CN107318863A

CN107318863A - A kind of Pesticidal combination

Info

Publication number: CN107318863A
Application number: CN201610273687.5A
Authority: CN
Inventors: 罗昌炎; 詹姆斯·T·布里斯托
Original assignee: Jiangsu Rotam Chemical Co Ltd
Current assignee: Jiangsu Rotam Chemical Co Ltd
Priority date: 2016-04-28
Filing date: 2016-04-28
Publication date: 2017-11-07
Anticipated expiration: 2036-04-28
Also published as: CN107318863B

Abstract

A kind of insecticides of the present invention, active component is made up of (A) mibemycin and (B) at least one anabasine compound, the active component（A）With（B）It is by weight ratio 1 to be by weight ratio:100‑100:1.Individually active, the of the invention Pesticidal combination compared to each compound, described active component（A）With（B）By weight ratio in foregoing ratio range, Pesticidal combination of the invention shows obvious synergistic activity.Described Pesticidal combination is used for the purposes for preventing or controlling harmful organism, especially controls the purposes of the insects such as Panonychus citri, Tetranychus cinnabarinus, Tetranychus urticae, pear sucker, aphid, diamondback moth, rice leaf roller, striped rice borer.The present invention also provides a kind of method prevented or control pest infestation, is included on target useful plant or its environment, object noxious livings or its environment, the propagating materials of target useful plant with any active component for wishing sequentially or simultaneously to apply described in the Pesticidal combination of the present invention（A）With（B）.

Description

A kind of Pesticidal combination

Technical field

The present invention relates to a kind of Pesticidal combination, active component is by least one new cigarette of (A) mibemycin and (B) Alkaloid compound is constituted.It is used for the purposes for preventing or controlling harmful organism the invention further relates to described Pesticidal combination.This hair It is bright also to provide a kind of protection seed to prevent soil insect and protect seedling root and branch to prevent the method for soil and foliar insect.

Background technology

In agricultural production, chemical agent is to prevent and treat the maximally efficient means of plant pest, still, with agricultural pests The influence of the extension of chemical prevention medication history, the agricultural chemicals not factor such as scientifical use, in recent years, agricultural pests resistance is increasingly tight Weight, the pest species for producing resistance are persistently increasing, and resistance level is higher, and resistance development speed is relatively fast.Agricultural pests Resistance problem turns into a global problem.

Mibemycin（Milbemectin）, its structural formula is formula（I）：

(Formulas I)

Mibemycin is ten hexa-atomic macrolide mixtures.Mibemycin belongs to microbial pesticide, by Environmental Protection Agency Regard as low dangerous insecticide.Mibemycin has good preventing and treating to a variety of evil mites of Tetranychidae, Xi Man sections and Eriophyidae Effect, while also there is good prevention effect to insects such as spot Liriomyza, aphid and aleyrodids.Mibemycin insecticidal spectrum is wide, Preferable prevention effect is respectively provided with to aphid, food tetranychid, malacosoma neustria, Enterozoa.It is most promising wide at present Spectrum, biological insecticides efficient, new, pest-resistant, without cross tolerance.The action principle of mibemycin and contact killing type and interior ooze type Insecticide desinsection principle it is different.It does not suppress the synthesis of protein, but the Cl- passages for causing glutamic acid to gate （Glutamate-gated chloride）Opening so that stream increase in Cl-, negatively charged Cl- causes neuron to stop Current potential hyperpolarization, prevents normal action potential from discharging, nerve conduction is obstructed, and ultimately results in insect paralysis dead.

The activity of the individual compounds is good；However, in low rate of application or they are not when being used for single insect It is that can meet the high request that insecticide, acaricide or nematicide must are fulfilled for.

Field of pest control occur a typical demand be need reduce prevent and treat active component close rate and Unfavorable environment or toxicological effects is reduced or avoids, while still allowing for the control of insect of effect.Also need to combine and knock down activity With extension preventing and treating time, i.e. snap action and the pest control agent of long-acting.

It is to repeat using another difficulty of insecticide and uniquely uses single Pesticidal compound in many cases Cause to produce the active component quick selection that is natural or adapting to drug-fast insect.Accordingly, it would be desirable to help to prevent or Overcome drug-fast pest control agent.

Therefore Agricultural pest control field continues the need for there is offer pesticide combination, and pesticide combination tends to provide improvement Characteristic, such as biological characteristics, synergism characteristic.

The content of the invention

The invention aims to solve above-mentioned technical problem there is provided a kind of Pesticidal combination, said composition is by inciting somebody to action Active component (A) mibemycin and (B) at least one anabasine compound are combined so that obtained composition is anti- Controlling has gain effect in effect, and has expanded insecticidal spectrum, improves the snap action and long-acting of control of insect, delays Drug-fast generation.

It is an object of the present invention to provide at least one solved in described problem, such as improve biological characteristics, carry For synergism characteristic, reduction close rate, expand activity profile or combine knock down activity and extension the preventing and treating time or the resistance to the action of a drug management kill Worm composition, delaying drug resistance.

The technical solution adopted for the present invention to solve the technical problems is：

A kind of Pesticidal combination, active component is made up of (A) mibemycin and (B) at least one anabasine compound, institute State active component（A）With（B）It is 1 by weight ratio:100-100:1, preferably 1:50-50:1, further preferably 1:40-40:1 further preferably 1:30-30:1, further preferably 1:25-25:1, more preferably 1:25-20:1, more preferably 1:25-15:1, more preferably 1:25-10:1, more It is preferred that 1:25-5:1, more preferably 1:20-5:1, more preferably 1:20-3:1, more preferably 1:20-2:1, more preferably 1:20-1:1, more It is preferred that 1:20-1:5；The active component（B）Selected from Diacloden, clothianidin or thiacloprid.

Diacloden, adopted name：Thiamethoxam, CAS: 153719-23-4;Chemical name：3- (the chloro- 1,3- of 2- Thiazole -5- ylmethyls) -5- methyl isophthalic acids, 3,5- oxadiazine -4- bases Asia（Nitro）Amine；

Clothianidin, adopted name：Clothianidin, CAS：210880-92-5；Chemical name：（E）-1-[（Chloro- 1, the 3- thiophenes of 2- Azoles -5- bases] methyl] -3- methyl -2- nitroguanidines；

Thiacloprid, adopted name Thiacloprid；CAS: 111988-49-9；Chemical name：(Z) -3- (6- chloro-3-pyridyls Methyl) the sub- cyanamide of -1,3- thiazoline -2- bases.

At least one anabasine compound of active component (A) mibemycin and (B) in the present invention is by weight ratio It for example can also be 1:100, 1:90,1:80, 1:70, 1:60, 1:50, 1:45, 1:40, 1:35, 1:30, 1:25, 1:24, 1:23, 1:22, 1:21, 1:20,1:19, 1:18, 1:17,1:16, 1:15, 1:14, 1:13,1:12, 1: 11, 1:10,1:9, 1:8, 1:7,1:6,1:5,1:4, 1:3, 1:2, 1:1, 2:1, 3:1, 4:1, 5:1, 10:1, 15:1,20:1, 25:1, 30:1, 35:1, 40:1, 45:1, 50:1, 60:1, 70:1, 80:1, 90:1, 100:1。

A kind of Pesticidal combination, active component is by (A) mibemycin and (B) at least one anabasine compound group Into, the active component (A) and（B）Weight account for the 5%-90% of the composition by weight altogether.

A kind of Pesticidal combination, active component is by (A) mibemycin and (B) at least one anabasine compound group Into, the active component (A) and（B）Weight account for the 5%-80% of the composition by weight altogether.

A kind of Pesticidal combination, active component is by (A) mibemycin and (B) at least one anabasine compound group Into, the active component (A) and（B）Weight account for the 5%-70% of the composition by weight altogether.

A kind of Pesticidal combination, active component is by (A) mibemycin and (B) at least one anabasine compound group Into, the active component (A) and（B）Weight account for the 5%-60% of the composition by weight altogether.

A kind of Pesticidal combination, active component is by (A) mibemycin and (B) at least one anabasine compound group Into, the active component (A) and（B）Weight account for the 5%-50% of the composition by weight altogether.

A kind of Pesticidal combination, active component is by (A) mibemycin and (B) at least one anabasine compound group Into, the active component (A) and（B）Weight account for the 5%-40% of the composition by weight altogether.

A kind of Pesticidal combination, active component is by (A) mibemycin and (B) at least one anabasine compound group Into, the active component (A) and（B）Weight account for the 5%-30% of the composition by weight altogether.

A kind of Pesticidal combination, active component is by (A) mibemycin and (B) at least one anabasine compound group Into, the active component (A) and（B）Weight account for the 5%-20% of the composition by weight altogether.

A kind of Pesticidal combination, active component is by (A) mibemycin and (B) at least one anabasine compound group Into, the active component (A) and（B）Weight account for the 5%-15% of the composition by weight altogether.

A kind of Pesticidal combination, active component is by (A) mibemycin and (B) at least one anabasine compound group Into, the active component (A) and（B）Weight to account for the composition altogether can also be, for example, 5%, 10%, 15% by weight, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%。

According to the Pesticidal combination of the present invention, also comprising surfactant and/or extender.

According to the Pesticidal combination of the present invention, the Pesticidal combination can be configured to any formulation agriculturally allowed.

According to the Pesticidal combination of the present invention, the formulation of the Pesticidal combination is missible oil, suspending agent, seed treatment dry powder Agent, seed treatment suspending agent, water dispersible granules, wettable powder, suspension emulsion, smoke agent, coated granule, extrusion granule, Aqueous emulsion, microcapsule suspending agent, microcapsule suspension-suspendinagent agent, dry suspending agent, ultra low volume liquids.

On the other hand, it is used to prevent present invention also offers a kind of Pesticidal combination by the present invention or controls harmful organism Purposes, wherein harmful organism be selected from Insecta（Insecta）, Arachnoidea (Arachnida), Nematoda（Nematoda）.

The harmful organism of the present invention may be selected from Lepidoptera, Diptera, coleoptera, Semiptera, Homoptera, Orthoptera, film wing Mesh, Isoptera, Siphonaptera, Blattaria, Thysanoptera, Acarina, nematode etc..

It is preferred that, Pesticidal combination of the invention is used to prevent and treat Panonychus citri, Tetranychus cinnabarinus, Tetranychus urticae, pear sucker, aphid Worm, diamondback moth, rice leaf roller, striped rice borer.

On the other hand, present invention also offers a kind of method prevented or control harmful organism, by the desinsection group of the present invention Compound acts on target useful plant or its environment, object noxious livings or its environment, the propagating materials of target useful plant.Institute It is seedling, rhizome, garden seedling, cutting or seed to state plant propagation material.

A kind of method for protecting useful plant to prevent pest infestation, including make the Pesticidal combination and target of the present invention Useful plant or its environment, object noxious livings or its environment, the propagating materials contact of target useful plant.

The present invention provides a kind of protection useful plant to prevent the method for pest infestation, and it is included in target useful plant Or wished sequentially or simultaneously with any on its environment, object noxious livings or its environment, the propagating materials of target useful plant Using comprising active component (A) and（B）Combination.

Present invention discover that：The Insecticidal combinations of the present invention can not only bring the additive property raising for insecticidal spectrum, but also real Now prevent or control harmful organism amazing " synergy " effect.

Term " synergy " used herein refers to inventive compound combination insecticidal effect and is more than each active component effect Sum, in other words, its effect is superadditivity.

The present invention provides a kind of Pesticidal combination, and active component is by (A) mibemycin and (B) at least one anabasine Compound group is into the active component（A）With（B）It is 1 by weight ratio:100-100:1, preferably 1:50-50:1, further preferably 1: 40-40:1 further preferably 1:30-30:1, further preferably 1:25-25:1, more preferably 1:25-20:1, more preferably 1:25-15:1, it is more excellent Select 1:25-10:1, more preferably 1:25-5:1, more preferably 1:20-5:1, more preferably 1:20-3:1, more preferably 1:20-2:1, it is more excellent Select 1:20-1:1, more preferably 1:20-1:5；The active component（B）Selected from clothianidin, Diacloden or thiacloprid.

A kind of Pesticidal combination individually active compared to each compound, of the invention, active component of the present invention（A） With（B）By weight ratio in foregoing ratio range, Pesticidal combination of the invention shows obvious synergistic activity.

The total amount of active component can be selected according to material elements in the present composition, to realize desired work With.The factor is for example, formulation, object to be administered, application process etc..The present invention a kind of Pesticidal combination, active component by (A) mibemycin and (B) at least one anabasine compound composition, the active component（A）With（B）Weight accounts for institute altogether Composition 5%-90% by weight, more preferably preferably 5%-80%, more preferably 5%-70%, more preferably 5%-60%, 5%-50% are stated, More preferably 5%-40%, more preferably 5%-30%, more preferably 5%-20%, more preferably 5%-15%, the active component（B）Selected from thiophene worm Amine, Diacloden or thiacloprid.

A kind of Pesticidal combination, active component is by (A) mibemycin and (B) at least one anabasine compound group Into, the active component (A) and（B）Weight to account for the composition altogether can also be, for example, 5%, 10%, 15% by weight, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, institute State active component（B）Selected from clothianidin, Diacloden or thiacloprid.

The Pesticidal combination of the present invention optionally includes agronomically acceptable surfactant or extender.

According to the present invention, term " filler ", which refers to, can be combined with active component or combines to make it easier for being applied to pair As（Such as plant, crop or careless class）Natural or synthetic organic or inorganic compound.Therefore, the filler is preferably lazy Property, it at least should be agricultural acceptable.The filler can be solid or liquid.

Applicable solid-filling agent, such as phyteral powdery type（For example soy meal, starch, grain dust, wood powder, bark powder, Sawdust, walnut shell powder, wheat bran, cellulose powder, coconut husk, the particle of corncob and tobacco stem, extract residual after plant essence Slag etc.）, clay class（Such as kaolin, bentonite, acid china clay）, talcum powder class, silica（Such as diatomite, silica sand, cloud Female, aqueous silicic acid, calcium silicates）, activated carbon, natural mineral matter class（Float stone, attapulgite and zeolite etc.）, fire diatomite, sand, Plastics medium etc.（Such as polyethylene, polypropylene, polyvinylidene chloride）, potassium chloride, calcium carbonate, the inorganic mineral of calcium phosphate etc. Property powder, ammonium sulfate, ammonium phosphate, urea, chemical fertilizer, the clay fertilizer of greening ammonium etc., these materials can be used alone or 2 kinds It is mixed above.

Applicable liquid filler can be selected in llowing group of materials, such as water, alcohol type（Such as methanol, ethanol, isopropyl Alcohol, butanol, ethylene glycol etc.）, ketone（Such as acetone, methyl ethyl ketone, isobutyrone, cyclohexanone）, ethers（Such as second Ether, dioxanes, methylcellulose, tetrahydrofuran etc.）, aliphatic hydrocarbon class（Such as kerosene, mineral oil）, aromatic series Hydrocarbon（Such as benzene,toluene,xylene, solvent naphtha, alkylnaphthalene, chlorinated aromatic hydrocarbons, chlorinated aliphatic hydrocarbon, chlorobenzene）, halogen Change hydrocarbon, amide-type, sulfone class, dimethyl sulfoxide (DMSO), mineral and vegetable oil, animal oil etc..

The Pesticidal combination of the present invention can also include additional other components, such as surfactant.Live on applicable surface Property agent has the emulsifying agent with ion or non-ionic nature, dispersant or a wetting agent, or these surfactants mixture.This The suitable of a little surfactants has AEO, polyoxyethylene alkylaryl ether, polyoxyethylene higher fatty acid Ester, the phosphate of polyoxyethylene alcohol or phenol, the fatty acid ester of polyalcohol, alkylaryl sodium sulfonate, naphthalene sulfonic acid polymer, sulfomethylated lignin Hydrochlorate, comb polymer molecule copolymer, butyl naphthalene sulfonate, alkylaryl sulfonates, sodium alkylsulfosuccinates, grease, fat Polyacrylate, the protein hydrolysate such as alcohol and ethylene oxide condensate, alkyltaurate.Suitable oligosaccharide thing or polymerization Thing, for example based on single vinyl monomer, acrylic acid, polyoxyethylene or polyoxypropylene or its with for example（It is polynary）Alcohol or（It is many Member）The combination of amine.When a kind of water insoluble in one kind and/or inert carrier in active component and when being applied in water, There must be surfactant.The ratio of surfactant is 5% to 40% weight of the Pesticidal combination of the present invention.

If appropriate, can also exist other addO-on therapies, for example protecting colloid, adhesive, adhesive, thickener, touch Become agent, bleeding agent, stabilizer, screening agent, sequestering agent, complex-forming agents.Generally, described active component can with it is normal Advise any solid or the liquid additive combination for preparation purpose.

The preparation of the present invention can be entered at least one of the active component and following material by known way Row mixing：Solvent or diluent, emulsifying agent, dispersant, and/or adhesive or fixative, wetting agent, waterproofing agent, if it is desired, Drier and colouring agent, stabilizer, pigment, defoamer, preservative, thickener, water and other processing aids can also be included. Can be by equably mixing and/or grinding active component with solid-filling agent or liquid filler, suitable surfactant To prepare the Pesticidal combination of the present invention.

The Pesticidal combination of the present invention can be used with itself, or can be according to its respective physically and/or chemically property Used with its dosage form or type of service prepared therefrom, for example aerosol, micro-capsule suspension, harl agent, thermal fog, micro- Capsule granula, granula subtilis, seed treatment suspending agent, ready to use solution agent, pulvis, missible oil, oil-in-water emulsion, water-in-oil type breast Agent, big granula, fine granule, oil-dispersing property pulvis, oil suspending agent, finish, foaming agent, paste, seed coat agent, colloidal suspending agent, suspended emulsion, Aqueous solvent, suspending agent, wettable powder, soluble powder, pulvis and granule, water-soluble granular formulation or tablet, seed treatment With in water solube powder, wettable powder, the natural prodcuts of activity component impregnation and synthetic, polymeric material with seed cladding Microcapsules in material, and the agent of ultra-low volume harl and hot mist preparation.

The Pesticidal combination of the present invention can also be applied with other active ingredient combinations, and other active components are for example killed Epiphyte pharmaceutical, bactericide, attractant, insecticide, acaricide, nematicide, growth regulator, herbicide, safener, fertilizer Or semiochemical etc..

The Pesticidal combination of the present invention, with good plant compatibility and favourable homeothermal animal toxicity, suitable for preventing and treating The harmful organism run into agricultural, forestry, protection Stored Product and material and health field, especially Insecta （Insecta）, Arachnoidea (Arachnida), Nematoda（Nematoda）.They have for the species of generally sensitive and resistance Activity, and activity is respectively provided with for all or single stage of development, and also realize that prevention or control harmful organism make us frightened " synergy " effect of happiness

Present invention also offers the purposes that a kind of Pesticidal combination by the present invention is used to preventing or controlling harmful organism.Herein Being meant using term " harmful organism " can be to the damnous any organism of normal condition of plant.Including Insecta （Insecta）, Arachnoidea (Arachnida), Nematoda（Nematoda）.

Insecta include Lepidoptera, coleoptera, Diptera, Semiptera, Homoptera, Hymenoptera, Thysanoptera, Isopoda, times Sufficient mesh, lip foot mesh, comprehensive mesh, Thysanoptera, Collembola, Collembola, Orthoptera, Blattaria, Dermaptera, Isoptera, Anoplura.

Lepidoptera pest, for example：Striped rice borer（chilosuppressalis（walker）, yellow rice borer （Tryporyzaincertulas（walker））, rice leaf roller（cnaphalocrocismedinalisGuenee）, cabbage heart Snout moth's larva（hellullaundalis）, dichocrocis punctiferalis（conogethespunctiferlis）, papilio xuthus Linnaeus（papilioxuthus）, it is white White butterfly（pierisrapaecrucivora）, straight burr rice hesperiidae（parnaraguttata）, tent caterpillar（malacosoma Neustria testacea）, gypsymoth（lymantriadispar）, fall webworms（hyphantriacunea）, east poison moth （euproctissubflava）, black line slug moth（scopelodescontracus）, bollworm （helicoverpaarmigera）, Pectinophora gossypiella（Pink bollworm）, cabbage looper（trichoplusiani）, wild cabbage night Moth（mamestrabrassicae）, beet armyworm（spodopteraexigua）, prodenia litura（spodopteralitura）、 Tea olethreutid（adoxophyesoranafasciata）, leaf roller（adoxophyeshonmai）, apricot yellow volume moth （archipsfuscocureanus）, Homonamagnanima（homonamagnanima）, diamondback moth（plutellaxylotella）, cotton Pink bollworm（pectinophoragossypiella）.

Coleopteran pest, for example：Rice weevil（sitophilusoryzaelinne）, citrus leaf mining first（Podagricomela nigricollis Che）, sitophilus zea-mais（S.zeamails）, grain weevil（S.granarius）, big daikon leaf beetle （Cabbageleafbeetle）, daicon leaf beetle（Daikon leaf beele）, flea beetle（fleabeetle）, grape flea beetle （Alticachalybea）, cabbage flea beetle（phyllotretastriolata）, cucumber flea beetle（Epitrixcucumeris）, cigarette Careless flea beetle（Ehirtipennis）, eggplant flea beetle（E.fuscula）, aulacophora femoralis（Aulacophoraindica（Gemlin）, leaf mustard It is chrysomelid（Phaedon cochleariae）Deng.

Diptera pest, for example：Rice leafminer（agromyzaoryzae）, hydrellia griseola（hydrelliagriseola）, it is non- Continent chrysanthemum liriomyza bryoniae（liriomyzatrifolii）, pea leaf dive fly（chromatomyiahorticola）, Liriomyza brponiae （liriomyzabryoniae）, delia platura（deliaplatura）, green onion ground Hylemyia Platura Meigen（deliaantiqua）Mediterranean fruitfly （ceratitiscapiatawiedgman）, Rhagoletis pomonella（Rhagoletispomonella）, cherry fruit fly （R.cingulata）.

Hemipteran pest, for example：Smelly stinkbug（megacoptapunctatissimum）, cabbage bug（eurydemarugosum）、 Big thorn white star stinkbug（eysarcorislewisi）, white star stinkbug（eysarcorisparvus）, green rice bug（nezaraviridula）、 Si Shi amber stinkbugs（plautiastali）, clerodendron trichotomum stinkbug（halymorphamista）, rice spiny coreid（cletuspunctiger）, in Magnificent Leptocorisa spp（leptocorisachinensis）, azelea lace bug（stephantispyrioides）, it is red must fleahopper （trigonotyluscoelestialium）.

Homoptera pest, such as rice green leafhopper（nephotettixcincticeps）, small brown rice planthopper （laodelphaxstriatellus）, brown plant-hopper（nilaparvatalugens）, white backed planthopper （sogatellafurcifera）, pear sucker（psyllapyrisuga）, diaphorina citri（diaphorinatabaci）, Bemisia tabaci （bemisiatabaci）, aphid（homoptera）, apple aphid（eriosomalanigerum）.

Hymenoptera（hymenoptera）Insect, such as yellow-winged cabbage sawfly（athaliarosaeruficornis）, japanese rose leaf Honeybee（argepagana）, Black Hills ant（formica japonica）, chestnut gall wasp（dryocsmuskuriphilus）Deng.

Thysanoptera, such as thrips（HaplothripsChinensisPriesner）.

Isopoda（Isopoda）, for example, Cape jasmine beach louse（Oniscus asellus）, pillworm（Armadilliudium vulgare）, ball pillworm（Porcellio scaber）.

Times sufficient mesh insect, for example, Blaniulus guttulatus.

Lip foot mesh insect, for example, ground Scolopendra (Geophilus carpophagusScutigera spp.).

Comprehensive mesh insect, for example, kahikatea worm (Scutigerella immaculata).

Thysanoptera insect, for example, silverfish (Lepisma saccharina).

Collembola insect, for example, arms Onychiurus arcticus (Onychiurus armatus).

Orthoptera pest, for example, family Xi (Acheta domesticus), mqb category category kind of (Gryllotalpa spp. ), it is Asiatic migratory locust (Locusta migratoriamigrator ioides), black locust category kind of (a Melanopluss pp.), husky Unconcerned locust (Schistocercagregaria).

Blattaria insect, for example, oriental cockroach (Blattaorientalis), American cockroach (Periplaneta Americana), leucophaea maderae (Leucophaea maderae), Groton bug (Blattella germanica).

Dermaptera insect, for example, European earwig (Forficula auricularia).

Isoptera insect, for example, Reticulitermes kind (Reticulitermes spp.).

Anoplura (Anoplura, Phthiraptera), such as Damalinia (Damalinia spp.), Haematopinus (Haematopinus spp.), Linognathus (Linognathus spp.), Pediculus (Pediculus spp.), Trichodectes (Trichodectes spp. )。

Arachnoidea（Arachnida）Insect.Such as panonychus citri（panonychus citri）, Tetranychus cinnabarinus （Tetranychus cinnabarinus）, panonychus ulmi（panonychus ulmi）, Tetranychus urticae（tetranychus urticae）, tetranychus viennensis（tetranychus viennensis）, oligonychus ununguis（oligonychus ununguis）Mandarin orange Tangerine beginning tetranychid（eotetranychus kankitus）, purplish red short hairs mite（brevipalpus phoenicis）, Bryobia praetiosa （bryobiapraetiosa）, wheat leaf roll mite（aceria tulipae）, grape erineum mite (Eriophyes vitis)（colomerus vitis）, tealeaves Goitre mite（calacarus carinatus）, yellow tea mite（polyphagotarsonemus latus）, long hair root mite （rhizoglyphus rostochiensis）, Acarus siro（Acarus siro）, citrus aceria（Aceria sheldoni）, steinman pin thorn goitre mite（Aculus schlechtendali）, Tetranychus（Tetranychus spp.）, Panonychus citri Category（Panonychus spp.）, wrinkle Genus Phyllocoptess（Phyllocoptruta spp.）, short whisker Acarapis（Brevipalpus spp.）Deng.

Nematoda（(Nematoda)）Representative biology have selected from Meloidogyne（Meloidogyne spp.）, different skin Turbatrix（Heterodera spp.）, ball Heterodera（Globodera spp.）, perforation line Eimeria（Radopholus spp.）, Pratylenchus（Pratylenchus spp.）, minute hand Turbatrix（Longidorus spp.）Deng.It is preferred that lower alignment The soybean cyst nematode Heterodera glycines of worm（Heterodera）, globodera rostochiensis（golbodera rostochiensis）, Root Knot line Worm（meloidogyne incognita）Deng.

According to the combination of the present invention for confrontation insect, such as insect, immature insect, insect at initial stage and insect ovum are Environment effective and that insect or their existence can be applied directly to.The insect bag controlled according to the Insecticidal combinations of the present invention Include agricultural/horticultural insect, insect pest, storage insect insect, clothes insect and the furniture insect of health.

The Pesticidal combination of the present invention is particularly suitable for preventing and treating Panonychus citri category, short whisker Acarapis, Tetranychus and wrinkle leaf Aculus One or more in category, Homoptera, Lepidoptera.The Pesticidal combination of the present invention can not only bring the additive property for insecticidal spectrum Improve, but also realize prevention or control harmful organism amazing " synergy " effect.

More preferred, Pesticidal combination of the invention is suitable for preventing and treating Panonychus citri, Tetranychus cinnabarinus, Tetranychus urticae, pears Wood louse, aphid, diamondback moth, rice leaf roller, striped rice borer.

On the other hand, present invention also offers a kind of method prevented or control harmful organism, by the desinsection group of the present invention Compound is applied to target useful plant or its environment, object noxious livings, the propagating materials of target useful plant.

The Pesticidal combination of the present invention shows particularly advantageous effect when being applied to such as following useful plant：Cereal Such as wheat, oat, barley, spelt (spelt), triticale and rye, and it is corn, jowar He Li, rice, sweet Sugarcane, soybean, sunflower, potato, cotton, rape (oil seed rape), canola (canola), tobacco, sweet tea Dish, fodder beet, asparagus, hops and fruit bearing plant (including the operatic circle such as apple and pears, drupe for example peach, honey peach, cherry, plum, Apricot, cedra fruits for example orange, grape cypress, bitter orange, twist Lu, cumquat, citrus and Sa Mo tangerines, nut for example pistachio, almond, Walnut and pecan, tropical fruit (tree) such as mango, papaya, pineapple, nipa palm and banana, and grape) and vegetables (including leaf vegetables Class such as hare's-lettuce, corn salad, fennel, Leaf lettuce, celery lettuce, Swiss chard, spinach and salad with witloof, wild cabbage such as cauliflower, Broccoli, Chinese leaf, Brassica oleracea (L.) convar. acephalavar. sabellicaL. (wrinkle leaves Wild cabbage, collard), kohlrabi, brussels sprout, red cabbage, white cabbage and savoy, fruit vegetables such as eggplant, Huang Melon, capsicum, edible squash, tomato, bush pumpkin and corn, root vegetables such as celeriac, rape, carrot include yellow product Kind, wild radish class include Raphanus sativus var. niger and Raphanus sativus var.radicula, Beet, celery, legume such as pea and soybean, and allium vegetables such as leek and onion).

The suitable useful plant of the present invention also includes the genetically modified plants converted by recombinant DNA technology.

It is particularly suitable for preventing or controls according to the Pesticidal combination of the present invention：

Pest and disease damage crop

Panonychus citri belongs to（Panonychus spp.）Citrus, apple fruits and vegetables, a kind of fruit, such as apple, pear, etc., drupe sets nut

Short whisker Acarapis（Brevipalpus spp.）Citrus, coffee, apple fruits and vegetables

Wrinkle Genus Phyllocoptess（Phyllocoptruta spp.）Citrus

Tetranychus（Tetranychus spp.）Citrus, apple fruits and vegetables, a kind of fruit, such as apple, pear, etc., drupe sets nut

Homoptera pest（Homoptera）Citrus, apple fruits and vegetables

Lepidoptera (Lepidoptera) citrus, apple fruits and vegetables

The present invention provides a kind of method prevented or control harmful organism, and it is useful that the Pesticidal combination of the present invention is applied into target Plant or its environment, object noxious livings or its environment, the propagating materials of target useful plant.

The present invention also provides a kind of method for protecting useful plant to prevent pest infestation, and it is included in the useful plant of target Wished serially or simultaneously with any on thing or its environment, object noxious livings or its environment, the propagating materials of target useful plant Ground administration of active ingredients by (A) and (B) combination.

Term " plant propagation material " is interpreted as referring to all plant parts for having a fertility, such as seed, and it can be used In breeding the latter, and vegetable matter such as cuttage bar or stem tuber（Such as potato）.Therefore, plant used herein Part includes plant propagation material.It is mentioned that such as seed, root, fruit, stem tuber, bulb, rhizome and plant part.Treat The germination plant and effective plant suppressed after being germinateed from soil or after emerging.Young plant can be before transplantation by being impregnated into Row whole or Local treatment are protected.Plant propagation material preferred seed.

Processing with the Pesticidal combination of the present invention to useful plant is directly carried out with conventional treatment method, at the routine Reason method for example impregnates, poured, being sprayed, atomizing, broadcasts sowing, dust, mist formation, broadcast sowing, foam, coating, being coated with, drip irrigation； In the case of propagating materials, especially in the case of seed, for the pulvis of dry seedses processing, seed treatment solution, slurry Expect processing water-soluble powder form, be coated by crust, by one or more layers etc..

The Pesticidal combination of the present invention can be used to protect useful plant or their propagating materials.Therefore, it is of the invention to kill Worm composition can in a usual manner, such as foliar spray is applied to useful plant.

The Pesticidal combination of the present invention not only includes can use what suitable device was applied to plant or seed to use composition, And the commercially available concentrate including that must be diluted with water before administration.

The present invention also provides a kind of in plant propagation material and growing plants organ, plant part and/or plant after The method that harmful organism is prevented and treated or prevented in thing, including the Pesticidal combination of the present invention is applied to plant propagation material or its ring On border.Plant propagation material preferred seed.

The method of the present invention can be applied to the seed of any physiological status.Preferred seed is in state durable enough, So as to without damage in processing procedure.Usually, seed can be harvested from field, remove from plant, be isolated from any fringe Axle, stem, the pulp or the seed of other non-seed vegetable materials of crust and surrounding.Seed can also be preferably stable on biology , to reach that processing will not cause the degree of biological damage to seed.Between seed harvest and seed sowing or it can broadcast Any time processing during the process of kind is applied to seed.Seed can also vernalization before and after treatments.

The seed of Pesticidal combination processing by the present invention can be stored, manages, sow and farming.

Seed treatment can by with it is any wish sequentially or simultaneously to its administration of active ingredients (A) and（B）.

Seed treatment occurs on unseeded seed, term " unseeded seed " be intended to include in seed harvest and The seed in any period between seed is in plant germination and growth purpose sowing in soil.Preferably, processing is broadcast in seed Occur before kind, so that the sowing seed is pretreated with the combination.Especially, seed pelleting or pellet seeds are at this It is preferred to invent in the processing of combination.After processing, the composition in each combination is attached on seed and therefore available for insect pest Preventing and treating.

The present invention also provides a kind of protection seed to prevent soil insect and protection seedling root and branch to prevent soil and blade face The method of insect, it is included in before sowing and/or makes the Insecticidal combinations of the invention of seed and insecticidal effective dose after vernalization Thing is contacted.

Therefore, a kind of method for protecting seed, seedling root and branch to be attacked to prevent soil and foliar insect, is included in sowing In the past and/or after vernalization contact seed and the Pesticidal combination of effective dose of the present invention.

The present invention also provides a kind of method for protecting vegetable seeds, and it includes making seed prior to seeding and/or after vernalization Contacted with the Pesticidal combination of the invention of effective dose.

The present invention also provide it is a kind of protect useful plant to prevent pest infestation method, including by the present invention desinsection Composition is applied to environment, habitat or the storage areas of useful plant growth.The environment of plant growth, habitat are to refer to make agriculture The supporter that crop takes root, grown, for example：Soil, water etc., specific raw material can use for example sand, float stone, vermiculite, Diatomite, agar-agar, gelling material, polymer substance, asbestos, wood chip, bark etc..It is preferred that soil.

The method that medicament is applied into soil, for example, be diluted in liquid preparation in water or do not dilute and be directly applied to plant The medium method in the root of body or the rice seedling bed of seedling, granule is disseminated to the side in the rice seedling bed of the root of plant or seedling Method has the method that pulvis, water dispersible granules etc. are sprayed in soil prior to seeding and integrally mixed with soil, and sowing is preceding or plants It will be sprayed on before planting plant after pulvis, water-dispersible grain dilution agent in implantation hole, seed furrow, in method sowed etc..

The present invention also provides a kind of method for protecting useful crop to prevent pest infestation, including joint, separate or according to Secondary administration of active ingredients (A) and（B）.In the case of separate administration, order does not influence generally on the result of prophylactico-therapeutic measures.

The present invention provides a kind of method prevented or control harmful organism, and the Pesticidal combination of the present invention is acted on into target Useful plant or its environment, object noxious livings, the propagating materials of target useful plant, other agricultural chemicals can apply activearm Before point (A) and (B), with active component (A) and (B) afterwards independently of each other simultaneously or in administration of active ingredients (A) and (B) Using, and in the case of active component (A) and (B) separate administration, each other agricultural chemicals can in administration of active ingredients (A) and (B) simultaneously, between administration of active ingredients (A) and (B) or applying Mil lived with administration of active ingredients (A) and (B) before Property component (A) and (B) after apply independently of each other.

On the other hand, processing of the invention can also produce following super additive effect：Improve plant growth, improve to high temperature Or low temperature tolerance, improve to arid or tolerance to water or soil salt content, improve Flowering quality, make harvesting simpler Just, accelerate ripe, raising harvesting yield, improve the quality of harvested products and/or improve its nutritive value, improve harvested products Bin stability and/or its processing characteristics.

The amount of application of composition for example changes according to usage type, agrotype, but the active component in combination is to provide Desired humidification（Prevention and control to harmful organism）Effective dose and can be by those of ordinary skill in the art The experiment and routine test known is determined.

It is common and favourable that the Pesticidal combination of the present invention is generally applied with following dosage：

- for leaf portion processing：0.05-3kg/ha, preferably 0.1-1kg/ha, more preferably 10-300 g/ha；More preferably 10-200g/ ha；More preferably 10-100g/ha；More preferably 10-50g/ha；For impregnating or instiling and apply, the dosage even can be with Reduction, particularly when applying inert base such as asbestos or pearl rock；

- for seed treatment：2-200g/100kg seeds, preferably 3-150g/100kg seeds；

- for soil treatment：0.1-5kg/ha, preferably 1-1kg/ha.

Above-mentioned dosage is only general exemplary dose, and those skilled in the art can be according to actual feelings during actual administration Condition and needs, rate of application is adjusted especially in accordance with the property and insect pest situation of pending plant or crop.

It should be pointed out that the present invention any embodiment or embodiment any technical characteristic can independently with this Any other embodiment of invention is combined with each other.That is, one or more technologies of any embodiment of the present invention Feature can all be reconfigured with any other technical characteristic.Thus technical characteristic reconfigure formed by technical characteristic be disclosed in Herein, as especially being recorded herein it.

The benefit of the Pesticidal combination of the present invention has at following 5 points：

A, compared with single compound activity, Pesticidal combination of the invention may indicate that the activity of collaboration；

B, the plant of the Pesticidal combination processing of the present invention, plant propagation material have reached the water for being demonstrated by being significantly improved It is flat；

C, the Pesticidal combination of the present invention reduce any undesirable pestinfestation and attack；

D, both use with, the problem of solving lasting period and quick-acting, so as to reduce times for spraying, reduces cost of labor；

E, the generation for having delayed resistance：Both mechanisms of action and the mode of action are entirely different, have after combination tag, stomach toxicity, The effect of ovicidal and reduction spawning rate and incubation rate, so that insect is more easy to be killed, so as to delay the generation of resistance；

F, the preventing and treating spectrum for having widened mibemycin, anabasine compound is to Homoptera, coleoptera, Diptera and Lepidoptera etc. Insect etc. has preferable prevention effect, after being combined with mibemycin, effectively prevents and treats mite class, aphid, diamondback moth, snout moth's larva, pears Endangered while wood louse.

Embodiment

Below with reference to embodiment, the invention will be further elaborated：

Example of formulations

The missible oil of embodiment 1

Mibemycin	1%
		Diacloden	10%
Cyclohexanone	20%
		Castor oil polyglycol ether（35mol oxirane）	5%
Calcium dodecyl benzene sulfonate	3%
		Xylene mixture	Complement to 100%

Said components are mixed to the liquid of transparent and homogeneous, that is, obtain the cream preparation of the present invention.Can be by being diluted with water Above-mentioned concentrate, obtains the emulsion of any required dilute strength available for plant protection.

The wettable powder of embodiment 2

Mibemycin	5%
		Clothianidin	50%
NaLS	2%
		Sodium lignin sulfonate	10%
White carbon	10%
		Kaolin	Complement to 100%

The active component is sufficiently mixed with the auxiliary agent, and mixture is fully ground in suitable flour mill, obtains wettable Property pulvis.The suspension for providing and wishing concentration can be provided with water.

The aqueous emulsion of embodiment 3

Mibemycin	1%
		Diacloden	10%
1-METHYLPYRROLIDONE	15%
		Neopelex	5%
Phenethyl phenol APEO	5%
		Water	Complement to 100%

Active component is added together with auxiliary agent, makes to be dissolved into homogeneous oil phase；Water-soluble component and water are mixed to prepare aqueous phase； It is under high-speed stirred, oil phase is mixed with water, the aqueous emulsion of the present invention is made.

The water dispersible granules of embodiment 4

Mibemycin	5%
		Thiacloprid	40%
Sodium lignin sulfonate	5%
		Lauryl sodium sulfate	10%
White carbon	5%
		Kaolin	Complement to 100%

Active component, dispersant, wetting agent, disintegrant and filler are well mixed in the ratio of formula, by air-flow crushing into Wettable powder, adds a certain amount of water mixing extruder grain.The water dispersible granules of the present invention are obtained after drying screening.

The microemulsion of embodiment 5

Mibemycin	1%
		Diacloden	5%
1-METHYLPYRROLIDONE	20%
		Ethoxylated castor oil	30%
AEO sulfosuccinic acid monoesters disodium	30%
		Water	Complement to 100%

Said components are mixed to the liquid of transparent and homogeneous, that is, obtain the microemulsion of the present invention.

The seed treatment dry powder doses of embodiment 6

Mibemycin	1%
		Diacloden	20%
Light mineral oil	10%
		Sodium lignin sulfonate	15%
High dispersive silicic acid	10%
		Talcum	20%
Kaolin	Complement to 100%

The active component is sufficiently mixed with the auxiliary agent, and mixture is fully ground in suitable flour mill, and obtaining can be straight Connect the pulvis for seed treatment.

The suspension emulsion of embodiment 7

Mibemycin	2%
		Thiacloprid	40%
SOLVESSO^TM200	10%
		Ethoxylated castor oil	4%
AEO sulfosuccinic acid monoesters disodium	10%
		MODIFIED LIGNOSULPHONATE	5%
Xanthans	0.5%
		Bentonite	1%
Glycerine	5%
		Defoamer	0.6%
Water	Complement to 100%

Mibemycin is dissolved in SOLVESSO^TMIn 200, ethoxylated castor oil is added, missible oil is obtained；By thiacloprid, fat On fat alcohol polyoxyethylene ether sulfosuccinic acid monoester disodium, MODIFIED LIGNOSULPHONATE, xanthans, bentonite, glycerine, water etc. State each component to mix in proportion, and through being sanded, be prepared into the suspending agent containing thiacloprid.Oil phase containing mibemycin is added Enter into the suspending agent containing thiacloprid, obtain suspension emulsion.

The aqueous emulsion of embodiment 8

Oil phase：

Mibemycin	1%
		Diacloden	5%
Methyl oleate	10%
		Polystyrene	3.7%

Aqueous phase：

Xanthans	0.07%
		The sodium salt of naphthalene sulfonic acids-formaldehyde condensation products of sulfonation	1%
Bactericide	0.2%
		Water	Complement to 100%

Mibemycin and thiacloprid are dissolved in methyl oleate, polystyrene is added and obtains oil phase；According to the group in formula Divide to be well mixed and obtain aqueous phase；Oil phase addition aqueous phase is obtained into aqueous emulsion under agitation.

The wettable powder of embodiment 9

Mibemycin	2%
		Clothianidin	30%
Sodium lignin sulfonate	7%
		NaLS	2%
Kaolin	Complement to 100%

Combinations thereof is mixed in proportion, and ground, crushes, is prepared into wettable powder.

The coated granule of embodiment 10

Mibemycin	2%
		Clothianidin	50%
Polyethylene glycol	3%
		The silicic acid of high degree of dispersion	1%
Calcium carbonate	Complement to 100%

In a mixer, by levigate active component even spread to the carrier soaked by polyethylene glycol.It can obtain in this way Obtain dust-free coated granules agent.

The wettable powder of embodiment 11

Mibemycin	5%
		Thiacloprid	25%
Sodium lignin sulfonate	10%
		Dodecyl sodium sulfate	3%
White carbon	5%
		Kaolin	Complement to 100%

Said components are mixed in proportion, and grinds, crush, wettable powder is prepared into.

Embodiment 12 extrudes granule

Mibemycin	1%
		Diacloden	10%
Sodium lignin sulfonate	4%
		Carboxymethyl cellulose	2%
White carbon	5%
		Kaolin	Complement to 100%

Active component is mixed and ground with auxiliary agent, mixture is moistened with water.The mixture is extruded, then done in the air stream It is dry.

The oil-suspending agent of embodiment 13

Mibemycin	3%
		Thiacloprid	45%
SOLVESSO ^TM200	10%
		Ethoxylated castor oil	4%
AEO sulfosuccinic acid monoesters disodium	10%
		MODIFIED LIGNOSULPHONATE	5%
Xanthans	0.5%
		Bentonite	1%
Glycerine	5%
		Defoamer	0.6%
Soybean oil	Complement to 100%

Mibemycin is dissolved in SOLVESSO^TMIn 200, ethoxylated castor oil is added, missible oil is obtained；By thiacloprid, AEO sulfosuccinic acid monoesters disodium, MODIFIED LIGNOSULPHONATE, xanthans, bentonite, glycerine, soybean The above-mentioned each component such as oil is mixed in proportion, and through being sanded, is prepared into suspending agent.Oil phase containing mibemycin is added to In suspending agent containing thiacloprid, oil-suspending agent is obtained.

The suspension emulsion of embodiment 14

Mibemycin	3%
		Thiacloprid	3%
SOLVESSO ^TM200	10%
		Ethoxylated castor oil	4%
AEO sulfosuccinic acid monoesters disodium	10%
		MODIFIED LIGNOSULPHONATE	5%
Xanthans	0.5%
		Bentonite	1%
Glycerine	5%
		Defoamer	0.6%
Water	Complement to 100%

Mibemycin is dissolved in SOLVESSO^TMIn 200, ethoxylated castor oil is added, is obtained containing mibemycin breast Oil；By thiacloprid, AEO sulfosuccinic acid monoesters disodium, MODIFIED LIGNOSULPHONATE, xanthans, swelling Soil, glycerine, the above-mentioned each component such as water is mixed in proportion, and through being sanded, is prepared into the suspending agent containing thiacloprid.Rice will be contained You are added in the suspending agent containing thiacloprid the oil phase of shellfish mycin, obtain suspension emulsion.

The microcapsule suspension-suspendinagent agent of embodiment 15

ATLOX^TM4913	4%
		Citric acid	0.05%
Catalyst	0.1%
		Water	13%
Mibemycin	3%
		PAPI	1.35%
SOLVESSO ^TM200	10%
		ATLOX^TM4913	16%
Dispersant LFH	0.3%
		Defoamer	0.16%
Urea	8.4%
		Thiacloprid	3%
Water	Complement to 100%

By poly methylene poly phenyl poly isocyanate（PAPI）, thiacloprid, SOLVESSO^TM200 oil phases formed, which are added, to be contained ATLOX^TMIn 4913 aqueous solution, emulsion is formed.Then heat and be incubated 50^oCatalyst reaction is added under C 2 hours.It is cold But the microcapsules containing thiacloprid is obtained afterwards.

ATLOX ^TM4913, dispersant LFH, defoamer, urea, mibemycin and water are mixed in proportion, and Through being sanded, suspension aqueous phase is prepared.

The obtained microcapsules containing thiacloprid is added in the suspension aqueous phase containing mibemycin, this is uniformly mixing to obtain The microcapsule suspending agent of invention.

The seed treatment suspension emulsion of embodiment 16

Mibemycin	5%
		Diacloden	10%
SOLVESSO ^TM200	20%
		Ethoxylated castor oil	5%
AEO sulfosuccinic acid monoesters disodium	10%
		Modified sodium lignosulfonate	5%
Xanthans	0.5%
		Glycerine	5%
Polyvinylpyrrolidone（PVP-K30）	1%
		Defoamer	0.6%
Water	Complement to 100%

Mibemycin is dissolved in SOLVESSO^TMIn 200, ethoxylated castor oil is added, is obtained containing mibemycin Missible oil；By Diacloden, AEO sulfosuccinic acid monoesters disodium, MODIFIED LIGNOSULPHONATE, xanthans, the third three Alcohol, polyvinylpyrrolidone, the above-mentioned each component such as water is mixed in proportion, and through being sanded, prepares the kind containing Diacloden Subprocessing suspending agent.

Oil phase containing mibemycin is added in the seed treatment suspending agent containing Diacloden, the seed of the present invention is obtained Handle suspension emulsion.

The smoke agent of embodiment 17

Mibemycin	5%
		Clothianidin	30%
Wood powder	10%
		Potassium chlorate	15%
Ammonium chloride	20%
		Diatomite	Complement to 100%

After component in formula is mixed, granular fumicants is configured to by crushing, and by preprepared spill lead placement In fumicants, smoke agent is obtained.

The wettable powder of embodiment 18

Mibemycin	5%
		Thiacloprid	25%
Lauryl sodium sulfate	1%
		Sodium lignin sulfonate	1%
White carbon	1%
		Kaolin	Complement to 100%

Active component, various auxiliary agents and filler etc. are mixed by the proportional components of formula, after ultra-fine pulverizer disintegrating, that is, obtained The wettable powder of the present invention.

The suspending agent of embodiment 19

Mibemycin	2%
		Clothianidin	20%
Alkyl dimethyl benzyl ammonium	10%
		Trisiloxanes APEO	8%
Polyvinyl alcohol	4%
		Propane diols	5%
Silicone	2%
		Water	Complement to 100%

Active component and various auxiliary agents are mixed with water, after high speed shear is scattered, sand mill is sanded, high dispersive is formed, steady Fixed suspension system, is made suspending agent.

The dry suspending agent of embodiment 20

Mibemycin	2%
		Clothianidin	20%
Alkyl dimethyl benzyl ammonium	10%
		Trisiloxanes APEO	8%
Polyvinyl alcohol	4%
		Propane diols	5%
Silicone	2%
		Kaolin	Complement to 100%

Active component and various auxiliary agents are mixed with water, after high speed shear is scattered, sand mill is sanded, high dispersive is formed, steady Fixed suspension system, is made suspending agent, and obtained water slurry is obtained to the dry suspending agent of the present invention by spray drying.

The active ingredient combination of embodiment 21

Mibemycin	20%
		Diacloden	80%

Mibemycin and Diacloden are mixed in proportion.

The active ingredient combination of embodiment 21

Mibemycin	25%
		Clothianidin	75%

Mibemycin and clothianidin are mixed in proportion.

The active ingredient combination of embodiment 22

Mibemycin	30%
		Thiacloprid	70%

Mibemycin and thiacloprid are mixed in proportion.

Proportioning is weight per distribution ratio in above example.

Embodiment

Crop protection products are made in different combination of active principles, are to develop and develop at present new crop protection products and anti- Control a kind of effective and quick way of agriculturally resistant insect.After the pestsides synthesis of different cultivars, three kinds of works are typically exhibited Use type：Summation action, synergistic effect and antagonism.But it is specially which kind of effect, it is impossible to predict, only pass through many experiments Just it can know that.Compound synergic is formulated well, due to significantly improving actual prevention effect, reduces the usage amount of agricultural chemicals, from And greatly delayed the generation speed of pest resistance to insecticide, it is the important means of integrated control disease.

Inventor has carried out lot of experiments by substantial amounts of screening test to the different ratio of mibemycin and Diacloden And effectiveness analysis, find in certain ratio range, resulting Pesticidal combination has gain effect, and not only It is the simple addition of two kinds of medicaments, is specifically illustrated with implementation below.

With reference to the experiment of the People's Republic of China (PRC) agricultural industry criteria (NY/T154.7-2009) farm-chemical indoor determination The synergy of the part mixture of criterion insecticide the 7th is determined, according to survey data, calculates the corrected mortality of each processing, and root The co-toxicity coefficient of mixture is calculated according to the abundant methods of Sun Yun（CTC values）.

Clear and definite two kinds of medicaments compound by a certain percentage after co-toxicity coefficient（CTC）, CTC<80 be anti-effect short of money, 80≤CTC ≤ 120 be summation action, and CTC ＞ 120 are synergistic effect.

Calculation formula is as follows：

Borer population * 100 living before the death rate (%)=(borer population living after borer population-medicine living before medicine)/medicine

Corrected mortality (%)=(the treatment group death rate-control group death rate)/(the 100- control groups death rate) * 100

Probit value (y) will be converted into for examination insect corrected mortality, concentration for the treatment of (μ g/ml) is converted into logarithm value (x), with most Small square law calculates concentration LC in suppression₅₀, then according to the abundant method calculating co-toxicity coefficients (CTC) of Sun Yun.Calculation formula is following (with Mil Shellfish mycin is standard agent, and 100) its toxicity index is：

Survey toxicity index (ATI)=(standard agent LC₅₀/ reagent agent LC₅₀)×100

B percentage contains in A percentage composition+B medicaments ATI × mixture in theoretical toxicity index (TTI)=A medicaments ATI × mixture Amount

Co-toxicity coefficient (CTC)=(mixture ATI/ mixture TTI) × 100

CTC<80 show as resisting effect short of money, and 80≤CTC≤120 show as summation action, and CTC ＞ 120 show as synergistic effect

Experiment 1：To the Toxicity Determination result of panonychus citri

Experiment determines the group of mibemycin, Diacloden and the two different proportion with reference to NY/T1154.14-2009 leaf dipping methods Close the indoor biological activity to test worm.

Using the first leaching leaf method that is followed by worm, by not in contact with the blade of the same size of any medicament in the decoction prepared Take out, dry naturally after middle immersion 5s, be put into insect box, then connect for examination larva, raise, often handle under the conditions of 25 DEG C 3 repetitions, it is 20 often to repeat test worm number used, while setting blank control, dead borer population is checked in 72h, the death rate and school is calculated The positive death rate, tries to achieve virulence regression equation and calculates LC50 values.If compareing the death rate is more than 10%, it is considered as invalid experiment.

Table 1：

As known from Table 1, the proportioning of preventing and treating panonychus citri, mibemycin and Diacloden is 1:100-100:When in 1 scope, Co-toxicity coefficient is all higher than 120, illustrates that both show as gain effect at mixture in the range of this.

Test the Toxicity Determination result of 2 pairs of pear suckers

Table 2：

As known from Table 2, the proportioning of preventing and treating pear sucker, mibemycin and Diacloden is 1:100-100:It is malicious altogether when in 1 scope Coefficient is all higher than 120, illustrates that both show as gain effect at mixture in the range of this.

Experiment 3:To the Toxicity Determination result of apple tree aphid

Table 3：

As known from Table 3, the proportioning of preventing and treating apple tree aphid, mibemycin and Diacloden is 1:100-100:When in 1 scope, Co-toxicity coefficient is all higher than 120, illustrates that both show as gain effect at mixture in the range of this.

Experiment 4：To the Toxicity Determination result of wild cabbage diamondback moth

Table 4：

As known from Table 4, wild cabbage diamondback moth is prevented and treated, the proportioning of mibemycin and Diacloden is 1:100-100:When in 1 scope, Co-toxicity coefficient is all higher than 120, illustrates that both show as gain effect at mixture in the range of this.

Experiment 5：To the Toxicity Determination result of paddy rice rice leaf roller

Table 5：

As known from Table 5, paddy rice rice leaf roller is prevented and treated, the proportioning of mibemycin and Diacloden is 1:100-100:1 scope In when, co-toxicity coefficient is all higher than 120, illustrates that both show as gain effect at mixture in the range of this.

Experiment 6：To the Toxicity Determination result of cotton Tetranychus cinnabarinus

Experiment determines the group of mibemycin, clothianidin and the two different proportion with reference to NY/T1154.14-2009 leaf dipping methods Close the indoor biological activity to test worm.

Table 6：

As known from Table 6, the proportioning of preventing and treating cotton Tetranychus cinnabarinus, mibemycin and clothianidin is 1:100-100:In 1 scope When, co-toxicity coefficient is all higher than 120, illustrates that both show as gain effect at mixture in the range of this.

Test the Toxicity Determination result of 7 pairs of pear suckers

Table 7：

As known from Table 7, the proportioning of preventing and treating pear sucker, mibemycin and clothianidin is 1:100-100:It is malicious altogether when in 1 scope Coefficient is all higher than 120, illustrates that both show as gain effect at mixture in the range of this.

Experiment 8：To the Toxicity Determination result of apple tree aphid

Table 8：

As known from Table 8, the proportioning of preventing and treating apple tree aphid, mibemycin and clothianidin is 1:100-100:When in 1 scope, Co-toxicity coefficient is all higher than 120, illustrates that both show as gain effect at mixture in the range of this.

Experiment 9：To the Toxicity Determination result of wild cabbage diamondback moth

Table 9：

As known from Table 9, wild cabbage diamondback moth is prevented and treated, the proportioning of mibemycin and clothianidin is 1:100-100:When in 1 scope, Co-toxicity coefficient is all higher than 120, illustrates that both show as gain effect at mixture in the range of this.

Experiment 10：To the Toxicity Determination result of paddy rice rice leaf roller

Table 10：

As known from Table 10, paddy rice rice leaf roller is prevented and treated, the proportioning of mibemycin and clothianidin is 1:100-100:1 scope In when, co-toxicity coefficient is all higher than 120, illustrates that both show as gain effect at mixture in the range of this.

Experiment 11：To the Toxicity Determination result of Kidney bean Tetranychus urticae

Experiment determines the group of mibemycin, thiacloprid and the two different proportion with reference to NY/T1154.14-2009 leaf dipping methods Close the indoor biological activity to test worm.

Table 11：

As known from Table 11, the proportioning of preventing and treating Kidney bean Tetranychus urticae, mibemycin and thiacloprid is 1:100-100:In 1 scope When, co-toxicity coefficient is all higher than 120, illustrates that both show as gain effect at mixture in the range of this.

Test the Toxicity Determination result of 12 pairs of pear suckers

Table 12：

As known from Table 12, pear sucker, mibemycin are prevented and treated：The proportioning of thiacloprid is 1:100-100:It is malicious altogether when in 1 scope Coefficient is all higher than 120, illustrates that both show as gain effect at mixture in the range of this.

Experiment 13：To the Toxicity Determination result of apple tree aphid

Table 13：

As known from Table 13, apple tree aphid, mibemycin are prevented and treated：The proportioning of thiacloprid is 1:100-100:When in 1 scope, Co-toxicity coefficient is all higher than 120, illustrates that both show as gain effect at mixture in the range of this.

Experiment 14：To the Toxicity Determination result of wild cabbage diamondback moth

Table 14：

As known from Table 14, wild cabbage diamondback moth is prevented and treated, the proportioning of mibemycin and thiacloprid is 1:100-100:In 1 scope When, co-toxicity coefficient is all higher than 120, illustrates that both show as gain effect at mixture in the range of this.

Experiment 15：To the Toxicity Determination result of paddy rice rice leaf roller

Table 15：

As known from Table 15, paddy rice rice leaf roller is prevented and treated, the proportioning of mibemycin and thiacloprid is 1:100-100:1 scope In when, co-toxicity coefficient is all higher than 120, illustrates that both show as gain effect at mixture in the range of this.

Test the experiment of 16 Meloidogyne incognitas

By soil, active compounds solution, Meloidogyne incognita (Meloidogyne incognita) ovum/larva suspension and Leaf lettuce seed is fitted into container.The Leaf lettuce germination and plant growth.Insect gall is formed on root.Required time Afterwards, the nematocidal effect in terms of % is determined by the formation of insect gall.100% represents without discovery insect gall;0% represents through handling plant Upper insect gall quantity is suitable with the insect gall quantity of unprocessed control group.

Table 16

In terms of the result of the test of table 16, mibemycin and Diacloden, clothianidin, the preventive effect that thiacloprid is observed after compounding are obvious Higher than preventive effect is calculated, obvious synergistic effect is shown.

Claims

1. a kind of Pesticidal combination, it is characterised in that：Active component is by (A) mibemycin and (B) at least one anabasine Compound group is into the active component（A）With（B）It is 1 by weight ratio:100-100:1, preferably 1:50-50:1, further preferably 1: 40-40:1 further preferably 1:30-30:1, further preferably 1:25-25:1, more preferably 1:25-20:1, more preferably 1:25-15:1, it is more excellent Select 1:25-10:1, more preferably 1:25-5:1, more preferably 1:20-5:1, more preferably 1:20-3:1, more preferably 1:20-2:1, it is more excellent Select 1:20-1:1, more preferably 1:20-1:5, the active component（B）Selected from Diacloden, clothianidin or thiacloprid.

2. Pesticidal combination according to claim 1, it is characterised in that：The active component（A）With（B）Weight accounts for described altogether Composition 5%-90% by weight, preferably 5%-80%, further preferably 5%-70%, more preferably more preferably 5%-60%, 5%-50%, more excellent Select 5%-40%, more preferably more preferably 5%-30%, more preferably 5%-20%, 5%-15%.

3. Pesticidal combination according to claim 1, it is characterised in that：Also include surfactant and/or extender.

4. Pesticidal combination according to claim 1, it is characterised in that：The formulation is missible oil, suspending agent, seed treatment Dry powder doses, seed treatment suspending agent, water dispersible granules, wettable powder, suspension emulsion, smoke agent, coated granule, extrusion particle Agent, aqueous emulsion, microcapsule suspending agent, microcapsule suspension-suspendinagent agent, dry suspending agent, ultra low volume liquids.

5. the Pesticidal combination described in claim 1 is used for the purposes for preventing or controlling harmful organism.

6. purposes according to claim 5, it is characterised in that：Wherein harmful organism is selected from Insecta（Insecta）, spider shape Guiding principle (Arachnida), Nematoda（Nematoda）.

7. purposes according to claim 5, it is characterised in that：The harmful organism is selected from Lepidoptera, Diptera, coleoptera, half Wing mesh, Homoptera, Orthoptera, Hymenoptera, Isoptera, Siphonaptera, Blattaria, Thysanoptera, Acarina, Meloidogyne.

8. purposes according to claim 5, it is characterised in that：The harmful organism is Panonychus citri, Tetranychus cinnabarinus, two variegated leafs Mite, pear sucker, aphid, diamondback moth, rice leaf roller, striped rice borer, root-knot nematode.

9. a kind of method prevented or control harmful organism, it is characterised in that：Including by the Pesticidal combination described in claim 1 Act on target useful plant or its environment, object noxious livings or its environment, the propagating materials of target useful plant.

10. method according to claim 9, it is characterised in that：The plant propagation material be seedling, rhizome, garden seedling, insert Bar or seed.

11. a kind of method prevented or control pest infestation, it is characterised in that：Including by the desinsection described in claim 1 Composition is contacted with target useful plant or its environment, object noxious livings or its environment, the propagating materials of target useful plant.

12. a kind of method prevented or control pest infestation, it is characterised in that：It is included in target useful plant or its ring Wish sequentially or simultaneously to apply power with any on border, object noxious livings or its environment, the propagating materials of target useful plant Profit requires the active component described in 1（A）With（B）.

13. it is a kind of in plant propagation material and preventing and treating or prevention in growing plants organ, plant part and/or plant after The method of harmful organism, it is characterised in that：Including by the Pesticidal combination described in claim 1 be applied to plant propagation material or It is environmentally.

14. a kind of method for protecting seed, seedling root and branch to be attacked to prevent soil and foliar insect, it is characterised in that：Including Seed is set to be contacted with the Pesticidal combination of the claims in the present invention 1 before sowing and/or after vernalization.