 1%-15% of the composition by weight altogether.

A kind of Pesticidal combination, active component are made up of (A) Ivermectin HCL and (B) four chlorantraniliprole, the active component (A) and（B）Weight to account for the composition altogether can also be, for example, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7% by weight, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%。

According to the Pesticidal combination of the present invention, also comprising surfactant and/or filler.

According to the Pesticidal combination of the present invention, the Pesticidal combination can be configured to any formulation agriculturally allowed.

According to the Pesticidal combination of the present invention, the formulation of the Pesticidal combination is missible oil, aqueous suspension agent, oil-suspending agent, Seed treatment dry powder doses, seed treatment suspending agent, water dispersible granules, wettable powder, suspension emulsion, smoke agent, coated granule, Extrude granule, aqueous emulsion, microcapsule suspending agent, microcapsule suspension-suspendinagent agent, dry suspending agent, ultra low volume liquids, electrostatic oil agent, Gel.

Described Pesticidal combination can be applied without dilution, and administration can also be diluted with water.

On the other hand, it is used to prevent present invention also offers a kind of Pesticidal combination by the present invention or controls harmful organism Purposes, wherein harmful organism is selected from Insecta（Insecta）, Arachnoidea (Arachnida), Nematoda（Nematoda）.

The harmful organism of the present invention may be selected from Lepidoptera, Diptera, coleoptera, Semiptera, Homoptera, Orthoptera, film wing Mesh, Isoptera, Siphonaptera, Blattaria, Thysanoptera, Acarina, nematode etc..

Preferably, Pesticidal combination of the invention is used to prevent and treat Panonychus citri, Tetranychus cinnabarinus, Tetranychus urticae, pear sucker, aphid Worm, diamondback moth, rice leaf roller, striped rice borer, root-knot nematode.

On the other hand, present invention also offers a kind of method prevented or control harmful organism, by the desinsection group of the present invention Compound acts on target useful plant or its environment, object noxious livings or its environment, the propagating materials of target useful plant.Institute It is seedling, rhizome, garden seedling, cutting or seed to state plant propagation material.

A kind of method for protecting useful plant to prevent pest infestation, including make the Pesticidal combination and target of the present invention The propagating materials contact of useful plant or its environment, object noxious livings or its environment, target useful plant.

The present invention provides a kind of protection useful plant to prevent the method for pest infestation, and it is included in target useful plant Or its environment, object noxious livings or its environment, target useful plant propagating materials on wished sequentially or simultaneously with any Using comprising active component (A) and（B）Combination.

Present invention discover that：The Insecticidal combinations of the present invention can not only bring the additive property raising for insecticidal spectrum, but also real Now prevent or control harmful organism amazing " synergy " effect.

Term " synergy " used herein refers to inventive compound combination insecticidal effect and is more than each active component effect Sum, in other words, its effect is superadditivity.

The present invention provides a kind of Pesticidal combination, and active component is made up of (A) Ivermectin HCL and (B) four chlorantraniliprole, institute State active component（A）With（B）It is 1 by weight ratio:1-1:100, preferably 1:1-1:50, further preferably 1:1-1:40, more preferably 1: 1-1:35, more preferably 1:1-1:30, more preferably 1:1-1:25, more preferably 1:1-1:20, more preferably 1:1-1:15, more preferably 1:1- 1:10。

Active component (A) Ivermectin HCL and (B) four chlorantraniliprole in the present invention for example can also be 1 by weight ratio: 100, 1:90,1:80, 1:70, 1:60, 1:50, 1:45, 1:40, 1:35, 1:30, 1:25,1:24, 1:23, 1: 22, 1:21, 1:20,1:19, 1:18, 1:17,1:16, 1:15, 1:14, 1:13,1:12, 1:11, 1:10,1:9, 1:8, 1:7,1:6,1:5,1:4, 1:3, 1:2, 1:1。

A kind of Pesticidal combination individually active compared to each compound, of the invention, active component of the present invention（A） With（B）By weight ratio in foregoing ratio range, Pesticidal combination of the invention shows obvious synergistic activity.

The total amount of active component can be selected according to material elements in the present composition, to realize desired work With.The factor is for example, formulation, object to be administered, application process etc..The present invention a kind of Pesticidal combination, active component by (A) Ivermectin HCL and (B) four chlorantraniliprole form, the active component（A）With（B）Weight accounts for the composition with weight altogether The 0.5%-90% of meter, preferably 1%-80%, more preferably 1%-70%, more preferably 1%-60%, more preferably 1%-50%, more preferably 1%-40%, More preferably 1%-30%, more preferably 1%-20%, more preferably 1%-15%.

A kind of Pesticidal combination, active component are made up of (A) Ivermectin HCL and (B) four chlorantraniliprole, the active component (A) and（B）Weight to account for the composition altogether can also be, for example, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7% by weight, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%。

The Pesticidal combination of the present invention optionally includes agronomically acceptable surfactant or filler.

According to the present invention, term " filler ", which refers to, can be combined with active component or combines to make it easier for being applied to pair As（Such as plant, crop or careless class）Natural or synthetic organic or inorganic compound.Therefore, the filler is preferably lazy Property, it is acceptable at least to should be agricultural.The filler can be solid or liquid.

Applicable solid-filling agent, such as phyteral powdery type（Such as soy meal, starch, grain dust, wood powder, bark powder, Sawdust, walnut shell powder, wheat bran, cellulose powder, coconut husk, the particle of corncob and tobacco stem, extract residual after plant essence Slag etc.）, clay class（Such as kaolin, bentonite, acid china clay etc.）, talcum powder class, silica（Such as diatomite, silica sand, cloud Female, aqueous silicic acid, calcium silicates）, activated carbon, natural mineral matter class（Float stone, attapulgite and zeolite etc.）, fire diatomite, sand, Plastics medium etc.（Such as polyethylene, polypropylene, polyvinylidene chloride etc.）, potassium chloride, calcium carbonate, the inorganic mineral of calcium phosphate etc. Property powder, ammonium sulfate, ammonium phosphate, urea, chemical fertilizer, the clay fertilizer of greening ammonium etc., these materials can be used alone or 2 kinds It is mixed above.

Applicable liquid filler can select in llowing group of materials, such as water, alcohol type（Such as methanol, ethanol, isopropyl Alcohol, butanol, ethylene glycol etc.）, ketone（Such as acetone, methyl ethyl ketone, isobutyrone, cyclohexanone etc.）, ethers（Such as second Ether, dioxanes, methylcellulose, tetrahydrofuran etc.）, aliphatic hydrocarbon class（Such as kerosene, mineral oil etc.）, aromatic series Hydrocarbon（Such as benzene,toluene,xylene, solvent naphtha, alkylnaphthalene, chlorinated aromatic hydrocarbons, chlorinated aliphatic hydrocarbon, chlorobenzene etc.）, halogen Change hydrocarbon, amide-type, sulfone class, dimethyl sulfoxide (DMSO), mineral and vegetable oil, animal oil etc..

The Pesticidal combination of the present invention can also include additional other components, such as surfactant.Live on applicable surface Property agent has the emulsifying agent with ion or non-ionic nature, dispersant or wetting agent, or the mixture of these surfactants.This The suitable of a little surfactants has AEO, polyoxyethylene alkylaryl ether, polyoxyethylene higher fatty acid Ester, the phosphate of polyoxyethylene alcohol or phenol, the fatty acid ester of polyalcohol, alkylaryl sodium sulfonate, naphthalene sulfonic acid polymer, sulfomethylated lignin Hydrochlorate, comb polymer molecule copolymer, butyl naphthalene sulfonate, alkylaryl sulfonates, sodium alkylsulfosuccinates, grease, fat Polyacrylate, the protein hydrolysate such as alcohol and ethylene oxide condensate, alkyltaurate.Suitable oligosaccharide thing or polymerization Thing, for example, based on single vinyl monomer, acrylic acid, polyoxyethylene or polyoxypropylene or its with for example（It is polynary）Alcohol or（It is more Member）The combination of amine.When a kind of not soluble in water in one kind in active component and/or inert carrier and when being applied in water, There must be surfactant.The ratio of surfactant is the 5%-40% weight of the Pesticidal combination of the present invention.

If appropriate, there may also be other addO-on therapies, such as protecting colloid, adhesive, adhesive, thickener, touch Become agent, bleeding agent, stabilizer, screening agent, sequestering agent, complex-forming agents.Generally, described active component can with it is normal Advise any solid or the liquid additive combination for preparation purpose.

The preparation of the present invention can be entered at least one of the active component and following material by known way Row mixing：Solvent or diluent, emulsifying agent, dispersant, and/or adhesive or fixative, wetting agent, waterproofing agent, if it is desired, Drier and colouring agent, stabilizer, pigment, defoamer, preservative, thickener, water and other processing aids can also be included. Can be by equably mixing and/or grinding active component with solid-filling agent or liquid filler, suitable surfactant To prepare the Pesticidal combination of the present invention.

The Pesticidal combination of the present invention can be used with itself, or can be according to its respective physically and/or chemically property Used with its dosage form or type of service prepared therefrom, for example, it is aerosol, micro-capsule suspension, harl agent, thermal fog, micro- Capsule granula, granula subtilis, seed treatment suspending agent, ready to use solution agent, pulvis, missible oil, oil-in-water emulsion, water-in-oil type breast Agent, big granula, fine granule, oil-dispersing property pulvis, oil suspending agent, finish, foaming agent, paste, seed coat agent, colloidal suspending agent, suspended emulsion, Aqueous solvent, suspending agent, wettable powder, soluble powder, pulvis and granule, water-soluble granular formulation or tablet, seed treatment With in water solube powder, wettable powder, the natural prodcuts of activity component impregnation and synthetic, polymeric material with seed cladding Microcapsules in material, and the agent of ultra-low volume harl and hot mist preparation.

The present invention the preferable formulation of Pesticidal combination for missible oil, aqueous suspension agent, oil-suspending agent, seed treatment dry powder doses, Seed treatment suspending agent, water dispersible granules, wettable powder, suspension emulsion, smoke agent, coated granule, extrusion granule, water and milk Agent, microcapsule suspending agent, microcapsule suspension-suspendinagent agent, dry suspending agent, ultra low volume liquids, electrostatic oil agent, gel.

The Pesticidal combination of the present invention can also be applied with other active ingredient combinations, and other active components for example kill Epiphyte pharmaceutical, bactericide, attractant, insecticide, acaricide, nematicide, growth regulator, herbicide, safener, fertilizer Or semiochemical etc..

The Pesticidal combination of the present invention, has good plant compatibility and favourable homeothermal animal toxicity, suitable for preventing and treating The harmful organism run into agricultural, forestry, protection Stored Product and material and health field, especially Insecta （Insecta）, Arachnoidea (Arachnida), Nematoda（Nematoda）.They have for generally sensitive and resistance species Activity, and activity is respectively provided with for all or single stage of development, and also realize that prevention or control harmful organism make us frightened " synergy " effect of happiness

Present invention also offers the purposes that a kind of Pesticidal combination by the present invention is used to preventing or controlling harmful organism.Herein Any organism for meaning to cause damage to the normal condition of plant using term " harmful organism ".Including Insecta （Insecta）, Arachnoidea (Arachnida), Nematoda（Nematoda）.

Insecta includes Lepidoptera, coleoptera, Diptera, Semiptera, Homoptera, Hymenoptera, Thysanoptera, Isopoda, times Sufficient mesh, lip foot mesh, comprehensive mesh, Thysanoptera, Collembola, Collembola, Orthoptera, Blattaria, Dermaptera, Isoptera, Anoplura.

Lepidoptera pest, such as：Striped rice borer（chilosuppressalis（walker）, yellow rice borer （Tryporyzaincertulas（walker））, rice leaf roller（cnaphalocrocismedinalisGuenee）, cabbage heart Snout moth's larva（hellullaundalis）, dichocrocis punctiferalis（conogethespunctiferlis）, papilio xuthus Linnaeus（papilioxuthus）, it is white White butterfly（pierisrapaecrucivora）, straight burr rice hesperiidae（parnaraguttata）, tent caterpillar（malacosoma Neustria testacea）, gypsymoth（lymantriadispar）, fall webworms（hyphantriacunea）, east poison moth （euproctissubflava）, black line slug moth（scopelodescontracus）, bollworm （helicoverpaarmigera）, Pectinophora gossypiella（Pink bollworm）, cabbage looper（trichoplusiani）, wild cabbage night Moth（mamestrabrassicae）, beet armyworm（spodopteraexigua）, prodenia litura（spodopteralitura）、 Tea olethreutid（adoxophyesoranafasciata）, leaf roller（adoxophyeshonmai）, apricot yellow volume moth （archipsfuscocureanus）, Homonamagnanima（homonamagnanima）, diamondback moth（plutellaxylotella）, cotton Pink bollworm（pectinophoragossypiella）.

Coleopteran pest, such as：Rice weevil（sitophilusoryzaelinne）, citrus leaf mining first（Podagricomela nigricollis Che）, sitophilus zea-mais（S.zeamails）, grain weevil（S.granarius）, big daikon leaf beetle （Cabbageleafbeetle）, daicon leaf beetle（Daikon leaf beele）, flea beetle（fleabeetle）, grape flea beetle （Alticachalybea）, cabbage flea beetle（phyllotretastriolata）, cucumber flea beetle（Epitrixcucumeris）, cigarette Careless flea beetle（Ehirtipennis）, eggplant flea beetle（E.fuscula）, aulacophora femoralis（Aulacophoraindica（Gemlin）, leaf mustard It is chrysomelid（Phaedon cochleariae）Deng.

Diptera pest, such as：Rice leafminer（agromyzaoryzae）, hydrellia griseola（hydrelliagriseola）, it is non- Continent chrysanthemum liriomyza bryoniae（liriomyzatrifolii）, pea leaf dive fly（chromatomyiahorticola）, Liriomyza brponiae （liriomyzabryoniae）, delia platura（deliaplatura）, green onion ground Hylemyia Platura Meigen（deliaantiqua）Mediterranean fruitfly （ceratitiscapiatawiedgman）, Rhagoletis pomonella（Rhagoletispomonella）, cherry fruit fly （R.cingulata）.

Hemipteran pest, such as：Smelly stinkbug（megacoptapunctatissimum）, cabbage bug（eurydemarugosum）、 Big thorn white star stinkbug（eysarcorislewisi）, white star stinkbug（eysarcorisparvus）, green rice bug（nezaraviridula）、 Si Shi amber stinkbugs（plautiastali）, clerodendron trichotomum stinkbug（halymorphamista）, rice spiny coreid（cletuspunctiger）, in Magnificent Leptocorisa spp（leptocorisachinensis）, azelea lace bug（stephantispyrioides）, it is red must fleahopper （trigonotyluscoelestialium）.

Homoptera pest, such as rice green leafhopper（nephotettixcincticeps）, small brown rice planthopper （laodelphaxstriatellus）, brown plant-hopper（nilaparvatalugens）, white backed planthopper （sogatellafurcifera）, pear sucker（psyllapyrisuga）, diaphorina citri（diaphorinatabaci）, Bemisia tabaci （bemisiatabaci）, aphid（homoptera）, apple aphid（eriosomalanigerum）.

Hymenoptera（hymenoptera）Insect, such as yellow-winged cabbage sawfly（athaliarosaeruficornis）, japanese rose leaf Honeybee（argepagana）, Black Hills ant（formica japonica）, chestnut gall wasp（dryocsmuskuriphilus）Deng.

Thysanoptera, such as thrips（HaplothripsChinensisPriesner）.

Isopoda（Isopoda）, for example, Cape jasmine beach louse（Oniscus asellus）, pillworm（Armadilliudium vulgare）, ball pillworm（Porcellio scaber）.

Sufficient mesh insect again, for example, Blaniulus guttulatus.

Lip foot mesh insect, for example, ground Scolopendra (Geophilus carpophagusScutigera spp.).

Comprehensive mesh insect, for example, kahikatea worm (Scutigerella immaculata).

Thysanoptera insect, for example, silverfish (Lepisma saccharina).

Collembola insect, for example, arms Onychiurus arcticus (Onychiurus armatus).

Orthoptera pest, for example, family Xi (Acheta domesticus), mqb category category kind of (Gryllotalpa spp. ), it is Asiatic migratory locust (Locusta migratoriamigrator ioides), black locust category kind of (a Melanopluss pp.), husky Unconcerned locust (Schistocercagregaria).

Blattaria insect, for example, oriental cockroach (Blattaorientalis), American cockroach (Periplaneta Americana), leucophaea maderae (Leucophaea maderae), Groton bug (Blattella germanica).

Dermaptera insect, for example, European earwig (Forficula auricularia).

Isoptera insect, for example, Reticulitermes kind (Reticulitermes spp.).

Anoplura (Anoplura, Phthiraptera), such as Damalinia (Damalinia spp.), Haematopinus (Haematopinus spp.), Linognathus (Linognathus spp.), Pediculus (Pediculus spp.), Trichodectes (Trichodectes spp. )。

Arachnoidea（Arachnida）Insect.Such as panonychus citri（panonychus citri）, Tetranychus cinnabarinus （Tetranychus cinnabarinus）, panonychus ulmi（panonychus ulmi）, Tetranychus urticae（tetranychus urticae）, tetranychus viennensis（tetranychus viennensis）, oligonychus ununguis（oligonychus ununguis）Mandarin orange Tangerine beginning tetranychid（eotetranychus kankitus）, purplish red short hairs mite（brevipalpus phoenicis）, Bryobia praetiosa （bryobiapraetiosa）, wheat leaf roll mite（aceria tulipae）, grape erineum mite (Eriophyes vitis)（colomerus vitis）, tealeaves Goitre mite（calacarus carinatus）, yellow tea mite（polyphagotarsonemus latus）, long hair root mite （rhizoglyphus rostochiensis）, Acarus siro（Acarus siro）, citrus aceria（Aceria sheldoni）, steinman pin thorn goitre mite（Aculus schlechtendali）, Tetranychus（Tetranychus spp.）, Panonychus citri Category（Panonychus spp.）, wrinkle Genus Phyllocoptess（Phyllocoptruta spp.）, short whisker Acarapis（Brevipalpus spp.）Deng.

Nematoda（(Nematoda)）Representative biology have selected from Meloidogyne（Meloidogyne spp.）, different skin Turbatrix（Heterodera spp.）, ball Heterodera（Globodera spp.）, perforation line Eimeria（Radopholus spp.）, Pratylenchus（Pratylenchus spp.）, minute hand Turbatrix（Longidorus spp.）Deng.It is preferred that lower alignment The soybean cyst nematode Heterodera glycines of worm（Heterodera）, globodera rostochiensis（golbodera rostochiensis）, Root Knot line Worm（meloidogyne incognita）Deng.

It is for confrontation insect, such as insect, immature insect, insect at initial stage and insect ovum according to the combination of the present invention Environment effective and that insect or their existence can be applied directly to.The insect bag controlled according to the Insecticidal combinations of the present invention Include agricultural/horticultural insect, insect pest, storage insect insect, clothes insect and the furniture insect of health.

The Pesticidal combination of the present invention is particularly suitable for preventing and treating Panonychus citri category, short whisker Acarapis, Tetranychus and wrinkle leaf Aculus Belong to, the one or more in Homoptera, Lepidoptera.The Pesticidal combination of the present invention can not only bring the additive property for insecticidal spectrum Improve, but also realize prevention or control harmful organism amazing " synergy " effect.

More preferred, Pesticidal combination of the invention is suitable for preventing and treating Panonychus citri, Tetranychus cinnabarinus, Tetranychus urticae, pears Wood louse, aphid, diamondback moth, rice leaf roller, striped rice borer, root-knot nematode.

On the other hand, present invention also offers a kind of method prevented or control harmful organism, by the desinsection group of the present invention Compound is applied to target useful plant or its environment, object noxious livings, the propagating materials of target useful plant.

The Pesticidal combination of the present invention shows particularly advantageous effect when being applied to such as following useful plant：Cereal Such as wheat, oat, barley, spelt (spelt), triticale and rye, and it is corn, jowar He Li, rice, sweet Sugarcane, soybean, sunflower, potato, cotton, rape (oil seed rape), canola (canola), tobacco, sweet tea Dish, fodder beet, asparagus, hops and fruit bearing plant (including the operatic circle such as apple and pears, drupe for example peach, honey peach, cherry, plum, Apricot, cedra fruits for example orange, grape cypress, bitter orange, twist Lu, cumquat, citrus and Sa Mo tangerines, nut for example pistachio, almond, Walnut and pecan, tropical fruit (tree) such as mango, papaya, pineapple, nipa palm and banana, and grape) and vegetables (including leaf vegetables Class such as hare's-lettuce, corn salad, fennel, Leaf lettuce, celery lettuce, Swiss chard, spinach and salad with witloof, wild cabbage such as cauliflower, Broccoli, Chinese leaf, Brassica oleracea (L.) convar. acephalavar. sabellicaL. (wrinkle leaves Wild cabbage, collard), kohlrabi, brussels sprout, red cabbage, white cabbage and savoy, fruit vegetables such as eggplant, Huang Melon, capsicum, edible squash, tomato, bush pumpkin and corn, root vegetables such as celeriac, rape, carrot include yellow product Kind, wild radish class include Raphanus sativus var. niger and Raphanus sativus var.radicula, Beet, celery, legume such as pea and soybean, and allium vegetables such as leek and onion).

The suitable useful plant of the present invention also includes the genetically modified plants converted by recombinant DNA technology.

It is particularly suitable for preventing or controls according to the Pesticidal combination of the present invention：

Pest and disease damage crop

Panonychus citri category（Panonychus spp.）Citrus, apple fruits and vegetables, a kind of fruit, such as apple, pear, etc., drupe, set nut

Short whisker Acarapis（Brevipalpus spp.）Citrus, coffee, apple fruits and vegetables

Wrinkle Genus Phyllocoptess（Phyllocoptruta spp.）Citrus

Tetranychus（Tetranychus spp.）Citrus, apple fruits and vegetables, a kind of fruit, such as apple, pear, etc., drupe, set nut

Homoptera pest（Homoptera）Citrus, apple fruits and vegetables

Lepidoptera (Lepidoptera) citrus, apple fruits and vegetables

The Pesticidal combination of the present invention is particularly suitable for preventing and treating Panonychus citri, Tetranychus cinnabarinus, Tetranychus urticae, pear sucker, aphid, small Diamond-back moth, rice leaf roller, striped rice borer, root-knot nematode.

The present invention provides a kind of method prevented or control harmful organism, and the Pesticidal combination of the present invention is applied into target Useful plant or its environment, object noxious livings or its environment, the propagating materials of target useful plant.

A kind of method for protecting useful plant to prevent pest infestation, including make the Pesticidal combination and target of the present invention The propagating materials contact of useful plant or its environment, object noxious livings or its environment, target useful plant.

The present invention also provides a kind of protection useful plant to prevent the method for pest infestation, and it is included in the useful plant of target Thing or its environment, object noxious livings or its environment, target useful plant propagating materials on wished serially or simultaneously with any Ground administration of active ingredients by (A) and (B) combination.

Term " plant propagation material " is interpreted as referring to all plant parts for having fertility, such as seed, and it can be used In breeding the latter, and vegetable matter such as cuttage bar or stem tuber（Such as potato）.Therefore, plant used herein Part includes plant propagation material.It is mentioned that such as seed, root, fruit, stem tuber, bulb, rhizome and plant part.Treat The germination plant and effective plant suppressed after being germinateed from soil or after emergence.Young plant can be before transplantation by being impregnated into Row whole or Local treatment are protected.Plant propagation material preferred seed.

Directly carried out with conventional treatment method with processing of the Pesticidal combination of the present invention to useful plant, at the routine Reason method for example impregnates, poured, being sprayed, atomizing, broadcasts sowing, dusts, and mist formation, broadcasts sowing, foams, coating, being coated with, drip irrigation； In the case of propagating materials, especially in the case of seed, for the pulvis of dry seedses processing, seed treatment solution, slurry Expect processing water-soluble powder form, by crust, pass through one or more layers coating etc..

The Pesticidal combination of the present invention can be used to protect useful plant or their propagating materials.Therefore, it is of the invention to kill Worm composition can in a usual manner, for example foliar spray is applied to useful plant；Conventional ground spray can be used in blade spraying Mist, air-spraying, particularly unmanned plane can also be used to spray.

The Pesticidal combination of the present invention not only includes can use what suitable device was applied to plant or seed to use composition, And the commercially available concentrate including that must be diluted with water before administration.

The present invention also provides one kind in plant propagation material and in growing plants organ, plant part and/or plant afterwards The method that harmful organism is prevented and treated or prevented in thing, including the Pesticidal combination of the present invention is applied to plant propagation material or its ring On border.Plant propagation material preferred seed.

The method of the present invention can be applied to the seed of any physiological status.Preferred seed is in state durable enough, So as to without damage in processing procedure.Usually, seed can be harvested from field, remove from plant, be isolated from any fringe Axle, stem, crust and the pulp of surrounding or the seed of other non-seed vegetable materials.Seed can also be stable preferably on biology , to reach the degree that processing will not cause biological damage to seed.It can harvest between seed sowing or broadcast at seed Any time processing during kind process is applied to seed.Seed can also vernalization before and after treatments.

The seed that Pesticidal combination by the present invention is handled can be stored, manage, sowing and farming.

Seed treatment can by with it is any wish sequentially or simultaneously to its administration of active ingredients (A) and（B）.

Seed treatment occurs on unseeded seed, term " unseeded seed " be intended to include in seed harvest and The seed in any period between seed is in plant germination and grows purpose sowing in soil.Preferably, handle and broadcast in seed Occur before kind, so as to which the sowing seed is pretreated with the combination.Especially, seed pelleting or pellet seeds are at this It is preferable to invent in the processing of combination.After processing, the composition in each combination is attached on seed and therefore available for insect pest Preventing and treating.

The present invention also provides a kind of protection seed to prevent soil insect and protection seedling root and branch to prevent soil and blade face The method of insect, it is included in before sowing and/or makes the Insecticidal combinations of the invention of seed and insecticidal effective dose after vernalization Thing contacts.

Therefore, a kind of method for protecting seed, seedling root and branch to be attacked to prevent soil and foliar insect, is included in sowing Contact seed and the Pesticidal combination of effective dose of the present invention in the past and/or after vernalization.

The present invention also provides a kind of method for protecting vegetable seeds, and it includes making seed prior to seeding and/or after vernalization Contacted with the Pesticidal combination of the invention of effective dose.

The present invention also provides a kind of method for protecting useful plant to prevent pest infestation, including the desinsection by the present invention Composition is applied to environment, habitat or the storage areas of useful plant growth.The environment of plant growth, habitat are to refer to make agriculture The supporter that crop takes root, grown, such as：Soil, water etc., specific raw material can use for example sand, float stone, vermiculite, Diatomite, agar-agar, gelling material, polymer substance, asbestos, wood chip, bark etc..It is preferred that soil.

The method of medicament is applied into soil, such as liquid preparation is diluted in water or do not diluted and is directly applied to plant The methods of in the root of body or the rice seedling bed of seedling, side granule being disseminated in the root of plant or the rice seedling bed of seedling Method has the method that pulvis, water dispersible granules etc. are sprayed in soil prior to seeding and integrally mixed with soil, before sowing or plants It will be sprayed on before kind plant after pulvis, water-dispersible grain dilution agent in implantation hole, seed furrow, in method sowed etc..

The Pesticidal combination of the present invention can also be applied with other active ingredient combinations, and other active components for example kill Epiphyte pharmaceutical, bactericide, attractant, insecticide, acaricide, nematicide, growth regulator, herbicide, safener, fertilizer Or semiochemical etc..

The present invention also provides a kind of method for protecting useful crop to prevent pest infestation, including combine, separate or according to Secondary administration of active ingredients (A) and（B）.In the case of separate administration, order does not influence generally on the result of Prevention method.

One kind is in plant propagation material and the preventing and treating or pre- in growing plants organ, plant part and/or plant afterwards The method of anti-harmful organism, including by described Pesticidal combination be applied to plant propagation material or its environmentally.

A kind of method for protecting seed, seedling root and branch to be attacked to prevent soil and foliar insect, is included in before sowing And/or seed is set to be contacted with Pesticidal combination of the present invention after vernalization.

The present invention provides a kind of method prevented or control harmful organism, and the Pesticidal combination of the present invention is acted on into target Useful plant or its environment, object noxious livings, the propagating materials of target useful plant, other agricultural chemicals can be using activearms Before point (A) and (B), with active component (A) and (B) afterwards independently of each other simultaneously or in administration of active ingredients (A) and (B) Using, and in the case of active component (A) and (B) separate administration, each other agricultural chemicals can in administration of active ingredients (A) and (B) simultaneously, between administration of active ingredients (A) and (B) or applying Mil lived with administration of active ingredients (A) and (B) before Property component (A) and (B) after apply independently of each other.

On the other hand, processing of the invention can also produce following super additive effect：Improve plant growth, improve to high temperature Or low temperature tolerance, improve to arid or to the tolerance of water or soil salt content, improve Flowering quality, make harvesting simpler Just, accelerate ripe, raising harvesting yield, improve the quality of harvested products and/or improve its nutritive value, improve harvested products Bin stability and/or its processing characteristics.

The amount of application of composition for example changes according to usage type, agrotype, but the active component in combination is to provide Desired humidification（Prevention and control to harmful organism）Effective dose and can be by those of ordinary skill in the art The experiment and routine test known determines.

It is common and favourable that the Pesticidal combination of the present invention is generally applied with following dosage：

- for leaf portion processing：0.05-3kg/ha, preferably 0.1-1kg/ha, more preferably 1-300 g/ha；More preferably 1-200g/ ha；More preferably 1-100g/ha；More preferably 1-50g/ha；For the administration that impregnates or instil, the dosage can also even drop It is low, particularly when applying inert base such as asbestos or pearl rock；

- for seed treatment：2-200g/100kg seeds, preferably 3-150g/100kg seeds;More preferably 3-100 g/100kg Seed

- for soil treatment：0.1-5kg/ha, preferably 1-1kg/ha, preferably 1-0.5kg/ha, more preferably 1-0.1 kg/ha

Above-mentioned dosage is only general exemplary dose, actual those skilled in the art when applying can according to actual conditions and Need, rate of application is adjusted especially in accordance with the property and insect pest situation of pending plant or crop.

The benefit of the Pesticidal combination of the present invention has at following 5 points：

A, compared with single compound activity, Pesticidal combination of the invention may indicate that the activity of collaboration；

B, the plant of Pesticidal combination of the invention processing, plant propagation material have reached the water for being demonstrated by being significantly improved It is flat；

C, Pesticidal combination of the invention reduces any undesirable pestinfestation and attack；

Both D are mixed, solve the problems, such as lasting period and quick-acting, so as to reduce times for spraying, reduce cost of labor；

E, the generation of resistance has been delayed：Both mechanisms of action and the mode of action are entirely different, have after combination tag, stomach toxicity, Ovicidal and the effect for reducing spawning rate and incubation rate, so that insect is more easy to be killed, so as to delay the generation of resistance；

F, widened Ivermectin HCL preventing and treating spectrum, after four chlorantraniliproles combine with Ivermectin HCL, can effectively prevent and treat mite class, aphid, Endangered while diamondback moth, snout moth's larva, pear sucker.

Embodiment

Below with reference to embodiment, the invention will be further elaborated：

Example of formulations

The missible oil of embodiment 1

Ivermectin HCL	1%
		Four chlorantraniliproles	4%
Cyclohexanone	20%
		Castor oil polyglycol ether（35mol oxirane）	5%
Calcium dodecyl benzene sulfonate	3%
		SOLVESSO TM200	Complement to 100%

Said components are mixed to the liquid of transparent and homogeneous, that is, obtain the cream preparation of the present invention.Can be by being diluted with water Above-mentioned concentrate, obtain the emulsion of any required dilute strength available for plant protection.

The wettable powder of embodiment 2

Ivermectin HCL	10%
		Four chlorantraniliproles	50%
NaLS	2%
		Sodium lignin sulfonate	10%
White carbon	10%
		Kaolin	Complement to 100%

The active component is sufficiently mixed with the auxiliary agent, and mixture is fully ground in suitable flour mill, is obtained wettable Property pulvis.It can be diluted with water and the suspension for wishing concentration is provided.

The aqueous emulsion of embodiment 3

Ivermectin HCL	1%
		Four chlorantraniliproles	5%
1-METHYLPYRROLIDONE	15%
		Neopelex	5%
Phenethyl phenol APEO	5%
		Water	Complement to 100%

Active component and auxiliary agent are added together, make to be dissolved into homogeneous oil phase；Water-soluble component and water are mixed to prepare aqueous phase； It is under high-speed stirred, oil phase is mixed with water, the aqueous emulsion of the present invention is made.

The water dispersible granules of embodiment 4

Ivermectin HCL	5%
		Four chlorantraniliproles	40%
Sodium lignin sulfonate	5%
		Lauryl sodium sulfate	10%
Sucrose	Complement to 100%

Active component, dispersant, wetting agent, disintegrant and filler are well mixed in the ratio of formula, by air-flow crushing into Wettable powder, add a certain amount of water mixing extruder grain.The water dispersible granules of the present invention are obtained after drying and sieving.

The microemulsion of embodiment 5

Ivermectin HCL	1%
		Four chlorantraniliproles	5%
1-METHYLPYRROLIDONE	20%
		Ethoxylated castor oil	30%
AEO sulfosuccinic acid monoesters disodium	30%
		Water	Complement to 100%

Said components are mixed to the liquid of transparent and homogeneous, that is, obtain the microemulsion of the present invention.

The seed treatment dry powder doses of embodiment 6

Ivermectin HCL	1.7%
		Four chlorantraniliproles	4.3%
Light mineral oil	10%
		Sodium lignin sulfonate	15%
High dispersive silicic acid	10%
		Talcum	20%
White Carbon black	Complement to 100%

The active component is sufficiently mixed with the auxiliary agent, and mixture is fully ground in suitable flour mill, and obtaining can be straight Connect the pulvis for seed treatment.

The suspension emulsion of embodiment 7

Ivermectin HCL	2%
		Four chlorantraniliproles	5%
SOLVESSO TM200	10%
		Ethoxylated castor oil	4%
AEO sulfosuccinic acid monoesters disodium	10%
		MODIFIED LIGNOSULPHONATE	5%
Xanthans	0.5%
		Bentonite	1%
Glycerine	5%
		Defoamer	0.6%
Water	Complement to 100%

Ivermectin HCL is dissolved in SOLVESSO ^TMIn 200, ethoxylated castor oil is added, obtains missible oil；By four chlorantraniliproles, AEO sulfosuccinic acid monoesters disodium, MODIFIED LIGNOSULPHONATE, xanthans, bentonite, glycerine, water etc. Above-mentioned each component mixes in proportion, and through being sanded, is prepared into the suspending agent containing four chlorantraniliproles.By the oil containing Ivermectin HCL It is added in the suspending agent containing four chlorantraniliproles, obtains suspension emulsion.

The aqueous emulsion of embodiment 8

Oil phase：

Ivermectin HCL	1%
		Four chlorantraniliproles	5%
Methyl oleate	10%
		Polystyrene	3.7%

Aqueous phase：

Xanthans	0.07%
		The sodium salt of naphthalene sulfonic acids-formaldehyde condensation products of sulfonation	1%
Bactericide	0.2%
		Water	Complement to 100%

Ivermectin HCL and four chlorantraniliproles are dissolved in methyl oleate, polystyrene is added and obtains oil phase；According in formula Component is well mixed to obtain aqueous phase；Oil phase addition aqueous phase is obtained into aqueous emulsion under agitation.

The wettable powder of embodiment 9

Ivermectin HCL	2%
		Four chlorantraniliproles	20%
Sodium lignin sulfonate	7%
		NaLS	2%
Lactose	Complement to 100%

Combinations thereof is mixed in proportion, and ground, crushes, is prepared into wettable powder.

The coated granule of embodiment 10

Ivermectin HCL	1.6%
		Four chlorantraniliproles	0.4%
Polyethylene glycol	3%
		The silicic acid of high degree of dispersion	1%
Calcium carbonate	Complement to 100%

In a mixer, by levigate active component even spread to the carrier soaked by polyethylene glycol.It can obtain in this way Obtain dust-free coated granules agent.

The soluble powder of embodiment 11

Ivermectin HCL	2%
		Four chlorantraniliproles	3%
Sodium lignin sulfonate	5%
		Dodecyl sodium sulfate	3%
Mannitol	Complement to 100%

Said components are mixed in proportion, and grinds, crush, are prepared into soluble powder.

Embodiment 12 extrudes granule

Ivermectin HCL	4%
		Four chlorantraniliproles	6%
Sodium lignin sulfonate	4%
		Carboxymethyl cellulose	2%
White carbon	5%
		Kaolin	Complement to 100%

Active component is mixed and ground with auxiliary agent, mixture is moistened with water.The mixture is extruded, then done in the air stream It is dry.

The oil-suspending agent of embodiment 13

Ivermectin HCL	1.8%
		Four chlorantraniliproles	3.2%
Ethoxylated castor oil	4%
		AEO sulfosuccinic acid monoesters disodium	10%
MODIFIED LIGNOSULPHONATE	5%
		Bentonite	1%
Defoamer	0.6%
		Soybean oil	Complement to 100%

By Ivermectin HCL, four chlorantraniliproles, ethoxylated castor oil, AEO sulfosuccinic acid monoesters disodium, The above-mentioned each component such as MODIFIED LIGNOSULPHONATE, bentonite, soybean oil mixes in proportion, and through being sanded, it is outstanding to be prepared into oil Floating agent.

The suspension emulsion of embodiment 14

Ivermectin HCL	3%
		Four chlorantraniliproles	3%
SOLVESSO TM200	10%
		Ethoxylated castor oil	4%
AEO sulfosuccinic acid monoesters disodium	10%
		MODIFIED LIGNOSULPHONATE	5%
Xanthans	0.5%
		Glycerine	5%
Defoamer	0.6%
		Water	Complement to 100%

Ivermectin HCL is dissolved in SOLVESSO^TMIn 200, ethoxylated castor oil is added, obtains missible oil containing Ivermectin HCL；Will Four chlorantraniliproles, AEO sulfosuccinic acid monoesters disodium, MODIFIED LIGNOSULPHONATE, xanthans, bentonite, The above-mentioned each component such as glycerine, water mixes in proportion, and through being sanded, is prepared into the suspending agent containing four chlorantraniliproles.It will contain The oil phase of Ivermectin HCL is added in the suspending agent containing four chlorantraniliproles, obtains suspension emulsion.

The microcapsule suspension-suspendinagent agent of embodiment 15

ATLOX TM4913	4%
		Citric acid	0.05%
Catalyst	0.1%
		Water	13%
Ivermectin HCL	2.2%
		PAPI	1.35%
SOLVESSO TM200	5%
		ATLOX TM4913	5%
Dispersant LFH	0.3%
		Defoamer	0.16%
Urea	5.5%
		Four chlorantraniliproles	6.8%
Water	Complement to 100%

By poly methylene poly phenyl poly isocyanate（PAPI）, Ivermectin HCL, SOLVESSO^TM200 oil phases formed, which add, to be contained ATLOX^TMIn 4913 aqueous solution, emulsion is formed.Then heat and be incubated 50^oCatalyst reaction is added under C 2 hours.It is cold But the microcapsules containing Ivermectin HCL is obtained afterwards.

ATLOX ^TM4913, dispersant LFH, defoamer, urea, four chlorantraniliproles and water mix in proportion, and Through being sanded, suspension aqueous phase is prepared.

The obtained microcapsules containing Ivermectin HCL is added in the suspension aqueous phase containing four chlorantraniliproles, is uniformly mixing to obtain The microcapsule suspension-suspendinagent agent of the present invention.

The seed treatment suspension emulsion of embodiment 16

Ivermectin HCL	5%
		Four chlorantraniliproles	10%
SOLVESSO TM200	20%
		Ethoxylated castor oil	5%
AEO sulfosuccinic acid monoesters disodium	10%
		Modified sodium lignosulfonate	5%
Xanthans	0.5%
		Glycerine	5%
Polyvinylpyrrolidone（PVP-K30）	1%
		Defoamer	0.6%
Water	Complement to 100%

Ivermectin HCL is dissolved in SOLVESSO^TMIn 200, ethoxylated castor oil is added, obtains the missible oil containing Ivermectin HCL； By four chlorantraniliproles, AEO sulfosuccinic acid monoesters disodium, MODIFIED LIGNOSULPHONATE, xanthans, the third three The above-mentioned each component such as alcohol, polyvinylpyrrolidone, water mixes in proportion, and through being sanded, is prepared containing four chlorantraniliproles Seed treatment suspending agent.

Oil phase containing Ivermectin HCL is added in the seed treatment suspending agent containing four chlorantraniliproles, obtains the kind of the present invention Subprocessing suspension emulsion.

The smoke agent of embodiment 17

Ivermectin HCL	5%
		Four chlorantraniliproles	15%
Wood powder	10%
		Potassium chlorate	15%
Ammonium chloride	20%
		Diatomite	Complement to 100%

After component in formula is mixed, granular fumicants is configured to by crushing, and by preprepared spill lead placement In fumicants, smoke agent is obtained.

The wettable powder of embodiment 18

Ivermectin HCL	5%
		Four chlorantraniliproles	25%
Lauryl sodium sulfate	1%
		Sodium lignin sulfonate	1%
White carbon	1%
		Kaolin	Complement to 100%

Active component, various auxiliary agents and filler etc. are mixed by the proportional components of formula, after ultra-fine pulverizer disintegrating, that is, obtained The wettable powder of the present invention.

The suspending agent of embodiment 19

Ivermectin HCL	2%
		Four chlorantraniliproles	10%
Alkyl dimethyl benzyl ammonium	10%
		Trisiloxanes APEO	8%
Polyvinyl alcohol	4%
		Propane diols	5%
Silicone	2%
		Water	Complement to 100%

Active component and various auxiliary agents are mixed with water, after high speed shear is scattered, sand mill is sanded, form high dispersive, steady Fixed suspension system, suspending agent is made.

The dry suspending agent of embodiment 20

Ivermectin HCL	2%
		Four chlorantraniliproles	8%
Alkyl dimethyl benzyl ammonium	10%
		Trisiloxanes APEO	8%
Polyvinyl alcohol	4%
		Propane diols	5%
Silicone	2%
		Kaolin	Complement to 100%

Active component and various auxiliary agents are mixed with water, after high speed shear is scattered, sand mill is sanded, form high dispersive, steady Fixed suspension system, suspending agent is made, obtained water slurry is obtained into the dry suspending agent of the present invention by spray drying.

The active ingredient compositions of embodiment 21

Ivermectin HCL	30%
		Four chlorantraniliproles	70%

Ivermectin HCL and four chlorantraniliproles are mixed in proportion.

The active ingredient compositions of embodiment 22

Ivermectin HCL	25%
		Four chlorantraniliproles	75%

Ivermectin HCL and four chlorantraniliproles are mixed in proportion.

The active ingredient compositions of embodiment 23

Ivermectin HCL	40%
		Four chlorantraniliproles	60%

Ivermectin HCL and four chlorantraniliproles are mixed in proportion.

Proportioning is weight per distribution ratio in above example.

The electrostatic oil agent of embodiment 24

Ivermectin HCL	1.2%
		Four chlorantraniliproles	3.8%
Calcium dodecyl benzene sulfonate	5%
		1-METHYLPYRROLIDONE	Complement to 100%

Said components are mixed evenly to obtain homogeneous phase.

The gel of embodiment 25

Ivermectin HCL	3%
		Four chlorantraniliproles	12%
Lauryl sodium sulfate	5%
		Gelling agent	1%
Water	Complement to 100%

Said components are ground in the ball mill of stirring, obtain delicate suspensions.The stabilization for being diluted with water to obtain active component is hanged Supernatant liquid, thus obtain the chlorantraniliprole gel of 3% Ivermectin HCL+12% four.

The ultra low volume liquids of embodiment 26

Ivermectin HCL	0.4%
		Four chlorantraniliproles	0.6%
Ethoxylated castor oil	5%
		Methyl oleate	Complement to 100%

Mentioned component is proportionally prepared, is uniformly mixing to obtain phase.Obtained composition is directly applied without dilution.

Embodiment

Crop protection products are made in different combination of active principles, are to develop and develop at present new crop protection products and prevent Control a kind of effective and quick way of agriculturally resistant insect.After the pestsides synthesis of different cultivars, three kinds of works are typically exhibited Use type：Summation action, synergistic effect and antagonism.But it is specially which kind of effect, it is unpredictable, only pass through many experiments Just it can know that.Compound synergic is formulated well, due to significantly improving actual prevention effect, reduces the usage amount of agricultural chemicals, from And greatly delayed the generation speed of pest resistance to insecticide, it is the important means of integrated control disease.

Inventor has carried out a large amount of examinations by substantial amounts of screening test to the different ratio of Ivermectin HCL and four chlorantraniliproles To test and effectiveness is analyzed, find in certain ratio range, resulting Pesticidal combination has gain effect, and not only Only it is the simple addition of two kinds of medicaments, is specifically illustrated with implementation below.

Tested with reference to the People's Republic of China (PRC) agricultural industry criteria (NY/T154.7-2009) farm-chemical indoor determination The synergy measure of the part mixture of criterion insecticide the 7th, according to survey data, calculate the corrected mortality of each processing, and root The co-toxicity coefficient of mixture is calculated according to the abundant methods of Sun Yun（CTC values）.

Clear and definite two kinds of medicaments compound by a certain percentage after co-toxicity coefficient（CTC）, CTC<80 be to resist effect short of money, 80≤CTC ≤ 120 be summation action, and CTC ＞ 120 are synergistic effect.

Calculation formula is as follows：

Borer population * 100 living before the death rate (%)=(borer population living after borer population-medicine living before medicine)/medicine

Corrected mortality (%)=(the treatment group death rate-control group death rate)/(the 100- control groups death rate) * 100

Probit value (y) will be converted into for examination insect corrected mortality, concentration for the treatment of (μ g/ml) is converted into logarithm value (x), with most Small square law calculates concentration LC in suppression₅₀, then according to the abundant method calculating co-toxicity coefficients (CTC) of Sun Yun.Calculation formula is following (with according to dimension Rhzomorph is standard agent, 100) its toxicity index is：

Survey toxicity index (ATI)=(standard agent LC₅₀/ reagent agent LC₅₀)×100

B percentage contains in A percentage composition+B medicaments ATI × mixture in theoretical toxicity index (TTI)=A medicaments ATI × mixture Amount

Co-toxicity coefficient (CTC)=(mixture ATI/ mixture TTI) × 100

CTC<80 show as resisting effect short of money, and 80≤CTC≤120 show as summation action, and CTC ＞ 120 show as synergistic effect.

Experiment 1：To the Toxicity Determination result of panonychus citri：

Experiment determines Ivermectin HCL, four chlorantraniliproles and the two different proportion with reference to NY/T1154.14-2009 leaf dipping methods Combine the indoor biological activity to test worm.

Using the first leaching leaf method that is followed by worm, by not in contact with the blade of the same size of any medicament in the decoction prepared Take out, naturally dry, be put into insect box after middle immersion 5s, then connect for examination larva, raise under the conditions of 25 DEG C, often handle 3 repetitions, it is 20 often to repeat test worm number used, while sets blank control, checks dead borer population in 72h, calculates the death rate and school The positive death rate, try to achieve virulence regression equation and calculate LC50 values.If compareing the death rate is more than 10%, it is considered as invalid experiment.

Table 1：

As known from Table 1, the proportioning of preventing and treating panonychus citri, Ivermectin HCL and four chlorantraniliproles is 1:1-1:When in 100 scope, Co-toxicity coefficient is all higher than 120, illustrates that both show as gain effect at mixture in the range of this.

Test the Toxicity Determination result of 2 pairs of pear suckers：

Experiment determines Ivermectin HCL, four chlorantraniliproles and the two different proportion with reference to NY/T1154.14-2009 leaf dipping methods Combine the indoor biological activity to test worm.

Using the first leaching leaf method that is followed by worm, by not in contact with the blade of the same size of any medicament in the decoction prepared Take out, naturally dry, be put into insect box after middle immersion 5s, then connect for examination larva, raise under the conditions of 25 DEG C, often handle 3 repetitions, it is 20 often to repeat test worm number used, while sets blank control, checks dead borer population in 72h, calculates the death rate and school The positive death rate, try to achieve virulence regression equation and calculate LC50 values.If compareing the death rate is more than 10%, it is considered as invalid experiment.

Table 2：

As known from Table 2, the proportioning of preventing and treating pear sucker, Ivermectin HCL and four chlorantraniliproles is 1:1-1:It is malicious altogether when in 100 scope Coefficient is all higher than 120, illustrates that both show as gain effect at mixture in the range of this.

Experiment 3:To the Toxicity Determination result of apple tree aphid：

Experiment determines Ivermectin HCL, four chlorantraniliproles and the two different proportion with reference to NY/T1154.14-2009 leaf dipping methods Combine the indoor biological activity to test worm.

Using the first leaching leaf method that is followed by worm, by not in contact with the blade of the same size of any medicament in the decoction prepared Take out, naturally dry, be put into insect box after middle immersion 5s, then connect for examination larva, raise under the conditions of 25 DEG C, often handle 3 repetitions, it is 20 often to repeat test worm number used, while sets blank control, checks dead borer population in 72h, calculates the death rate and school The positive death rate, try to achieve virulence regression equation and calculate LC50 values.If compareing the death rate is more than 10%, it is considered as invalid experiment.

Table 3：

As known from Table 3, the proportioning of preventing and treating apple tree aphid, Ivermectin HCL and four chlorantraniliproles is 1:1-1:When in 100 scope, Co-toxicity coefficient is all higher than 120, illustrates that both show as gain effect at mixture in the range of this.

Experiment 4：To the Toxicity Determination result of wild cabbage diamondback moth：

Experiment determines Ivermectin HCL, four chlorantraniliproles and the two different proportion with reference to NY/T1154.14-2009 leaf dipping methods Combine the indoor biological activity to test worm.

Using the first leaching leaf method that is followed by worm, by not in contact with the blade of the same size of any medicament in the decoction prepared Take out, naturally dry, be put into insect box after middle immersion 5s, then connect for examination larva, raise under the conditions of 25 DEG C, often handle 3 repetitions, it is 20 often to repeat test worm number used, while sets blank control, checks dead borer population in 72h, calculates the death rate and school The positive death rate, try to achieve virulence regression equation and calculate LC50 values.If compareing the death rate is more than 10%, it is considered as invalid experiment.

Table 4：

As known from Table 4, the proportioning of preventing and treating wild cabbage diamondback moth, Ivermectin HCL and four chlorantraniliproles is 1:1-1:When in 100 scope, Co-toxicity coefficient is all higher than 120, illustrates that both show as gain effect at mixture in the range of this.

Experiment 5：To the Toxicity Determination result of paddy rice rice leaf roller：

Experiment determines Ivermectin HCL, four chlorantraniliproles and the two different proportion with reference to NY/T1154.14-2009 leaf dipping methods Combine the indoor biological activity to test worm.

Using the first leaching leaf method that is followed by worm, by not in contact with the blade of the same size of any medicament in the decoction prepared Take out, naturally dry, be put into insect box after middle immersion 5s, then connect for examination larva, raise under the conditions of 25 DEG C, often handle 3 repetitions, it is 20 often to repeat test worm number used, while sets blank control, checks dead borer population in 72h, calculates the death rate and school The positive death rate, try to achieve virulence regression equation and calculate LC50 values.If compareing the death rate is more than 10%, it is considered as invalid experiment.

Table 5：

As known from Table 5, the proportioning of preventing and treating paddy rice rice leaf roller, Ivermectin HCL and four chlorantraniliproles is 1:1-1:100 scope In when, co-toxicity coefficient is all higher than 120,

Illustrate that both show as gain effect at mixture in the range of this.

Experiment 6：To the Toxicity Determination result of cotton Tetranychus cinnabarinus：

Experiment determines Ivermectin HCL, four chlorantraniliproles and the two different proportion with reference to NY/T1154.14-2009 leaf dipping methods Combine the indoor biological activity to test worm.

Using the first leaching leaf method that is followed by worm, by not in contact with the blade of the same size of any medicament in the decoction prepared Take out, naturally dry, be put into insect box after middle immersion 5s, then connect for examination larva, raise under the conditions of 25 DEG C, often handle 3 repetitions, it is 20 often to repeat test worm number used, while sets blank control, checks dead borer population in 72h, calculates the death rate and school The positive death rate, try to achieve virulence regression equation and calculate LC50 values.If compareing the death rate is more than 10%, it is considered as invalid experiment.

Table 6：

As known from Table 6, the proportioning of preventing and treating cotton Tetranychus cinnabarinus, Ivermectin HCL and four chlorantraniliproles is 1:1-1:In 100 scope When, co-toxicity coefficient is all higher than 120, illustrates that both show as gain effect at mixture in the range of this.

Experiment 7：To the Toxicity Determination result of Kidney bean Tetranychus urticae：

Experiment determines Ivermectin HCL, four chlorantraniliproles and the two different proportion with reference to NY/T1154.14-2009 leaf dipping methods Combine the indoor biological activity to test worm.

Using the first leaching leaf method that is followed by worm, by not in contact with the blade of the same size of any medicament in the decoction prepared Take out, naturally dry, be put into insect box after middle immersion 5s, then connect for examination larva, raise under the conditions of 25 DEG C, often handle 3 repetitions, it is 20 often to repeat test worm number used, while sets blank control, checks dead borer population in 72h, calculates the death rate and school The positive death rate, try to achieve virulence regression equation and calculate LC50 values.If compareing the death rate is more than 10%, it is considered as invalid experiment.

Table 7：

As known from Table 7, the proportioning of preventing and treating Kidney bean Tetranychus urticae, Ivermectin HCL and four chlorantraniliproles is 1:1-1:In 100 scope When, co-toxicity coefficient is all higher than 120, illustrates that both show as gain effect at mixture in the range of this.

Claims (14)

1. A kind of 1. Pesticidal combination, it is characterised in that：Active component is made up of (A) Ivermectin HCL and (B) four chlorantraniliprole, institute State active component（A）With（B）It is 1 by weight ratio:1-1:100, preferably 1:1-1:50, further preferably 1:1-1:40, more preferably 1: 1-1:35, more preferably 1:1-1:30, more preferably 1:1-1:25, more preferably 1:1-1:20, more preferably 1:1-1:15, more preferably 1:1- 1:10。
2. 2. Pesticidal combination according to claim 1, it is characterised in that：The active component（A）With（B）Weight accounts for described altogether Composition 0.5%-90% by weight, preferably 1%-80%, further preferably 1%-70%, more preferably 1%-60%, more preferably 1%-50%, more It is preferred that 1%-40%, more preferably 1%-30%, more preferably 1%-20%, more preferably 1%-15%.
3. 3. Pesticidal combination according to claim 1, it is characterised in that：Also include surfactant and/or filler.
4. 4. Pesticidal combination according to claim 1, it is characterised in that：The formulation is missible oil, aqueous suspension agent, oil suspension Agent, seed treatment dry powder doses, seed treatment suspending agent, water dispersible granules, wettable powder, suspension emulsion, smoke agent, coated granule Agent, extrusion granule, aqueous emulsion, microcapsule suspending agent, microcapsule suspension-suspendinagent agent, dry suspending agent, ultra low volume liquids, electrostatic oil Agent, gel.
5. 5. the Pesticidal combination described in claim 1 is used for the purposes for preventing or controlling harmful organism.
6. 6. purposes according to claim 5, it is characterised in that：Wherein harmful organism is selected from Insecta（Insecta）, spider shape Guiding principle (Arachnida), Nematoda（Nematoda）.
7. 7. purposes according to claim 5, it is characterised in that：The harmful organism is selected from Lepidoptera, Diptera, elytrum Mesh, Semiptera, Homoptera, Orthoptera, Hymenoptera, Isoptera, Siphonaptera, Blattaria, Thysanoptera, Acarina, Meloidogyne.
8. 8. purposes according to claim 5, it is characterised in that：The harmful organism is Panonychus citri, Tetranychus cinnabarinus, two variegated leafs Mite, pear sucker, aphid, diamondback moth, rice leaf roller, striped rice borer, root-knot nematode.
9. A kind of 9. method prevented or control harmful organism, it is characterised in that：Including by the Pesticidal combination described in claim 1 Act on target useful plant or its environment, object noxious livings or its environment, the propagating materials of target useful plant.
10. 10. according to the method for claim 9, it is characterised in that：The plant propagation material be seedling, rhizome, garden seedling, insert Bar or seed.
11. A kind of 11. method prevented or control pest infestation, it is characterised in that：Including by the desinsection described in claim 1 Composition contacts with target useful plant or its environment, object noxious livings or its environment, the propagating materials of target useful plant.
12. A kind of 12. method prevented or control pest infestation, it is characterised in that：It is included in target useful plant or its ring Border, object noxious livings or its environment, target useful plant propagating materials on it is any wish sequentially or simultaneously to apply weigh Profit requires the active component described in 1（A）With（B）.
13. 13. a kind of prevent and treat or prevent in plant propagation material and in growing plants organ, plant part and/or plant afterwards The method of harmful organism, it is characterised in that：Including by the Pesticidal combination described in claim 1 be applied to plant propagation material or It is environmentally.
14. A kind of 14. method for protecting seed, seedling root and branch to be attacked to prevent soil and foliar insect, it is characterised in that：Including Seed is set to be contacted with the Pesticidal combination of the claims in the present invention 1 before sowing and/or after vernalization.