CN107569560A - A kind of concocting method of Fructus Aurantii - Google Patents
A kind of concocting method of Fructus Aurantii Download PDFInfo
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Abstract
The invention provides a kind of concocting method of Fructus Aurantii, take clean Fructus Aurantii, 50 DEG C of profit systems 20 minutes in the rearmounted medicine processing devices of pumpdown time 6min, be the thick thin slices of 2mm with section machine-cut thickness, 45 50 DEG C of forced air drying 4h, weed out it is broken fall flesh core, obtain Fructus Aurantii Praeparata；By machine for stir-frying Chinese medicine be heated to temperature for 140 160 DEG C when, add wheat bran, add Fructus Aurantii Praeparata, the mass ratio of amount of wheat bran and Fructus Aurantii Praeparata dosage is 1~1.5：10,3~4min of frying, take out, weed out wheat bran, cool and produce.Fructus Aurantii aurantiamarin, neohesperidin, aurantiin, the rue aurantiin isoreactivity component content of the inventive method processing are high, and chemical addition agent is not used, it is effective avoid active constituents of medicine because using chemical addition agent and caused by structural change, be effectively guaranteed curative effect of medication and drug safety.
Description
Technical field
The present invention relates to Chinese medicine Fructus Aurantii, and in particular to a kind of processing method of Fructus Aurantii Praeparata.
Technical background
Fructus Aurantii is《Chinese Pharmacopoeia》The herbal medicine included, property is bitter, pungent, sour, warm, medicinal source be rutaceae bitter orange and its
The drying immature fruit of variety.Research shows that Fructus Aurantii contains abundant aurantiamarin, neohesperidin, aurantiin, rue shaddock
The compositions such as skin glycosides.Aurantiamarin by extend norepinephrine induce vein contraction time and strengthen intravenous tension (heating,
Still have this effect under acid poisoning state), and the adhesion that can reduce leucocyte and vascular endothelial cell reduces inflammation after disintegration with dividing a word with a hyphen at the end of a line
The release of property material (such as histamine, bradykinin, complement, leukotriene, prostaglandin, excessive free radical), so that blood capillary
Pipe permeability reduces；Blood viscosity can also be reduced, accelerates velocity of blood flow, it is stagnant so as to improve the microcirculation stasis of blood, improve Lymphatic Circulation,
Accelerate tissue fluid backflow, mitigate oedema, be the medicine for treating hypertension and miocardial infarction available for the toughness of enhancing capillary
Thing.Neohesperidin play the role of cure capillary fragility and blood plasma in protein permeability it is too high, be once referred to as maintain hair
Thin vasopermeability vitamin or citrin.Aurantiin is a kind of Flavanones compound, has anti-inflammatory, antiviral, anti-
Cancer, anti-mutation, antiallergy, antiulcer, analgesia, hypotensive activity, energy hypercholesterolemia, the formation for reducing thrombus, improve local
Microcirculation and nutrition supply, cardiovascular and cerebrovascular disease is prevented and treated available for production.There is document to show, rue aurantiin and aurantiamarin compatibility
Play the role of to small intestine movement of mice propulsion positive.Aurantiamarin, neohesperidin, aurantiin, the structural formula of rue aurantiin are as follows：
Fructus Aurantii concocting method is more, and Mr. Wang Xiaotao is studied Han dynasty to the multi-section major medical document of the Qing Dynasty 160,
《Successive dynasties Chinese medicine preparation normal congruence allusion quotation》The middle processing by Fructus Aurantii is processed by net system, cutting, big gun sorts out net system, cutting, bran stir-fry, stir-fry
Make, the system of processing, vinegar system, charcoal processing, wine system, pulp-water system, swill system, face frying, cannon system, simmer system, rice frying, radish system, crotons system, bar
Beans vinegar system, rhizoma atractylodis radish system, dried lacquer fennel system, sophora flower system, steam, salt system, honey system etc. 23 kinds of concocting methods, wherein bran fry side
It is most long that method continues to use the time, using most.Version in 2015《Chinese Pharmacopoeia》Regulation Fructus Aurantii Praeparata concocting method is：Impurity is removed, is washed
Only, run through, shave, weeded out after drying it is broken fall flesh core, stir-baked FRUCTUS AURANTII in bran fries method (general rule 0213) to take Fructus Aurantii piece, according to bran and fries extremely
Discoloration is deep, occasionally there is focal spot；Wherein each link of processing procedure is without objective quantifiable index, and operation is with certain in concocting process
Blindness, with the development of process of preparing machinery, current most medicine materical crude slice factories employ the machinery of automation or semi-automation
Metaplasia is produced, and reduces human error to a certain extent, but because control of the different manufacturing enterprises to processing procedure parameter is inconsistent,
The setting of parameter also has larger difference mostly or with experience, ununified standard, the quality of the product processed.
Because the compositions such as aurantiamarin, neohesperidin, aurantiin, rue aurantiin contain substantial amounts of hydroxyl, conventional concocting method is easily made
Into ingredients from lossing or altered chemical structure, in the presence of by oxidant or reducing agent (such as sodium sulfite, glutathione), pole
Redox reaction easily occurs, causes active component structural change, so as to lose pharmacological activity, or even increase toxicity.
The content of the invention
To solve the above problems, the invention provides a kind of concocting method of Fructus Aurantii, Fructus Aurantii aurantiamarin that this method processes,
Neohesperidin, aurantiin, rue aurantiin isoreactivity component content are high, and curative effect of medication has been effectively ensured.
Unless otherwise specified, number of the present invention is parts by weight, and the percentage is mass percent.
To achieve the above object, the technical scheme is that：
A kind of concocting method of Fructus Aurantii, it is characterised in that comprise the following steps：Fructus Aurantii is cleaned, is placed in medicine processing device, is taken out
Vacuum, 10~40min are made in 30~60 DEG C of profits, the thin slice for being 1~2mm with section machine-cut thickness, 45~70 DEG C of forced air dryings 2~
6h, weed out it is broken fall flesh core, obtain Fructus Aurantii Praeparata；By machine for stir-frying Chinese medicine be heated to temperature for 140-220 DEG C when, add wheat bran, add
The mass ratio of Fructus Aurantii Praeparata, amount of wheat bran and Fructus Aurantii Praeparata dosage is 1~1.5：10,3~7min of frying, take out, weed out wheat bran,
Cool and produce.
According to one embodiment of the invention, the concocting method of above-mentioned Fructus Aurantii, it is characterised in that comprise the following steps：
Clean Fructus Aurantii is taken, is placed in medicine processing device, pumpdown time 6min makes 20 minutes after 30~60 DEG C of profits, with section machine-cut thickness
For 2mm thin slice, during 55 DEG C of forced air dryings 2, weed out it is broken fall flesh core, obtain Fructus Aurantii Praeparata；Machine for stir-frying Chinese medicine is heated into temperature is
At 140-220 DEG C, wheat bran is added, adds Fructus Aurantii Praeparata, the mass ratio of amount of wheat bran and Fructus Aurantii Praeparata dosage is 1~1.5：10,
3~7min of frying, take out, weed out wheat bran, cool and produce.
According to one embodiment of the invention, the concocting method of above-mentioned Fructus Aurantii, it is characterised in that comprise the following steps：
Take clean Fructus Aurantii, be placed in medicine processing device, pumpdown time 6min after 45 DEG C of profit 20min processed, with section machine-cut thickness be 1~
Thin slice thick 2mm, 55 DEG C of forced air dryings 2 hours, weed out it is broken fall flesh core, obtain Fructus Aurantii Praeparata；Machine for stir-frying Chinese medicine is heated to temperature
For 140-220 DEG C when, add wheat bran, add Fructus Aurantii Praeparata, the mass ratio of amount of wheat bran and Fructus Aurantii Praeparata dosage is 1~1.5：
10,3~7min of frying, take out, weed out wheat bran, cool and produce.
According to one embodiment of the invention, the concocting method of above-mentioned Fructus Aurantii, it is characterised in that comprise the following steps：
Clean Fructus Aurantii is taken, 45 DEG C~50 DEG C profit 10~40min of system in medicine processing device are placed in after pumpdown time 6min, with section machine-cut thickness
Spend for thin slice thick 2mm, 55 DEG C of forced air dryings 2 hours, weed out it is broken fall flesh core, obtain Fructus Aurantii Praeparata；Machine for stir-frying Chinese medicine is heated to
When temperature is 140-220 DEG C, add wheat bran, add Fructus Aurantii Praeparata, the mass ratio of amount of wheat bran and Fructus Aurantii Praeparata dosage for 1~
1.5：10,3~7min of frying, take out, weed out wheat bran, cool and produce.
According to one embodiment of the invention, the concocting method of above-mentioned Fructus Aurantii, it is characterised in that comprise the following steps：
Clean Fructus Aurantii is taken, 50 DEG C of profits in medicine processing device are placed in after pumpdown time 6min and are made 20 minutes, are 2mm thickness with section machine-cut thickness
Thin slice, 45~70 DEG C of forced air dryings 2 hours, weed out it is broken fall flesh core, obtain Fructus Aurantii Praeparata；Machine for stir-frying Chinese medicine is heated into temperature is
At 140-220 DEG C, wheat bran is added, adds Fructus Aurantii Praeparata, the mass ratio of amount of wheat bran and Fructus Aurantii Praeparata dosage is 1~1.5：10,
3~7min of frying, take out, weed out wheat bran, cool and produce.
According to one embodiment of the invention, the concocting method of above-mentioned Fructus Aurantii, it is characterised in that comprise the following steps：
Clean Fructus Aurantii is taken, 50 DEG C of profits in medicine processing device are placed in after pumpdown time 6min and are made 20 minutes, are 2mm thickness with section machine-cut thickness
Thin slice, in 45-50 DEG C of 2~6h of forced air drying, weed out it is broken fall flesh core, obtain Fructus Aurantii Praeparata；Machine for stir-frying Chinese medicine is heated to temperature
For 140-220 DEG C when, add wheat bran, add Fructus Aurantii Praeparata, the mass ratio of amount of wheat bran and Fructus Aurantii Praeparata dosage is 1~1.5：
10,3~7min of frying, take out, weed out wheat bran, cool and produce.
According to one embodiment of the invention, the concocting method of above-mentioned Fructus Aurantii, it is characterised in that comprise the following steps：
Take clean Fructus Aurantii, 50 DEG C of profit systems 20 minutes, are 2mm thick with section machine-cut thickness in the rearmounted medicine processing devices of pumpdown time 6min
Thin slice, 45-50 DEG C of forced air drying 4h, weed out it is broken fall flesh core, obtain Fructus Aurantii Praeparata；It is 140- that machine for stir-frying Chinese medicine is heated into temperature
At 220 DEG C, wheat bran is added, adds Fructus Aurantii Praeparata, the mass ratio of amount of wheat bran and Fructus Aurantii Praeparata dosage is 1~1.5：10, frying 3
~7min, take out, weed out wheat bran, cool and produce.
According to one embodiment of the invention, the concocting method of above-mentioned Fructus Aurantii, it is characterised in that comprise the following steps：
Clean Fructus Aurantii is taken, is placed in medicine processing device, pumpdown time 6min makes 20 minutes after 30~60 DEG C of profits, with section machine-cut thickness
For 2mm thin slice, during 55 DEG C of forced air dryings 2, weed out it is broken fall flesh core, obtain Fructus Aurantii Praeparata；Machine for stir-frying Chinese medicine is heated into temperature is
At 140-160 DEG C, wheat bran is added, adds Fructus Aurantii Praeparata, the mass ratio of amount of wheat bran and Fructus Aurantii Praeparata dosage is 1~1.5：10,
3~4min of frying, take out, weed out wheat bran, cool and produce.
According to one embodiment of the invention, the concocting method of above-mentioned Fructus Aurantii, it is characterised in that comprise the following steps：
Take clean Fructus Aurantii, be placed in medicine processing device, pumpdown time 6min after 45 DEG C of profit 20min processed, with section machine-cut thickness be 1~
Thin slice thick 2mm, 55 DEG C of forced air dryings 2 hours, weed out it is broken fall flesh core, obtain Fructus Aurantii Praeparata；Machine for stir-frying Chinese medicine is heated to temperature
For 140-160 DEG C when, add wheat bran, add Fructus Aurantii Praeparata, the mass ratio of amount of wheat bran and Fructus Aurantii Praeparata dosage is 1~1.5：
10,3~4min of frying, take out, weed out wheat bran, cool and produce.
According to one embodiment of the invention, the concocting method of above-mentioned Fructus Aurantii, it is characterised in that comprise the following steps：
Clean Fructus Aurantii is taken, 45 DEG C~50 DEG C profit 10~40min of system in medicine processing device are placed in after pumpdown time 6min, with section machine-cut thickness
Spend for thin slice thick 2mm, 55 DEG C of forced air dryings 2 hours, weed out it is broken fall flesh core, obtain Fructus Aurantii Praeparata；Machine for stir-frying Chinese medicine is heated to
When temperature is 140-160 DEG C, add wheat bran, add Fructus Aurantii Praeparata, the mass ratio of amount of wheat bran and Fructus Aurantii Praeparata dosage for 1~
1.5：10,3~4min of frying, take out, weed out wheat bran, cool and produce.
According to one embodiment of the invention, the concocting method of above-mentioned Fructus Aurantii, it is characterised in that comprise the following steps：
Clean Fructus Aurantii is taken, 50 DEG C of profits in medicine processing device are placed in after pumpdown time 6min and are made 20 minutes, are 2mm thickness with section machine-cut thickness
Thin slice, 45~70 DEG C of forced air dryings 2 hours, weed out it is broken fall flesh core, obtain Fructus Aurantii Praeparata；Machine for stir-frying Chinese medicine is heated into temperature is
At 140-160 DEG C, wheat bran is added, adds Fructus Aurantii Praeparata, the mass ratio of amount of wheat bran and Fructus Aurantii Praeparata dosage is 1~1.5：10,
3~4min of frying, take out, weed out wheat bran, cool and produce.
According to one embodiment of the invention, the concocting method of above-mentioned Fructus Aurantii, it is characterised in that comprise the following steps：
Clean Fructus Aurantii is taken, 50 DEG C of profits in medicine processing device are placed in after pumpdown time 6min and are made 20 minutes, are 2mm thickness with section machine-cut thickness
Thin slice, in 45-50 DEG C of 2~6h of forced air drying, weed out it is broken fall flesh core, obtain Fructus Aurantii Praeparata；Machine for stir-frying Chinese medicine is heated to temperature
For 140-160 DEG C when, add wheat bran, add Fructus Aurantii Praeparata, the mass ratio of amount of wheat bran and Fructus Aurantii Praeparata dosage is 1~1.5：
10,3~4min of frying, take out, weed out wheat bran, cool and produce.
According to one embodiment of the invention, the concocting method of above-mentioned Fructus Aurantii, it is characterised in that comprise the following steps：
Take clean Fructus Aurantii, 50 DEG C of profit systems 20 minutes, are 2mm thick with section machine-cut thickness in the rearmounted medicine processing devices of pumpdown time 6min
Thin slice, 45-50 DEG C of forced air drying 4h, weed out it is broken fall flesh core, obtain Fructus Aurantii Praeparata；It is 140- that machine for stir-frying Chinese medicine is heated into temperature
At 160 DEG C, wheat bran is added, adds Fructus Aurantii Praeparata, the mass ratio of amount of wheat bran and Fructus Aurantii Praeparata dosage is 1~1.5：10, frying 3
~4min, take out, weed out wheat bran, cool and produce.
Beneficial effect of the present invention：
The invention provides a kind of concocting method of Fructus Aurantii, Fructus Aurantii is cleaned, is placed in medicine processing device, is vacuumized, pass through leaching
Moisten a system such as temperature and infiltrating time, slice thickness, drying temperature and time, frying temperature and time, wheat bran medicinal material amount ratio
The control of row parameter, it is achieved thereby that the Fructus Aurantii aurantiamarin processed, neohesperidin, aurantiin, rue aurantiin isoreactivity composition
Content is high, the effect of being effectively guaranteed medicine.Chemical addition agent is not used in concocting method of the present invention, effectively avoids medicine
Active component because using chemical addition agent and caused by structural change, be effectively guaranteed curative effect of medication and drug safety.This
The Fructus Aurantii that invention processes can significantly reduce oxygen consumption of myocardium, vasoconstriction, reduce the cerebrovascular and renal vascular resistance, effective increase
Coronary flow and renal hemodynamic blood；And Renal vascular can be shunk by cardiac stimulant, suppress reabsorption, increase filtration pressure and the row of performance
Sodium diuresis；Also to unpregnancy and, pregnant rabbit isolated uterine, uterus in place and the uterus impotence of unpregnancy rabbit have obvious excitement
Effect, the increase of the uterine contractile rhythm and pace of moving things can be made.Concocting method of the present invention is simple, is adapted to industrialized production.
Embodiment
The present invention is specifically described below by specific embodiment, it is pointed out here that following examples are served only for this hair
It is bright to be further described, it is impossible to be interpreted as limiting the scope of the invention, the person skilled in the art of this area can root
Some nonessential modifications and adaptations are made to the present invention according to foregoing invention content.All raw materials of the present invention and reagent are commercially available
Product.
Instrument：
Medicine processing device：Hangzhou Jinzhu Machinery Co., Ltd., product type：KRY-2000, complete machine power：4.5KW is specified, electricity
Pressure：380V.Fully automatic high-speed medicine cutter：Hangzhou Jinzhu Machinery Co., Ltd., product type：NECQ300, cutting knife are formed：56mm,
Complete machine power：2.5KW.Baking oven：DHG-9240A types electric heating constant-temperature blowing drying box (Yuhua Instrument Co., Ltd., Gongyi City)
Reagent (used in liquid phase measurement)：Rue aurantiin (lot number：P1207548, pure degree≤98%, the upper smooth high-tech stock of Haitai
Part Co., Ltd)；Aurantiin (lot number：110722-200309, Nat'l Pharmaceutical ＆ Biological Products Control Institute)；Aurantiamarin (lot number：
P1212250, pure degree≤98%, the upper smooth Science and Technology Co., Ltd. of Haitai)；Neohesperidin (lot number：111857-201102, in
Food and medicine calibrating research institute of state)；The Fructus Aurantii medicinal material place of production：The western Yongkang in Shapingba District, Chongqing City occupies 7 groups of west city, Jiangxi Province Yichuan camphor tree
Set city, Chongqing Tongliang County.
(1) foundation of analysis method
Embodiment 1
Rue aurantiin, aurantiin, aurantiamarin, neohesperidin content in Fructus Aurantii are determined using HPLC methods.
The preparation of need testing solution：Fructus Aurantii Praeparata powder (crossing No. 2 sieves) 0.5g is weighed, it is accurately weighed, put 100mL round bottoms burning
In bottle, precision adds methanol 50mL, weighed weight, is heated to reflux 1.5h (75 DEG C), lets cool, weighed weight, supplied and subtracted with methanol
The weight of mistake, shakes up, and filters into 50mL volumetric flasks, 0.22 μm of filter membrane filtration, takes subsequent filtrate, produces.
The preparation of reference substance solution：Rue aurantiin, aurantiin, aurantiamarin, appropriate neohesperidin are taken respectively, and precision claims
It is fixed, in 10mL measuring bottles, add methanol to dissolve and be diluted to scale, every 1mL aurantiins containing rue 0.283mg/mL, aurantiin is made
1.074mg/mL, aurantiamarin 0.210mg/mL, neohesperidin 1.001mg/mL, are produced.
Chromatographic condition：Chromatographic column：WelchC18 (250 × 4.6mm, 5 μm), mobile phase are acetonitrile (A)：
0.1% phosphoric acid (B)=16：84 isocratic elutions, volume flow 1.0mL/min, Detection wavelength 283nm, the μ L of sample size 10, post
25 DEG C of temperature.
The selection of mobile phase：Acetonitrile (A)：0.1% phosphoric acid (B)
Calculation
Reference substance concentration is CMark, peak area AMark, sample concentration CSample, peak area ASample, sample weighting amount m, moisture a, sample
Product content W (mg/g).
W=AMark*CMark/CMark*50/m/(1-a)
(2) preparation of Fructus Aurantii Praeparata
Embodiment 2
Fructus Aurantii medicinal material quality is hard, for the ease of cutting, it is necessary to the profit system of progress.Clean Fructus Aurantii 5kg is taken, puts demulcen respectively
In machine, pumpdown time 6min, made 20 minutes after 30 DEG C, 45 DEG C, 50 DEG C, 60 DEG C of profits, shave (2mm), 55 DEG C of air blast are done
When dry 2, weed out it is broken fall flesh core, produce different temperatures profit system medicine materical crude slice.Various kinds is determined using the analysis method of embodiment 1 respectively
The content of rue aurantiin, aurantiin, aurantiamarin, neohesperidin, as a result see the table below 1 in product.
The different infiltration temperature Fructus Aurantii Praeparata Contents of Main Components of table 1 compare (mg.g-1)
| Infiltration temperature | Rue aurantiin | Aurantiin | Aurantiamarin | Neohesperidin | Component content summation can be surveyed |
| 30℃ | 3.1943 | 59.6967 | 2.7001 | 56.6108 | 122.2020 |
| 45℃ | 3.4375 | 65.7805 | 2.8702 | 58.3615 | 130.4497 |
| 50℃ | 3.6803 | 67.6223 | 3.0803 | 60.1206 | 134.5035 |
| 60℃ | 3.5381 | 63.9801 | 2.6100 | 58.0302 | 128.1584 |
As can be seen from Table 1, when infiltrating 20min for 30 DEG C, Fructus Aurantii medicinal material is harder, and pinching medicinal material to centre along edge can not
Bending, nonelastic, cutting process is slow, cutting process fragment and more in flakes；During 45 DEG C of infiltrations, medicinal material is pinched not along edge to centre
It can bend, it is nonelastic, but medicinal material cutting is smooth, and less with fragment in flakes, piece shape is good；When with 50 DEG C of infiltration 20min, Fructus Aurantii medicine
Material is softer, and being pinched along edge to centre to bend, and flexible, cutting is smooth, and in flakes and fragment is few, and piece type is good；Infiltrated when with 60 DEG C
During 20min, Fructus Aurantii medicinal material is softer, and being pinched along edge to centre to bend, and flexible, cutting is smooth, and in flakes and fragment is few, piece type
It is good, but Contents of Main Components has declined.With reference to the assay result of the main component at a temperature of each profit system, with 45 DEG C -50
DEG C effect of impregnation is preferable.
Embodiment 3
Clean Fructus Aurantii 5kg is taken, 45 DEG C of profit 20min processed in medicine processing device is put, is cut into the thick piece of 1mm, 1.5mm, 2mm respectively,
55 DEG C of forced air dryings 2 hours, are produced.Determine main component rue aurantiin, aurantiin, aurantiamarin, neohesperidin in each sample
Content, as a result see the table below 2.
The different slice thickness Contents of Main Components of table 2 compare (mg.g-1)
| Slice thickness | Rue aurantiin | Aurantiin | Aurantiamarin | Neohesperidin | General flavone |
| 1mm | 3.2111 | 61.4133 | 2.4431 | 56.4902 | 123.5577 |
| 1.5mm | 3.2429 | 61.0987 | 2.5003 | 55.9063 | 122.7483 |
| 2mm | 3.5331 | 65.5954 | 2.5624 | 58.6750 | 130.3659 |
It can be seen that from upper table 2, when slice thickness is 2mm, the content of each principle active component is higher.
Embodiment 4
Clean Fructus Aurantii 5kg is taken, puts in medicine processing device 45 DEG C, 50 DEG C of profit systems 10,20,30min, 40min, respectively shave
(2mm), 55 DEG C of forced air dryings 2 hours, is produced.Determine main component rue aurantiin in each sample, aurantiin, aurantiamarin, new
The content of aurantiamarin, as a result see the table below 3.
The different infiltrating time Fructus Aurantii Praeparata Contents of Main Components of table 3 compare (mg.g-1)
| Infiltrating time | Rue aurantiin | Aurantiin | Aurantiamarin | Neohesperidin | General flavone |
| 45℃20min | 3.5331 | 65.5954 | 2.5624 | 58.6750 | 130.3659 |
| 45℃30min | 3.4471 | 60.3683 | 2.6438 | 54.7277 | 121.1870 |
| 45℃40min | 3.4941 | 63.4259 | 2.7450 | 58.0993 | 127.7643 |
| 50℃20min | 3.6803 | 67.6223 | 3.0803 | 60.1206 | 134.5035 |
| 50℃30min | 3.3951 | 61.8018 | 2.7695 | 56.7162 | 124.6826 |
| 50℃40min | 3.9247 | 68.2544 | 2.8276 | 61.3881 | 136.3948 |
As can be seen from Table 3, infiltrated 20 minutes and 40 minutes with 50 DEG C, the content of each main component is higher, to save
Time and cutting process, infiltrate 20 minutes preferably with 50 DEG C.
Embodiment 5
Clean Fructus Aurantii 5kg is taken, 50 DEG C of profits in medicine processing device is put and makes 20 minutes, 2mm thin slices are cut, respectively at different temperatures air blast
2h is dried, is produced.Main component rue aurantiin, aurantiin, aurantiamarin, the content of neohesperidin in each sample are determined, as a result
It see the table below 4.
The different drying temperature Fructus Aurantii Praeparata Contents of Main Components of table 4 compare (mg.g-1)
| Drying temperature DEG C | Rue aurantiin | Aurantiin | Aurantiamarin | Neohesperidin | General flavone |
| 45-50 | 3.8111 | 62.7164 | 3.4479 | 53.7481 | 123.7235 |
| 55-60 | 3.3720 | 54.4745 | 3.2209 | 50.2485 | 111.3158 |
| 65-70 | 3.5916 | 58.5954 | 3.3344 | 51.9983 | 117.5197 |
As can be seen from Table 4, it is higher with 2 hours contents of 45-50 DEG C of forced air drying.
Embodiment 6
Clean Fructus Aurantii 5kg is taken, 50 DEG C of profits in medicine processing device is put and makes 20 minutes, 2mm thin slices are cut, respectively at 45-50 DEG C of air blast
2h, 4h, 6h are dried, is produced.Main component rue aurantiin, aurantiin, aurantiamarin, neohesperidin contain in measure each sample
Amount, as a result see the table below 5.
The different drying time Fructus Aurantii Praeparata Contents of Main Components of table 5 compare (mg.g-1)
| Drying time | Rue aurantiin | Aurantiin | Aurantiamarin | Neohesperidin | General flavone |
| 2h | 3.8111 | 62.7164 | 3.4479 | 53.7481 | 123.7235 |
| 4h | 4.4781 | 68.7122 | 3.3968 | 56.0966 | 132.6837 |
| 6h | 3.3981 | 55.7036 | 3.0160 | 50.1760 | 112.2937 |
As can be seen from Table 5, higher with 4 hours contents of 45-50 DEG C of forced air drying, moisture also complies with regulation.
(3) stir-baked FRUCTUS AURANTII in bran medicine materical crude slice
Embodiment 7
By machine for stir-frying Chinese medicine be heated to temperature for 140-160 DEG C when, add the wheat bran of different moisture content and granularity, add Fructus Aurantii drink
Piece (takes clean Fructus Aurantii, 50 DEG C of profit systems 20 minutes, are 2mm with section machine-cut thickness in the rearmounted medicine processing devices of pumpdown time 6min
Thick thin slice, 45-50 DEG C of forced air drying 4h, weed out it is broken fall flesh core, obtain Fructus Aurantii Praeparata) 5Kg, stir rapidly, fry 3min extremely
When surface is in yellow or buff, takes out, weed out wheat bran, cool.Determine main component rue aurantiin, shaddock ped in each sample
Glycosides, aurantiamarin, the content of neohesperidin, as a result see the table below 6.
The Fructus Aurantii Contents of Main Components of the wheat bran frying of the different moisture content of table 6 and granularity compares (mg.g-1)
As can be seen from Table 6, wheat bran flavones ingredient content after 105 DEG C are baked decreases, and different-grain diameter
Wheat bran is on flavones content without influence.
Embodiment 8
Machine for stir-frying Chinese medicine is heated to temperature as 140-160 DEG C, adds wheat bran medicinal material 1：10 wheat bran, add Fructus Aurantii piece and (take and wash
Net Fructus Aurantii, 50 DEG C of profit systems 20 minutes in the rearmounted medicine processing devices of pumpdown time 6min, it is thick thin of 2mm with section machine-cut thickness
Piece, 45-50 DEG C of forced air drying 4h, weed out it is broken fall flesh core, obtain Fructus Aurantii Praeparata) 5Kg, stir rapidly, respectively frying difference when
Between, take out, weed out wheat bran, cool.Determine main component rue aurantiin, aurantiin, aurantiamarin, neohesperidin in each sample
Content, it as a result see the table below 7.
The Fructus Aurantii Contents of Main Components of the different frying times of table 7 compares (mg.g-1)
As can be seen from Table 7, when frying temperature is 140-160 DEG C, wheat bran medicinal material ratio is 1：When 10, general flavone contains
It is to be reduced with the extension of frying time, with frying 3min general flavone content highests, and when frying was by 7 minutes, medicine materical crude slice is
Start focal spot occur.
Embodiment 9
Machine for stir-frying Chinese medicine is heated to temperature as 140-160 DEG C, add different wheat bran medicinal materials than wheat bran, add Fructus Aurantii piece and (take
Clean Fructus Aurantii, 50 DEG C of profit systems 20 minutes in the rearmounted medicine processing devices of pumpdown time 6min, it is thick thin of 2mm with section machine-cut thickness
Piece, 45-50 DEG C of forced air drying 4h, weed out it is broken fall flesh core, obtain Fructus Aurantii Praeparata) 5Kg, stir rapidly, respectively frying 3 minutes, 4
Minute, take out, weed out wheat bran, cool.Content is determined, as a result see the table below 8.
The different wheat bran medicinal materials of table 8 compare (mg.g than the Fructus Aurantii Contents of Main Components of frying-1)
As can be seen from Table 8, when wheat bran medicinal material ratio respectively 1：10、1.25：10、1.5：When 10, frying 3-4 minutes
When, the content of general flavone is with 1：10 highests, with increasing for amount of wheat bran, general flavone content has downward trend.
Embodiment 10
140-160 DEG C, 160-180 DEG C, 180-200 DEG C, 200-220 DEG C of different frying temperature have been investigated in experiment, have been tied
Fruit when temperature be higher than 160 DEG C after, Fructus Aurantii Praeparata will soon stir-bake to brown, the time is too short, is unfavorable for operating, thus select frying temperature for
140-160 DEG C is preferred.
In summary, the processing procedure of stir-baked FRUCTUS AURANTII in bran is that machine for stir-frying Chinese medicine is heated into 140-160 DEG C, is sprinkled into wheat bran, bran immediately
Skin dosage is the 1/10 of medicinal material amount, adds net Fructus Aurantii Praeparata, frying 3 minutes, takes out immediately, is sieved, and weeds out wheat bran and comes off
Fruit stone, put and dry in the air, pack, produce.
Claims (10)
1. a kind of concocting method of Fructus Aurantii, it is characterised in that comprise the following steps：Fructus Aurantii is cleaned, is placed in medicine processing device, is taken out true
Sky, 10~40min are made in 30~60 DEG C of profits, the thin slice for being 1~2mm with section machine-cut thickness, 45~70 DEG C of forced air dryings 2~
6h, weed out it is broken fall flesh core, obtain Fructus Aurantii Praeparata；By machine for stir-frying Chinese medicine be heated to temperature for 140-220 DEG C when, add wheat bran, add
The mass ratio of Fructus Aurantii Praeparata, amount of wheat bran and Fructus Aurantii Praeparata dosage is 1~1.5：10,3~7min of frying, take out, weed out wheat bran,
Cool and produce.
2. concocting method as claimed in claim 1, it is characterised in that comprise the following steps：Clean Fructus Aurantii is taken, is placed in demulcen
In machine, pumpdown time 6min makes 20 minutes after 30~60 DEG C of profits, the thin slice for being 2mm with section machine-cut thickness, 55 DEG C of air blast
Dry 2 when, weed out it is broken fall flesh core, obtain Fructus Aurantii Praeparata；By machine for stir-frying Chinese medicine be heated to temperature for 140-220 DEG C when, add wheat bran,
The mass ratio of addition Fructus Aurantii Praeparata, amount of wheat bran and Fructus Aurantii Praeparata dosage is 1~1.5：10,3~7min of frying, take out, weed out
Wheat bran, cool and produce.
3. concocting method as claimed in claim 1, it is characterised in that comprise the following steps：Clean Fructus Aurantii is taken, is placed in demulcen
In machine, pumpdown time 6min is after 45 DEG C of profit 20min processed, with the thin slice that section machine-cut thickness is 1~2mm thickness, 55 DEG C of air blast
Dry 2 hours, weed out it is broken fall flesh core, obtain Fructus Aurantii Praeparata；By machine for stir-frying Chinese medicine be heated to temperature for 140-220 DEG C when, add bran
The mass ratio of skin, addition Fructus Aurantii Praeparata, amount of wheat bran and Fructus Aurantii Praeparata dosage is 1~1.5：10,3~7min of frying, take out, sieve
Wheat bran is removed, cools and produces.
4. concocting method as claimed in claim 1, it is characterised in that comprise the following steps：Clean Fructus Aurantii is taken, when vacuumizing
Between 45 DEG C~50 DEG C profit 10~40min of system in medicine processing device are placed in after 6min, be the thick thin slices of 2mm with section machine-cut thickness, 55 DEG C
Forced air drying 2 hours, weed out it is broken fall flesh core, obtain Fructus Aurantii Praeparata；By machine for stir-frying Chinese medicine be heated to temperature for 140-220 DEG C when, add
Enter wheat bran, add Fructus Aurantii Praeparata, the mass ratio of amount of wheat bran and Fructus Aurantii Praeparata dosage is 1~1.5：10,3~7min of frying, take
Go out, weed out wheat bran, cool and produce.
5. concocting method as claimed in claim 1, it is characterised in that comprise the following steps：Clean Fructus Aurantii is taken, when vacuumizing
Between 50 DEG C of profit systems are placed in medicine processing device after 6min 20 minutes, be the thick thin slices of 2mm with section machine-cut thickness, 45~70 DEG C of air blast are done
Dry 2 hours, weed out it is broken fall flesh core, obtain Fructus Aurantii Praeparata；By machine for stir-frying Chinese medicine be heated to temperature for 140-220 DEG C when, add wheat bran,
The mass ratio of addition Fructus Aurantii Praeparata, amount of wheat bran and Fructus Aurantii Praeparata dosage is 1~1.5：10,3~7min of frying, take out, weed out
Wheat bran, cool and produce.
6. concocting method as claimed in claim 1, it is characterised in that comprise the following steps：Clean Fructus Aurantii is taken, when vacuumizing
Between 50 DEG C of profit systems 20 minutes in the rearmounted medicine processing devices of 6min, be the thick thin slices of 2mm with section machine-cut thickness, 45-50 DEG C of forced air drying
4h, weed out it is broken fall flesh core, obtain Fructus Aurantii Praeparata；By machine for stir-frying Chinese medicine be heated to temperature for 140-220 DEG C when, add wheat bran, add
The mass ratio of Fructus Aurantii Praeparata, amount of wheat bran and Fructus Aurantii Praeparata dosage is 1~1.5：10,3~7min of frying, take out, weed out wheat bran,
Cool and produce.
7. concocting method as claimed in claim 1, it is characterised in that comprise the following steps：Clean Fructus Aurantii is taken, is placed in demulcen
In machine, pumpdown time 6min makes 20 minutes after 30~60 DEG C of profits, the thin slice for being 2mm with section machine-cut thickness, 55 DEG C of air blast
Dry 2 when, weed out it is broken fall flesh core, obtain Fructus Aurantii Praeparata；By machine for stir-frying Chinese medicine be heated to temperature for 140-160 DEG C when, add wheat bran,
The mass ratio of addition Fructus Aurantii Praeparata, amount of wheat bran and Fructus Aurantii Praeparata dosage is 1~1.5：10,3~4min of frying, take out, weed out
Wheat bran, cool and produce.
8. concocting method as claimed in claim 1, it is characterised in that comprise the following steps：Clean Fructus Aurantii is taken, is placed in demulcen
In machine, pumpdown time 6min is after 45 DEG C of profit 20min processed, with the thin slice that section machine-cut thickness is 1~2mm thickness, 55 DEG C of air blast
Dry 2 hours, weed out it is broken fall flesh core, obtain Fructus Aurantii Praeparata；By machine for stir-frying Chinese medicine be heated to temperature for 140-160 DEG C when, add bran
The mass ratio of skin, addition Fructus Aurantii Praeparata, amount of wheat bran and Fructus Aurantii Praeparata dosage is 1~1.5：10,3~4min of frying, take out, sieve
Wheat bran is removed, cools and produces.
9. concocting method as claimed in claim 1, it is characterised in that comprise the following steps：Clean Fructus Aurantii is taken, when vacuumizing
Between 45 DEG C~50 DEG C profit 10~40min of system in medicine processing device are placed in after 6min, be the thick thin slices of 2mm with section machine-cut thickness, 55 DEG C
Forced air drying 2 hours, weed out it is broken fall flesh core, obtain Fructus Aurantii Praeparata；By machine for stir-frying Chinese medicine be heated to temperature for 140-160 DEG C when, add
Enter wheat bran, add Fructus Aurantii Praeparata, the mass ratio of amount of wheat bran and Fructus Aurantii Praeparata dosage is 1~1.5：10,3~4min of frying, take
Go out, weed out wheat bran, cool and produce.
10. concocting method as claimed in claim 1, it is characterised in that comprise the following steps：Clean Fructus Aurantii is taken, is vacuumized
50 DEG C of profits are made 20 minutes in the rearmounted medicine processing devices of time 6min, are the thick thin slices of 2mm with section machine-cut thickness, and 45-50 DEG C of air blast is done
Dry 4h, weed out it is broken fall flesh core, obtain Fructus Aurantii Praeparata；By machine for stir-frying Chinese medicine be heated to temperature for 140-160 DEG C when, add wheat bran, add
Enter Fructus Aurantii Praeparata, the mass ratio of amount of wheat bran and Fructus Aurantii Praeparata dosage is 1~1.5：10,3~4min of frying, take out, weed out bran
Skin, cool and produce.
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| CN108498609A (en) * | 2018-04-26 | 2018-09-07 | 安徽亿源药业股份有限公司 | A kind of concocting method of Fructus Aurantii Praeparata |
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| US20080182772A1 (en) * | 2007-01-30 | 2008-07-31 | Noel Marie Hill | Natural cleaning solution adapted for use with baby products |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108379511A (en) * | 2018-04-24 | 2018-08-10 | 烟台金蕊女性用品有限公司 | A kind of preparation process of Chinese medicine application cream that alleviating menalgia |
| CN108498609A (en) * | 2018-04-26 | 2018-09-07 | 安徽亿源药业股份有限公司 | A kind of concocting method of Fructus Aurantii Praeparata |
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