CN107582962A - A kind of formula and its extraction process for atrophic gastritis - Google Patents
A kind of formula and its extraction process for atrophic gastritis Download PDFInfo
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- CN107582962A CN107582962A CN201710404136.2A CN201710404136A CN107582962A CN 107582962 A CN107582962 A CN 107582962A CN 201710404136 A CN201710404136 A CN 201710404136A CN 107582962 A CN107582962 A CN 107582962A
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Abstract
A kind of formula and its extraction process for atrophic gastritis.Radix Codonopsis, the bighead atractylodes rhizome, radix scutellariae, radix salviae miltiorrhizae, curcuma zedoary, Fructus Aurantii, coix seed, hairyvein agrimony, oldenlandia diffusa, Sculellaria barbata, dandelion, the taste medicinal material of waxgourd seed 12 add water to cook 2 times, every time 10 times of amount water, 1 hour every time, collecting decoction, filtration, filtrate are concentrated into relative density 1.38~1.40, add ethanol precipitation 3 times, first time alcohol content is 70%, and second and third alcohol content is 80%, stand 12 hours every time, filtration, filtrate recycling ethanol, obtains concentrate, dry, gained medicinal powder is main ingredient raw material.Prescription Chinese medicine is extracted the present invention and purifying process, after the effective substance mixing of acquisition, as the main ingredient raw material of atrophic gastritis side, laid the foundation to prepare the related formulation of atrophic gastritis curative for effect, safely controllable, that dose is small to biddability is good.
Description
Technical field
The present invention relates to the field of Chinese medicines, specifically, is related to a kind of formula for atrophic gastritis and its extraction
Technique.
Background technology
Atrophic gastritis side is as preparation in the institute of institute of traditional Chinese medicine of Tianzhang City, and clinically prolonged application is in atrophic
Gastritis with intestinal metaplasia, it is weakness of the spleen and the stomach and damp and hot caused by abdominal distension stomachache belch receive the diseases such as difference, obtain good result.The party is directed to
Atrophic gastritis caused by weakness of the spleen and the stomach and syndrome of dampness-heat, intestinal metaplasia and atypical hyperplasia patient's curative effect are especially prominent, substantially may be used
Reverse atypical hyperplasia lesion.To gasteremphraxis, stomachache, it is noisy, receive poor, bitter taste halitosis, yellow urine, just the disease such as knot have it is preferably clinical
Curative effect.
Atrophic gastritis is one of clinical common frdquently encountered disease.The diseases such as traditional Chinese medical science category " epigastric pain " " noisy " " abdominal distension " " stomach ruffian "
Category, main pathogenesis are：Ferritic is weakness of the spleen and the stomach or eating and drinking without temperance, injures taste and causes spleen fortune mistake strong, the imbalance of taste ascending or descending movement of vital Qi is wet
From interior life, accumulate longization heat, it is wet mutually to be tied with hot, stay and further hinder transporting and transforming function of the spleen and stomach function in stomach, cause stomachache, noisy, abdominal distension, feeling of fullness
The diseases such as discomfort, pathological examination can behave as stomach glands atrophy, intestinal metaplasia, atypical hyperplasia.The disease is also known as precancerous lesion,
Its sick incidence of disease height is detrimental to health.The party have replenish qi to invigorate the spleen, Qinghua is damp and hot, removing toxic substances blood circulation-promoting functions, can reverse prevention stomach
Mucous membrane canceration.
At present, doctor trained in Western medicine is without specific drug, can only anti symptom treatment, such as acid suppression, promote WeiDongLi Capsule or neutralize hydrochloric acid in gastric juice, curative effect is general
Symptom and prognosis can not be improved completely, long-term use has certain side effect, and price is partial to costliness.In order to adapt to clinical requirement,
Preferably release sufferer sufferings, the present invention is with atrophic gastritis caused by treating insufficiency of the spleen weak and syndrome of dampness-heat, intestinal metaplasia and not
Typical hyperplasia patient is object, develops and develop i.e. safety and for the purpose of effective Chinese medicine preparation.
The content of the invention
Inventive formulation with Radix Codonopsis, the bighead atractylodes rhizome, radix scutellariae, radix salviae miltiorrhizae, curcuma zedoary, Fructus Aurantii, coix seed, hairyvein agrimony, oldenlandia diffusa,
Sculellaria barbata, dandelion, the taste medicinal material of waxgourd seed 12 form atrophic gastritis side according to a certain percentage, and by using water extracting alcohol
Prescription Chinese medicine is extracted heavy method and purifying process, after the effective substance mixing of acquisition, as atrophic gastritis
The main ingredient raw material of side, to prepare the related agent of atrophic gastritis curative for effect, safely controllable, that dose is small to biddability is good
Type lays the foundation.
In order to solve the above-mentioned technical problem, the invention provides following technical scheme：One kind is used for atrophic stomach
Scorching formula, including Radix Codonopsis 10-20g, bighead atractylodes rhizome 9-16g, radix scutellariae 8-14g, radix salviae miltiorrhizae 12-18g, coix seed 25-35g, hairyvein agrimony
7-13g, oldenlandia diffusa 10-15g, Sculellaria barbata 10-17g, dandelion 10-16g, waxgourd seed 9-12g, curcuma zedoary 8-12g, Fructus Aurantii
10-13g。
Present invention also offers a kind of formula extraction process for atrophic gastritis, its step are as follows：
Radix Codonopsis, the bighead atractylodes rhizome, radix scutellariae, radix salviae miltiorrhizae, curcuma zedoary, Fructus Aurantii, coix seed, hairyvein agrimony, oldenlandia diffusa, Sculellaria barbata, Pu Gong
English, the taste medicinal material of waxgourd seed 12 add water to cook 2 times, measure water for 10 times every time, 1 hour every time, collecting decoction filtered, and filtrate is concentrated into
Relative density 1.38~1.40, adds ethanol precipitation 3 times, and first time alcohol content is 70%, and second and third alcohol content is 80%, often
It is secondary to stand 12 hours, filtration, filtrate recycling ethanol, concentrate is obtained, dried, gained medicinal powder is main ingredient raw material；
Content after extraction purification, addition dextrin is appropriate, and equivalent is progressively increased after method mixing, with 70% ethanol softwood, system
Grain, 60 DEG C of dryings, whole grain, produces atrophic gastritis granule.
Atrophic gastritis caused by the present invention has weakness of the spleen and the stomach and syndrome of dampness-heat, intestinal metaplasia and atypical hyperplasia patient treat
Imitate especially prominent, atypical hyperplasia lesion can be reversed substantially, to gasteremphraxis, stomachache, it is noisy, receive poor, bitter taste halitosis, yellow urine, just tie
There is preferable clinical efficacy Deng disease.
Embodiment
Embodiment 1
Weigh Radix Codonopsis 150g, bighead atractylodes rhizome 100g, radix scutellariae 100g, radix salviae miltiorrhizae 150g, coix seed 300g, hairyvein agrimony 100g, Fructus Aurantii
10g, oldenlandia diffusa 150g, Sculellaria barbata 150g, dandelion 150g, waxgourd seed 100g, curcuma zedoary 100g, appropriate dextrin.
Extraction process is shown as to Radix Codonopsis, the bighead atractylodes rhizome, radix scutellariae, radix salviae miltiorrhizae, curcuma zedoary, Fructus Aurantii, coix seed, hairyvein agrimony, long-noded pit viper
Tongue grass, Sculellaria barbata, dandelion, waxgourd seed are extracted and purified, and particular content is mainly as follows：Radix Codonopsis, the bighead atractylodes rhizome, radix scutellariae, Zi Dan
Ginseng, curcuma zedoary, Fructus Aurantii, coix seed, hairyvein agrimony, oldenlandia diffusa, Sculellaria barbata, dandelion, the taste medicinal material of waxgourd seed 12 add water to cook 2
Secondary, 10 times of amount water, 1 hour every time, collecting decoction, is filtered every time, and it is left that filtrate is concentrated into (70 DEG C) of relative density 1.38~1.40
The right side, adds ethanol precipitation 3 times, and first time alcohol content is 70%, and second and third alcohol content is 80%, stands 12 hours every time, filter
Cross, filtrate recycling ethanol, obtain concentrate, dry, gained medicinal powder is main ingredient raw material.
Extract Radix Codonopsis, the bighead atractylodes rhizome, radix scutellariae, radix salviae miltiorrhizae, fry curcuma zedoary, Fructus Aurantii, coix seed, hairyvein agrimony, oldenlandia diffusa, half
Lotus, dandelion, waxgourd seed, merge the content after extraction purification, addition dextrin is appropriate, and equivalent is progressively increased after method mixing, with 70%
Ethanol softwood, granulation, 60 DEG C of dryings, whole grain, produces atrophic gastritis granule.
Claims (2)
1. a kind of formula for atrophic gastritis, it is characterised in that including Radix Codonopsis 10-20g, bighead atractylodes rhizome 9-16g, radix scutellariae 8-
14g, radix salviae miltiorrhizae 12-18g, coix seed 25-35g, hairyvein agrimony 7-13g, oldenlandia diffusa 10-15g, Sculellaria barbata 10-17g, Pu Gong
English 10-16g, waxgourd seed 9-12g, curcuma zedoary 8-12g, Fructus Aurantii 10-13g.
2. a kind of formula extraction process for atrophic gastritis, it is characterised in that its step is as follows：
Radix Codonopsis, the bighead atractylodes rhizome, radix scutellariae, radix salviae miltiorrhizae, curcuma zedoary, Fructus Aurantii, coix seed, hairyvein agrimony, oldenlandia diffusa, Sculellaria barbata, dandelion, winter
The taste medicinal material of melon seeds 12 is added water to cook 2 times, and 10 times of amount water, 1 hour every time, collecting decoction, is filtered, filtrate is concentrated into relatively close every time
Degree 1.38~1.40, adds ethanol precipitation 3 times, and first time alcohol content is 70%, and second and third alcohol content is 80%, is stood every time
12 hours, filtration, filtrate recycling ethanol, concentrate is obtained, dried, gained medicinal powder is main ingredient raw material；
Content after extraction purification, addition dextrin is appropriate, and equivalent is progressively increased after method mixing, with 70% ethanol softwood, pelletizes, and 60
DEG C drying, whole grain, produces atrophic gastritis granule.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710404136.2A CN107582962A (en) | 2017-06-01 | 2017-06-01 | A kind of formula and its extraction process for atrophic gastritis |
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| CN201710404136.2A CN107582962A (en) | 2017-06-01 | 2017-06-01 | A kind of formula and its extraction process for atrophic gastritis |
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| CN201710404136.2A Pending CN107582962A (en) | 2017-06-01 | 2017-06-01 | A kind of formula and its extraction process for atrophic gastritis |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1446136A2 (en) * | 2001-10-26 | 2004-08-18 | Metaproteomics, LLC | Curcuminoid compositions exhibiting synergistic inhibition of the expression and/or activity of cyclooxygenase-2 |
| CN105435121A (en) * | 2015-12-28 | 2016-03-30 | 天长市中医院 | Shenzhu pharmaceutical composition for treating atrophic gastritis and application thereof |
-
2017
- 2017-06-01 CN CN201710404136.2A patent/CN107582962A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1446136A2 (en) * | 2001-10-26 | 2004-08-18 | Metaproteomics, LLC | Curcuminoid compositions exhibiting synergistic inhibition of the expression and/or activity of cyclooxygenase-2 |
| CN105435121A (en) * | 2015-12-28 | 2016-03-30 | 天长市中医院 | Shenzhu pharmaceutical composition for treating atrophic gastritis and application thereof |
Non-Patent Citations (2)
| Title |
|---|
| 方亮: "《药剂学》", 31 March 2016, 中国医药科技出版社 * |
| 邓修: "《中药制药工程与技术》", 31 May 2008, 华东理工大学出版社 * |
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Application publication date: 20180116 |